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Compile Data Set for Download or QSAR

Found 328 hits with Last Name = 'bellamacina' and Initial = 'c'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM106896
PNG
(US8592455, 96)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C23H22F3N5O2/c1-12-10-31(11-16(27)22(12)32)19-7-8-28-9-18(19)30-23(33)17-6-5-15(26)21(29-17)20-13(24)3-2-4-14(20)25/h2-9,12,16,22,32H,10-11,27H2,1H3,(H,30,33)/t12-,16+,22+/m0/s1
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0.00100n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin)


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM106896
PNG
(US8592455, 96)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C23H22F3N5O2/c1-12-10-31(11-16(27)22(12)32)19-7-8-28-9-18(19)30-23(33)17-6-5-15(26)21(29-17)20-13(24)3-2-4-14(20)25/h2-9,12,16,22,32H,10-11,27H2,1H3,(H,30,33)/t12-,16+,22+/m0/s1
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0.00100n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin)


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM106803
PNG
(US8592455, 3)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1nc(c(F)cc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C23H23F3N6O2/c1-11-9-32(10-16(28)22(11)33)18-5-6-29-8-17(18)30-23(34)21-15(27)7-14(26)20(31-21)19-12(24)3-2-4-13(19)25/h2-8,11,16,22,33H,9-10,27-28H2,1H3,(H,30,34)/t11-,16+,22+/m0/s1
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0.00100n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin)


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50445133
PNG
(CHEMBL3103869)
Show SMILES N[C@@H]1CN(CC[C@H]1O)c1ccncc1NC(=O)c1nc(ccc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C22H22F2N6O2/c23-12-2-1-3-13(24)20(12)16-5-4-14(25)21(28-16)22(32)29-17-10-27-8-6-18(17)30-9-7-19(31)15(26)11-30/h1-6,8,10,15,19,31H,7,9,11,25-26H2,(H,29,32)/t15-,19-/m1/s1
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0.00200n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin)


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM106896
PNG
(US8592455, 96)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C23H22F3N5O2/c1-12-10-31(11-16(27)22(12)32)19-7-8-28-9-18(19)30-23(33)17-6-5-15(26)21(29-17)20-13(24)3-2-4-14(20)25/h2-9,12,16,22,32H,10-11,27H2,1H3,(H,30,33)/t12-,16+,22+/m0/s1
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0.00200n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin)


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50445124
PNG
(CHEMBL3103868)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C22H22F2N6O/c23-14-4-1-5-15(24)20(14)17-7-6-16(26)21(28-17)22(31)29-18-11-27-9-8-19(18)30-10-2-3-13(25)12-30/h1,4-9,11,13H,2-3,10,12,25-26H2,(H,29,31)/t13-/m0/s1
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0.00200n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) using Biotin-AGAGRSRHSSYPAGT-OH as substrate after 2 hrs by AlphaScreen assay


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM106803
PNG
(US8592455, 3)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1nc(c(F)cc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C23H23F3N6O2/c1-11-9-32(10-16(28)22(11)33)18-5-6-29-8-17(18)30-23(34)21-15(27)7-14(26)20(31-21)19-12(24)3-2-4-13(19)25/h2-8,11,16,22,33H,9-10,27-28H2,1H3,(H,30,34)/t11-,16+,22+/m0/s1
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0.00200n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin)


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM106803
PNG
(US8592455, 3)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1nc(c(F)cc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C23H23F3N6O2/c1-11-9-32(10-16(28)22(11)33)18-5-6-29-8-17(18)30-23(34)21-15(27)7-14(26)20(31-21)19-12(24)3-2-4-13(19)25/h2-8,11,16,22,33H,9-10,27-28H2,1H3,(H,30,34)/t11-,16+,22+/m0/s1
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0.00300n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin)


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM50445124
PNG
(CHEMBL3103868)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C22H22F2N6O/c23-14-4-1-5-15(24)20(14)17-7-6-16(26)21(28-17)22(31)29-18-11-27-9-8-19(18)30-10-2-3-13(25)12-30/h1,4-9,11,13H,2-3,10,12,25-26H2,(H,29,31)/t13-/m0/s1
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0.00400n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) using Biotin-AGAGRSRHSSYPAGT-OH as substrate after 2 hrs by AlphaScreen assay


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM50445124
PNG
(CHEMBL3103868)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C22H22F2N6O/c23-14-4-1-5-15(24)20(14)17-7-6-16(26)21(28-17)22(31)29-18-11-27-9-8-19(18)30-10-2-3-13(25)12-30/h1,4-9,11,13H,2-3,10,12,25-26H2,(H,29,31)/t13-/m0/s1
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0.00600n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin) using Biotin-AGAGRSRHSSYPAGT-OH as substrate after 2 hrs by AlphaScreen assay


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM50445133
PNG
(CHEMBL3103869)
Show SMILES N[C@@H]1CN(CC[C@H]1O)c1ccncc1NC(=O)c1nc(ccc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C22H22F2N6O2/c23-12-2-1-3-13(24)20(12)16-5-4-14(25)21(28-16)22(32)29-17-10-27-8-6-18(17)30-9-7-19(31)15(26)11-30/h1-6,8,10,15,19,31H,7,9,11,25-26H2,(H,29,32)/t15-,19-/m1/s1
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0.00600n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin)


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM50445133
PNG
(CHEMBL3103869)
Show SMILES N[C@@H]1CN(CC[C@H]1O)c1ccncc1NC(=O)c1nc(ccc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C22H22F2N6O2/c23-12-2-1-3-13(24)20(12)16-5-4-14(25)21(28-16)22(32)29-17-10-27-8-6-18(17)30-9-7-19(31)15(26)11-30/h1-6,8,10,15,19,31H,7,9,11,25-26H2,(H,29,32)/t15-,19-/m1/s1
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0.00700n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin)


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50387298
PNG
(CHEMBL2048872)
Show SMILES N[C@@H]1CCCN(C1)c1c(C=C2SC(O)=NC2=O)cccc1-c1ccccc1
Show InChI InChI=1S/C21H21N3O2S/c22-16-9-5-11-24(13-16)19-15(12-18-20(25)23-21(26)27-18)8-4-10-17(19)14-6-2-1-3-7-14/h1-4,6-8,10,12,16H,5,9,11,13,22H2,(H,23,25,26)/t16-/m1/s1
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0.0170n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin)


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM50387298
PNG
(CHEMBL2048872)
Show SMILES N[C@@H]1CCCN(C1)c1c(C=C2SC(O)=NC2=O)cccc1-c1ccccc1
Show InChI InChI=1S/C21H21N3O2S/c22-16-9-5-11-24(13-16)19-15(12-18-20(25)23-21(26)27-18)8-4-10-17(19)14-6-2-1-3-7-14/h1-4,6-8,10,12,16H,5,9,11,13,22H2,(H,23,25,26)/t16-/m1/s1
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0.160n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin)


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM50387298
PNG
(CHEMBL2048872)
Show SMILES N[C@@H]1CCCN(C1)c1c(C=C2SC(O)=NC2=O)cccc1-c1ccccc1
Show InChI InChI=1S/C21H21N3O2S/c22-16-9-5-11-24(13-16)19-15(12-18-20(25)23-21(26)27-18)8-4-10-17(19)14-6-2-1-3-7-14/h1-4,6-8,10,12,16H,5,9,11,13,22H2,(H,23,25,26)/t16-/m1/s1
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0.230n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin)


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50162815
PNG
(CHEMBL3793035)
Show SMILES Cc1cc(nc(N)n1)-c1ccncc1NC(=O)c1nc(ccc1N)-c1ccccc1F
Show InChI InChI=1S/C22H18FN7O/c1-12-10-18(30-22(25)27-12)14-8-9-26-11-19(14)29-21(31)20-16(24)6-7-17(28-20)13-4-2-3-5-15(13)23/h2-11H,24H2,1H3,(H,29,31)(H2,25,27,30)
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<1n/an/an/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Pim1 (unknown origin) using BAD peptide preincubated for 15 mins followed by ATP addition measured after 60 to 100 mins by Kinase-Glo r...


Bioorg Med Chem Lett 26: 2328-32 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.037
BindingDB Entry DOI: 10.7270/Q2WD42F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM106896
PNG
(US8592455, 96)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C23H22F3N5O2/c1-12-10-31(11-16(27)22(12)32)19-7-8-28-9-18(19)30-23(33)17-6-5-15(26)21(29-17)20-13(24)3-2-4-14(20)25/h2-9,12,16,22,32H,10-11,27H2,1H3,(H,30,33)/t12-,16+,22+/m0/s1
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<1n/an/an/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Pim2 (unknown origin) using BAD peptide preincubated for 15 mins followed by ATP addition measured after 60 to 100 mins by Kinase-Glo r...


Bioorg Med Chem Lett 26: 2328-32 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.037
BindingDB Entry DOI: 10.7270/Q2WD42F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM50005211
PNG
(CHEMBL3103866)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1ccccc1Cl
Show InChI InChI=1S/C22H23ClN6O/c23-16-6-2-1-5-15(16)18-8-7-17(25)21(27-18)22(30)28-19-12-26-10-9-20(19)29-11-3-4-14(24)13-29/h1-2,5-10,12,14H,3-4,11,13,24-25H2,(H,28,30)/t14-/m0/s1
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<1n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) using NH2-AGAGRSRHSSYPAGT-OH as substrate by Kinase-Glo assay


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50445125
PNG
(CHEMBL3103864)
Show SMILES COc1ccccc1-c1ccc(N)c(n1)C(=O)Nc1cnccc1N1CCC[C@H](N)C1
Show InChI InChI=1S/C23H26N6O2/c1-31-21-7-3-2-6-16(21)18-9-8-17(25)22(27-18)23(30)28-19-13-26-11-10-20(19)29-12-4-5-15(24)14-29/h2-3,6-11,13,15H,4-5,12,14,24-25H2,1H3,(H,28,30)/t15-/m0/s1
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<1n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) using NH2-AGAGRSRHSSYPAGT-OH as substrate by Kinase-Glo assay


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM50445125
PNG
(CHEMBL3103864)
Show SMILES COc1ccccc1-c1ccc(N)c(n1)C(=O)Nc1cnccc1N1CCC[C@H](N)C1
Show InChI InChI=1S/C23H26N6O2/c1-31-21-7-3-2-6-16(21)18-9-8-17(25)22(27-18)23(30)28-19-13-26-11-10-20(19)29-12-4-5-15(24)14-29/h2-3,6-11,13,15H,4-5,12,14,24-25H2,1H3,(H,28,30)/t15-/m0/s1
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<1n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin) using NH2-AGAGRSRHSSYPAGT-OH as substrate by Kinase-Glo assay


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50005209
PNG
(CHEMBL3103867)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1ccccc1F
Show InChI InChI=1S/C22H23FN6O/c23-16-6-2-1-5-15(16)18-8-7-17(25)21(27-18)22(30)28-19-12-26-10-9-20(19)29-11-3-4-14(24)13-29/h1-2,5-10,12,14H,3-4,11,13,24-25H2,(H,28,30)/t14-/m0/s1
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<1n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) using NH2-AGAGRSRHSSYPAGT-OH as substrate by Kinase-Glo assay


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM50005211
PNG
(CHEMBL3103866)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1ccccc1Cl
Show InChI InChI=1S/C22H23ClN6O/c23-16-6-2-1-5-15(16)18-8-7-17(25)21(27-18)22(30)28-19-12-26-10-9-20(19)29-11-3-4-14(24)13-29/h1-2,5-10,12,14H,3-4,11,13,24-25H2,(H,28,30)/t14-/m0/s1
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<1n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin) using NH2-AGAGRSRHSSYPAGT-OH as substrate by Kinase-Glo assay


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50005211
PNG
(CHEMBL3103866)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1ccccc1Cl
Show InChI InChI=1S/C22H23ClN6O/c23-16-6-2-1-5-15(16)18-8-7-17(25)21(27-18)22(30)28-19-12-26-10-9-20(19)29-11-3-4-14(24)13-29/h1-2,5-10,12,14H,3-4,11,13,24-25H2,(H,28,30)/t14-/m0/s1
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<1n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) using NH2-AGAGRSRHSSYPAGT-OH as substrate by Kinase-Glo assay


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM50005209
PNG
(CHEMBL3103867)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1ccccc1F
Show InChI InChI=1S/C22H23FN6O/c23-16-6-2-1-5-15(16)18-8-7-17(25)21(27-18)22(30)28-19-12-26-10-9-20(19)29-11-3-4-14(24)13-29/h1-2,5-10,12,14H,3-4,11,13,24-25H2,(H,28,30)/t14-/m0/s1
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<1n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin) using NH2-AGAGRSRHSSYPAGT-OH as substrate by Kinase-Glo assay


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50445129
PNG
(CHEMBL3103860)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1ccccn1
Show InChI InChI=1S/C21H23N7O/c22-14-4-3-11-28(13-14)19-8-10-24-12-18(19)27-21(29)20-15(23)6-7-17(26-20)16-5-1-2-9-25-16/h1-2,5-10,12,14H,3-4,11,13,22-23H2,(H,27,29)/t14-/m0/s1
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<1n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) using NH2-AGAGRSRHSSYPAGT-OH as substrate by Kinase-Glo assay


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50445127
PNG
(CHEMBL3103862)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1ccncc1
Show InChI InChI=1S/C21H23N7O/c22-15-2-1-11-28(13-15)19-7-10-25-12-18(19)27-21(29)20-16(23)3-4-17(26-20)14-5-8-24-9-6-14/h3-10,12,15H,1-2,11,13,22-23H2,(H,27,29)/t15-/m0/s1
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<1n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) using NH2-AGAGRSRHSSYPAGT-OH as substrate by Kinase-Glo assay


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50445128
PNG
(CHEMBL3103861)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1cccnc1
Show InChI InChI=1S/C21H23N7O/c22-15-4-2-10-28(13-15)19-7-9-25-12-18(19)27-21(29)20-16(23)5-6-17(26-20)14-3-1-8-24-11-14/h1,3,5-9,11-12,15H,2,4,10,13,22-23H2,(H,27,29)/t15-/m0/s1
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<1n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) using NH2-AGAGRSRHSSYPAGT-OH as substrate by Kinase-Glo assay


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM50005209
PNG
(CHEMBL3103867)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1ccccc1F
Show InChI InChI=1S/C22H23FN6O/c23-16-6-2-1-5-15(16)18-8-7-17(25)21(27-18)22(30)28-19-12-26-10-9-20(19)29-11-3-4-14(24)13-29/h1-2,5-10,12,14H,3-4,11,13,24-25H2,(H,28,30)/t14-/m0/s1
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<1n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) using NH2-AGAGRSRHSSYPAGT-OH as substrate by Kinase-Glo assay


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50005209
PNG
(CHEMBL3103867)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1ccccc1F
Show InChI InChI=1S/C22H23FN6O/c23-16-6-2-1-5-15(16)18-8-7-17(25)21(27-18)22(30)28-19-12-26-10-9-20(19)29-11-3-4-14(24)13-29/h1-2,5-10,12,14H,3-4,11,13,24-25H2,(H,28,30)/t14-/m0/s1
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<1n/an/an/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Pim1 (unknown origin) using BAD peptide preincubated for 15 mins followed by ATP addition measured after 60 to 100 mins by Kinase-Glo r...


Bioorg Med Chem Lett 26: 2328-32 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.037
BindingDB Entry DOI: 10.7270/Q2WD42F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50156374
PNG
(CHEMBL3792428)
Show SMILES Nc1cc(ccn1)-c1ccncc1NC(=O)c1nc(ccc1N)-c1ccccc1F
Show InChI InChI=1S/C22H17FN6O/c23-16-4-2-1-3-15(16)18-6-5-17(24)21(28-18)22(30)29-19-12-26-9-8-14(19)13-7-10-27-20(25)11-13/h1-12H,24H2,(H2,25,27)(H,29,30)
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<1n/an/an/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Pim1 (unknown origin) using BAD peptide preincubated for 15 mins followed by ATP addition measured after 60 to 100 mins by Kinase-Glo r...


Bioorg Med Chem Lett 26: 2328-32 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.037
BindingDB Entry DOI: 10.7270/Q2WD42F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50445126
PNG
(CHEMBL3103863)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1ccnc(N)n1
Show InChI InChI=1S/C20H23N9O/c21-12-2-1-9-29(11-12)17-6-7-24-10-16(17)27-19(30)18-13(22)3-4-14(26-18)15-5-8-25-20(23)28-15/h3-8,10,12H,1-2,9,11,21-22H2,(H,27,30)(H2,23,25,28)/t12-/m0/s1
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1n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin)


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50161838
PNG
(CHEMBL3792922)
Show SMILES Cc1cc(nc(N)n1)-c1ccncc1NC(=O)c1nc(ccc1N)-c1nccs1
Show InChI InChI=1S/C19H16N8OS/c1-10-8-14(27-19(21)24-10)11-4-5-22-9-15(11)26-17(28)16-12(20)2-3-13(25-16)18-23-6-7-29-18/h2-9H,20H2,1H3,(H,26,28)(H2,21,24,27)
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<1n/an/an/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Pim1 (unknown origin) using BAD peptide preincubated for 15 mins followed by ATP addition measured after 60 to 100 mins by Kinase-Glo r...


Bioorg Med Chem Lett 26: 2328-32 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.037
BindingDB Entry DOI: 10.7270/Q2WD42F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50161839
PNG
(CHEMBL3792736)
Show SMILES Nc1cc(nc(n1)C(F)(F)F)-c1ccncc1NC(=O)c1nc(ccc1N)-c1nccs1
Show InChI InChI=1S/C19H13F3N8OS/c20-19(21,22)18-29-12(7-14(24)30-18)9-3-4-25-8-13(9)28-16(31)15-10(23)1-2-11(27-15)17-26-5-6-32-17/h1-8H,23H2,(H,28,31)(H2,24,29,30)
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<1n/an/an/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Pim1 (unknown origin) using BAD peptide preincubated for 15 mins followed by ATP addition measured after 60 to 100 mins by Kinase-Glo r...


Bioorg Med Chem Lett 26: 2328-32 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.037
BindingDB Entry DOI: 10.7270/Q2WD42F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50161840
PNG
(CHEMBL3792425)
Show SMILES Nc1cc(nc(n1)C(F)(F)F)-c1ccncc1NC(=O)c1nc(ccc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C22H14F5N7O/c23-11-2-1-3-12(24)18(11)14-5-4-13(28)19(31-14)20(35)32-16-9-30-7-6-10(16)15-8-17(29)34-21(33-15)22(25,26)27/h1-9H,28H2,(H,32,35)(H2,29,33,34)
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<1n/an/an/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Pim1 (unknown origin) using BAD peptide preincubated for 15 mins followed by ATP addition measured after 60 to 100 mins by Kinase-Glo r...


Bioorg Med Chem Lett 26: 2328-32 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.037
BindingDB Entry DOI: 10.7270/Q2WD42F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50160995
PNG
(CHEMBL3793938)
Show SMILES Cc1nc(N)cc(n1)-c1ccncc1NC(=O)c1nc(ccc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C22H17F2N7O/c1-11-28-17(9-19(26)29-11)12-7-8-27-10-18(12)31-22(32)21-15(25)5-6-16(30-21)20-13(23)3-2-4-14(20)24/h2-10H,25H2,1H3,(H,31,32)(H2,26,28,29)
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<1n/an/an/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Pim1 (unknown origin) using BAD peptide preincubated for 15 mins followed by ATP addition measured after 60 to 100 mins by Kinase-Glo r...


Bioorg Med Chem Lett 26: 2328-32 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.037
BindingDB Entry DOI: 10.7270/Q2WD42F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50161843
PNG
(CHEMBL3794146)
Show SMILES COc1cc(cc(N)n1)-c1ccncc1NC(=O)c1nc(ccc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C23H18F2N6O2/c1-33-20-10-12(9-19(27)31-20)13-7-8-28-11-18(13)30-23(32)22-16(26)5-6-17(29-22)21-14(24)3-2-4-15(21)25/h2-11H,26H2,1H3,(H2,27,31)(H,30,32)
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<1n/an/an/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Pim1 (unknown origin) using BAD peptide preincubated for 15 mins followed by ATP addition measured after 60 to 100 mins by Kinase-Glo r...


Bioorg Med Chem Lett 26: 2328-32 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.037
BindingDB Entry DOI: 10.7270/Q2WD42F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM106896
PNG
(US8592455, 96)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C23H22F3N5O2/c1-12-10-31(11-16(27)22(12)32)19-7-8-28-9-18(19)30-23(33)17-6-5-15(26)21(29-17)20-13(24)3-2-4-14(20)25/h2-9,12,16,22,32H,10-11,27H2,1H3,(H,30,33)/t12-,16+,22+/m0/s1
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<1n/an/an/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Pim1 (unknown origin) using BAD peptide preincubated for 15 mins followed by ATP addition measured after 60 to 100 mins by Kinase-Glo r...


Bioorg Med Chem Lett 26: 2328-32 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.037
BindingDB Entry DOI: 10.7270/Q2WD42F0
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50162818
PNG
(CHEMBL3793067)
Show SMILES Cc1cc(cc(N)n1)-c1ccncc1NC(=O)c1nc(ccc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C23H18F2N6O/c1-12-9-13(10-20(27)29-12)14-7-8-28-11-19(14)31-23(32)22-17(26)5-6-18(30-22)21-15(24)3-2-4-16(21)25/h2-11H,26H2,1H3,(H2,27,29)(H,31,32)
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<1n/an/an/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Pim1 (unknown origin) using BAD peptide preincubated for 15 mins followed by ATP addition measured after 60 to 100 mins by Kinase-Glo r...


Bioorg Med Chem Lett 26: 2328-32 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.037
BindingDB Entry DOI: 10.7270/Q2WD42F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50161002
PNG
(CHEMBL3792742)
Show SMILES Cc1cc(cc(N)n1)-c1ccncc1NC(=O)c1nc(ccc1N)-c1ccccc1F
Show InChI InChI=1S/C23H19FN6O/c1-13-10-14(11-21(26)28-13)15-8-9-27-12-20(15)30-23(31)22-18(25)6-7-19(29-22)16-4-2-3-5-17(16)24/h2-12H,25H2,1H3,(H2,26,28)(H,30,31)
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<1n/an/an/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Pim1 (unknown origin) using BAD peptide preincubated for 15 mins followed by ATP addition measured after 60 to 100 mins by Kinase-Glo r...


Bioorg Med Chem Lett 26: 2328-32 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.037
BindingDB Entry DOI: 10.7270/Q2WD42F0
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM106896
PNG
(US8592455, 96)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C23H22F3N5O2/c1-12-10-31(11-16(27)22(12)32)19-7-8-28-9-18(19)30-23(33)17-6-5-15(26)21(29-17)20-13(24)3-2-4-14(20)25/h2-9,12,16,22,32H,10-11,27H2,1H3,(H,30,33)/t12-,16+,22+/m0/s1
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<1n/an/an/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Pim3 (unknown origin) using BAD peptide preincubated for 15 mins followed by ATP addition measured after 60 to 100 mins by Kinase-Glo r...


Bioorg Med Chem Lett 26: 2328-32 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.037
BindingDB Entry DOI: 10.7270/Q2WD42F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50156380
PNG
(CHEMBL3793927)
Show SMILES Nc1cc(ccn1)-c1ccncc1NC(=O)c1nc(ccc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C22H16F2N6O/c23-14-2-1-3-15(24)20(14)17-5-4-16(25)21(29-17)22(31)30-18-11-27-8-7-13(18)12-6-9-28-19(26)10-12/h1-11H,25H2,(H2,26,28)(H,30,31)
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2n/an/an/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Pim1 (unknown origin) using BAD peptide preincubated for 15 mins followed by ATP addition measured after 60 to 100 mins by Kinase-Glo r...


Bioorg Med Chem Lett 26: 2328-32 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.037
BindingDB Entry DOI: 10.7270/Q2WD42F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50445123
PNG
(CHEMBL3103865)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C23H23F3N6O/c24-23(25,26)16-6-2-1-5-15(16)18-8-7-17(28)21(30-18)22(33)31-19-12-29-10-9-20(19)32-11-3-4-14(27)13-32/h1-2,5-10,12,14H,3-4,11,13,27-28H2,(H,31,33)/t14-/m0/s1
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3n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin)


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM50445123
PNG
(CHEMBL3103865)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C23H23F3N6O/c24-23(25,26)16-6-2-1-5-15(16)18-8-7-17(28)21(30-18)22(33)31-19-12-29-10-9-20(19)32-11-3-4-14(27)13-32/h1-2,5-10,12,14H,3-4,11,13,27-28H2,(H,31,33)/t14-/m0/s1
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3n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin)


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM50445126
PNG
(CHEMBL3103863)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1ccnc(N)n1
Show InChI InChI=1S/C20H23N9O/c21-12-2-1-9-29(11-12)17-6-7-24-10-16(17)27-19(30)18-13(22)3-4-14(26-18)15-5-8-25-20(23)28-15/h3-8,10,12H,1-2,9,11,21-22H2,(H,27,30)(H2,23,25,28)/t12-/m0/s1
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3n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin)


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM50445129
PNG
(CHEMBL3103860)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1ccccn1
Show InChI InChI=1S/C21H23N7O/c22-14-4-3-11-28(13-14)19-8-10-24-12-18(19)27-21(29)20-15(23)6-7-17(26-20)16-5-1-2-9-25-16/h1-2,5-10,12,14H,3-4,11,13,22-23H2,(H,27,29)/t14-/m0/s1
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3n/an/an/an/an/an/an/an/a



Global Discovery Chemistry/Oncology& Exploratory Chemistry, Novartis Institutes for Biomedical Research , 4560 Horton Street, Emeryville, California 94608, United States.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin)


ACS Med Chem Lett 4: 1193-7 (2013)


Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50156379
PNG
(CHEMBL3792474)
Show SMILES Nc1cncc(n1)-c1ccncc1NC(=O)c1nc(ccc1N)-c1ccccc1F
Show InChI InChI=1S/C21H16FN7O/c22-14-4-2-1-3-12(14)16-6-5-15(23)20(28-16)21(30)29-18-9-25-8-7-13(18)17-10-26-11-19(24)27-17/h1-11H,23H2,(H2,24,27)(H,29,30)
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3n/an/an/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Pim1 (unknown origin) using BAD peptide preincubated for 15 mins followed by ATP addition measured after 60 to 100 mins by Kinase-Glo r...


Bioorg Med Chem Lett 26: 2328-32 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.037
BindingDB Entry DOI: 10.7270/Q2WD42F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM50005209
PNG
(CHEMBL3103867)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1ccccc1F
Show InChI InChI=1S/C22H23FN6O/c23-16-6-2-1-5-15(16)18-8-7-17(25)21(27-18)22(30)28-19-12-26-10-9-20(19)29-11-3-4-14(24)13-29/h1-2,5-10,12,14H,3-4,11,13,24-25H2,(H,28,30)/t14-/m0/s1
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<3n/an/an/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Pim3 (unknown origin) using BAD peptide preincubated for 15 mins followed by ATP addition measured after 60 to 100 mins by Kinase-Glo r...


Bioorg Med Chem Lett 26: 2328-32 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.037
BindingDB Entry DOI: 10.7270/Q2WD42F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM50156374
PNG
(CHEMBL3792428)
Show SMILES Nc1cc(ccn1)-c1ccncc1NC(=O)c1nc(ccc1N)-c1ccccc1F
Show InChI InChI=1S/C22H17FN6O/c23-16-4-2-1-3-15(16)18-6-5-17(24)21(28-18)22(30)29-19-12-26-9-8-14(19)13-7-10-27-20(25)11-13/h1-12H,24H2,(H2,25,27)(H,29,30)
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3n/an/an/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Pim3 (unknown origin) using BAD peptide preincubated for 15 mins followed by ATP addition measured after 60 to 100 mins by Kinase-Glo r...


Bioorg Med Chem Lett 26: 2328-32 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.037
BindingDB Entry DOI: 10.7270/Q2WD42F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM50005209
PNG
(CHEMBL3103867)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1ccccc1F
Show InChI InChI=1S/C22H23FN6O/c23-16-6-2-1-5-15(16)18-8-7-17(25)21(27-18)22(30)28-19-12-26-10-9-20(19)29-11-3-4-14(24)13-29/h1-2,5-10,12,14H,3-4,11,13,24-25H2,(H,28,30)/t14-/m0/s1
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<3n/an/an/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Pim2 (unknown origin) using BAD peptide preincubated for 15 mins followed by ATP addition measured after 60 to 100 mins by Kinase-Glo r...


Bioorg Med Chem Lett 26: 2328-32 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.037
BindingDB Entry DOI: 10.7270/Q2WD42F0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM50162815
PNG
(CHEMBL3793035)
Show SMILES Cc1cc(nc(N)n1)-c1ccncc1NC(=O)c1nc(ccc1N)-c1ccccc1F
Show InChI InChI=1S/C22H18FN7O/c1-12-10-18(30-22(25)27-12)14-8-9-26-11-19(14)29-21(31)20-16(24)6-7-17(28-20)13-4-2-3-5-15(13)23/h2-11H,24H2,1H3,(H,29,31)(H2,25,27,30)
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<3n/an/an/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Pim2 (unknown origin) using BAD peptide preincubated for 15 mins followed by ATP addition measured after 60 to 100 mins by Kinase-Glo r...


Bioorg Med Chem Lett 26: 2328-32 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.037
BindingDB Entry DOI: 10.7270/Q2WD42F0
More data for this
Ligand-Target Pair
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