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Compile Data Set for Download or QSAR

Found 2354 hits with Last Name = 'henderson' and Initial = 'j'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166333
PNG
(US9067949, 190)
Show SMILES COc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C18H16ClNO4S/c1-23-17-9-13(25(21,22)12-4-2-3-11(19)7-12)8-14-15-10-20-6-5-16(15)24-18(14)17/h2-4,7-9,20H,5-6,10H2,1H3
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US Patent
0.0500 -58.8n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50427363
PNG
(CHEMBL2326002)
Show SMILES CC(C)[C@@](C)(O)[C@@H]1CN(CCN1)c1nc(-c2n[nH]c3ncccc23)c(F)cc1Cl
Show InChI InChI=1S/C20H24ClFN6O/c1-11(2)20(3,29)15-10-28(8-7-23-15)19-13(21)9-14(22)17(25-19)16-12-5-4-6-24-18(12)27-26-16/h4-6,9,11,15,23,29H,7-8,10H2,1-3H3,(H,24,26,27)/t15-,20+/m0/s1
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0.0800n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full-length recombinant PKC theta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 60 mins by scintillation counting analysis...


J Med Chem 56: 1799-810 (2013)


Article DOI: 10.1021/jm301465a
BindingDB Entry DOI: 10.7270/Q2M046R2
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166213
PNG
(US9067949, 70)
Show SMILES COc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C20H18N2O4S/c1-25-19-10-14(9-15-16-11-21-6-5-18(16)26-20(15)19)27(23,24)13-2-3-17-12(8-13)4-7-22-17/h2-4,7-10,21-22H,5-6,11H2,1H3
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US Patent
0.0830 -57.5n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50427364
PNG
(CHEMBL2326001)
Show SMILES CC(C)[C@@](C)(O)[C@@H]1CN(CCN1)c1nc(-c2n[nH]c3ncccc23)c(F)cc1F
Show InChI InChI=1S/C20H24F2N6O/c1-11(2)20(3,29)15-10-28(8-7-23-15)19-14(22)9-13(21)17(25-19)16-12-5-4-6-24-18(12)27-26-16/h4-6,9,11,15,23,29H,7-8,10H2,1-3H3,(H,24,26,27)/t15-,20+/m0/s1
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0.100n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full-length recombinant PKC theta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 60 mins by scintillation counting analysis...


J Med Chem 56: 1799-810 (2013)


Article DOI: 10.1021/jm301465a
BindingDB Entry DOI: 10.7270/Q2M046R2
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50427365
PNG
(CHEMBL2326000)
Show SMILES CC(C)[C@@](C)(O)[C@@H]1CN(CCN1)c1nc(-c2n[nH]c3ncccc23)c(F)cc1CO
Show InChI InChI=1S/C21H27FN6O2/c1-12(2)21(3,30)16-10-28(8-7-23-16)20-13(11-29)9-15(22)18(25-20)17-14-5-4-6-24-19(14)27-26-17/h4-6,9,12,16,23,29-30H,7-8,10-11H2,1-3H3,(H,24,26,27)/t16-,21+/m0/s1
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0.100n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full-length recombinant PKC theta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 60 mins by scintillation counting analysis...


J Med Chem 56: 1799-810 (2013)


Article DOI: 10.1021/jm301465a
BindingDB Entry DOI: 10.7270/Q2M046R2
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50427367
PNG
(CHEMBL2325998)
Show SMILES CC(C)[C@@](C)(O)[C@@H]1CN(CCN1)c1nc(-c2n[nH]c3ncccc23)c(F)cc1O
Show InChI InChI=1S/C20H25FN6O2/c1-11(2)20(3,29)15-10-27(8-7-22-15)19-14(28)9-13(21)17(24-19)16-12-5-4-6-23-18(12)26-25-16/h4-6,9,11,15,22,28-29H,7-8,10H2,1-3H3,(H,23,25,26)/t15-,20+/m0/s1
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0.100n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full-length recombinant PKC theta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 60 mins by scintillation counting analysis...


J Med Chem 56: 1799-810 (2013)


Article DOI: 10.1021/jm301465a
BindingDB Entry DOI: 10.7270/Q2M046R2
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166328
PNG
(US9067949, 185)
Show SMILES COc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1csc2ccccc12
Show InChI InChI=1S/C20H17NO4S2/c1-24-17-9-12(8-14-15-10-21-7-6-16(15)25-20(14)17)27(22,23)19-11-26-18-5-3-2-4-13(18)19/h2-5,8-9,11,21H,6-7,10H2,1H3
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US Patent
0.100 -57.1n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166358
PNG
(US9067949, 215)
Show SMILES CCOc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C19H19NO4S/c1-2-23-18-11-14(25(21,22)13-6-4-3-5-7-13)10-15-16-12-20-9-8-17(16)24-19(15)18/h3-7,10-11,20H,2,8-9,12H2,1H3
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US Patent
0.110 -56.8n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166331
PNG
(US9067949, 188)
Show SMILES COc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C18H15ClFNO4S/c1-24-17-8-13(26(22,23)12-5-10(19)4-11(20)6-12)7-14-15-9-21-3-2-16(15)25-18(14)17/h4-8,21H,2-3,9H2,1H3
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US Patent
0.110 -56.8n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166303
PNG
(US9067949, 160)
Show SMILES COc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C19H17F2NO5S/c1-25-17-9-13(8-14-15-10-22-6-5-16(15)27-18(14)17)28(23,24)12-4-2-3-11(7-12)26-19(20)21/h2-4,7-9,19,22H,5-6,10H2,1H3
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US Patent
0.110 -56.8n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166197
PNG
(US9067949, 54)
Show SMILES COc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H17NO4S/c1-22-17-10-13(24(20,21)12-5-3-2-4-6-12)9-14-15-11-19-8-7-16(15)23-18(14)17/h2-6,9-10,19H,7-8,11H2,1H3
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US Patent
0.120 -56.6n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166310
PNG
(US9067949, 167)
Show SMILES COc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C19H16F3NO4S/c1-26-17-9-13(8-14-15-10-23-6-5-16(15)27-18(14)17)28(24,25)12-4-2-3-11(7-12)19(20,21)22/h2-4,7-9,23H,5-6,10H2,1H3
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US Patent
0.130 -56.4n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166244
PNG
(US9067949, 101 | US9067949, 143)
Show SMILES Clc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C19H15ClN2O3S/c20-16-9-13(8-14-15-10-21-5-4-18(15)25-19(14)16)26(23,24)12-1-2-17-11(7-12)3-6-22-17/h1-3,6-9,21-22H,4-5,10H2
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US Patent
0.130 -56.4n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166244
PNG
(US9067949, 101 | US9067949, 143)
Show SMILES Clc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C19H15ClN2O3S/c20-16-9-13(8-14-15-10-21-5-4-18(15)25-19(14)16)26(23,24)12-1-2-17-11(7-12)3-6-22-17/h1-3,6-9,21-22H,4-5,10H2
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US Patent
0.130 -56.4n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166225
PNG
(US9067949, 81a | US9067949, 82a | US9067949, 82b)
Show SMILES CC1NCCc2oc3c(Cl)cc(cc3c12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H16ClNO3S/c1-11-17-14-9-13(24(21,22)12-5-3-2-4-6-12)10-15(19)18(14)23-16(17)7-8-20-11/h2-6,9-11,20H,7-8H2,1H3
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US Patent
0.150 -56.1n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166326
PNG
(US9067949, 183)
Show SMILES COc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1cn(C)c2ccccc12
Show InChI InChI=1S/C21H20N2O4S/c1-23-12-20(14-5-3-4-6-17(14)23)28(24,25)13-9-15-16-11-22-8-7-18(16)27-21(15)19(10-13)26-2/h3-6,9-10,12,22H,7-8,11H2,1-2H3
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US Patent
0.160 -55.9n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166327
PNG
(US9067949, 184)
Show SMILES COc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1ccc2sccc2c1
Show InChI InChI=1S/C20H17NO4S2/c1-24-18-10-14(9-15-16-11-21-6-4-17(16)25-20(15)18)27(22,23)13-2-3-19-12(8-13)5-7-26-19/h2-3,5,7-10,21H,4,6,11H2,1H3
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US Patent
0.160 -55.9n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166193
PNG
(US9067949, 50)
Show SMILES Cn1cc(c2ccccc12)S(=O)(=O)c1cc(Cl)c2oc3CCNCc3c2c1
Show InChI InChI=1S/C20H17ClN2O3S/c1-23-11-19(13-4-2-3-5-17(13)23)27(24,25)12-8-14-15-10-22-7-6-18(15)26-20(14)16(21)9-12/h2-5,8-9,11,22H,6-7,10H2,1H3
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US Patent
0.170 -55.8n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166335
PNG
(US9067949, 192)
Show SMILES COc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1cccs1
Show InChI InChI=1S/C16H15NO4S2/c1-20-14-8-10(23(18,19)15-3-2-6-22-15)7-11-12-9-17-5-4-13(12)21-16(11)14/h2-3,6-8,17H,4-5,9H2,1H3
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US Patent
0.170 -55.8n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166311
PNG
(US9067949, 168)
Show SMILES COc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C19H16F3NO5S/c1-26-17-9-13(8-14-15-10-23-6-5-16(15)27-18(14)17)29(24,25)12-4-2-3-11(7-12)28-19(20,21)22/h2-4,7-9,23H,5-6,10H2,1H3
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US Patent
0.190 -55.5n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166306
PNG
(US9067949, 163)
Show SMILES COc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C18H16FNO4S/c1-23-16-9-11(25(21,22)17-5-3-2-4-14(17)19)8-12-13-10-20-7-6-15(13)24-18(12)16/h2-5,8-9,20H,6-7,10H2,1H3
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0.190 -55.5n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50427370
PNG
(CHEMBL2326007)
Show SMILES CC(C)[C@@](C)(O)[C@@H]1CN(CCN1)c1ccc(F)c(n1)-c1n[nH]c2ncccc12
Show InChI InChI=1S/C20H25FN6O/c1-12(2)20(3,28)15-11-27(10-9-22-15)16-7-6-14(21)18(24-16)17-13-5-4-8-23-19(13)26-25-17/h4-8,12,15,22,28H,9-11H2,1-3H3,(H,23,25,26)/t15-,20+/m0/s1
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Article
PubMed
0.200n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of full-length recombinant PKC theta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 60 mins by scintillation counting analysis...


J Med Chem 56: 1799-810 (2013)


Article DOI: 10.1021/jm301465a
BindingDB Entry DOI: 10.7270/Q2M046R2
More data for this
Ligand-Target Pair
Adenosine receptor A2


(Homo sapiens (Human))
BDBM303248
PNG
(2-amino-N-[(1-ethyl-2- oxo-3-pyridyl)methyl]-8- me...)
Show SMILES CCn1cccc(CNC(=O)c2nc(N)nc3c(OC)cccc23)c1=O
Show InChI InChI=1S/C18H19N5O3/c1-3-23-9-5-6-11(17(23)25)10-20-16(24)15-12-7-4-8-13(26-2)14(12)21-18(19)22-15/h4-9H,3,10H2,1-2H3,(H,20,24)(H2,19,21,22)
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US Patent
0.200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim...


US Patent US10138212 (2018)


BindingDB Entry DOI: 10.7270/Q2WM1GGB
More data for this
Ligand-Target Pair
Adenosine receptor A2


(Homo sapiens (Human))
BDBM50139771
PNG
(CHEMBL3765580 | US10138212, Example 12)
Show SMILES COc1cccc2c(nc(N)nc12)C(=O)NCc1cccc2cccnc12
Show InChI InChI=1S/C20H17N5O2/c1-27-15-9-3-8-14-17(15)24-20(21)25-18(14)19(26)23-11-13-6-2-5-12-7-4-10-22-16(12)13/h2-10H,11H2,1H3,(H,23,26)(H2,21,24,25)
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0.200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim...


US Patent US10138212 (2018)


BindingDB Entry DOI: 10.7270/Q2WM1GGB
More data for this
Ligand-Target Pair
Adenosine receptor A2


(Homo sapiens (Human))
BDBM303246
PNG
(2-amino-N-[(3,6- dimethyl-2- pyridyl)methyl]-8- me...)
Show SMILES COc1cccc2c(nc(N)nc12)C(=O)NCc1nc(C)ccc1C
Show InChI InChI=1S/C18H19N5O2/c1-10-7-8-11(2)21-13(10)9-20-17(24)16-12-5-4-6-14(25-3)15(12)22-18(19)23-16/h4-8H,9H2,1-3H3,(H,20,24)(H2,19,22,23)
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0.200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim...


US Patent US10138212 (2018)


BindingDB Entry DOI: 10.7270/Q2WM1GGB
More data for this
Ligand-Target Pair
Adenosine receptor A2


(Homo sapiens (Human))
BDBM50200981
PNG
(CHEMBL3960148 | US10138212, Example 6)
Show SMILES COc1cccc2c(nc(N)nc12)C(=O)NCc1cccc(n1)C1CCC1
Show InChI InChI=1S/C20H21N5O2/c1-27-16-10-4-8-14-17(16)24-20(21)25-18(14)19(26)22-11-13-7-3-9-15(23-13)12-5-2-6-12/h3-4,7-10,12H,2,5-6,11H2,1H3,(H,22,26)(H2,21,24,25)
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0.200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim...


US Patent US10138212 (2018)


BindingDB Entry DOI: 10.7270/Q2WM1GGB
More data for this
Ligand-Target Pair
Adenosine receptor A2


(Homo sapiens (Human))
BDBM50201006
PNG
(CHEMBL3923709 | US10138212, Example 5)
Show SMILES COc1cccc2c(nc(N)nc12)C(=O)NCc1cccc(n1)C(C)C
Show InChI InChI=1S/C19H21N5O2/c1-11(2)14-8-4-6-12(22-14)10-21-18(25)17-13-7-5-9-15(26-3)16(13)23-19(20)24-17/h4-9,11H,10H2,1-3H3,(H,21,25)(H2,20,23,24)
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0.200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim...


US Patent US10138212 (2018)


BindingDB Entry DOI: 10.7270/Q2WM1GGB
More data for this
Ligand-Target Pair
Adenosine receptor A2


(Homo sapiens (Human))
BDBM50201019
PNG
(CHEMBL3973920 | US10138212, Example 44)
Show SMILES COc1cccc2c(nc(N)nc12)C(=O)NCc1cccc(COc2ccccc2F)n1
Show InChI InChI=1S/C23H20FN5O3/c1-31-19-11-5-8-16-20(19)28-23(25)29-21(16)22(30)26-12-14-6-4-7-15(27-14)13-32-18-10-3-2-9-17(18)24/h2-11H,12-13H2,1H3,(H,26,30)(H2,25,28,29)
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0.200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim...


US Patent US10138212 (2018)


BindingDB Entry DOI: 10.7270/Q2WM1GGB
More data for this
Ligand-Target Pair
Adenosine receptor A2


(Homo sapiens (Human))
BDBM50139773
PNG
(CHEMBL3765379 | US10138212, Example 101)
Show SMILES Nc1nc(C(=O)NCc2cccc3cccnc23)c2cccc(OC(F)(F)F)c2n1
Show InChI InChI=1S/C20H14F3N5O2/c21-20(22,23)30-14-8-2-7-13-16(14)27-19(24)28-17(13)18(29)26-10-12-5-1-4-11-6-3-9-25-15(11)12/h1-9H,10H2,(H,26,29)(H2,24,27,28)
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0.200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim...


US Patent US10138212 (2018)


BindingDB Entry DOI: 10.7270/Q2WM1GGB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166309
PNG
(US9067949, 166)
Show SMILES COc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C18H16FNO4S/c1-23-17-9-13(25(21,22)12-4-2-3-11(19)7-12)8-14-15-10-20-6-5-16(15)24-18(14)17/h2-4,7-9,20H,5-6,10H2,1H3
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0.200 -55.4n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166194
PNG
(US9067949, 51)
Show SMILES Clc1cc(cc2c3CNCCc3oc12)S(=O)(=O)n1ccc2ccccc12
Show InChI InChI=1S/C19H15ClN2O3S/c20-16-10-13(9-14-15-11-21-7-5-18(15)25-19(14)16)26(23,24)22-8-6-12-3-1-2-4-17(12)22/h1-4,6,8-10,21H,5,7,11H2
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0.200 -55.4n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166344
PNG
(US9067949, 201)
Show SMILES Cc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C19H16F3NO3S/c1-11-7-14(9-15-16-10-23-6-5-17(16)26-18(11)15)27(24,25)13-4-2-3-12(8-13)19(20,21)22/h2-4,7-9,23H,5-6,10H2,1H3
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US Patent
0.220 -55.1n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166196
PNG
(US9067949, 53)
Show SMILES Cc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H17NO3S/c1-12-9-14(23(20,21)13-5-3-2-4-6-13)10-15-16-11-19-8-7-17(16)22-18(12)15/h2-6,9-10,19H,7-8,11H2,1H3
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0.220 -55.1n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166347
PNG
(US9067949, 204)
Show SMILES Cc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1ccc2sccc2c1
Show InChI InChI=1S/C20H17NO3S2/c1-12-8-15(10-16-17-11-21-6-4-18(17)24-20(12)16)26(22,23)14-2-3-19-13(9-14)5-7-25-19/h2-3,5,7-10,21H,4,6,11H2,1H3
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0.230 -55.0n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166334
PNG
(US9067949, 191)
Show SMILES COc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C18H15Cl2NO4S/c1-24-17-8-13(26(22,23)12-5-10(19)4-11(20)6-12)7-14-15-9-21-3-2-16(15)25-18(14)17/h4-8,21H,2-3,9H2,1H3
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0.230 -55.0n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166233
PNG
(US9067949, 90)
Show SMILES Clc1cc(cc2c3CCNCCc3oc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H16ClNO3S/c19-16-11-13(24(21,22)12-4-2-1-3-5-12)10-15-14-6-8-20-9-7-17(14)23-18(15)16/h1-5,10-11,20H,6-9H2
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US Patent
0.25 -54.8n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166276
PNG
(US9067949, 133)
Show SMILES Clc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1csc2ccccc12
Show InChI InChI=1S/C19H14ClNO3S2/c20-15-8-11(7-13-14-9-21-6-5-16(14)24-19(13)15)26(22,23)18-10-25-17-4-2-1-3-12(17)18/h1-4,7-8,10,21H,5-6,9H2
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0.260 -54.7n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM104371
PNG
(US8575186, 134/183/184 | US8575186, 199 | US857518...)
Show SMILES CN1C2CCC1c1c(C2)n(C)c2ccc(cc12)S(=O)(=O)c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C23H23N3O2S/c1-25-15-3-7-21(25)23-18-13-17(5-8-20(18)26(2)22(23)12-15)29(27,28)16-4-6-19-14(11-16)9-10-24-19/h4-6,8-11,13,15,21,24H,3,7,12H2,1-2H3
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0.260n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
The relative affinities of the various compounds for the 5-HT6 receptor were measured in a radioligand binding assay, using a sintillation proximity ...


US Patent US8575186 (2013)


BindingDB Entry DOI: 10.7270/Q2BR8QTS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166330
PNG
(US9067949, 187)
Show SMILES COc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1ccsc1
Show InChI InChI=1S/C16H15NO4S2/c1-20-15-7-11(23(18,19)10-3-5-22-9-10)6-12-13-8-17-4-2-14(13)21-16(12)15/h3,5-7,9,17H,2,4,8H2,1H3
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0.270 -54.6n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM104408
PNG
(US8575186, 171/172 | US8575186, 188)
Show SMILES Cn1c2CC3CCC(N3)c2c2cc(ccc12)S(=O)(=O)c1csc2ccccc12
Show InChI InChI=1S/C22H20N2O2S2/c1-24-18-9-7-14(11-16(18)22-17-8-6-13(23-17)10-19(22)24)28(25,26)21-12-27-20-5-3-2-4-15(20)21/h2-5,7,9,11-13,17,23H,6,8,10H2,1H3
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0.280n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
The relative affinities of the various compounds for the 5-HT6 receptor were measured in a radioligand binding assay, using a sintillation proximity ...


US Patent US8575186 (2013)


BindingDB Entry DOI: 10.7270/Q2BR8QTS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166332
PNG
(US9067949, 189)
Show SMILES COc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H16ClNO4S/c1-23-17-9-13(25(21,22)12-4-2-11(19)3-5-12)8-14-15-10-20-7-6-16(15)24-18(14)17/h2-5,8-9,20H,6-7,10H2,1H3
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0.280 -54.5n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166338
PNG
(US9067949, 195)
Show SMILES Cc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C18H16ClNO3S/c1-11-7-14(24(21,22)13-4-2-3-12(19)8-13)9-15-16-10-20-6-5-17(16)23-18(11)15/h2-4,7-9,20H,5-6,10H2,1H3
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US Patent
0.280 -54.5n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM104331
PNG
(US8575186, 177 | US8575186, 178 | US8575186, 94/16...)
Show SMILES Cn1c2CC3CCC(N3)c2c2cc(ccc12)S(=O)(=O)c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C22H21N3O2S/c1-25-20-7-4-16(12-17(20)22-19-5-2-14(24-19)11-21(22)25)28(26,27)15-3-6-18-13(10-15)8-9-23-18/h3-4,6-10,12,14,19,23-24H,2,5,11H2,1H3
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US Patent
0.280n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
The relative affinities of the various compounds for the 5-HT6 receptor were measured in a radioligand binding assay, using a sintillation proximity ...


US Patent US8575186 (2013)


BindingDB Entry DOI: 10.7270/Q2BR8QTS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50364980
PNG
(CHEMBL1950775)
Show SMILES Cn1c2CC3CCC(N3)c2c2cc(ccc12)S(=O)(=O)c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C22H21N3O2S/c1-25-20-7-4-16(12-17(20)22-19-5-2-14(24-19)11-21(22)25)28(26,27)15-3-6-18-13(10-15)8-9-23-18/h3-4,6-10,12,14,19,23-24H,2,5,11H2,1H3
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0.280n/an/an/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT6 serotonin receptor by scintillation proximity assay


Bioorg Med Chem Lett 22: 1494-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.022
BindingDB Entry DOI: 10.7270/Q2RB753Z
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50364981
PNG
(CHEMBL1950776)
Show SMILES Cn1c2CC3CCC(N3)c2c2cc(ccc12)S(=O)(=O)c1csc2ccccc12
Show InChI InChI=1S/C22H20N2O2S2/c1-24-18-9-7-14(11-16(18)22-17-8-6-13(23-17)10-19(22)24)28(25,26)21-12-27-20-5-3-2-4-15(20)21/h2-5,7,9,11-13,17,23H,6,8,10H2,1H3
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0.280n/an/an/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT6 serotonin receptor by scintillation proximity assay


Bioorg Med Chem Lett 22: 1494-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.022
BindingDB Entry DOI: 10.7270/Q2RB753Z
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM104378
PNG
(US8575186, 141)
Show SMILES Cc1cc(cc2c3C4CCC(Cc3n(C)c12)N4)S(=O)(=O)c1csc2ccccc12
Show InChI InChI=1S/C23H22N2O2S2/c1-13-9-15(29(26,27)21-12-28-20-6-4-3-5-16(20)21)11-17-22-18-8-7-14(24-18)10-19(22)25(2)23(13)17/h3-6,9,11-12,14,18,24H,7-8,10H2,1-2H3
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US Patent
0.290n/an/an/an/an/an/an/an/a



Albany Molecular Research, Inc.

US Patent


Assay Description
The relative affinities of the various compounds for the 5-HT6 receptor were measured in a radioligand binding assay, using a sintillation proximity ...


US Patent US8575186 (2013)


BindingDB Entry DOI: 10.7270/Q2BR8QTS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM166345
PNG
(US9067949, 202)
Show SMILES Cc1cc(cc2c3CNCCc3oc12)S(=O)(=O)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C19H17F2NO4S/c1-11-7-14(9-15-16-10-22-6-5-17(16)26-18(11)15)27(23,24)13-4-2-3-12(8-13)25-19(20)21/h2-4,7-9,19,22H,5-6,10H2,1H3
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US Patent
0.300 -54.4n/an/an/an/an/a7.525



Albany Molecular Research, Inc.

US Patent


Assay Description
For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...


US Patent US9067949 (2015)


BindingDB Entry DOI: 10.7270/Q23777FB
More data for this
Ligand-Target Pair
Adenosine receptor A2


(Homo sapiens (Human))
BDBM303251
PNG
(2-amino-N-(8- isoquinolylmethyl)-8- methoxy-quinaz...)
Show SMILES COc1cccc2c(nc(N)nc12)C(=O)NCc1cccc2ccncc12
Show InChI InChI=1S/C20H17N5O2/c1-27-16-7-3-6-14-17(16)24-20(21)25-18(14)19(26)23-10-13-5-2-4-12-8-9-22-11-15(12)13/h2-9,11H,10H2,1H3,(H,23,26)(H2,21,24,25)
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US Patent
0.300n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim...


US Patent US10138212 (2018)


BindingDB Entry DOI: 10.7270/Q2WM1GGB
More data for this
Ligand-Target Pair
Adenosine receptor A2


(Homo sapiens (Human))
BDBM303181
PNG
(2-amino-N-[(6- cyclopropyl-2- pyridyl)methyl]-8- m...)
Show SMILES COc1cccc2c(nc(N)nc12)C(=O)NCc1cccc(n1)C1CC1
Show InChI InChI=1S/C19H19N5O2/c1-26-15-7-3-5-13-16(15)23-19(20)24-17(13)18(25)21-10-12-4-2-6-14(22-12)11-8-9-11/h2-7,11H,8-10H2,1H3,(H,21,25)(H2,20,23,24)
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0.300n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim...


US Patent US10138212 (2018)


BindingDB Entry DOI: 10.7270/Q2WM1GGB
More data for this
Ligand-Target Pair
Adenosine receptor A2


(Homo sapiens (Human))
BDBM303280
PNG
(2-amino-N-[[6-[(4- fluorophenoxy)methyl]- 2-pyridy...)
Show SMILES COc1cccc2c(nc(N)nc12)C(=O)NCc1cccc(COc2ccc(F)cc2)n1
Show InChI InChI=1S/C23H20FN5O3/c1-31-19-7-3-6-18-20(19)28-23(25)29-21(18)22(30)26-12-15-4-2-5-16(27-15)13-32-17-10-8-14(24)9-11-17/h2-11H,12-13H2,1H3,(H,26,30)(H2,25,28,29)
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US Patent
0.300n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim...


US Patent US10138212 (2018)


BindingDB Entry DOI: 10.7270/Q2WM1GGB
More data for this
Ligand-Target Pair
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