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Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Hepatocyte growth factor receptor' and Monomerid = 50306505   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50306505
PNG
(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(CC(=O)Nc4ccc(F)cc4)C(F)(F)F)cc3F)c2s1
Show InChI InChI=1S/C27H20F5N5O2S/c1-37-13-20(34-14-37)23-11-19-26(40-23)22(8-9-33-19)39-21-7-6-17(10-18(21)29)35-24(27(30,31)32)12-25(38)36-16-4-2-15(28)3-5-16/h2-11,13-14,24,35H,12H2,1H3,(H,36,38)
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PC sid
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Article
PubMed
n/an/a 90n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-fused c-Met expressed in baculovirus infected high five cells by DELFIA


Bioorg Med Chem Lett 20: 848-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.099
BindingDB Entry DOI: 10.7270/Q2XW4JWR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50306505
PNG
(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(CC(=O)Nc4ccc(F)cc4)C(F)(F)F)cc3F)c2s1
Show InChI InChI=1S/C27H20F5N5O2S/c1-37-13-20(34-14-37)23-11-19-26(40-23)22(8-9-33-19)39-21-7-6-17(10-18(21)29)35-24(27(30,31)32)12-25(38)36-16-4-2-15(28)3-5-16/h2-11,13-14,24,35H,12H2,1H3,(H,36,38)
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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 370n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of TPR-fused Met autophosphorylation expressed in HEK293T cells after 150 mins by ELISA


Bioorg Med Chem Lett 20: 848-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.099
BindingDB Entry DOI: 10.7270/Q2XW4JWR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50306505
PNG
(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(CC(=O)Nc4ccc(F)cc4)C(F)(F)F)cc3F)c2s1
Show InChI InChI=1S/C27H20F5N5O2S/c1-37-13-20(34-14-37)23-11-19-26(40-23)22(8-9-33-19)39-21-7-6-17(10-18(21)29)35-24(27(30,31)32)12-25(38)36-16-4-2-15(28)3-5-16/h2-11,13-14,24,35H,12H2,1H3,(H,36,38)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 400n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of c-MET in human DU145 cells by scattering assay


Bioorg Med Chem Lett 20: 848-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.099
BindingDB Entry DOI: 10.7270/Q2XW4JWR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50306505
PNG
(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(CC(=O)Nc4ccc(F)cc4)C(F)(F)F)cc3F)c2s1
Show InChI InChI=1S/C27H20F5N5O2S/c1-37-13-20(34-14-37)23-11-19-26(40-23)22(8-9-33-19)39-21-7-6-17(10-18(21)29)35-24(27(30,31)32)12-25(38)36-16-4-2-15(28)3-5-16/h2-11,13-14,24,35H,12H2,1H3,(H,36,38)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 400n/an/an/an/an/an/a



MethylGene Inc

Curated by ChEMBL


Assay Description
Inhibition of c-MET in human A549 cells by wound healing assay


Bioorg Med Chem Lett 20: 848-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.099
BindingDB Entry DOI: 10.7270/Q2XW4JWR
More data for this
Ligand-Target Pair