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Found 2 Enz. Inhib. hit(s) with Target = 'Prostaglandin E synthase' and Monomerid = 50302404
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50302404(6-bromo-2-(2-chloro-6-fluorophenyl)-9-isopropyl-1H...)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]PGH2 from human recombinant PGES1 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50302404(6-bromo-2-(2-chloro-6-fluorophenyl)-9-isopropyl-1H...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cells assessed as blockade of PGH2 to PGE2 conversion in presence of 50% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed