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Compile Data Set for Download or QSAR

Found 680 hits with Last Name = 'corti' and Initial = 'l'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50136154
PNG
(4-[(4-Fluoro-phenoxy)-phenyl-methyl]-piperidine | ...)
Show SMILES Fc1ccc(OC(C2CCNCC2)c2ccccc2)cc1
Show InChI InChI=1S/C18H20FNO/c19-16-6-8-17(9-7-16)21-18(14-4-2-1-3-5-14)15-10-12-20-13-11-15/h1-9,15,18,20H,10-13H2
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0.400n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50136143
PNG
(4-[(4-Nitro-phenoxy)-phenyl-methyl]-piperidine | C...)
Show SMILES [O-][N+](=O)c1ccc(OC(C2CCNCC2)c2ccccc2)cc1
Show InChI InChI=1S/C18H20N2O3/c21-20(22)16-6-8-17(9-7-16)23-18(14-4-2-1-3-5-14)15-10-12-19-13-11-15/h1-9,15,18-19H,10-13H2
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0.600n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50030004
PNG
(1-((S)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthal...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(C(C)=O)c2C1
Show InChI InChI=1S/C18H27NO/c1-4-11-19(12-5-2)16-10-9-15-7-6-8-17(14(3)20)18(15)13-16/h6-8,16H,4-5,9-13H2,1-3H3/t16-/m0/s1
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0.700n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]- 8-OH-DPAT binding to 5-HT1A-receptor from rat cerebral cortex membranes


Bioorg Med Chem Lett 1: 257-262 (1991)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50030004
PNG
(1-((S)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthal...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(C(C)=O)c2C1
Show InChI InChI=1S/C18H27NO/c1-4-11-19(12-5-2)16-10-9-15-7-6-8-17(14(3)20)18(15)13-16/h6-8,16H,4-5,9-13H2,1-3H3/t16-/m0/s1
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0.700n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity against rat hippocampal 5-hydroxytryptamine 1A (5-HT1A) receptor determined using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 4036-43 (1996)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50030004
PNG
(1-((S)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthal...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(C(C)=O)c2C1
Show InChI InChI=1S/C18H27NO/c1-4-11-19(12-5-2)16-10-9-15-7-6-8-17(14(3)20)18(15)13-16/h6-8,16H,4-5,9-13H2,1-3H3/t16-/m0/s1
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0.700n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity of 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM22416
PNG
((3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-f...)
Show SMILES Fc1ccc(cc1)[C@@H]1CCNC[C@H]1COc1ccc2OCOc2c1
Show InChI InChI=1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2/t14-,17-/m0/s1
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0.700n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50005536
PNG
(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)
Show SMILES OC1(N2CCN=C2c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H13ClN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2
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0.800n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity against norepinephrine transporter (NET) by displacement of [3H]nisoxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50136145
PNG
(4-[(4-Fluoro-phenyl)-(4-methoxy-phenoxy)-methyl]-p...)
Show SMILES COc1ccc(OC(C2CCNCC2)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C19H22FNO2/c1-22-17-6-8-18(9-7-17)23-19(15-10-12-21-13-11-15)14-2-4-16(20)5-3-14/h2-9,15,19,21H,10-13H2,1H3
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0.900n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50136200
PNG
(4-[(4-Fluoro-phenoxy)-(4-fluoro-phenyl)-methyl]-pi...)
Show SMILES Fc1ccc(OC(C2CCNCC2)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C18H19F2NO/c19-15-3-1-13(2-4-15)18(14-9-11-21-12-10-14)22-17-7-5-16(20)6-8-17/h1-8,14,18,21H,9-12H2
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0.900n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50030012
PNG
(1-(7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1...)
Show SMILES CCCN(CCC)C1CCc2cccc(C(C)=O)c2C1
Show InChI InChI=1S/C18H27NO/c1-4-11-19(12-5-2)16-10-9-15-7-6-8-17(14(3)20)18(15)13-16/h6-8,16H,4-5,9-13H2,1-3H3
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0.900n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity of 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50053667
PNG
(CHEMBL552643 | Trifluoro-methanesulfonic acid (S)-...)
Show SMILES CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)[C@H]1CCc2c(F)ccc(OS(=O)(=O)C(F)(F)F)c2C1
Show InChI InChI=1S/C27H36F4N2O5S/c1-2-13-32(14-5-6-15-33-24(34)17-26(18-25(33)35)11-3-4-12-26)19-7-8-20-21(16-19)23(10-9-22(20)28)38-39(36,37)27(29,30)31/h9-10,19H,2-8,11-18H2,1H3/t19-/m0/s1
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0.900n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity against rat hippocampal 5-hydroxytryptamine 1A (5-HT1A) receptor determined using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 4036-43 (1996)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50136144
PNG
(4-[(3-Fluoro-phenoxy)-phenyl-methyl]-piperidine | ...)
Show SMILES Fc1cccc(OC(C2CCNCC2)c2ccccc2)c1
Show InChI InChI=1S/C18H20FNO/c19-16-7-4-8-17(13-16)21-18(14-5-2-1-3-6-14)15-9-11-20-12-10-15/h1-8,13,15,18,20H,9-12H2
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1n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50136135
PNG
(3-(Phenyl-piperidin-4-yl-methoxy)-benzonitrile | C...)
Show SMILES N#Cc1cccc(OC(C2CCNCC2)c2ccccc2)c1
Show InChI InChI=1S/C19H20N2O/c20-14-15-5-4-8-18(13-15)22-19(16-6-2-1-3-7-16)17-9-11-21-12-10-17/h1-8,13,17,19,21H,9-12H2
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1n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50136154
PNG
(4-[(4-Fluoro-phenoxy)-phenyl-methyl]-piperidine | ...)
Show SMILES Fc1ccc(OC(C2CCNCC2)c2ccccc2)cc1
Show InChI InChI=1S/C18H20FNO/c19-16-6-8-17(9-7-16)21-18(14-4-2-1-3-5-14)15-10-12-20-13-11-15/h1-9,15,18,20H,10-13H2
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1.10n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50053661
PNG
(8-{4-[((R)-5-Fluoro-8-furan-2-yl-1,2,3,4-tetrahydr...)
Show SMILES CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)[C@@H]1CCc2c(F)ccc(-c3ccco3)c2C1
Show InChI InChI=1S/C30H39FN2O3/c1-2-15-32(16-5-6-17-33-28(34)20-30(21-29(33)35)13-3-4-14-30)22-9-10-23-25(19-22)24(11-12-26(23)31)27-8-7-18-36-27/h7-8,11-12,18,22H,2-6,9-10,13-17,19-21H2,1H3/t22-/m1/s1
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1.10n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity against rat hippocampal 5-hydroxytryptamine 1A (5-HT1A) receptor determined using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 4036-43 (1996)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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1.20n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat hippocampus mambranes


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50016777
PNG
(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Show SMILES CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3/t14-/m1/s1
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1.30n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity against rat hippocampal 5-hydroxytryptamine 1A (5-HT1A) receptor determined using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 4036-43 (1996)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50016777
PNG
(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Show SMILES CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3/t14-/m1/s1
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1.30n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibiting the binding of [3H]- 8-OH-DPAT to 5-HT1A-receptor from cerebral cortex membranes of rat


Bioorg Med Chem Lett 1: 257-262 (1991)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50016777
PNG
(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Show SMILES CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3/t14-/m1/s1
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1.30n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity of 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50136138
PNG
(4-[(3,5-Difluoro-phenoxy)-phenyl-methyl]-piperidin...)
Show SMILES Fc1cc(F)cc(OC(C2CCNCC2)c2ccccc2)c1
Show InChI InChI=1S/C18H19F2NO/c19-15-10-16(20)12-17(11-15)22-18(13-4-2-1-3-5-13)14-6-8-21-9-7-14/h1-5,10-12,14,18,21H,6-9H2
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1.40n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50136135
PNG
(3-(Phenyl-piperidin-4-yl-methoxy)-benzonitrile | C...)
Show SMILES N#Cc1cccc(OC(C2CCNCC2)c2ccccc2)c1
Show InChI InChI=1S/C19H20N2O/c20-14-15-5-4-8-18(13-15)22-19(16-6-2-1-3-7-16)17-9-11-21-12-10-17/h1-8,13,17,19,21H,9-12H2
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1.40n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50136135
PNG
(3-(Phenyl-piperidin-4-yl-methoxy)-benzonitrile | C...)
Show SMILES N#Cc1cccc(OC(C2CCNCC2)c2ccccc2)c1
Show InChI InChI=1S/C19H20N2O/c20-14-15-5-4-8-18(13-15)22-19(16-6-2-1-3-7-16)17-9-11-21-12-10-17/h1-8,13,17,19,21H,9-12H2
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1.40n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50136133
PNG
(4-[(3-Chloro-phenoxy)-phenyl-methyl]-piperidine | ...)
Show SMILES Clc1cccc(OC(C2CCNCC2)c2ccccc2)c1
Show InChI InChI=1S/C18H20ClNO/c19-16-7-4-8-17(13-16)21-18(14-5-2-1-3-6-14)15-9-11-20-12-10-15/h1-8,13,15,18,20H,9-12H2
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1.5n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50030026
PNG
(((R)-8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Show SMILES CCCN(CCC)[C@@H]1CCc2cccc(OC)c2C1
Show InChI InChI=1S/C17H27NO/c1-4-11-18(12-5-2)15-10-9-14-7-6-8-17(19-3)16(14)13-15/h6-8,15H,4-5,9-13H2,1-3H3/t15-/m1/s1
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1.5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]- 8-OH-DPAT binding to 5-HT1A-receptor from rat cerebral cortex membranes


Bioorg Med Chem Lett 1: 257-262 (1991)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50030026
PNG
(((R)-8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Show SMILES CCCN(CCC)[C@@H]1CCc2cccc(OC)c2C1
Show InChI InChI=1S/C17H27NO/c1-4-11-18(12-5-2)15-10-9-14-7-6-8-17(19-3)16(14)13-15/h6-8,15H,4-5,9-13H2,1-3H3/t15-/m1/s1
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1.5n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity of 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50030019
PNG
((S)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalene...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(C(=O)OC)c2C1
Show InChI InChI=1S/C18H27NO2/c1-4-11-19(12-5-2)15-10-9-14-7-6-8-16(17(14)13-15)18(20)21-3/h6-8,15H,4-5,9-13H2,1-3H3/t15-/m0/s1
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1.70n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]- 8-OH-DPAT binding to 5-HT1A-receptor from rat cerebral cortex membranes


Bioorg Med Chem Lett 1: 257-262 (1991)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50030019
PNG
((S)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalene...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(C(=O)OC)c2C1
Show InChI InChI=1S/C18H27NO2/c1-4-11-19(12-5-2)15-10-9-14-7-6-8-16(17(14)13-15)18(20)21-3/h6-8,15H,4-5,9-13H2,1-3H3/t15-/m0/s1
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1.70n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity of 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50030025
PNG
(1-((R)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthal...)
Show SMILES CCCN(CCC)[C@@H]1CCc2cccc(C(C)=O)c2C1
Show InChI InChI=1S/C18H27NO/c1-4-11-19(12-5-2)16-10-9-15-7-6-8-17(14(3)20)18(15)13-16/h6-8,16H,4-5,9-13H2,1-3H3/t16-/m1/s1
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1.80n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]- 8-OH-DPAT binding to 5-HT1A-receptor from rat cerebral cortex membranes


Bioorg Med Chem Lett 1: 257-262 (1991)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011247
PNG
(7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3/t14-/m0/s1
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1.80n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity of 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50030025
PNG
(1-((R)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthal...)
Show SMILES CCCN(CCC)[C@@H]1CCc2cccc(C(C)=O)c2C1
Show InChI InChI=1S/C18H27NO/c1-4-11-19(12-5-2)16-10-9-15-7-6-8-17(14(3)20)18(15)13-16/h6-8,16H,4-5,9-13H2,1-3H3/t16-/m1/s1
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1.80n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity of 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011247
PNG
(7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3/t14-/m0/s1
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1.80n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibiting the binding of [3H]- 8-OH-DPAT to 5-HT1A-receptor from cerebral cortex membranes of rat


Bioorg Med Chem Lett 1: 257-262 (1991)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50030025
PNG
(1-((R)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthal...)
Show SMILES CCCN(CCC)[C@@H]1CCc2cccc(C(C)=O)c2C1
Show InChI InChI=1S/C18H27NO/c1-4-11-19(12-5-2)16-10-9-15-7-6-8-17(14(3)20)18(15)13-16/h6-8,16H,4-5,9-13H2,1-3H3/t16-/m1/s1
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1.80n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity against rat hippocampal 5-hydroxytryptamine 1A (5-HT1A) receptor determined using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 4036-43 (1996)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011247
PNG
(7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3/t14-/m0/s1
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1.80n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity against rat hippocampal 5-hydroxytryptamine 1A (5-HT1A) receptor determined using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 4036-43 (1996)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50053678
PNG
(((S)-8-Furan-2-yl-1,2,3,4-tetrahydro-naphthalen-2-...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(-c3ccco3)c2C1
Show InChI InChI=1S/C20H27NO/c1-3-12-21(13-4-2)17-11-10-16-7-5-8-18(19(16)15-17)20-9-6-14-22-20/h5-9,14,17H,3-4,10-13,15H2,1-2H3/t17-/m0/s1
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1.80n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity against rat hippocampal 5-hydroxytryptamine 1A (5-HT1A) receptor determined using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 4036-43 (1996)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50136132
PNG
(4-[(3-Fluoro-5-methoxy-phenoxy)-phenyl-methyl]-pip...)
Show SMILES COc1cc(F)cc(OC(C2CCNCC2)c2ccccc2)c1
Show InChI InChI=1S/C19H22FNO2/c1-22-17-11-16(20)12-18(13-17)23-19(14-5-3-2-4-6-14)15-7-9-21-10-8-15/h2-6,11-13,15,19,21H,7-10H2,1H3
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1.90n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50136144
PNG
(4-[(3-Fluoro-phenoxy)-phenyl-methyl]-piperidine | ...)
Show SMILES Fc1cccc(OC(C2CCNCC2)c2ccccc2)c1
Show InChI InChI=1S/C18H20FNO/c19-16-7-4-8-17(13-16)21-18(14-5-2-1-3-6-14)15-9-11-20-12-10-15/h1-8,13,15,18,20H,9-12H2
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1.90n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50136131
PNG
(4-[(4-Bromo-phenoxy)-phenyl-methyl]-piperidine | C...)
Show SMILES Brc1ccc(OC(C2CCNCC2)c2ccccc2)cc1
Show InChI InChI=1S/C18H20BrNO/c19-16-6-8-17(9-7-16)21-18(14-4-2-1-3-5-14)15-10-12-20-13-11-15/h1-9,15,18,20H,10-13H2
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2n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50136169
PNG
(3-Fluoro-5-(phenyl-piperidin-4-yl-methoxy)-phenol ...)
Show SMILES Oc1cc(F)cc(OC(C2CCNCC2)c2ccccc2)c1
Show InChI InChI=1S/C18H20FNO2/c19-15-10-16(21)12-17(11-15)22-18(13-4-2-1-3-5-13)14-6-8-20-9-7-14/h1-5,10-12,14,18,20-21H,6-9H2
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2n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50136157
PNG
(4-(Phenoxy-phenyl-methyl)-piperidine | CHEMBL44718...)
Show SMILES C1CC(CCN1)C(Oc1ccccc1)c1ccccc1
Show InChI InChI=1S/C18H21NO/c1-3-7-15(8-4-1)18(16-11-13-19-14-12-16)20-17-9-5-2-6-10-17/h1-10,16,18-19H,11-14H2
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2.30n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50136143
PNG
(4-[(4-Nitro-phenoxy)-phenyl-methyl]-piperidine | C...)
Show SMILES [O-][N+](=O)c1ccc(OC(C2CCNCC2)c2ccccc2)cc1
Show InChI InChI=1S/C18H20N2O3/c21-20(22)16-6-8-17(9-7-16)23-18(14-4-2-1-3-5-14)15-10-12-19-13-11-15/h1-9,15,18-19H,10-13H2
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2.40n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50013016
PNG
(7-Dipropylamino-5,6,7,8-tetrahydro-naphthalene-1-c...)
Show SMILES CCCN(CCC)C1CCc2cccc(C(=O)OC)c2C1
Show InChI InChI=1S/C18H27NO2/c1-4-11-19(12-5-2)15-10-9-14-7-6-8-16(17(14)13-15)18(20)21-3/h6-8,15H,4-5,9-13H2,1-3H3
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2.40n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity of 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50136133
PNG
(4-[(3-Chloro-phenoxy)-phenyl-methyl]-piperidine | ...)
Show SMILES Clc1cccc(OC(C2CCNCC2)c2ccccc2)c1
Show InChI InChI=1S/C18H20ClNO/c19-16-7-4-8-17(13-16)21-18(14-5-2-1-3-6-14)15-9-11-20-12-10-15/h1-8,13,15,18,20H,9-12H2
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2.60n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50136171
PNG
(3-Fluoro-5-(phenyl-piperidin-4-yl-methoxy)-benzoni...)
Show SMILES Fc1cc(OC(C2CCNCC2)c2ccccc2)cc(c1)C#N
Show InChI InChI=1S/C19H19FN2O/c20-17-10-14(13-21)11-18(12-17)23-19(15-4-2-1-3-5-15)16-6-8-22-9-7-16/h1-5,10-12,16,19,22H,6-9H2
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2.60n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50030010
PNG
(((S)-8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(OC)c2C1
Show InChI InChI=1S/C17H27NO/c1-4-11-18(12-5-2)15-10-9-14-7-6-8-17(19-3)16(14)13-15/h6-8,15H,4-5,9-13H2,1-3H3/t15-/m0/s1
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2.80n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]- 8-OH-DPAT binding to 5-HT1A-receptor from rat cerebral cortex membranes


Bioorg Med Chem Lett 1: 257-262 (1991)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50030010
PNG
(((S)-8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(OC)c2C1
Show InChI InChI=1S/C17H27NO/c1-4-11-18(12-5-2)15-10-9-14-7-6-8-17(19-3)16(14)13-15/h6-8,15H,4-5,9-13H2,1-3H3/t15-/m0/s1
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2.80n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity of 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50136172
PNG
(4-[(3-Fluoro-phenoxy)-(3-fluoro-phenyl)-methyl]-pi...)
Show SMILES Fc1cccc(OC(C2CCNCC2)c2cccc(F)c2)c1
Show InChI InChI=1S/C18H19F2NO/c19-15-4-1-3-14(11-15)18(13-7-9-21-10-8-13)22-17-6-2-5-16(20)12-17/h1-6,11-13,18,21H,7-10H2
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2.80n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50030027
PNG
((7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-y...)
Show SMILES CCCN(CCC)C1CCc2cccc(C(=O)c3ccccc3)c2C1
Show InChI InChI=1S/C23H29NO/c1-3-15-24(16-4-2)20-14-13-18-11-8-12-21(22(18)17-20)23(25)19-9-6-5-7-10-19/h5-12,20H,3-4,13-17H2,1-2H3
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2.80n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity of 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


Citation and Details
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50136133
PNG
(4-[(3-Chloro-phenoxy)-phenyl-methyl]-piperidine | ...)
Show SMILES Clc1cccc(OC(C2CCNCC2)c2ccccc2)c1
Show InChI InChI=1S/C18H20ClNO/c19-16-7-4-8-17(13-16)21-18(14-5-2-1-3-6-14)15-9-11-20-12-10-15/h1-8,13,15,18,20H,9-12H2
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3n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50136138
PNG
(4-[(3,5-Difluoro-phenoxy)-phenyl-methyl]-piperidin...)
Show SMILES Fc1cc(F)cc(OC(C2CCNCC2)c2ccccc2)c1
Show InChI InChI=1S/C18H19F2NO/c19-15-10-16(20)12-17(11-15)22-18(13-4-2-1-3-5-13)14-6-8-21-9-7-14/h1-5,10-12,14,18,21H,6-9H2
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3.40n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50136191
PNG
(4-[(3-Iodo-phenoxy)-phenyl-methyl]-piperidine | CH...)
Show SMILES Ic1cccc(OC(C2CCNCC2)c2ccccc2)c1
Show InChI InChI=1S/C18H20INO/c19-16-7-4-8-17(13-16)21-18(14-5-2-1-3-6-14)15-9-11-20-12-10-15/h1-8,13,15,18,20H,9-12H2
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3.70n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)

More data for this
Ligand-Target Pair
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