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Found 26 Enz. Inhib. hit(s) with Target = 'Cathepsin D' and Monomerid = 912
TargetCathepsin D(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity against human cathepsin DChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Bos taurus)
TBA

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of cathepsin D.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50: 00.0500nMAssay Description:Inhibition of human cathepsin D using GKPILFFRLK(DNP)-D-RNH2) labeled MCA as substrate preincubated for 10 mins followed by substrate addition measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of secreted cathepsin D in human MDA-MB-231 cells using Mca-Gly-Lys-Pro-Ile-Leu-PhePhe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate pretreated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  0.173nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of human liver cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-PhePhe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate pretreated for 15 mins followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of human liver cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate preincubated for 15 mins followe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of human placenta CatD using Abz-Lys-Pro-Ala-Glu-Phe-Nph-Ala-Leu as substrate preincubated for 10 mins followed by substrate addition and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  0.550nMAssay Description:Inhibition of human cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  0.693nMAssay Description:Inhibition of cathepsin D by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  0.693nMAssay Description:Inhibition of recombinant human liver Cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate incubated for 120 mi...More data for this Ligand-Target Pair
In DepthDetails PubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50: <1nMAssay Description:Inhibition of Cathepsin D (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50: <1nMAssay Description:Inhibition of cathepsin D (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against human liver Cathepsin D using Cathepsin D assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  2.33nMAssay Description:Inhibition of cathepsin D (unknown origin) using hemoglobin as substrate after 30 min by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticleMMDB

TargetCathepsin D(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  5nMAssay Description:Inhibition of cathepsin D in human MCF7 cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Bos taurus)
TBA

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  10nMAssay Description:Tested for inhibition of Cathepsin D from bovineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Bos taurus)
TBA

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  28nMAssay Description:Inhibition of bovine cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Bos taurus)
TBA

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  28nMAssay Description:Compound was tested for inhibition of bovine cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Bos taurus)
TBA

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  28nMAssay Description:Inhibitory activity was evaluated against bovine cathepsin D (sigma)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  100nMAssay Description:Inhibition of cathepsin D in human MDA-MB-231 cells using Mca-Gly-Lys-Pro-Ile-Leu-PhePhe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate pretreated for 4 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of cathepsin D in human MDA-MB-231 cells using Mca-Gly-Lys-Pro-Ile-Leu-PhePhe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate pretreated for 4 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of cathepsin D in human MCF7 cells treated for 1 hr measured after washout and trypsin treatment by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human liver cathepsin D after 30 mins by fluorometric end-point assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Homo sapiens (Human))
University Of Queensland

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataKd:  0.00371nMAssay Description:Binding affinity against Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB