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Compile Data Set for Download or QSAR

Found 335 hits with Last Name = 'forn' and Initial = 'j'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003524
PNG
(CHEMBL3216197 | CHEMBL544141 | [4-(2,2-Diphenyl-pr...)
Show SMILES Cl.Cl.CC(C(=O)N1CCN(CC1)C(C#N)c1cccnc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H26N4O/c1-26(22-10-4-2-5-11-22,23-12-6-3-7-13-23)25(31)30-17-15-29(16-18-30)24(19-27)21-9-8-14-28-20-21/h2-14,20,24H,15-18H2,1H3
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n/an/a 1.90n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50005224
PNG
(2-({Acetyl-[5-(16-methoxy-hexadecyloxy)-tetrahydro...)
Show SMILES CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(C1)OCCCCCCCCCCCCCCCCOC
Show InChI InChI=1S/C33H57N2O6/c1-4-34-22-18-17-21-31(34)26-35(29(2)36)33(37)41-28-30-25-32(40-27-30)39-24-20-16-14-12-10-8-6-5-7-9-11-13-15-19-23-38-3/h17-18,21-22,30,32H,4-16,19-20,23-28H2,1-3H3/q+1
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n/an/a 2.10n/an/an/an/an/an/a



J. Uriach & Cía.S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF induced aggregation of rabbit platelets.


J Med Chem 35: 676-83 (1992)


Article DOI: 10.1021/jm00082a007
BindingDB Entry DOI: 10.7270/Q298860P
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003499
PNG
(CHEMBL338940 | [4-(3-Hydroxy-3,3-diphenyl-propiony...)
Show SMILES OC(CC(=O)N1CCN(CC1)C(C#N)c1ccncc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H26N4O2/c27-20-24(21-11-13-28-14-12-21)29-15-17-30(18-16-29)25(31)19-26(32,22-7-3-1-4-8-22)23-9-5-2-6-10-23/h1-14,24,32H,15-19H2
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n/an/a 2.70n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Cyclooxygenase-1 (COX-1)


(Homo sapiens (Human))
BDBM17638
PNG
(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1
Show InChI InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
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n/an/a 3n/an/an/an/an/an/a



J. Uriach & Cía. S.A.

Curated by ChEMBL


Assay Description
Inhibition of Prostaglandin G/H synthase 1 in U-937 cells from human histiocytic lymphoma


J Med Chem 44: 350-61 (2001)


Article DOI: 10.1021/jm0009383
BindingDB Entry DOI: 10.7270/Q29W0DSN
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50005227
PNG
(2-({Acetyl-[5-(6-decyloxy-hexyloxy)-tetrahydro-fur...)
Show SMILES CCCCCCCCCCOCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1
Show InChI InChI=1S/C32H55N2O6/c1-4-6-7-8-9-10-11-16-21-37-22-17-12-13-18-23-38-31-24-29(26-39-31)27-40-32(36)34(28(3)35)25-30-19-14-15-20-33(30)5-2/h14-15,19-20,29,31H,4-13,16-18,21-27H2,1-3H3/q+1
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n/an/a 4.10n/an/an/an/an/an/a



J. Uriach & Cía.S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF induced aggregation of rabbit platelets.


J Med Chem 35: 676-83 (1992)


Article DOI: 10.1021/jm00082a007
BindingDB Entry DOI: 10.7270/Q298860P
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50011053
PNG
(CHEMBL125576 | Tetrahydrofuran derivative)
Show SMILES CCCCCCCCCCCCCCCNOC(=O)CC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1
Show InChI InChI=1S/C33H56N3O6/c1-4-6-7-8-9-10-11-12-13-14-15-16-18-21-34-42-32(38)24-29-23-31(40-26-29)27-41-33(39)36(28(3)37)25-30-20-17-19-22-35(30)5-2/h17,19-20,22,29,31,34H,4-16,18,21,23-27H2,1-3H3/q+1
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n/an/a 4.5n/an/an/an/an/an/a



J. Uriach & Cía.S.A.

Curated by ChEMBL


Assay Description
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%


J Med Chem 34: 373-86 (1991)


Article DOI: 10.1021/jm00105a058
BindingDB Entry DOI: 10.7270/Q2DF6Q51
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50005225
PNG
(2-{[Acetyl-(5-hexadecyloxymethyl-tetrahydro-furan-...)
Show SMILES CCCCCCCCCCCCCCCCOCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1
Show InChI InChI=1S/C33H57N2O5/c1-4-6-7-8-9-10-11-12-13-14-15-16-17-20-23-38-28-32-24-30(26-39-32)27-40-33(37)35(29(3)36)25-31-21-18-19-22-34(31)5-2/h18-19,21-22,30,32H,4-17,20,23-28H2,1-3H3/q+1
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n/an/a 6.80n/an/an/an/an/an/a



J. Uriach & Cía.S.A.

Curated by ChEMBL


Assay Description
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%


J Med Chem 34: 373-86 (1991)


Article DOI: 10.1021/jm00105a058
BindingDB Entry DOI: 10.7270/Q2DF6Q51
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003525
PNG
(CHEMBL133742 | [4-(2,3-Diphenyl-acryloyl)-piperazi...)
Show SMILES O=C(N1CCN(CC1)C(C#N)c1cccnc1)C(=C\c1ccccc1)\c1ccccc1
Show InChI InChI=1S/C26H24N4O/c27-19-25(23-12-7-13-28-20-23)29-14-16-30(17-15-29)26(31)24(22-10-5-2-6-11-22)18-21-8-3-1-4-9-21/h1-13,18,20,25H,14-17H2/b24-18+
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n/an/a 7.5n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50011106
PNG
(2-{[Acetyl-(4-octadecyloxymethyl-[1,3]dioxolan-2-y...)
Show SMILES CCCCCCCCCCCCCCCNOC(=O)CC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1
Show InChI InChI=1S/C32H54N3O7/c1-4-6-7-8-9-10-11-12-13-14-15-16-18-21-33-42-30(37)23-29-25-39-31(41-29)26-40-32(38)35(27(3)36)24-28-20-17-19-22-34(28)5-2/h17,19-20,22,29,31,33H,4-16,18,21,23-26H2,1-3H3/q+1
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n/an/a 7.5n/an/an/an/an/an/a



J. Uriach & Cía.S.A.

Curated by ChEMBL


Assay Description
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%


J Med Chem 34: 373-86 (1991)


Article DOI: 10.1021/jm00105a058
BindingDB Entry DOI: 10.7270/Q2DF6Q51
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50011053
PNG
(CHEMBL125576 | Tetrahydrofuran derivative)
Show SMILES CCCCCCCCCCCCCCCNOC(=O)CC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1
Show InChI InChI=1S/C33H56N3O6/c1-4-6-7-8-9-10-11-12-13-14-15-16-18-21-34-42-32(38)24-29-23-31(40-26-29)27-41-33(39)36(28(3)37)25-30-20-17-19-22-35(30)5-2/h17,19-20,22,29,31,34H,4-16,18,21,23-27H2,1-3H3/q+1
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n/an/a 8n/an/an/an/an/an/a



J. Uriach & Cía.S.A.

Curated by ChEMBL


Assay Description
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%


J Med Chem 34: 373-86 (1991)


Article DOI: 10.1021/jm00105a058
BindingDB Entry DOI: 10.7270/Q2DF6Q51
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50011055
PNG
(2-{[Acetyl-(4-hexadecyloxymethyl-tetrahydro-furan-...)
Show SMILES CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1
Show InChI InChI=1S/C33H57N2O5/c1-4-6-7-8-9-10-11-12-13-14-15-16-17-20-23-38-26-30-24-32(39-27-30)28-40-33(37)35(29(3)36)25-31-21-18-19-22-34(31)5-2/h18-19,21-22,30,32H,4-17,20,23-28H2,1-3H3/q+1
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n/an/a 8.20n/an/an/an/an/an/a



J. Uriach & Cía.S.A.

Curated by ChEMBL


Assay Description
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%


J Med Chem 34: 373-86 (1991)


Article DOI: 10.1021/jm00105a058
BindingDB Entry DOI: 10.7270/Q2DF6Q51
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50005225
PNG
(2-{[Acetyl-(5-hexadecyloxymethyl-tetrahydro-furan-...)
Show SMILES CCCCCCCCCCCCCCCCOCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1
Show InChI InChI=1S/C33H57N2O5/c1-4-6-7-8-9-10-11-12-13-14-15-16-17-20-23-38-28-32-24-30(26-39-32)27-40-33(37)35(29(3)36)25-31-21-18-19-22-34(31)5-2/h18-19,21-22,30,32H,4-17,20,23-28H2,1-3H3/q+1
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n/an/a 8.60n/an/an/an/an/an/a



J. Uriach & Cía.S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF induced aggregation of rabbit platelets.


J Med Chem 35: 676-83 (1992)


Article DOI: 10.1021/jm00082a007
BindingDB Entry DOI: 10.7270/Q298860P
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50005225
PNG
(2-{[Acetyl-(5-hexadecyloxymethyl-tetrahydro-furan-...)
Show SMILES CCCCCCCCCCCCCCCCOCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1
Show InChI InChI=1S/C33H57N2O5/c1-4-6-7-8-9-10-11-12-13-14-15-16-17-20-23-38-28-32-24-30(26-39-32)27-40-33(37)35(29(3)36)25-31-21-18-19-22-34(31)5-2/h18-19,21-22,30,32H,4-17,20,23-28H2,1-3H3/q+1
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n/an/a 8.60n/an/an/an/an/an/a



J. Uriach & Cía.S.A.

Curated by ChEMBL


Assay Description
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%


J Med Chem 34: 373-86 (1991)


Article DOI: 10.1021/jm00105a058
BindingDB Entry DOI: 10.7270/Q2DF6Q51
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045990
PNG
(CHEMBL102070 | N-(3-{4-[Cyano-(2-methyl-pyridin-3-...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(NC(=O)c1cccnc1)c1ccccc1
Show InChI InChI=1S/C27H28N6O2/c1-20-23(10-6-12-30-20)25(18-28)32-13-15-33(16-14-32)26(34)17-24(21-7-3-2-4-8-21)31-27(35)22-9-5-11-29-19-22/h2-12,19,24-25H,13-17H2,1H3,(H,31,35)
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n/an/a 8.90n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Cyclooxygenase


(Homo sapiens (Human))
BDBM17638
PNG
(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1
Show InChI InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
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n/an/a 9n/an/an/an/an/an/a



J. Uriach & Cía. S.A.

Curated by ChEMBL


Assay Description
Inhibition of Prostaglandin G/H synthase 2 in 143.98.2 from human osteosarcoma cells


J Med Chem 44: 350-61 (2001)


Article DOI: 10.1021/jm0009383
BindingDB Entry DOI: 10.7270/Q29W0DSN
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045970
PNG
(CHEMBL102918 | N-(3-{4-[Cyano-(2-methyl-pyridin-3-...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(NC(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H29N5O2/c1-21-24(13-8-14-30-21)26(20-29)32-15-17-33(18-16-32)27(34)19-25(22-9-4-2-5-10-22)31-28(35)23-11-6-3-7-12-23/h2-14,25-26H,15-19H2,1H3,(H,31,35)
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n/an/a 9.10n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003506
PNG
(CHEMBL322184 | CHEMBL545771 | {4-[2-(Benzhydryl-am...)
Show SMILES O=C(CNC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C26H27N5O/c27-18-24(23-12-7-13-28-19-23)30-14-16-31(17-15-30)25(32)20-29-26(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,19,24,26,29H,14-17,20H2
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n/an/a 9.10n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003506
PNG
(CHEMBL322184 | CHEMBL545771 | {4-[2-(Benzhydryl-am...)
Show SMILES O=C(CNC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C26H27N5O/c27-18-24(23-12-7-13-28-19-23)30-14-16-31(17-15-30)25(32)20-29-26(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,19,24,26,29H,14-17,20H2
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n/an/a 9.10n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50046012
PNG
(CHEMBL100497 | [4-(3-Benzylamino-3-phenyl-propiony...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(NCc1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H31N5O/c1-22-25(13-8-14-30-22)27(20-29)32-15-17-33(18-16-32)28(34)19-26(24-11-6-3-7-12-24)31-21-23-9-4-2-5-10-23/h2-14,26-27,31H,15-19,21H2,1H3
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n/an/a 9.10n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50005231
PNG
(2-{[Acetyl-(5-hexadecyloxy-tetrahydro-furan-3-ylme...)
Show SMILES CCCCCCCCCCCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1
Show InChI InChI=1S/C32H55N2O5/c1-4-6-7-8-9-10-11-12-13-14-15-16-17-20-23-37-31-24-29(26-38-31)27-39-32(36)34(28(3)35)25-30-21-18-19-22-33(30)5-2/h18-19,21-22,29,31H,4-17,20,23-27H2,1-3H3/q+1
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n/an/a 9.70n/an/an/an/an/an/a



J. Uriach & Cía.S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF induced aggregation of rabbit platelets.


J Med Chem 35: 676-83 (1992)


Article DOI: 10.1021/jm00082a007
BindingDB Entry DOI: 10.7270/Q298860P
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003522
PNG
((4-Diphenylacetyl-piperazin-1-yl)-pyridin-3-yl-ace...)
Show SMILES O=C(C(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C25H24N4O/c26-18-23(22-12-7-13-27-19-22)28-14-16-29(17-15-28)25(30)24(20-8-3-1-4-9-20)21-10-5-2-6-11-21/h1-13,19,23-24H,14-17H2
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n/an/a 10n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003473
PNG
(CHEMBL317193 | [4-(3,3-Diphenyl-acryloyl)-piperazi...)
Show SMILES O=C(C=C(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C26H24N4O/c27-19-25(23-12-7-13-28-20-23)29-14-16-30(17-15-29)26(31)18-24(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,18,20,25H,14-17H2
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n/an/a 10n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003473
PNG
(CHEMBL317193 | [4-(3,3-Diphenyl-acryloyl)-piperazi...)
Show SMILES O=C(C=C(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C26H24N4O/c27-19-25(23-12-7-13-28-20-23)29-14-16-30(17-15-29)26(31)18-24(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,18,20,25H,14-17H2
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n/an/a 10n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced platelet aggregation in male rabbits


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50005237
PNG
(2-{[Acetyl-(5-octadecyloxymethyl-tetrahydro-furan-...)
Show SMILES CCCCCCCCCCCCCCCCCCOCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1
Show InChI InChI=1S/C35H61N2O5/c1-4-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22-25-40-30-34-26-32(28-41-34)29-42-35(39)37(31(3)38)27-33-23-20-21-24-36(33)5-2/h20-21,23-24,32,34H,4-19,22,25-30H2,1-3H3/q+1
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n/an/a 11n/an/an/an/an/an/a



J. Uriach & Cía.S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF induced aggregation of rabbit platelets.


J Med Chem 35: 676-83 (1992)


Article DOI: 10.1021/jm00082a007
BindingDB Entry DOI: 10.7270/Q298860P
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50011058
PNG
(CHEMBL124534 | Tetrahydrofuran derivative)
Show SMILES CCCCCCCCCCCCCCCNOC(=O)CC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1
Show InChI InChI=1S/C33H56N3O6/c1-4-6-7-8-9-10-11-12-13-14-15-16-18-21-34-42-32(38)24-31-23-29(26-40-31)27-41-33(39)36(28(3)37)25-30-20-17-19-22-35(30)5-2/h17,19-20,22,29,31,34H,4-16,18,21,23-27H2,1-3H3/q+1
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n/an/a 11n/an/an/an/an/an/a



J. Uriach & Cía.S.A.

Curated by ChEMBL


Assay Description
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%


J Med Chem 34: 373-86 (1991)


Article DOI: 10.1021/jm00105a058
BindingDB Entry DOI: 10.7270/Q2DF6Q51
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003514
PNG
(CHEMBL3216401 | CHEMBL545075 | [4-(2-Benzyl-3-phen...)
Show SMILES Cl.Cl.O=C(C(Cc1ccccc1)Cc1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C27H28N4O/c28-20-26(24-12-7-13-29-21-24)30-14-16-31(17-15-30)27(32)25(18-22-8-3-1-4-9-22)19-23-10-5-2-6-11-23/h1-13,21,25-26H,14-19H2
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n/an/a 11n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045982
PNG
(CHEMBL103596 | [4-(3-Methylamino-3-phenyl-propiony...)
Show SMILES CNC(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1C)c1ccccc1
Show InChI InChI=1S/C22H27N5O/c1-17-19(9-6-10-25-17)21(16-23)26-11-13-27(14-12-26)22(28)15-20(24-2)18-7-4-3-5-8-18/h3-10,20-21,24H,11-15H2,1-2H3
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n/an/a 11n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50005232
PNG
((R)-2-{[Acetyl-(2-methoxy-3-octadecylcarbamoyloxy-...)
Show SMILES CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1cccc[n+]1CC)C(C)=O)OC
Show InChI InChI=1S/C34H59N3O6/c1-5-7-8-9-10-11-12-13-14-15-16-17-18-19-20-22-25-35-33(39)42-28-32(41-4)29-43-34(40)37(30(3)38)27-31-24-21-23-26-36(31)6-2/h21,23-24,26,32H,5-20,22,25,27-29H2,1-4H3/p+1
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n/an/a 11n/an/an/an/an/an/a



J. Uriach & Cía.S.A.

Curated by ChEMBL


Assay Description
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%


J Med Chem 34: 373-86 (1991)


Article DOI: 10.1021/jm00105a058
BindingDB Entry DOI: 10.7270/Q2DF6Q51
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50005232
PNG
((R)-2-{[Acetyl-(2-methoxy-3-octadecylcarbamoyloxy-...)
Show SMILES CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1cccc[n+]1CC)C(C)=O)OC
Show InChI InChI=1S/C34H59N3O6/c1-5-7-8-9-10-11-12-13-14-15-16-17-18-19-20-22-25-35-33(39)42-28-32(41-4)29-43-34(40)37(30(3)38)27-31-24-21-23-26-36(31)6-2/h21,23-24,26,32H,5-20,22,25,27-29H2,1-4H3/p+1
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n/an/a 12n/an/an/an/an/an/a



J. Uriach & Cía.S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF induced aggregation of rabbit platelets.


J Med Chem 35: 676-83 (1992)


Article DOI: 10.1021/jm00082a007
BindingDB Entry DOI: 10.7270/Q298860P
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50005232
PNG
((R)-2-{[Acetyl-(2-methoxy-3-octadecylcarbamoyloxy-...)
Show SMILES CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1cccc[n+]1CC)C(C)=O)OC
Show InChI InChI=1S/C34H59N3O6/c1-5-7-8-9-10-11-12-13-14-15-16-17-18-19-20-22-25-35-33(39)42-28-32(41-4)29-43-34(40)37(30(3)38)27-31-24-21-23-26-36(31)6-2/h21,23-24,26,32H,5-20,22,25,27-29H2,1-4H3/p+1
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n/an/a 12n/an/an/an/an/an/a



J. Uriach & Cía.S.A.

Curated by ChEMBL


Assay Description
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%


J Med Chem 34: 373-86 (1991)


Article DOI: 10.1021/jm00105a058
BindingDB Entry DOI: 10.7270/Q2DF6Q51
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045983
PNG
(CHEMBL103393 | [3-{4-[Cyano-(2-methyl-pyridin-3-yl...)
Show SMILES COC(=O)NC(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1C)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H26F3N5O3/c1-16-19(4-3-9-29-16)21(15-28)31-10-12-32(13-11-31)22(33)14-20(30-23(34)35-2)17-5-7-18(8-6-17)24(25,26)27/h3-9,20-21H,10-14H2,1-2H3,(H,30,34)
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n/an/a 12n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50046017
PNG
((2-Methyl-pyridin-3-yl)-[4-(4,4,4-trifluoro-3-phen...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C22H23F3N4O/c1-16-18(8-5-9-27-16)20(15-26)28-10-12-29(13-11-28)21(30)14-19(22(23,24)25)17-6-3-2-4-7-17/h2-9,19-20H,10-14H2,1H3
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n/an/a 12n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced platelet aggregation in male rabbits


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Cyclooxygenase


(Homo sapiens (Human))
BDBM50102311
PNG
(3-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-6...)
Show SMILES Cc1cnc2c(c(nn2c1C)-c1ccc(cc1)S(C)(=O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C21H18FN3O2S/c1-13-12-23-21-19(15-4-8-17(22)9-5-15)20(24-25(21)14(13)2)16-6-10-18(11-7-16)28(3,26)27/h4-12H,1-3H3
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n/an/a 12n/an/an/an/an/an/a



J. Uriach & Cía. S.A.

Curated by ChEMBL


Assay Description
Inhibition of Prostaglandin G/H synthase 2 in 143.98.2 from human osteosarcoma cells


J Med Chem 44: 350-61 (2001)


Article DOI: 10.1021/jm0009383
BindingDB Entry DOI: 10.7270/Q29W0DSN
More data for this
Ligand-Target Pair
Cyclooxygenase


(Homo sapiens (Human))
BDBM50102309
PNG
(3-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-7...)
Show SMILES Cc1ccnc2c(c(nn12)-c1ccc(cc1)S(C)(=O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C20H16FN3O2S/c1-13-11-12-22-20-18(14-3-7-16(21)8-4-14)19(23-24(13)20)15-5-9-17(10-6-15)27(2,25)26/h3-12H,1-2H3
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n/an/a 12n/an/an/an/an/an/a



J. Uriach & Cía. S.A.

Curated by ChEMBL


Assay Description
Inhibition of Prostaglandin G/H synthase 2 in 143.98.2 from human osteosarcoma cells


J Med Chem 44: 350-61 (2001)


Article DOI: 10.1021/jm0009383
BindingDB Entry DOI: 10.7270/Q29W0DSN
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50005229
PNG
(2-{[Acetyl-(5-octadecyloxy-tetrahydro-furan-3-ylme...)
Show SMILES CCCCCCCCCCCCCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1
Show InChI InChI=1S/C34H59N2O5/c1-4-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22-25-39-33-26-31(28-40-33)29-41-34(38)36(30(3)37)27-32-23-20-21-24-35(32)5-2/h20-21,23-24,31,33H,4-19,22,25-29H2,1-3H3/q+1
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n/an/a 13n/an/an/an/an/an/a



J. Uriach & Cía.S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF induced aggregation of rabbit platelets.


J Med Chem 35: 676-83 (1992)


Article DOI: 10.1021/jm00082a007
BindingDB Entry DOI: 10.7270/Q298860P
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045959
PNG
(CHEMBL103476 | {4-[2-(Benzhydryl-amino)-propionyl]...)
Show SMILES C[C@H](NC(c1ccccc1)c1ccccc1)C(=O)N1CCN(CC1)C(C#N)c1cccnc1C
Show InChI InChI=1S/C28H31N5O/c1-21-25(14-9-15-30-21)26(20-29)32-16-18-33(19-17-32)28(34)22(2)31-27(23-10-5-3-6-11-23)24-12-7-4-8-13-24/h3-15,22,26-27,31H,16-19H2,1-2H3/t22-,26?/m0/s1
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n/an/a 13n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045993
PNG
((3-{4-[Cyano-(2-methyl-pyridin-3-yl)-methyl]-piper...)
Show SMILES CCOC(=O)NC(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1C)c1ccccc1
Show InChI InChI=1S/C24H29N5O3/c1-3-32-24(31)27-21(19-8-5-4-6-9-19)16-23(30)29-14-12-28(13-15-29)22(17-25)20-10-7-11-26-18(20)2/h4-11,21-22H,3,12-16H2,1-2H3,(H,27,31)
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n/an/a 14n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045972
PNG
((2-Methyl-pyridin-3-yl)-[4-(4,4,4-trifluoro-3-hydr...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(O)(c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C22H23F3N4O2/c1-16-18(8-5-9-27-16)19(15-26)28-10-12-29(13-11-28)20(30)14-21(31,22(23,24)25)17-6-3-2-4-7-17/h2-9,19,31H,10-14H2,1H3
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n/an/a 14n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced platelet aggregation in male rabbits


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50011058
PNG
(CHEMBL124534 | Tetrahydrofuran derivative)
Show SMILES CCCCCCCCCCCCCCCNOC(=O)CC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1
Show InChI InChI=1S/C33H56N3O6/c1-4-6-7-8-9-10-11-12-13-14-15-16-18-21-34-42-32(38)24-31-23-29(26-40-31)27-41-33(39)36(28(3)37)25-30-20-17-19-22-35(30)5-2/h17,19-20,22,29,31,34H,4-16,18,21,23-27H2,1-3H3/q+1
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n/an/a 14n/an/an/an/an/an/a



J. Uriach & Cía.S.A.

Curated by ChEMBL


Assay Description
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%


J Med Chem 34: 373-86 (1991)


Article DOI: 10.1021/jm00105a058
BindingDB Entry DOI: 10.7270/Q2DF6Q51
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50005230
PNG
(2-[(Acetyl-{5-[6-(biphenyl-4-ylmethoxy)-hexyloxy]-...)
Show SMILES CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(C1)OCCCCCCOCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C35H45N2O6/c1-3-36-20-10-9-15-33(36)24-37(28(2)38)35(39)43-27-30-23-34(42-26-30)41-22-12-5-4-11-21-40-25-29-16-18-32(19-17-29)31-13-7-6-8-14-31/h6-10,13-20,30,34H,3-5,11-12,21-27H2,1-2H3/q+1
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n/an/a 15n/an/an/an/an/an/a



J. Uriach & Cía.S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF induced aggregation of rabbit platelets.


J Med Chem 35: 676-83 (1992)


Article DOI: 10.1021/jm00082a007
BindingDB Entry DOI: 10.7270/Q298860P
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50005226
PNG
(2-[(Acetyl-{5-[6-(5-phenyl-pentyloxy)-hexyloxy]-te...)
Show SMILES CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(C1)OCCCCCCOCCCCCc1ccccc1
Show InChI InChI=1S/C33H49N2O6/c1-3-34-20-12-11-19-31(34)25-35(28(2)36)33(37)41-27-30-24-32(40-26-30)39-23-15-5-4-13-21-38-22-14-7-10-18-29-16-8-6-9-17-29/h6,8-9,11-12,16-17,19-20,30,32H,3-5,7,10,13-15,18,21-27H2,1-2H3/q+1
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n/an/a 15n/an/an/an/an/an/a



J. Uriach & Cía.S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF induced aggregation of rabbit platelets.


J Med Chem 35: 676-83 (1992)


Article DOI: 10.1021/jm00082a007
BindingDB Entry DOI: 10.7270/Q298860P
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50011072
PNG
(CHEMBL126958 | Dioxolane derivative)
Show SMILES CCCCCCCCCCCCCCCCCNOC(=O)CC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1
Show InChI InChI=1S/C34H58N3O7/c1-4-6-7-8-9-10-11-12-13-14-15-16-17-18-20-23-35-44-32(39)25-31-27-41-33(43-31)28-42-34(40)37(29(3)38)26-30-22-19-21-24-36(30)5-2/h19,21-22,24,31,33,35H,4-18,20,23,25-28H2,1-3H3/q+1
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n/an/a 15n/an/an/an/an/an/a



J. Uriach & Cía.S.A.

Curated by ChEMBL


Assay Description
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%


J Med Chem 34: 373-86 (1991)


Article DOI: 10.1021/jm00105a058
BindingDB Entry DOI: 10.7270/Q2DF6Q51
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003503
PNG
(1-(3,3-Diphenyl-propionyl)-4-(pyridin-3-ylamino)-p...)
Show SMILES O=C(CC(c1ccccc1)c1ccccc1)N1CCC(CC1)(Nc1cccnc1)C#N
Show InChI InChI=1S/C26H26N4O/c27-20-26(29-23-12-7-15-28-19-23)13-16-30(17-14-26)25(31)18-24(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-12,15,19,24,29H,13-14,16-18H2
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n/an/a 15n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50011109
PNG
(2-{[Acetyl-(4-hexadecyloxymethyl-[1,3]dioxolan-2-y...)
Show SMILES CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1
Show InChI InChI=1S/C32H55N2O6/c1-4-6-7-8-9-10-11-12-13-14-15-16-17-20-23-37-25-30-26-38-31(40-30)27-39-32(36)34(28(3)35)24-29-21-18-19-22-33(29)5-2/h18-19,21-22,30-31H,4-17,20,23-27H2,1-3H3/q+1
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n/an/a 15n/an/an/an/an/an/a



J. Uriach & Cía.S.A.

Curated by ChEMBL


Assay Description
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%


J Med Chem 34: 373-86 (1991)


Article DOI: 10.1021/jm00105a058
BindingDB Entry DOI: 10.7270/Q2DF6Q51
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50005235
PNG
(2-{[Acetyl-(5-octadecyloxy-tetrahydro-furan-3-ylme...)
Show SMILES CCCCCCCCCCCCCCCCCCOC1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1
Show InChI InChI=1S/C34H59N2O5/c1-4-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22-25-39-33-26-31(28-40-33)29-41-34(38)36(30(3)37)27-32-23-20-21-24-35(32)5-2/h20-21,23-24,31,33H,4-19,22,25-29H2,1-3H3/q+1/t31-,33?/m0/s1
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n/an/a 16n/an/an/an/an/an/a



J. Uriach & Cía.S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF induced aggregation of rabbit platelets.


J Med Chem 35: 676-83 (1992)


Article DOI: 10.1021/jm00082a007
BindingDB Entry DOI: 10.7270/Q298860P
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045964
PNG
((3-{4-[Cyano-(2-methyl-pyridin-3-yl)-methyl]-piper...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(NC(=O)Oc1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H29N5O3/c1-21-24(13-8-14-30-21)26(20-29)32-15-17-33(18-16-32)27(34)19-25(22-9-4-2-5-10-22)31-28(35)36-23-11-6-3-7-12-23/h2-14,25-26H,15-19H2,1H3,(H,31,35)
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n/an/a 16n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045995
PNG
(CHEMBL100641 | [4-(3-Hydroxy-3,3-diphenyl-propiony...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H28N4O2/c1-21-24(13-8-14-29-21)25(20-28)30-15-17-31(18-16-30)26(32)19-27(33,22-9-4-2-5-10-22)23-11-6-3-7-12-23/h2-14,25,33H,15-19H2,1H3
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n/an/a 17n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50011055
PNG
(2-{[Acetyl-(4-hexadecyloxymethyl-tetrahydro-furan-...)
Show SMILES CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1
Show InChI InChI=1S/C33H57N2O5/c1-4-6-7-8-9-10-11-12-13-14-15-16-17-20-23-38-26-30-24-32(39-27-30)28-40-33(37)35(29(3)36)25-31-21-18-19-22-34(31)5-2/h18-19,21-22,30,32H,4-17,20,23-28H2,1-3H3/q+1
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n/an/a 18n/an/an/an/an/an/a



J. Uriach & Cía.S.A.

Curated by ChEMBL


Assay Description
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%


J Med Chem 34: 373-86 (1991)


Article DOI: 10.1021/jm00105a058
BindingDB Entry DOI: 10.7270/Q2DF6Q51
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50046027
PNG
(CHEMBL103231 | N-(3-{4-[Cyano-(2-methyl-pyridin-3-...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(NS(=O)(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H29N5O3S/c1-21-24(13-8-14-29-21)26(20-28)31-15-17-32(18-16-31)27(33)19-25(22-9-4-2-5-10-22)30-36(34,35)23-11-6-3-7-12-23/h2-14,25-26,30H,15-19H2,1H3
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n/an/a 18n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced platelet aggregation in male rabbits


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50045991
PNG
(CHEMBL100642 | [4-(3,3-Diphenyl-propionyl)-piperaz...)
Show SMILES Cc1ncccc1C(C#N)N1CCN(CC1)C(=O)CC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H28N4O/c1-21-24(13-8-14-29-21)26(20-28)30-15-17-31(18-16-30)27(32)19-25(22-9-4-2-5-10-22)23-11-6-3-7-12-23/h2-14,25-26H,15-19H2,1H3
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n/an/a 18n/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced platelet aggregation


J Med Chem 36: 2984-97 (1993)


Article DOI: 10.1021/jm00072a019
BindingDB Entry DOI: 10.7270/Q2ZS2VKZ
More data for this
Ligand-Target Pair
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