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Compile Data Set for Download or QSAR

Found 240 hits with Last Name = 'hingorani' and Initial = 'gp'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215854
PNG
(CHEMBL301829)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cc(ccc1C(O)=O)C(F)(F)F
Show InChI InChI=1S/C24H19F3O4/c25-24(26,27)17-7-9-18(23(29)30)20(12-17)15-6-8-19-21(11-15)31-13-16(22(19)28)10-14-4-2-1-3-5-14/h1-9,11-12,16,22,28H,10,13H2,(H,29,30)/t16-,22+/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215854
PNG
(CHEMBL301829)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cc(ccc1C(O)=O)C(F)(F)F
Show InChI InChI=1S/C24H19F3O4/c25-24(26,27)17-7-9-18(23(29)30)20(12-17)15-6-8-19-21(11-15)31-13-16(22(19)28)10-14-4-2-1-3-5-14/h1-9,11-12,16,22,28H,10,13H2,(H,29,30)/t16-,22+/m0/s1
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n/an/a 2.40n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215738
PNG
(CHEMBL52675)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cc(F)ccc1C(O)=O
Show InChI InChI=1S/C23H19FO4/c24-17-7-9-18(23(26)27)20(12-17)15-6-8-19-21(11-15)28-13-16(22(19)25)10-14-4-2-1-3-5-14/h1-9,11-12,16,22,25H,10,13H2,(H,26,27)/t16-,22+/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215863
PNG
(CHEMBL52449)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cc(F)ccc1NS(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C23H19F4NO4S/c24-17-7-9-20(28-33(30,31)23(25,26)27)19(12-17)15-6-8-18-21(11-15)32-13-16(22(18)29)10-14-4-2-1-3-5-14/h1-9,11-12,16,22,28-29H,10,13H2/t16-,22+/m0/s1
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n/an/a 3.80n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215737
PNG
(CHEMBL50425)
Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)-c1cc(Cl)ccc1C(O)=O
Show InChI InChI=1S/C29H23ClO4/c30-23-11-13-24(29(32)33)26(16-23)21-10-12-25-27(15-21)34-17-22(28(25)31)14-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-13,15-16,22,28,31H,14,17H2,(H,32,33)/t22-,28+/m0/s1
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n/an/a 4n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215740
PNG
(CHEMBL48906)
Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)-c1cc(F)ccc1C(O)=O
Show InChI InChI=1S/C29H23FO4/c30-23-11-13-24(29(32)33)26(16-23)21-10-12-25-27(15-21)34-17-22(28(25)31)14-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-13,15-16,22,28,31H,14,17H2,(H,32,33)/t22-,28+/m0/s1
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n/an/a 4n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215740
PNG
(CHEMBL48906)
Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)-c1cc(F)ccc1C(O)=O
Show InChI InChI=1S/C29H23FO4/c30-23-11-13-24(29(32)33)26(16-23)21-10-12-25-27(15-21)34-17-22(28(25)31)14-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-13,15-16,22,28,31H,14,17H2,(H,32,33)/t22-,28+/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215855
PNG
(CHEMBL51467)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cc(F)cc(F)c1C(O)=O
Show InChI InChI=1S/C23H18F2O4/c24-16-10-18(21(23(27)28)19(25)11-16)14-6-7-17-20(9-14)29-12-15(22(17)26)8-13-4-2-1-3-5-13/h1-7,9-11,15,22,26H,8,12H2,(H,27,28)/t15-,22+/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215738
PNG
(CHEMBL52675)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cc(F)ccc1C(O)=O
Show InChI InChI=1S/C23H19FO4/c24-17-7-9-18(23(26)27)20(12-17)15-6-8-19-21(11-15)28-13-16(22(19)25)10-14-4-2-1-3-5-14/h1-9,11-12,16,22,25H,10,13H2,(H,26,27)/t16-,22+/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50037218
PNG
(1-((3S,4R)-3-Biphenyl-4-ylmethyl-4-hydroxy-chroman...)
Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)C1(CCCC1)C(O)=O
Show InChI InChI=1S/C28H28O4/c29-26-22(16-19-8-10-21(11-9-19)20-6-2-1-3-7-20)18-32-25-17-23(12-13-24(25)26)28(27(30)31)14-4-5-15-28/h1-3,6-13,17,22,26,29H,4-5,14-16,18H2,(H,30,31)/t22-,26+/m0/s1
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n/an/a 5.5n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4-induced CD11b up-regulation on isolated human neutrophils in whole blood


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215853
PNG
(CHEMBL417364)
Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)-c1cc(ccc1C(O)=O)C(F)(F)F
Show InChI InChI=1S/C30H23F3O4/c31-30(32,33)23-11-13-24(29(35)36)26(16-23)21-10-12-25-27(15-21)37-17-22(28(25)34)14-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-13,15-16,22,28,34H,14,17H2,(H,35,36)/t22-,28+/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215737
PNG
(CHEMBL50425)
Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)-c1cc(Cl)ccc1C(O)=O
Show InChI InChI=1S/C29H23ClO4/c30-23-11-13-24(29(32)33)26(16-23)21-10-12-25-27(15-21)34-17-22(28(25)31)14-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-13,15-16,22,28,31H,14,17H2,(H,32,33)/t22-,28+/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50037218
PNG
(1-((3S,4R)-3-Biphenyl-4-ylmethyl-4-hydroxy-chroman...)
Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)C1(CCCC1)C(O)=O
Show InChI InChI=1S/C28H28O4/c29-26-22(16-19-8-10-21(11-9-19)20-6-2-1-3-7-20)18-32-25-17-23(12-13-24(25)26)28(27(30)31)14-4-5-15-28/h1-3,6-13,17,22,26,29H,4-5,14-16,18H2,(H,30,31)/t22-,26+/m0/s1
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n/an/a 6.40n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to inhibit [3H]LTB4 binding to LTB4 receptors on guinea pig spleen membranes


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215854
PNG
(CHEMBL301829)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cc(ccc1C(O)=O)C(F)(F)F
Show InChI InChI=1S/C24H19F3O4/c25-24(26,27)17-7-9-18(23(29)30)20(12-17)15-6-8-19-21(11-15)31-13-16(22(19)28)10-14-4-2-1-3-5-14/h1-9,11-12,16,22,28H,10,13H2,(H,29,30)/t16-,22+/m0/s1
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n/an/a 6.80n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215853
PNG
(CHEMBL417364)
Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)-c1cc(ccc1C(O)=O)C(F)(F)F
Show InChI InChI=1S/C30H23F3O4/c31-30(32,33)23-11-13-24(29(35)36)26(16-23)21-10-12-25-27(15-21)37-17-22(28(25)34)14-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-13,15-16,22,28,34H,14,17H2,(H,35,36)/t22-,28+/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215854
PNG
(CHEMBL301829)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cc(ccc1C(O)=O)C(F)(F)F
Show InChI InChI=1S/C24H19F3O4/c25-24(26,27)17-7-9-18(23(29)30)20(12-17)15-6-8-19-21(11-15)31-13-16(22(19)28)10-14-4-2-1-3-5-14/h1-9,11-12,16,22,28H,10,13H2,(H,29,30)/t16-,22+/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215737
PNG
(CHEMBL50425)
Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)-c1cc(Cl)ccc1C(O)=O
Show InChI InChI=1S/C29H23ClO4/c30-23-11-13-24(29(32)33)26(16-23)21-10-12-25-27(15-21)34-17-22(28(25)31)14-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-13,15-16,22,28,31H,14,17H2,(H,32,33)/t22-,28+/m0/s1
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n/an/a 8n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50037218
PNG
(1-((3S,4R)-3-Biphenyl-4-ylmethyl-4-hydroxy-chroman...)
Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)C1(CCCC1)C(O)=O
Show InChI InChI=1S/C28H28O4/c29-26-22(16-19-8-10-21(11-9-19)20-6-2-1-3-7-20)18-32-25-17-23(12-13-24(25)26)28(27(30)31)14-4-5-15-28/h1-3,6-13,17,22,26,29H,4-5,14-16,18H2,(H,30,31)/t22-,26+/m0/s1
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n/an/a 8.40n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215739
PNG
(CHEMBL52374)
Show SMILES OCc1ccc(cc1-c1ccc2[C@H](O)[C@@H](Cc3ccccc3)COc2c1)C(F)(F)F
Show InChI InChI=1S/C24H21F3O3/c25-24(26,27)19-8-6-17(13-28)21(12-19)16-7-9-20-22(11-16)30-14-18(23(20)29)10-15-4-2-1-3-5-15/h1-9,11-12,18,23,28-29H,10,13-14H2/t18-,23+/m0/s1
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n/an/a 9n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215861
PNG
(CHEMBL298724)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cccc(F)c1C(O)=O
Show InChI InChI=1S/C23H19FO4/c24-19-8-4-7-17(21(19)23(26)27)15-9-10-18-20(12-15)28-13-16(22(18)25)11-14-5-2-1-3-6-14/h1-10,12,16,22,25H,11,13H2,(H,26,27)/t16-,22+/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215861
PNG
(CHEMBL298724)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cccc(F)c1C(O)=O
Show InChI InChI=1S/C23H19FO4/c24-19-8-4-7-17(21(19)23(26)27)15-9-10-18-20(12-15)28-13-16(22(18)25)11-14-5-2-1-3-6-14/h1-10,12,16,22,25H,11,13H2,(H,26,27)/t16-,22+/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215741
PNG
(CHEMBL418264)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cc(Cl)ccc1C(O)=O
Show InChI InChI=1S/C23H19ClO4/c24-17-7-9-18(23(26)27)20(12-17)15-6-8-19-21(11-15)28-13-16(22(19)25)10-14-4-2-1-3-5-14/h1-9,11-12,16,22,25H,10,13H2,(H,26,27)/t16-,22+/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215738
PNG
(CHEMBL52675)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cc(F)ccc1C(O)=O
Show InChI InChI=1S/C23H19FO4/c24-17-7-9-18(23(26)27)20(12-17)15-6-8-19-21(11-15)28-13-16(22(19)25)10-14-4-2-1-3-5-14/h1-9,11-12,16,22,25H,10,13H2,(H,26,27)/t16-,22+/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215854
PNG
(CHEMBL301829)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cc(ccc1C(O)=O)C(F)(F)F
Show InChI InChI=1S/C24H19F3O4/c25-24(26,27)17-7-9-18(23(29)30)20(12-17)15-6-8-19-21(11-15)31-13-16(22(19)28)10-14-4-2-1-3-5-14/h1-9,11-12,16,22,28H,10,13H2,(H,29,30)/t16-,22+/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215741
PNG
(CHEMBL418264)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cc(Cl)ccc1C(O)=O
Show InChI InChI=1S/C23H19ClO4/c24-17-7-9-18(23(26)27)20(12-17)15-6-8-19-21(11-15)28-13-16(22(19)25)10-14-4-2-1-3-5-14/h1-9,11-12,16,22,25H,10,13H2,(H,26,27)/t16-,22+/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215738
PNG
(CHEMBL52675)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cc(F)ccc1C(O)=O
Show InChI InChI=1S/C23H19FO4/c24-17-7-9-18(23(26)27)20(12-17)15-6-8-19-21(11-15)28-13-16(22(19)25)10-14-4-2-1-3-5-14/h1-9,11-12,16,22,25H,10,13H2,(H,26,27)/t16-,22+/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215740
PNG
(CHEMBL48906)
Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)-c1cc(F)ccc1C(O)=O
Show InChI InChI=1S/C29H23FO4/c30-23-11-13-24(29(32)33)26(16-23)21-10-12-25-27(15-21)34-17-22(28(25)31)14-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-13,15-16,22,28,31H,14,17H2,(H,32,33)/t22-,28+/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215863
PNG
(CHEMBL52449)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cc(F)ccc1NS(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C23H19F4NO4S/c24-17-7-9-20(28-33(30,31)23(25,26)27)19(12-17)15-6-8-18-21(11-15)32-13-16(22(18)29)10-14-4-2-1-3-5-14/h1-9,11-12,16,22,28-29H,10,13H2/t16-,22+/m0/s1
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n/an/a 15n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215868
PNG
(CHEMBL51535)
Show SMILES NS(=O)(=O)c1ccc(F)cc1-c1ccc2[C@H](O)[C@@H](Cc3ccccc3)COc2c1
Show InChI InChI=1S/C22H20FNO4S/c23-17-7-9-21(29(24,26)27)19(12-17)15-6-8-18-20(11-15)28-13-16(22(18)25)10-14-4-2-1-3-5-14/h1-9,11-12,16,22,25H,10,13H2,(H2,24,26,27)/t16-,22+/m0/s1
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n/an/a 17n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50045244
PNG
((S)-3-[(S)-2-((R)-2-Acetylamino-3-phenyl-propionyl...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C47H59N7O10/c1-6-27(3)40(45(61)52-38(47(63)64)24-32-26-48-34-21-15-14-20-33(32)34)54-46(62)41(28(4)7-2)53-44(60)37(25-39(56)57)51-43(59)36(23-31-18-12-9-13-19-31)50-42(58)35(49-29(5)55)22-30-16-10-8-11-17-30/h8-21,26-28,35-38,40-41,48H,6-7,22-25H2,1-5H3,(H,49,55)(H,50,58)(H,51,59)(H,52,61)(H,53,60)(H,54,62)(H,56,57)(H,63,64)/t27-,28-,35+,36-,37-,38-,40-,41-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Effective concentration against Endothelin B receptor from rat cerebellum


J Med Chem 36: 2585-94 (1993)


Article DOI: 10.1021/jm00070a001
BindingDB Entry DOI: 10.7270/Q2V69K6K
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215859
PNG
(CHEMBL51775)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cc(F)ccc1-c1nn[nH]n1
Show InChI InChI=1S/C23H19FN4O2/c24-17-7-9-18(23-25-27-28-26-23)20(12-17)15-6-8-19-21(11-15)30-13-16(22(19)29)10-14-4-2-1-3-5-14/h1-9,11-12,16,22,29H,10,13H2,(H,25,26,27,28)/t16-,22+/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215861
PNG
(CHEMBL298724)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cccc(F)c1C(O)=O
Show InChI InChI=1S/C23H19FO4/c24-19-8-4-7-17(21(19)23(26)27)15-9-10-18-20(12-15)28-13-16(22(18)25)11-14-5-2-1-3-6-14/h1-10,12,16,22,25H,11,13H2,(H,26,27)/t16-,22+/m0/s1
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n/an/a 22n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215743
PNG
(CHEMBL51219)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1ccc(F)cc1C(O)=O
Show InChI InChI=1S/C23H19FO4/c24-17-7-9-18(20(12-17)23(26)27)15-6-8-19-21(11-15)28-13-16(22(19)25)10-14-4-2-1-3-5-14/h1-9,11-12,16,22,25H,10,13H2,(H,26,27)/t16-,22+/m0/s1
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n/an/a 24n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215744
PNG
(CHEMBL299150)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cccc(c1C(O)=O)C(F)(F)F
Show InChI InChI=1S/C24H19F3O4/c25-24(26,27)19-8-4-7-17(21(19)23(29)30)15-9-10-18-20(12-15)31-13-16(22(18)28)11-14-5-2-1-3-6-14/h1-10,12,16,22,28H,11,13H2,(H,29,30)/t16-,22+/m0/s1
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n/an/a 24n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Endothelin receptor


(RAT)
BDBM50045239
PNG
(Ac-D-Dip-Leu-Asp-Ile-Ile-Trp | Ac-D-Dip-Leu-Asp-Il...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C50H65N7O10/c1-8-29(5)42(47(63)55-39(50(66)67)25-34-27-51-36-23-17-16-22-35(34)36)57-48(64)43(30(6)9-2)56-46(62)38(26-40(59)60)53-45(61)37(24-28(3)4)54-49(65)44(52-31(7)58)41(32-18-12-10-13-19-32)33-20-14-11-15-21-33/h10-23,27-30,37-39,41-44,51H,8-9,24-26H2,1-7H3,(H,52,58)(H,53,61)(H,54,65)(H,55,63)(H,56,62)(H,57,64)(H,59,60)(H,66,67)/t29-,30-,37-,38-,39-,42-,43-,44+/m0/s1
MMDB

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n/an/a 25n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity against Endothelin receptor from rat heart ventricle


J Med Chem 36: 2585-94 (1993)


Article DOI: 10.1021/jm00070a001
BindingDB Entry DOI: 10.7270/Q2V69K6K
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215737
PNG
(CHEMBL50425)
Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)-c1cc(Cl)ccc1C(O)=O
Show InChI InChI=1S/C29H23ClO4/c30-23-11-13-24(29(32)33)26(16-23)21-10-12-25-27(15-21)34-17-22(28(25)31)14-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-13,15-16,22,28,31H,14,17H2,(H,32,33)/t22-,28+/m0/s1
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n/an/a 26n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215741
PNG
(CHEMBL418264)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cc(Cl)ccc1C(O)=O
Show InChI InChI=1S/C23H19ClO4/c24-17-7-9-18(23(26)27)20(12-17)15-6-8-19-21(11-15)28-13-16(22(19)25)10-14-4-2-1-3-5-14/h1-9,11-12,16,22,25H,10,13H2,(H,26,27)/t16-,22+/m0/s1
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n/an/a 26n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215738
PNG
(CHEMBL52675)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cc(F)ccc1C(O)=O
Show InChI InChI=1S/C23H19FO4/c24-17-7-9-18(23(26)27)20(12-17)15-6-8-19-21(11-15)28-13-16(22(19)25)10-14-4-2-1-3-5-14/h1-9,11-12,16,22,25H,10,13H2,(H,26,27)/t16-,22+/m0/s1
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n/an/a 27n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215853
PNG
(CHEMBL417364)
Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)-c1cc(ccc1C(O)=O)C(F)(F)F
Show InChI InChI=1S/C30H23F3O4/c31-30(32,33)23-11-13-24(29(35)36)26(16-23)21-10-12-25-27(15-21)37-17-22(28(25)34)14-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-13,15-16,22,28,34H,14,17H2,(H,35,36)/t22-,28+/m0/s1
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n/an/a 27n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215741
PNG
(CHEMBL418264)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cc(Cl)ccc1C(O)=O
Show InChI InChI=1S/C23H19ClO4/c24-17-7-9-18(23(26)27)20(12-17)15-6-8-19-21(11-15)28-13-16(22(19)25)10-14-4-2-1-3-5-14/h1-9,11-12,16,22,25H,10,13H2,(H,26,27)/t16-,22+/m0/s1
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n/an/a 30n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215742
PNG
(CHEMBL51492)
Show SMILES O[C@@H]1[C@@H](CCc2ccccc2)COc2cc(ccc12)-c1cc(F)ccc1C(O)=O
Show InChI InChI=1S/C24H21FO4/c25-18-9-11-19(24(27)28)21(13-18)16-8-10-20-22(12-16)29-14-17(23(20)26)7-6-15-4-2-1-3-5-15/h1-5,8-13,17,23,26H,6-7,14H2,(H,27,28)/t17-,23+/m0/s1
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n/an/a 32n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215742
PNG
(CHEMBL51492)
Show SMILES O[C@@H]1[C@@H](CCc2ccccc2)COc2cc(ccc12)-c1cc(F)ccc1C(O)=O
Show InChI InChI=1S/C24H21FO4/c25-18-9-11-19(24(27)28)21(13-18)16-8-10-20-22(12-16)29-14-17(23(20)26)7-6-15-4-2-1-3-5-15/h1-5,8-13,17,23,26H,6-7,14H2,(H,27,28)/t17-,23+/m0/s1
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n/an/a 35n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50045240
PNG
((S)-2-[(S)-2-((2S,5S)-2-{(S)-2-[(S)-2-((R)-2-Acety...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C49H65N7O8/c1-8-30(5)42(47(61)54-41(49(63)64)27-35-28-50-37-23-17-16-22-36(35)37)56-48(62)43(31(6)9-2)55-46(60)40(26-34-20-14-11-15-21-34)53-44(58)38(24-29(3)4)52-45(59)39(51-32(7)57)25-33-18-12-10-13-19-33/h10-23,28-31,38-43,50H,8-9,24-27H2,1-7H3,(H,51,57)(H,52,59)(H,53,58)(H,54,61)(H,55,60)(H,56,62)(H,63,64)/t30-,31-,38-,39+,40-,41-,42-,43-/m0/s1
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n/an/a 36n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Effective concentration against Endothelin B receptor from rat cerebellum


J Med Chem 36: 2585-94 (1993)


Article DOI: 10.1021/jm00070a001
BindingDB Entry DOI: 10.7270/Q2V69K6K
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215868
PNG
(CHEMBL51535)
Show SMILES NS(=O)(=O)c1ccc(F)cc1-c1ccc2[C@H](O)[C@@H](Cc3ccccc3)COc2c1
Show InChI InChI=1S/C22H20FNO4S/c23-17-7-9-21(29(24,26)27)19(12-17)15-6-8-18-20(11-15)28-13-16(22(18)25)10-14-4-2-1-3-5-14/h1-9,11-12,16,22,25H,10,13H2,(H2,24,26,27)/t16-,22+/m0/s1
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n/an/a 37n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215853
PNG
(CHEMBL417364)
Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)-c1cc(ccc1C(O)=O)C(F)(F)F
Show InChI InChI=1S/C30H23F3O4/c31-30(32,33)23-11-13-24(29(35)36)26(16-23)21-10-12-25-27(15-21)37-17-22(28(25)34)14-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-13,15-16,22,28,34H,14,17H2,(H,35,36)/t22-,28+/m0/s1
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n/an/a 38n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215855
PNG
(CHEMBL51467)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cc(F)cc(F)c1C(O)=O
Show InChI InChI=1S/C23H18F2O4/c24-16-10-18(21(23(27)28)19(25)11-16)14-6-7-17-20(9-14)29-12-15(22(17)26)8-13-4-2-1-3-5-13/h1-7,9-11,15,22,26H,8,12H2,(H,27,28)/t15-,22+/m0/s1
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n/an/a 40n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Endothelin receptor


(RAT)
BDBM50368647
PNG
(CHEMBL1788127)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC([O-])=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C([O-])=O
Show InChI InChI=1S/C50H65N7O10/c1-8-29(5)42(47(63)55-39(50(66)67)25-34-27-51-36-23-17-16-22-35(34)36)57-48(64)43(30(6)9-2)56-46(62)38(26-40(59)60)53-45(61)37(24-28(3)4)54-49(65)44(52-31(7)58)41(32-18-12-10-13-19-32)33-20-14-11-15-21-33/h10-23,27-30,37-39,41-44,51H,8-9,24-26H2,1-7H3,(H,52,58)(H,53,61)(H,54,65)(H,55,63)(H,56,62)(H,57,64)(H,59,60)(H,66,67)/p-2/t29-,30-,37-,38-,39-,42-,43-,44+/m0/s1
MMDB

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n/an/a 40n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity against Endothelin receptor from rat heart ventricle


J Med Chem 36: 2585-94 (1993)


Article DOI: 10.1021/jm00070a001
BindingDB Entry DOI: 10.7270/Q2V69K6K
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215861
PNG
(CHEMBL298724)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cccc(F)c1C(O)=O
Show InChI InChI=1S/C23H19FO4/c24-19-8-4-7-17(21(19)23(26)27)15-9-10-18-20(12-15)28-13-16(22(18)25)11-14-5-2-1-3-6-14/h1-10,12,16,22,25H,11,13H2,(H,26,27)/t16-,22+/m0/s1
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n/an/a 40n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215863
PNG
(CHEMBL52449)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cc(F)ccc1NS(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C23H19F4NO4S/c24-17-7-9-20(28-33(30,31)23(25,26)27)19(12-17)15-6-8-18-21(11-15)32-13-16(22(18)29)10-14-4-2-1-3-5-14/h1-9,11-12,16,22,28-29H,10,13H2/t16-,22+/m0/s1
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n/an/a 44n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50215744
PNG
(CHEMBL299150)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1cccc(c1C(O)=O)C(F)(F)F
Show InChI InChI=1S/C24H19F3O4/c25-24(26,27)19-8-4-7-17(21(19)23(29)30)15-9-10-18-20(12-15)31-13-16(22(18)28)11-14-5-2-1-3-6-14/h1-10,12,16,22,28H,11,13H2,(H,29,30)/t16-,22+/m0/s1
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n/an/a 46n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.


Bioorg Med Chem Lett 8: 1781-6 (1998)


Article DOI: 10.1016/s0960-894x(98)00275-3
BindingDB Entry DOI: 10.7270/Q2RR21F1
More data for this
Ligand-Target Pair
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