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Compile Data Set for Download or QSAR

Found 7 hits Enz. Inhib. hit(s) with Target = 'Hepatocyte growth factor receptor' and Monomerid = 50317323   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317323
PNG
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39)
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PubMed
n/an/a 12n/an/an/an/an/an/a



Laboratoires ChemRF Inc. / ChemRF Laboratories Inc.

Curated by ChEMBL


Assay Description
Inhibition of human c-Met


Bioorg Med Chem Lett 25: 3706-10 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.034
BindingDB Entry DOI: 10.7270/Q2SJ1NDW
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317323
PNG
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39)
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Article
PubMed
n/an/a 150n/an/an/an/an/an/a



MethylGene Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 20: 2745-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.073
BindingDB Entry DOI: 10.7270/Q24T6JJ6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317323
PNG
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39)
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Article
PubMed
n/an/a 400n/an/an/an/an/an/a



MethylGene Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met-mediated cell migration of human A549 cells by would healing


Bioorg Med Chem Lett 20: 2745-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.073
BindingDB Entry DOI: 10.7270/Q24T6JJ6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317323
PNG
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39)
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Article
PubMed
n/an/a 500n/an/an/an/an/an/a



MethylGene Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human MKN45 cells


Bioorg Med Chem Lett 20: 2745-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.073
BindingDB Entry DOI: 10.7270/Q24T6JJ6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317323
PNG
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39)
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Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



MethylGene Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met-mediated scattering in HGF-stimulated human DU145 cells


Bioorg Med Chem Lett 20: 2745-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.073
BindingDB Entry DOI: 10.7270/Q24T6JJ6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317323
PNG
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39)
PDB
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KEGG

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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 6.87E+3n/an/an/an/an/an/a



Laboratoires ChemRF Inc./ChemRF Laboratories Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human MKN45 cells


Bioorg Med Chem Lett 25: 3810-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.080
BindingDB Entry DOI: 10.7270/Q2028T99
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317323
PNG
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 6.87E+3n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of phosphorylation of c-Met in human MKN45 cells


Bioorg Med Chem Lett 25: 2527-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR
More data for this
Ligand-Target Pair