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Compile Data Set for Download or QSAR

Found 38 hits with Last Name = 'baber' and Initial = 'g'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31183
PNG
(thiazol-2-amine, 14)
Show SMILES Nc1nc(cs1)-c1ccccc1Cl
Show InChI InChI=1S/C9H7ClN2S/c10-7-4-2-1-3-6(7)8-5-13-9(11)12-8/h1-5H,(H2,11,12)
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n/an/a 700n/an/an/an/an/an/a



University of Virginia at Charlottesville



Assay Description
His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31183
PNG
(thiazol-2-amine, 14)
Show SMILES Nc1nc(cs1)-c1ccccc1Cl
Show InChI InChI=1S/C9H7ClN2S/c10-7-4-2-1-3-6(7)8-5-13-9(11)12-8/h1-5H,(H2,11,12)
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n/an/a 1.10E+3n/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31175
PNG
(thiazol-2-amine, 5)
Show SMILES Nc1nc(cs1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C10H7F3N2S/c11-10(12,13)7-3-1-6(2-4-7)8-5-16-9(14)15-8/h1-5H,(H2,14,15)
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n/an/a 3.00E+3n/an/an/an/an/an/a



University of Virginia at Charlottesville



Assay Description
His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31186
PNG
(thiazol-2-amine, 18)
Show SMILES CCCc1sc(N)nc1-c1ccc(OC)cc1
Show InChI InChI=1S/C13H16N2OS/c1-3-4-11-12(15-13(14)17-11)9-5-7-10(16-2)8-6-9/h5-8H,3-4H2,1-2H3,(H2,14,15)
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n/an/a 3.20E+3n/an/an/an/an/an/a



University of Virginia at Charlottesville



Assay Description
His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31185
PNG
(thiazol-2-amine, 17)
Show SMILES CCc1sc(N)nc1-c1ccc(OC)cc1
Show InChI InChI=1S/C12H14N2OS/c1-3-10-11(14-12(13)16-10)8-4-6-9(15-2)7-5-8/h4-7H,3H2,1-2H3,(H2,13,14)
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n/an/a 3.20E+3n/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31182
PNG
(thiazol-2-amine, 13)
Show SMILES Cc1ccccc1-c1csc(N)n1
Show InChI InChI=1S/C10H10N2S/c1-7-4-2-3-5-8(7)9-6-13-10(11)12-9/h2-6H,1H3,(H2,11,12)
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n/an/a 3.30E+3n/an/an/an/an/an/a



University of Virginia at Charlottesville



Assay Description
His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31185
PNG
(thiazol-2-amine, 17)
Show SMILES CCc1sc(N)nc1-c1ccc(OC)cc1
Show InChI InChI=1S/C12H14N2OS/c1-3-10-11(14-12(13)16-10)8-4-6-9(15-2)7-5-8/h4-7H,3H2,1-2H3,(H2,13,14)
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n/an/a 3.50E+3n/an/an/an/an/an/a



University of Virginia at Charlottesville



Assay Description
His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31182
PNG
(thiazol-2-amine, 13)
Show SMILES Cc1ccccc1-c1csc(N)n1
Show InChI InChI=1S/C10H10N2S/c1-7-4-2-3-5-8(7)9-6-13-10(11)12-9/h2-6H,1H3,(H2,11,12)
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n/an/a 5.00E+3n/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31178
PNG
(thiazol-2-amine, 8)
Show SMILES Nc1nc(cs1)-c1ccc2OCOc2c1
Show InChI InChI=1S/C10H8N2O2S/c11-10-12-7(4-15-10)6-1-2-8-9(3-6)14-5-13-8/h1-4H,5H2,(H2,11,12)
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n/an/a 6.50E+3n/an/an/an/an/an/a



University of Virginia at Charlottesville



Assay Description
His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31179
PNG
(thiazol-2-amine, 9)
Show SMILES Nc1nc(cs1)-c1cccc(Cl)c1
Show InChI InChI=1S/C9H7ClN2S/c10-7-3-1-2-6(4-7)8-5-13-9(11)12-8/h1-5H,(H2,11,12)
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n/an/a 6.50E+3n/an/an/an/an/an/a



University of Virginia at Charlottesville



Assay Description
His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31175
PNG
(thiazol-2-amine, 5)
Show SMILES Nc1nc(cs1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C10H7F3N2S/c11-10(12,13)7-3-1-6(2-4-7)8-5-16-9(14)15-8/h1-5H,(H2,14,15)
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n/an/a 9.00E+3n/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31178
PNG
(thiazol-2-amine, 8)
Show SMILES Nc1nc(cs1)-c1ccc2OCOc2c1
Show InChI InChI=1S/C10H8N2O2S/c11-10-12-7(4-15-10)6-1-2-8-9(3-6)14-5-13-8/h1-4H,5H2,(H2,11,12)
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n/an/a 9.00E+3n/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31179
PNG
(thiazol-2-amine, 9)
Show SMILES Nc1nc(cs1)-c1cccc(Cl)c1
Show InChI InChI=1S/C9H7ClN2S/c10-7-3-1-2-6(4-7)8-5-13-9(11)12-8/h1-5H,(H2,11,12)
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n/an/a 1.20E+4n/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31176
PNG
(thiazol-2-amine, 6)
Show SMILES COc1ccc(cc1)-c1csc(N)n1
Show InChI InChI=1S/C10H10N2OS/c1-13-8-4-2-7(3-5-8)9-6-14-10(11)12-9/h2-6H,1H3,(H2,11,12)
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n/an/a 1.20E+4n/an/an/an/an/an/a



University of Virginia at Charlottesville



Assay Description
His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31187
PNG
(thiazol-2-amine, 19)
Show SMILES CCc1sc(N)nc1-c1cccc(C)c1
Show InChI InChI=1S/C12H14N2S/c1-3-10-11(14-12(13)15-10)9-6-4-5-8(2)7-9/h4-7H,3H2,1-2H3,(H2,13,14)
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n/an/a 1.65E+4n/an/an/an/an/an/a



University of Virginia at Charlottesville



Assay Description
His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31188
PNG
(thiazol-2-amine, 20)
Show SMILES CCc1sc(N)nc1-c1ccccc1OC
Show InChI InChI=1S/C12H14N2OS/c1-3-10-11(14-12(13)16-10)8-6-4-5-7-9(8)15-2/h4-7H,3H2,1-2H3,(H2,13,14)
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n/an/a 1.70E+4n/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31177
PNG
(thiazol-2-amine, 7)
Show SMILES COc1ccc(cc1OC)-c1csc(N)n1
Show InChI InChI=1S/C11H12N2O2S/c1-14-9-4-3-7(5-10(9)15-2)8-6-16-11(12)13-8/h3-6H,1-2H3,(H2,12,13)
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n/an/a 1.80E+4n/an/an/an/an/an/a



University of Virginia at Charlottesville



Assay Description
His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31188
PNG
(thiazol-2-amine, 20)
Show SMILES CCc1sc(N)nc1-c1ccccc1OC
Show InChI InChI=1S/C12H14N2OS/c1-3-10-11(14-12(13)16-10)8-6-4-5-7-9(8)15-2/h4-7H,3H2,1-2H3,(H2,13,14)
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n/an/a 1.80E+4n/an/an/an/an/an/a



University of Virginia at Charlottesville



Assay Description
His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31176
PNG
(thiazol-2-amine, 6)
Show SMILES COc1ccc(cc1)-c1csc(N)n1
Show InChI InChI=1S/C10H10N2OS/c1-13-8-4-2-7(3-5-8)9-6-14-10(11)12-9/h2-6H,1H3,(H2,11,12)
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n/an/a 1.85E+4n/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31184
PNG
(thiazol-2-amine, 16)
Show SMILES Nc1nc(cs1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C9H6Cl2N2S/c10-5-1-2-6(7(11)3-5)8-4-14-9(12)13-8/h1-4H,(H2,12,13)
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n/an/a 2.05E+4n/an/an/an/an/an/a



University of Virginia at Charlottesville



Assay Description
His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31181
PNG
(thiazol-2-amine, 11)
Show SMILES COc1cccc(c1)-c1csc(N)n1
Show InChI InChI=1S/C10H10N2OS/c1-13-8-4-2-3-7(5-8)9-6-14-10(11)12-9/h2-6H,1H3,(H2,11,12)
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n/an/a 2.25E+4n/an/an/an/an/an/a



University of Virginia at Charlottesville



Assay Description
His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31186
PNG
(thiazol-2-amine, 18)
Show SMILES CCCc1sc(N)nc1-c1ccc(OC)cc1
Show InChI InChI=1S/C13H16N2OS/c1-3-4-11-12(15-13(14)17-11)9-5-7-10(16-2)8-6-9/h5-8H,3-4H2,1-2H3,(H2,14,15)
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n/an/a 2.35E+4n/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31180
PNG
(thiazol-2-amine, 10)
Show SMILES Cc1cccc(c1)-c1csc(N)n1
Show InChI InChI=1S/C10H10N2S/c1-7-3-2-4-8(5-7)9-6-13-10(11)12-9/h2-6H,1H3,(H2,11,12)
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n/an/a 3.60E+4n/an/an/an/an/an/a



University of Virginia at Charlottesville



Assay Description
His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31177
PNG
(thiazol-2-amine, 7)
Show SMILES COc1ccc(cc1OC)-c1csc(N)n1
Show InChI InChI=1S/C11H12N2O2S/c1-14-9-4-3-7(5-10(9)15-2)8-6-16-11(12)13-8/h3-6H,1-2H3,(H2,12,13)
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n/an/a 4.05E+4n/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31184
PNG
(thiazol-2-amine, 16)
Show SMILES Nc1nc(cs1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C9H6Cl2N2S/c10-5-1-2-6(7(11)3-5)8-4-14-9(12)13-8/h1-4H,(H2,12,13)
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n/an/a 4.90E+4n/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31181
PNG
(thiazol-2-amine, 11)
Show SMILES COc1cccc(c1)-c1csc(N)n1
Show InChI InChI=1S/C10H10N2OS/c1-13-8-4-2-3-7(5-8)9-6-14-10(11)12-9/h2-6H,1H3,(H2,11,12)
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n/an/a 6.10E+4n/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31187
PNG
(thiazol-2-amine, 19)
Show SMILES CCc1sc(N)nc1-c1cccc(C)c1
Show InChI InChI=1S/C12H14N2S/c1-3-10-11(14-12(13)15-10)9-6-4-5-8(2)7-9/h4-7H,3H2,1-2H3,(H2,13,14)
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n/an/a 6.60E+4n/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31180
PNG
(thiazol-2-amine, 10)
Show SMILES Cc1cccc(c1)-c1csc(N)n1
Show InChI InChI=1S/C10H10N2S/c1-7-3-2-4-8(5-7)9-6-13-10(11)12-9/h2-6H,1H3,(H2,11,12)
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n/an/a 1.10E+5n/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31189
PNG
(thiazol-2-amine, 21)
Show SMILES CCOc1ccc(cc1)-c1nc(N)sc1CC
Show InChI InChI=1S/C13H16N2OS/c1-3-11-12(15-13(14)17-11)9-5-7-10(8-6-9)16-4-2/h5-8H,3-4H2,1-2H3,(H2,14,15)
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n/an/a>5.00E+5n/an/an/an/an/an/a



University of Virginia at Charlottesville



Assay Description
His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31189
PNG
(thiazol-2-amine, 21)
Show SMILES CCOc1ccc(cc1)-c1nc(N)sc1CC
Show InChI InChI=1S/C13H16N2OS/c1-3-11-12(15-13(14)17-11)9-5-7-10(8-6-9)16-4-2/h5-8H,3-4H2,1-2H3,(H2,14,15)
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n/an/a>5.00E+5n/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31194
PNG
(thiazol-2-amine, 12)
Show SMILES Nc1nc(cs1)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C10H7F3N2OS/c11-10(12,13)16-7-3-1-2-6(4-7)8-5-17-9(14)15-8/h1-5H,(H2,14,15)
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n/an/a>7.00E+5n/an/an/an/an/an/a



University of Virginia at Charlottesville



Assay Description
His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31195
PNG
(thiazol-2-amine, 15)
Show SMILES COc1ccccc1-c1csc(N)n1
Show InChI InChI=1S/C10H10N2OS/c1-13-9-5-3-2-4-7(9)8-6-14-10(11)12-8/h2-6H,1H3,(H2,11,12)
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Virginia at Charlottesville



Assay Description
His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31190
PNG
(thiazol-2-amine, 1)
Show SMILES Nc1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C9H8N2S/c10-9-11-8(6-12-9)7-4-2-1-3-5-7/h1-6H,(H2,10,11)
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n/an/an/an/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31191
PNG
(thiazol-2-amine, 2)
Show SMILES Cc1ccc(cc1)-c1csc(N)n1
Show InChI InChI=1S/C10H10N2S/c1-7-2-4-8(5-3-7)9-6-13-10(11)12-9/h2-6H,1H3,(H2,11,12)
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n/an/an/an/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31192
PNG
(thiazol-2-amine, 3)
Show SMILES Cc1ccc(-c2csc(N)n2)c(C)c1
Show InChI InChI=1S/C11H12N2S/c1-7-3-4-9(8(2)5-7)10-6-14-11(12)13-10/h3-6H,1-2H3,(H2,12,13)
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n/an/an/an/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31195
PNG
(thiazol-2-amine, 15)
Show SMILES COc1ccccc1-c1csc(N)n1
Show InChI InChI=1S/C10H10N2OS/c1-13-9-5-3-2-4-7(9)8-6-14-10(11)12-8/h2-6H,1H3,(H2,11,12)
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n/an/an/an/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31194
PNG
(thiazol-2-amine, 12)
Show SMILES Nc1nc(cs1)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C10H7F3N2OS/c11-10(12,13)16-7-3-1-2-6(4-7)8-5-17-9(14)15-8/h1-5H,(H2,14,15)
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n/an/an/an/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31193
PNG
(thiazol-2-amine, 4)
Show SMILES Nc1nc2c(ccc3ccccc23)s1
Show InChI InChI=1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13)
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n/an/an/an/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair