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Compile Data Set for Download or QSAR

Found 74 hits with Last Name = 'hayase' and Initial = 'm'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50121716
PNG
((3-methyl-4-(3-(pyridin-3-ylmethylamino)propoxy)be...)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1ccc(C)cn1
Show InChI InChI=1S/C25H25N3O3/c1-17-9-10-20(28-14-17)24(29)25-18(2)23-21(7-3-8-22(23)31-25)30-13-5-12-27-16-19-6-4-11-26-15-19/h3-4,6-11,14-15,27H,5,12-13,16H2,1-2H3
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n/an/a 0.390n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220561
PNG
(CHEMBL173370)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1nc2ccccc2n1C
Show InChI InChI=1S/C27H26N4O3/c1-18-24-22(33-15-7-14-29-17-19-8-6-13-28-16-19)11-5-12-23(24)34-26(18)25(32)27-30-20-9-3-4-10-21(20)31(27)2/h3-6,8-13,16,29H,7,14-15,17H2,1-2H3
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n/an/a 0.400n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220562
PNG
(CHEMBL171506)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1nc2ccccc2n1CC=C
Show InChI InChI=1S/C29H28N4O3/c1-3-16-33-23-11-5-4-10-22(23)32-29(33)27(34)28-20(2)26-24(12-6-13-25(26)36-28)35-17-8-15-31-19-21-9-7-14-30-18-21/h3-7,9-14,18,31H,1,8,15-17,19H2,2H3
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n/an/a 0.580n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220565
PNG
(CHEMBL170524)
Show SMILES Cc1nc(sc1C)C(=O)c1oc2cccc(OCCCNCc3cccnc3)c2c1C
Show InChI InChI=1S/C24H25N3O3S/c1-15-21-19(29-12-6-11-26-14-18-7-5-10-25-13-18)8-4-9-20(21)30-23(15)22(28)24-27-16(2)17(3)31-24/h4-5,7-10,13,26H,6,11-12,14H2,1-3H3
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n/an/a 0.710n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220569
PNG
(CHEMBL422896)
Show SMILES CC(C)n1c(nc2ccccc12)C(=O)c1oc2cccc(OCCCNCc3cccnc3)c2c1C
Show InChI InChI=1S/C29H30N4O3/c1-19(2)33-23-11-5-4-10-22(23)32-29(33)27(34)28-20(3)26-24(12-6-13-25(26)36-28)35-16-8-15-31-18-21-9-7-14-30-17-21/h4-7,9-14,17,19,31H,8,15-16,18H2,1-3H3
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n/an/a 1.30n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50121720
PNG
((1-METHYL-1H-IMIDAZOL-2-YL)-(3-METHYL-4-{3-[(PYRID...)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1nccn1C
Show InChI InChI=1S/C23H24N4O3/c1-16-20-18(29-13-5-10-25-15-17-6-4-9-24-14-17)7-3-8-19(20)30-22(16)21(28)23-26-11-12-27(23)2/h3-4,6-9,11-12,14,25H,5,10,13,15H2,1-2H3
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n/an/a 1.30n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220559
PNG
(CHEMBL422746)
Show SMILES Cc1csc(n1)C(=O)c1oc2cccc(OCCCNCc3cccnc3)c2c1C
Show InChI InChI=1S/C23H23N3O3S/c1-15-14-30-23(26-15)21(27)22-16(2)20-18(7-3-8-19(20)29-22)28-11-5-10-25-13-17-6-4-9-24-12-17/h3-4,6-9,12,14,25H,5,10-11,13H2,1-2H3
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n/an/a 2n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220571
PNG
(CHEMBL355250)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1ccccn1
Show InChI InChI=1S/C24H23N3O3/c1-17-22-20(29-14-6-12-26-16-18-7-5-11-25-15-18)9-4-10-21(22)30-24(17)23(28)19-8-2-3-13-27-19/h2-5,7-11,13,15,26H,6,12,14,16H2,1H3
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n/an/a 3.5n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50109882
PNG
(3-(3-methyl-2-((2,3,4-trifluorophenoxy)methyl)benz...)
Show SMILES Cc1c(COc2ccc(F)c(F)c2F)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C25H23F3N2O3/c1-16-22(15-32-21-9-8-18(26)24(27)25(21)28)33-20-7-2-6-19(23(16)20)31-12-4-11-30-14-17-5-3-10-29-13-17/h2-3,5-10,13,30H,4,11-12,14-15H2,1H3
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n/an/a 3.70n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans (Nmt) assessed as inhibitory concentration (nM); 3.7-9.4 nM


Bioorg Med Chem Lett 12: 607-10 (2002)


Article DOI: 10.1016/s0960-894x(01)00808-3
BindingDB Entry DOI: 10.7270/Q2PC34K1
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50219310
PNG
(CHEMBL155469)
Show SMILES Cc1c(COc2ccc(cc2)C#N)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C26H25N3O3/c1-19-25(18-31-22-10-8-20(15-27)9-11-22)32-24-7-2-6-23(26(19)24)30-14-4-13-29-17-21-5-3-12-28-16-21/h2-3,5-12,16,29H,4,13-14,17-18H2,1H3
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n/an/a 3.70n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans N-Myristoyltransferase (Nmt)


Bioorg Med Chem Lett 12: 607-10 (2002)


Article DOI: 10.1016/s0960-894x(01)00808-3
BindingDB Entry DOI: 10.7270/Q2PC34K1
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50109879
PNG
(CHEMBL155301 | Non peptidic, 4 | {3-[2-(2,3-Difluo...)
Show SMILES Cc1c(COc2cccc(F)c2F)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C25H24F2N2O3/c1-17-23(16-31-22-10-2-7-19(26)25(22)27)32-21-9-3-8-20(24(17)21)30-13-5-12-29-15-18-6-4-11-28-14-18/h2-4,6-11,14,29H,5,12-13,15-16H2,1H3
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n/an/a 3.70n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans (Nmt) assessed as inhibitory concentration (nM)


Bioorg Med Chem Lett 12: 607-10 (2002)


Article DOI: 10.1016/s0960-894x(01)00808-3
BindingDB Entry DOI: 10.7270/Q2PC34K1
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50219305
PNG
(CHEMBL347895)
Show SMILES Cc1c(COc2ccccc2F)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C25H25FN2O3/c1-18-24(17-30-21-9-3-2-8-20(21)26)31-23-11-4-10-22(25(18)23)29-14-6-13-28-16-19-7-5-12-27-15-19/h2-5,7-12,15,28H,6,13-14,16-17H2,1H3
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n/an/a 3.70n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans (Nmt) assessed as inhibitory concentration


Bioorg Med Chem Lett 12: 607-10 (2002)


Article DOI: 10.1016/s0960-894x(01)00808-3
BindingDB Entry DOI: 10.7270/Q2PC34K1
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50219312
PNG
(CHEMBL158172)
Show SMILES Cc1c(COc2ccc(F)cc2)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C25H25FN2O3/c1-18-24(17-30-21-10-8-20(26)9-11-21)31-23-7-2-6-22(25(18)23)29-14-4-13-28-16-19-5-3-12-27-15-19/h2-3,5-12,15,28H,4,13-14,16-17H2,1H3
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n/an/a 3.70n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans (Nmt) assessed as inhibitory concentration (nM)


Bioorg Med Chem Lett 12: 607-10 (2002)


Article DOI: 10.1016/s0960-894x(01)00808-3
BindingDB Entry DOI: 10.7270/Q2PC34K1
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50109879
PNG
(CHEMBL155301 | Non peptidic, 4 | {3-[2-(2,3-Difluo...)
Show SMILES Cc1c(COc2cccc(F)c2F)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C25H24F2N2O3/c1-17-23(16-31-22-10-2-7-19(26)25(22)27)32-21-9-3-8-20(24(17)21)30-13-5-12-29-15-18-6-4-11-28-14-18/h2-4,6-11,14,29H,5,12-13,15-16H2,1H3
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n/an/a 3.70n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans N-Myristoyltransferase (CaNmt) assessed as inhibitory concentration using substrate peptide and myristot...


Bioorg Med Chem Lett 12: 607-10 (2002)


Article DOI: 10.1016/s0960-894x(01)00808-3
BindingDB Entry DOI: 10.7270/Q2PC34K1
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50219303
PNG
(CHEMBL345893)
Show SMILES Cc1c(COc2ccc(F)cc2F)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C25H24F2N2O3/c1-17-24(16-31-21-9-8-19(26)13-20(21)27)32-23-7-2-6-22(25(17)23)30-12-4-11-29-15-18-5-3-10-28-14-18/h2-3,5-10,13-14,29H,4,11-12,15-16H2,1H3
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n/an/a 3.70n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans (Nmt) assessed as inhibitory concentration (nM)


Bioorg Med Chem Lett 12: 607-10 (2002)


Article DOI: 10.1016/s0960-894x(01)00808-3
BindingDB Entry DOI: 10.7270/Q2PC34K1
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50219312
PNG
(CHEMBL158172)
Show SMILES Cc1c(COc2ccc(F)cc2)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C25H25FN2O3/c1-18-24(17-30-21-10-8-20(26)9-11-21)31-23-7-2-6-22(25(18)23)29-14-4-13-28-16-19-5-3-12-27-15-19/h2-3,5-12,15,28H,4,13-14,16-17H2,1H3
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n/an/a 5.20n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans N-Myristoyltransferase (CaNmt) assessed as inhibitory concentration using substrate peptide and myristot...


Bioorg Med Chem Lett 12: 607-10 (2002)


Article DOI: 10.1016/s0960-894x(01)00808-3
BindingDB Entry DOI: 10.7270/Q2PC34K1
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50109882
PNG
(3-(3-methyl-2-((2,3,4-trifluorophenoxy)methyl)benz...)
Show SMILES Cc1c(COc2ccc(F)c(F)c2F)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C25H23F3N2O3/c1-16-22(15-32-21-9-8-18(26)24(27)25(21)28)33-20-7-2-6-19(23(16)20)31-12-4-11-30-14-17-5-3-10-29-13-17/h2-3,5-10,13,30H,4,11-12,14-15H2,1H3
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n/an/a 5.60n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans Nmt (CaNmt)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50109882
PNG
(3-(3-methyl-2-((2,3,4-trifluorophenoxy)methyl)benz...)
Show SMILES Cc1c(COc2ccc(F)c(F)c2F)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C25H23F3N2O3/c1-16-22(15-32-21-9-8-18(26)24(27)25(21)28)33-20-7-2-6-19(23(16)20)31-12-4-11-30-14-17-5-3-10-29-13-17/h2-3,5-10,13,30H,4,11-12,14-15H2,1H3
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n/an/a 5.70n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans N-Myristoyltransferase (CaNmt) assessed as inhibitory concentration using substrate peptide and myristot...


Bioorg Med Chem Lett 12: 607-10 (2002)


Article DOI: 10.1016/s0960-894x(01)00808-3
BindingDB Entry DOI: 10.7270/Q2PC34K1
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50219303
PNG
(CHEMBL345893)
Show SMILES Cc1c(COc2ccc(F)cc2F)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C25H24F2N2O3/c1-17-24(16-31-21-9-8-19(26)13-20(21)27)32-23-7-2-6-22(25(17)23)30-12-4-11-29-15-18-5-3-10-28-14-18/h2-3,5-10,13-14,29H,4,11-12,15-16H2,1H3
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n/an/a 7.5n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans N-Myristoyltransferase (CaNmt) assessed as inhibitory concentration using substrate peptide and myristot...


Bioorg Med Chem Lett 12: 607-10 (2002)


Article DOI: 10.1016/s0960-894x(01)00808-3
BindingDB Entry DOI: 10.7270/Q2PC34K1
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50219305
PNG
(CHEMBL347895)
Show SMILES Cc1c(COc2ccccc2F)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C25H25FN2O3/c1-18-24(17-30-21-9-3-2-8-20(21)26)31-23-11-4-10-22(25(18)23)29-14-6-13-28-16-19-7-5-12-27-15-19/h2-5,7-12,15,28H,6,13-14,16-17H2,1H3
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n/an/a 8.30n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans N-Myristoyltransferase (CaNmt) assessed as inhibitory concentration using substrate peptide and myristot...


Bioorg Med Chem Lett 12: 607-10 (2002)


Article DOI: 10.1016/s0960-894x(01)00808-3
BindingDB Entry DOI: 10.7270/Q2PC34K1
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50219310
PNG
(CHEMBL155469)
Show SMILES Cc1c(COc2ccc(cc2)C#N)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C26H25N3O3/c1-19-25(18-31-22-10-8-20(15-27)9-11-22)32-24-7-2-6-23(26(19)24)30-14-4-13-29-17-21-5-3-12-28-16-21/h2-3,5-12,16,29H,4,13-14,17-18H2,1H3
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n/an/a 9.40n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans N-Myristoyltransferase (CaNmt) assessed as inhibitory concentration using substrate peptide and myristot...


Bioorg Med Chem Lett 12: 607-10 (2002)


Article DOI: 10.1016/s0960-894x(01)00808-3
BindingDB Entry DOI: 10.7270/Q2PC34K1
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50219308
PNG
(CHEMBL351774)
Show SMILES Cc1c(COc2ccccc2C#N)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C26H25N3O3/c1-19-25(18-31-22-9-3-2-8-21(22)15-27)32-24-11-4-10-23(26(19)24)30-14-6-13-29-17-20-7-5-12-28-16-20/h2-5,7-12,16,29H,6,13-14,17-18H2,1H3
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n/an/a 17n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans N-Myristoyltransferase (CaNmt) assessed as inhibitory concentration using substrate peptide and myristot...


Bioorg Med Chem Lett 12: 607-10 (2002)


Article DOI: 10.1016/s0960-894x(01)00808-3
BindingDB Entry DOI: 10.7270/Q2PC34K1
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50219309
PNG
(CHEMBL158185)
Show SMILES Cc1c(COc2ccc(Br)cc2F)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C25H24BrFN2O3/c1-17-24(16-31-21-9-8-19(26)13-20(21)27)32-23-7-2-6-22(25(17)23)30-12-4-11-29-15-18-5-3-10-28-14-18/h2-3,5-10,13-14,29H,4,11-12,15-16H2,1H3
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n/an/a 28n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans N-Myristoyltransferase (CaNmt) assessed as inhibitory concentration using substrate peptide and myristot...


Bioorg Med Chem Lett 12: 607-10 (2002)


Article DOI: 10.1016/s0960-894x(01)00808-3
BindingDB Entry DOI: 10.7270/Q2PC34K1
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220564
PNG
(CHEMBL353541)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C25H22F3N3O3/c1-16-21-19(33-13-5-11-30-15-17-6-3-10-29-14-17)8-2-9-20(21)34-24(16)23(32)22-18(25(26,27)28)7-4-12-31-22/h2-4,6-10,12,14,30H,5,11,13,15H2,1H3
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n/an/a 43n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220566
PNG
(CHEMBL172471)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(O)c1ccccn1
Show InChI InChI=1S/C24H25N3O3/c1-17-22-20(29-14-6-12-26-16-18-7-5-11-25-15-18)9-4-10-21(22)30-24(17)23(28)19-8-2-3-13-27-19/h2-5,7-11,13,15,23,26,28H,6,12,14,16H2,1H3
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n/an/a 47n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220563
PNG
(CHEMBL353249)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1cccnc1
Show InChI InChI=1S/C24H23N3O3/c1-17-22-20(29-13-5-12-26-15-18-6-3-10-25-14-18)8-2-9-21(22)30-24(17)23(28)19-7-4-11-27-16-19/h2-4,6-11,14,16,26H,5,12-13,15H2,1H3
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n/an/a 62n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50219311
PNG
(CHEMBL346363)
Show SMILES Cc1c(COc2ccccc2)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C25H26N2O3/c1-19-24(18-29-21-9-3-2-4-10-21)30-23-12-5-11-22(25(19)23)28-15-7-14-27-17-20-8-6-13-26-16-20/h2-6,8-13,16,27H,7,14-15,17-18H2,1H3
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n/an/a 72n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans N-Myristoyltransferase (CaNmt) assessed as inhibitory concentration using substrate peptide and myristot...


Bioorg Med Chem Lett 12: 607-10 (2002)


Article DOI: 10.1016/s0960-894x(01)00808-3
BindingDB Entry DOI: 10.7270/Q2PC34K1
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50219304
PNG
(CHEMBL433886)
Show SMILES Cc1c(COc2ccc(Cl)cc2)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C25H25ClN2O3/c1-18-24(17-30-21-10-8-20(26)9-11-21)31-23-7-2-6-22(25(18)23)29-14-4-13-28-16-19-5-3-12-27-15-19/h2-3,5-12,15,28H,4,13-14,16-17H2,1H3
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n/an/a 73n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans N-Myristoyltransferase (CaNmt) assessed as inhibitory concentration using substrate peptide and myristot...


Bioorg Med Chem Lett 12: 607-10 (2002)


Article DOI: 10.1016/s0960-894x(01)00808-3
BindingDB Entry DOI: 10.7270/Q2PC34K1
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220560
PNG
(CHEMBL173962)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1nccs1
Show InChI InChI=1S/C22H21N3O3S/c1-15-19-17(27-11-4-9-24-14-16-5-3-8-23-13-16)6-2-7-18(19)28-21(15)20(26)22-25-10-12-29-22/h2-3,5-8,10,12-13,24H,4,9,11,14H2,1H3
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n/an/a 91n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50101969
PNG
(3-Methyl-4-{3-[(pyridin-3-ylmethyl)-amino]-propoxy...)
Show SMILES CCOC(=O)c1oc2cccc(OCCCNCc3cccnc3)c2c1C
Show InChI InChI=1S/C21H24N2O4/c1-3-25-21(24)20-15(2)19-17(8-4-9-18(19)27-20)26-12-6-11-23-14-16-7-5-10-22-13-16/h4-5,7-10,13,23H,3,6,11-12,14H2,1-2H3
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n/an/a 100n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans N-Myristoyltransferase (CaNmt) assessed as inhibitory concentration using substrate peptide and myristot...


Bioorg Med Chem Lett 12: 607-10 (2002)


Article DOI: 10.1016/s0960-894x(01)00808-3
BindingDB Entry DOI: 10.7270/Q2PC34K1
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50219306
PNG
(CHEMBL154079)
Show SMILES Cc1c(COc2cccc(F)c2)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C25H25FN2O3/c1-18-24(17-30-21-8-2-7-20(26)14-21)31-23-10-3-9-22(25(18)23)29-13-5-12-28-16-19-6-4-11-27-15-19/h2-4,6-11,14-15,28H,5,12-13,16-17H2,1H3
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n/an/a 110n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans N-Myristoyltransferase (CaNmt) assessed as inhibitory concentration using substrate peptide and myristot...


Bioorg Med Chem Lett 12: 607-10 (2002)


Article DOI: 10.1016/s0960-894x(01)00808-3
BindingDB Entry DOI: 10.7270/Q2PC34K1
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220569
PNG
(CHEMBL422896)
Show SMILES CC(C)n1c(nc2ccccc12)C(=O)c1oc2cccc(OCCCNCc3cccnc3)c2c1C
Show InChI InChI=1S/C29H30N4O3/c1-19(2)33-23-11-5-4-10-22(23)32-29(33)27(34)28-20(3)26-24(12-6-13-25(26)36-28)35-16-8-15-31-18-21-9-7-14-30-17-21/h4-7,9-14,17,19,31H,8,15-16,18H2,1-3H3
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n/an/a 480n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Aspergillus fumigatus Nmt (AfNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50109886
PNG
(3-(3-methyl-2-(phenylthiomethyl)benzofuran-4-yloxy...)
Show SMILES Cc1c(CSc2ccccc2)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C25H26N2O2S/c1-19-24(18-30-21-9-3-2-4-10-21)29-23-12-5-11-22(25(19)23)28-15-7-14-27-17-20-8-6-13-26-16-20/h2-6,8-13,16,27H,7,14-15,17-18H2,1H3
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n/an/a 620n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans N-Myristoyltransferase (CaNmt) assessed as inhibitory concentration using substrate peptide and myristot...


Bioorg Med Chem Lett 12: 607-10 (2002)


Article DOI: 10.1016/s0960-894x(01)00808-3
BindingDB Entry DOI: 10.7270/Q2PC34K1
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50219307
PNG
(CHEMBL345610)
Show SMILES Cc1c(CCc2ccccc2)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C26H28N2O2/c1-20-23(14-13-21-8-3-2-4-9-21)30-25-12-5-11-24(26(20)25)29-17-7-16-28-19-22-10-6-15-27-18-22/h2-6,8-12,15,18,28H,7,13-14,16-17,19H2,1H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans N-Myristoyltransferase (CaNmt) assessed as inhibitory concentration using substrate peptide and myristot...


Bioorg Med Chem Lett 12: 607-10 (2002)


Article DOI: 10.1016/s0960-894x(01)00808-3
BindingDB Entry DOI: 10.7270/Q2PC34K1
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220570
PNG
(CHEMBL172455)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1ccccc1
Show InChI InChI=1S/C25H24N2O3/c1-18-23-21(29-15-7-14-27-17-19-8-6-13-26-16-19)11-5-12-22(23)30-25(18)24(28)20-9-3-2-4-10-20/h2-6,8-13,16,27H,7,14-15,17H2,1H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220568
PNG
(CHEMBL368134)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1ccco1
Show InChI InChI=1S/C23H22N2O4/c1-16-21-18(27-13-5-11-25-15-17-6-3-10-24-14-17)7-2-8-19(21)29-23(16)22(26)20-9-4-12-28-20/h2-4,6-10,12,14,25H,5,11,13,15H2,1H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220567
PNG
(CHEMBL355170)
Show SMILES Cc1c(Cc2ccccn2)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C24H25N3O2/c1-18-23(15-20-8-2-3-13-27-20)29-22-10-4-9-21(24(18)22)28-14-6-12-26-17-19-7-5-11-25-16-19/h2-5,7-11,13,16,26H,6,12,14-15,17H2,1H3
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n/an/a 1.90E+3n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50219302
PNG
(CHEMBL155240)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)Nc1ccccc1
Show InChI InChI=1S/C25H25N3O3/c1-18-23-21(30-15-7-14-27-17-19-8-6-13-26-16-19)11-5-12-22(23)31-24(18)25(29)28-20-9-3-2-4-10-20/h2-6,8-13,16,27H,7,14-15,17H2,1H3,(H,28,29)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans N-Myristoyltransferase (CaNmt) assessed as inhibitory concentration using substrate peptide and myristot...


Bioorg Med Chem Lett 12: 607-10 (2002)


Article DOI: 10.1016/s0960-894x(01)00808-3
BindingDB Entry DOI: 10.7270/Q2PC34K1
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50121716
PNG
((3-methyl-4-(3-(pyridin-3-ylmethylamino)propoxy)be...)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1ccc(C)cn1
Show InChI InChI=1S/C25H25N3O3/c1-17-9-10-20(28-14-17)24(29)25-18(2)23-21(7-3-8-22(23)31-25)30-13-5-12-27-16-19-6-4-11-26-15-19/h3-4,6-11,14-15,27H,5,12-13,16H2,1-2H3
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n/an/a 4.10E+3n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against aspergillus fumigatus Nmt (AfNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220565
PNG
(CHEMBL170524)
Show SMILES Cc1nc(sc1C)C(=O)c1oc2cccc(OCCCNCc3cccnc3)c2c1C
Show InChI InChI=1S/C24H25N3O3S/c1-15-21-19(29-12-6-11-26-14-18-7-5-10-25-13-18)8-4-9-20(21)30-23(15)22(28)24-27-16(2)17(3)31-24/h4-5,7-10,13,26H,6,11-12,14H2,1-3H3
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n/an/a 4.30E+3n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Aspergillus fumigatus Nmt (AfNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220562
PNG
(CHEMBL171506)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1nc2ccccc2n1CC=C
Show InChI InChI=1S/C29H28N4O3/c1-3-16-33-23-11-5-4-10-22(23)32-29(33)27(34)28-20(2)26-24(12-6-13-25(26)36-28)35-17-8-15-31-19-21-9-7-14-30-18-21/h3-7,9-14,18,31H,1,8,15-17,19H2,2H3
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n/an/a 5.10E+3n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Aspergillus fumigatus Nmt (AfNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220564
PNG
(CHEMBL353541)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C25H22F3N3O3/c1-16-21-19(33-13-5-11-30-15-17-6-3-10-29-14-17)8-2-9-20(21)34-24(16)23(32)22-18(25(26,27)28)7-4-12-31-22/h2-4,6-10,12,14,30H,5,11,13,15H2,1H3
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n/an/a 1.10E+4n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Aspergillus fumigatus Nmt (AfNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50219307
PNG
(CHEMBL345610)
Show SMILES Cc1c(CCc2ccccc2)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C26H28N2O2/c1-20-23(14-13-21-8-3-2-4-9-21)30-25-12-5-11-24(26(20)25)29-17-7-16-28-19-22-10-6-15-27-18-22/h2-6,8-12,15,18,28H,7,13-14,16-17,19H2,1H3
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n/an/a 1.20E+4n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against human N-Myristoyltransferase (HsNmt) assessed as inhibitory concentration using substrate peptide and myristotyl-CoA at 0...


Bioorg Med Chem Lett 12: 607-10 (2002)


Article DOI: 10.1016/s0960-894x(01)00808-3
BindingDB Entry DOI: 10.7270/Q2PC34K1
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220561
PNG
(CHEMBL173370)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1nc2ccccc2n1C
Show InChI InChI=1S/C27H26N4O3/c1-18-24-22(33-15-7-14-29-17-19-8-6-13-28-16-19)11-5-12-23(24)34-26(18)25(32)27-30-20-9-3-4-10-21(20)31(27)2/h3-6,8-13,16,29H,7,14-15,17H2,1-2H3
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n/an/a 1.30E+4n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Aspergillus fumigatus Nmt (AfNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220559
PNG
(CHEMBL422746)
Show SMILES Cc1csc(n1)C(=O)c1oc2cccc(OCCCNCc3cccnc3)c2c1C
Show InChI InChI=1S/C23H23N3O3S/c1-15-14-30-23(26-15)21(27)22-16(2)20-18(7-3-8-19(20)29-22)28-11-5-10-25-13-17-6-4-9-24-12-17/h3-4,6-9,12,14,25H,5,10-11,13H2,1-2H3
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n/an/a 1.80E+4n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Aspergillus fumigatus Nmt (AfNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50219308
PNG
(CHEMBL351774)
Show SMILES Cc1c(COc2ccccc2C#N)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C26H25N3O3/c1-19-25(18-31-22-9-3-2-8-21(22)15-27)32-24-11-4-10-23(26(19)24)30-14-6-13-29-17-20-7-5-12-28-16-20/h2-5,7-12,16,29H,6,13-14,17-18H2,1H3
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n/an/a 1.90E+4n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against human N-Myristoyltransferase (HsNmt) assessed as inhibitory concentration using substrate peptide and myristotyl-CoA at 0...


Bioorg Med Chem Lett 12: 607-10 (2002)


Article DOI: 10.1016/s0960-894x(01)00808-3
BindingDB Entry DOI: 10.7270/Q2PC34K1
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220560
PNG
(CHEMBL173962)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1nccs1
Show InChI InChI=1S/C22H21N3O3S/c1-15-19-17(27-11-4-9-24-14-16-5-3-8-23-13-16)6-2-7-18(19)28-21(15)20(26)22-25-10-12-29-22/h2-3,5-8,10,12-13,24H,4,9,11,14H2,1H3
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n/an/a 2.50E+4n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Nmt (HsNmt) using 0.5 uM peptide GNAASAR-R-NH2 and 0.5 uM myristoyl-CoA


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50121720
PNG
((1-METHYL-1H-IMIDAZOL-2-YL)-(3-METHYL-4-{3-[(PYRID...)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1nccn1C
Show InChI InChI=1S/C23H24N4O3/c1-16-20-18(29-13-5-10-25-15-17-6-4-9-24-14-17)7-3-8-19(20)30-22(16)21(28)23-26-11-12-27(23)2/h3-4,6-9,11-12,14,25H,5,10,13,15H2,1-2H3
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n/an/a 3.00E+4n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Aspergillus fumigatus Nmt (AfNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220571
PNG
(CHEMBL355250)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1ccccn1
Show InChI InChI=1S/C24H23N3O3/c1-17-22-20(29-14-6-12-26-16-18-7-5-11-25-15-18)9-4-10-21(22)30-24(17)23(28)19-8-2-3-13-27-19/h2-5,7-11,13,15,26H,6,12,14,16H2,1H3
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n/an/a 4.20E+4n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Aspergillus fumigatus Nmt (AfNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50109879
PNG
(CHEMBL155301 | Non peptidic, 4 | {3-[2-(2,3-Difluo...)
Show SMILES Cc1c(COc2cccc(F)c2F)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C25H24F2N2O3/c1-17-23(16-31-22-10-2-7-19(26)25(22)27)32-21-9-3-8-20(24(17)21)30-13-5-12-29-15-18-6-4-11-28-14-18/h2-4,6-11,14,29H,5,12-13,15-16H2,1H3
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n/an/a 6.20E+4n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against human N-Myristoyltransferase (HsNmt) assessed as inhibitory concentration using substrate peptide and myristotyl-CoA at 0...


Bioorg Med Chem Lett 12: 607-10 (2002)


Article DOI: 10.1016/s0960-894x(01)00808-3
BindingDB Entry DOI: 10.7270/Q2PC34K1
More data for this
Ligand-Target Pair
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