BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2328 hits with Last Name = 'kaller' and Initial = 'mr'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124548
PNG
(US8759532, 226)
Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2[C@@H]2CCC(=O)C2)cc1
Show InChI InChI=1S/C24H19N3O3/c28-17-10-7-16(14-17)19-4-3-13-25-24(19)30-18-11-8-15(9-12-18)22(29)23-26-20-5-1-2-6-21(20)27-23/h1-6,8-9,11-13,16H,7,10,14H2,(H,26,27)/t16-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0210n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124500
PNG
(US8759532, 176 | US8759532, 223)
Show SMILES CC(=O)N1CCC[C@@H](C1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C26H24N4O3/c1-17(31)30-15-5-6-19(16-30)21-7-4-14-27-26(21)33-20-12-10-18(11-13-20)24(32)25-28-22-8-2-3-9-23(22)29-25/h2-4,7-14,19H,5-6,15-16H2,1H3,(H,28,29)/t19-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0240n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124523
PNG
(US8759532, 201)
Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2C2CCC(=O)CC2)cc1
Show InChI InChI=1S/C25H21N3O3/c29-18-11-7-16(8-12-18)20-4-3-15-26-25(20)31-19-13-9-17(10-14-19)23(30)24-27-21-5-1-2-6-22(21)28-24/h1-6,9-10,13-16H,7-8,11-12H2,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0285n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM115431
PNG
(US8637500, 301 | US8637500, 454 | US8637500, 455)
Show SMILES CC(=O)N1CCCC(C1)c1cccnc1Oc1ccc(Nc2ccc(C)cn2)cc1
Show InChI InChI=1S/C24H26N4O2/c1-17-7-12-23(26-15-17)27-20-8-10-21(11-9-20)30-24-22(6-3-13-25-24)19-5-4-14-28(16-19)18(2)29/h3,6-13,15,19H,4-5,14,16H2,1-2H3,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0400n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...


US Patent US8637500 (2014)


BindingDB Entry DOI: 10.7270/Q2XP73MV
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM115430
PNG
(US8637500, 299)
Show SMILES CN(C)C(=O)N1CCC(CC1)c1nccnc1Oc1ccc(Nc2ccc(C)cn2)cc1
Show InChI InChI=1S/C24H28N6O2/c1-17-4-9-21(27-16-17)28-19-5-7-20(8-6-19)32-23-22(25-12-13-26-23)18-10-14-30(15-11-18)24(31)29(2)3/h4-9,12-13,16,18H,10-11,14-15H2,1-3H3,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0450n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...


US Patent US8637500 (2014)


BindingDB Entry DOI: 10.7270/Q2XP73MV
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124500
PNG
(US8759532, 176 | US8759532, 223)
Show SMILES CC(=O)N1CCC[C@@H](C1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C26H24N4O3/c1-17(31)30-15-5-6-19(16-30)21-7-4-14-27-26(21)33-20-12-10-18(11-13-20)24(32)25-28-22-8-2-3-9-23(22)29-25/h2-4,7-14,19H,5-6,15-16H2,1H3,(H,28,29)/t19-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0503n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124551
PNG
(US8759532, 230)
Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2[C@@H]2CCCOCC2)cc1
Show InChI InChI=1S/C25H23N3O3/c29-23(24-27-21-7-1-2-8-22(21)28-24)18-9-11-19(12-10-18)31-25-20(6-3-14-26-25)17-5-4-15-30-16-13-17/h1-3,6-12,14,17H,4-5,13,15-16H2,(H,27,28)/t17-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0505n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM115427
PNG
(US8637500, 296)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1nccnc1Oc1ccc(Nc2ccc(C)cn2)cc1
Show InChI InChI=1S/C25H29N5O2/c1-17(2)25(31)30-14-10-19(11-15-30)23-24(27-13-12-26-23)32-21-7-5-20(6-8-21)29-22-9-4-18(3)16-28-22/h4-9,12-13,16-17,19H,10-11,14-15H2,1-3H3,(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0550n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...


US Patent US8637500 (2014)


BindingDB Entry DOI: 10.7270/Q2XP73MV
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM115428
PNG
(US8637500, 297)
Show SMILES CCOC(=O)N1CCC(CC1)c1nccnc1Oc1ccc(Nc2ccc(C)cn2)cc1
Show InChI InChI=1S/C24H27N5O3/c1-3-31-24(30)29-14-10-18(11-15-29)22-23(26-13-12-25-22)32-20-7-5-19(6-8-20)28-21-9-4-17(2)16-27-21/h4-9,12-13,16,18H,3,10-11,14-15H2,1-2H3,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0560n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...


US Patent US8637500 (2014)


BindingDB Entry DOI: 10.7270/Q2XP73MV
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124550
PNG
(US8759532, 228)
Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2[C@H]2CCNC(=O)CC2)cc1
Show InChI InChI=1S/C25H22N4O3/c30-22-12-9-16(13-15-26-22)19-4-3-14-27-25(19)32-18-10-7-17(8-11-18)23(31)24-28-20-5-1-2-6-21(20)29-24/h1-8,10-11,14,16H,9,12-13,15H2,(H,26,30)(H,28,29)/t16-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0595n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124522
PNG
(US8759532, 199)
Show SMILES CC(=O)N1CCCC[C@@H]1c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C26H24N4O3/c1-17(31)30-16-5-4-10-23(30)20-7-6-15-27-26(20)33-19-13-11-18(12-14-19)24(32)25-28-21-8-2-3-9-22(21)29-25/h2-3,6-9,11-15,23H,4-5,10,16H2,1H3,(H,28,29)/t23-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0645n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124596
PNG
(US8759532, 280)
Show SMILES COc1ccncc1-c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C25H18N4O3/c1-31-22-12-14-26-15-19(22)18-5-4-13-27-25(18)32-17-10-8-16(9-11-17)23(30)24-28-20-6-2-3-7-21(20)29-24/h2-15H,1H3,(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0725n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124465
PNG
(US8759532, 132 | US8759532, 208)
Show SMILES CN1C[C@@H](CC1=O)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C24H20N4O3/c1-28-14-16(13-21(28)29)18-5-4-12-25-24(18)31-17-10-8-15(9-11-17)22(30)23-26-19-6-2-3-7-20(19)27-23/h2-12,16H,13-14H2,1H3,(H,26,27)/t16-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0748n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124559
PNG
(US8759532, 240)
Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2C2CCCC(=O)CC2)cc1
Show InChI InChI=1S/C26H23N3O3/c30-19-6-3-5-17(10-13-19)21-7-4-16-27-26(21)32-20-14-11-18(12-15-20)24(31)25-28-22-8-1-2-9-23(22)29-25/h1-2,4,7-9,11-12,14-17H,3,5-6,10,13H2,(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0770n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124578
PNG
(US8759532, 262)
Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2[C@H]2CCC(=O)C2)cc1
Show InChI InChI=1S/C24H19N3O3/c28-17-10-7-16(14-17)19-4-3-13-25-24(19)30-18-11-8-15(9-12-18)22(29)23-26-20-5-1-2-6-21(20)27-23/h1-6,8-9,11-13,16H,7,10,14H2,(H,26,27)/t16-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0957n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM115424
PNG
(US8637500, 293)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cccnc1Oc1ccc(Nc2ccc(C)cn2)cc1
Show InChI InChI=1S/C26H30N4O2/c1-18(2)26(31)30-15-12-20(13-16-30)23-5-4-14-27-25(23)32-22-9-7-21(8-10-22)29-24-11-6-19(3)17-28-24/h4-11,14,17-18,20H,12-13,15-16H2,1-3H3,(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0980n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...


US Patent US8637500 (2014)


BindingDB Entry DOI: 10.7270/Q2XP73MV
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124518
PNG
(US8759532, 195)
Show SMILES O[C@H]1CC[C@@H](CC1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C25H23N3O3/c29-18-11-7-16(8-12-18)20-4-3-15-26-25(20)31-19-13-9-17(10-14-19)23(30)24-27-21-5-1-2-6-22(21)28-24/h1-6,9-10,13-16,18,29H,7-8,11-12H2,(H,27,28)/t16-,18-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.101n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124593
PNG
(US8759532, 277)
Show SMILES COc1cnccc1-c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2n1C
Show InChI InChI=1S/C26H20N4O3/c1-30-22-8-4-3-7-21(22)29-25(30)24(31)17-9-11-18(12-10-17)33-26-20(6-5-14-28-26)19-13-15-27-16-23(19)32-2/h3-16H,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.121n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124521
PNG
(US8759532, 198)
Show SMILES O=C1CCC(CC1)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1
Show InChI InChI=1S/C24H21N3O2S/c28-18-11-7-16(8-12-18)20-4-3-15-25-23(20)29-19-13-9-17(10-14-19)26-24-27-21-5-1-2-6-22(21)30-24/h1-6,9-10,13-16H,7-8,11-12H2,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.123n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM115425
PNG
(US8637500, 294)
Show SMILES COCC(=O)N1CCC(CC1)c1cccnc1Oc1ccc(Nc2ccc(C)cn2)cc1
Show InChI InChI=1S/C25H28N4O3/c1-18-5-10-23(27-16-18)28-20-6-8-21(9-7-20)32-25-22(4-3-13-26-25)19-11-14-29(15-12-19)24(30)17-31-2/h3-10,13,16,19H,11-12,14-15,17H2,1-2H3,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.132n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...


US Patent US8637500 (2014)


BindingDB Entry DOI: 10.7270/Q2XP73MV
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124476
PNG
(US8759532, 146)
Show SMILES C[C@H](Cc1ccc(F)cc1)NC(=O)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C29H23FN4O3/c1-18(17-19-8-12-21(30)13-9-19)32-28(36)23-5-4-16-31-29(23)37-22-14-10-20(11-15-22)26(35)27-33-24-6-2-3-7-25(24)34-27/h2-16,18H,17H2,1H3,(H,32,36)(H,33,34)/t18-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.135n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124562
PNG
(US8759532, 243 | US8759532, 250)
Show SMILES O[C@@H]1CCC[C@H](C1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C25H23N3O3/c29-18-6-3-5-17(15-18)20-7-4-14-26-25(20)31-19-12-10-16(11-13-19)23(30)24-27-21-8-1-2-9-22(21)28-24/h1-2,4,7-14,17-18,29H,3,5-6,15H2,(H,27,28)/t17-,18-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.145n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124447
PNG
(US8759532, 103)
Show SMILES CC(=O)N1CCC(CC1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C26H24N4O3/c1-17(31)30-15-12-18(13-16-30)21-5-4-14-27-26(21)33-20-10-8-19(9-11-20)24(32)25-28-22-6-2-3-7-23(22)29-25/h2-11,14,18H,12-13,15-16H2,1H3,(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.158n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124583
PNG
(US8759532, 267)
Show SMILES Fc1ncccc1-c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C24H15FN4O2/c25-22-17(5-3-13-26-22)18-6-4-14-27-24(18)31-16-11-9-15(10-12-16)21(30)23-28-19-7-1-2-8-20(19)29-23/h1-14H,(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.162n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124463
PNG
(US8759532, 130)
Show SMILES O[C@@H]1CC[C@H](C1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C24H21N3O3/c28-17-10-7-16(14-17)19-4-3-13-25-24(19)30-18-11-8-15(9-12-18)22(29)23-26-20-5-1-2-6-21(20)27-23/h1-6,8-9,11-13,16-17,28H,7,10,14H2,(H,26,27)/t16-,17-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.167n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124412
PNG
(US8759532, 65)
Show SMILES O=C(NC1(Cc2ccccc2)CC1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C30H24N4O3/c35-26(27-32-24-10-4-5-11-25(24)33-27)21-12-14-22(15-13-21)37-29-23(9-6-18-31-29)28(36)34-30(16-17-30)19-20-7-2-1-3-8-20/h1-15,18H,16-17,19H2,(H,32,33)(H,34,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.168n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124600
PNG
(US8759532, 284)
Show SMILES O=C1CC[C@H](C1)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1
Show InChI InChI=1S/C23H19N3O2S/c27-17-10-7-15(14-17)19-4-3-13-24-22(19)28-18-11-8-16(9-12-18)25-23-26-20-5-1-2-6-21(20)29-23/h1-6,8-9,11-13,15H,7,10,14H2,(H,25,26)/t15-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.169n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124444
PNG
(US8759532, 99)
Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2C2CCOCC2)cc1
Show InChI InChI=1S/C24H21N3O3/c28-22(23-26-20-5-1-2-6-21(20)27-23)17-7-9-18(10-8-17)30-24-19(4-3-13-25-24)16-11-14-29-15-12-16/h1-10,13,16H,11-12,14-15H2,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
PDB
UniChem

Similars

PDB
US Patent
n/an/a 0.170n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM115429
PNG
(US8637500, 298)
Show SMILES Cc1ccc(Nc2ccc(Oc3nccnc3C3CCN(CC3)C(=O)C3CC3)cc2)nc1
Show InChI InChI=1S/C25H27N5O2/c1-17-2-9-22(28-16-17)29-20-5-7-21(8-6-20)32-24-23(26-12-13-27-24)18-10-14-30(15-11-18)25(31)19-3-4-19/h2,5-9,12-13,16,18-19H,3-4,10-11,14-15H2,1H3,(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.171n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...


US Patent US8637500 (2014)


BindingDB Entry DOI: 10.7270/Q2XP73MV
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124458
PNG
(US8759532, 124)
Show SMILES CC(=O)N1CCC(CC1)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1
Show InChI InChI=1S/C25H24N4O2S/c1-17(30)29-15-12-18(13-16-29)21-5-4-14-26-24(21)31-20-10-8-19(9-11-20)27-25-28-22-6-2-3-7-23(22)32-25/h2-11,14,18H,12-13,15-16H2,1H3,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.175n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124394
PNG
(US8759532, 46)
Show SMILES Cc1ccc(cn1)-c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C25H18N4O2/c1-16-8-9-18(15-27-16)20-5-4-14-26-25(20)31-19-12-10-17(11-13-19)23(30)24-28-21-6-2-3-7-22(21)29-24/h2-15H,1H3,(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.177n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124432
PNG
(US8759532, 85)
Show SMILES N(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2-c2cccnc2)cc1
Show InChI InChI=1S/C23H17N5O/c1-2-8-21-20(7-1)27-23(28-21)26-17-9-11-18(12-10-17)29-22-19(6-4-14-25-22)16-5-3-13-24-15-16/h1-15H,(H2,26,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.179n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM115422
PNG
(US8637500, 291)
Show SMILES Cc1ccc(Nc2ccc(Oc3ncccc3C3CCN(CC3)S(C)(=O)=O)cc2)nc1
Show InChI InChI=1S/C23H26N4O3S/c1-17-5-10-22(25-16-17)26-19-6-8-20(9-7-19)30-23-21(4-3-13-24-23)18-11-14-27(15-12-18)31(2,28)29/h3-10,13,16,18H,11-12,14-15H2,1-2H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.189n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...


US Patent US8637500 (2014)


BindingDB Entry DOI: 10.7270/Q2XP73MV
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124435
PNG
(US8759532, 88)
Show SMILES CC(=O)N1CCC(=CC1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C26H22N4O3/c1-17(31)30-15-12-18(13-16-30)21-5-4-14-27-26(21)33-20-10-8-19(9-11-20)24(32)25-28-22-6-2-3-7-23(22)29-25/h2-12,14H,13,15-16H2,1H3,(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.194n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124466
PNG
(US8759532, 134)
Show SMILES CN1C[C@H](CC1=O)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1
Show InChI InChI=1S/C23H20N4O2S/c1-27-14-15(13-21(27)28)18-5-4-12-24-22(18)29-17-10-8-16(9-11-17)25-23-26-19-6-2-3-7-20(19)30-23/h2-12,15H,13-14H2,1H3,(H,25,26)/t15-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.195n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124541
PNG
(US8759532, 219)
Show SMILES OC[C@H]1CC[C@@H](C1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C25H23N3O3/c29-15-16-7-8-18(14-16)20-4-3-13-26-25(20)31-19-11-9-17(10-12-19)23(30)24-27-21-5-1-2-6-22(21)28-24/h1-6,9-13,16,18,29H,7-8,14-15H2,(H,27,28)/t16-,18-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.199n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM99011
PNG
(US8497265, 467)
Show SMILES Cc1ccc(cn1)-c1cnc(nc1OC1CN(C1)c1ccc2ccccc2n1)N1CCC(CO)CC1
Show InChI InChI=1S/C28H30N6O2/c1-19-6-7-22(14-29-19)24-15-30-28(33-12-10-20(18-35)11-13-33)32-27(24)36-23-16-34(17-23)26-9-8-21-4-2-3-5-25(21)31-26/h2-9,14-15,20,23,35H,10-13,16-18H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.200n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).


US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124465
PNG
(US8759532, 132 | US8759532, 208)
Show SMILES CN1C[C@@H](CC1=O)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C24H20N4O3/c1-28-14-16(13-21(28)29)18-5-4-12-25-24(18)31-17-10-8-15(9-11-17)22(30)23-26-19-6-2-3-7-20(19)27-23/h2-12,16H,13-14H2,1H3,(H,26,27)/t16-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.207n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124542
PNG
(US8759532, 220)
Show SMILES OC[C@@H]1CC[C@@H](C1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C25H23N3O3/c29-15-16-7-8-18(14-16)20-4-3-13-26-25(20)31-19-11-9-17(10-12-19)23(30)24-27-21-5-1-2-6-22(21)28-24/h1-6,9-13,16,18,29H,7-8,14-15H2,(H,27,28)/t16-,18+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.212n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124494
PNG
(US8759532, 168)
Show SMILES CC(=O)N1CCCC(=C1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C26H22N4O3/c1-17(31)30-15-5-6-19(16-30)21-7-4-14-27-26(21)33-20-12-10-18(11-13-20)24(32)25-28-22-8-2-3-9-23(22)29-25/h2-4,7-14,16H,5-6,15H2,1H3,(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.214n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124561
PNG
(US8759532, 242)
Show SMILES CN1CCC(CCC1=O)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C26H24N4O3/c1-30-16-14-17(10-13-23(30)31)20-5-4-15-27-26(20)33-19-11-8-18(9-12-19)24(32)25-28-21-6-2-3-7-22(21)29-25/h2-9,11-12,15,17H,10,13-14,16H2,1H3,(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.218n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124423
PNG
(US8759532, 76 | US8759532, 79)
Show SMILES Cc1ccc(cn1)-c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1
Show InChI InChI=1S/C24H18N4OS/c1-16-8-9-17(15-26-16)20-5-4-14-25-23(20)29-19-12-10-18(11-13-19)27-24-28-21-6-2-3-7-22(21)30-24/h2-15H,1H3,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.219n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM98900
PNG
(US8497265, 226)
Show SMILES OCC1CCN(CC1)c1ccc(Br)c(OC2CN(C2)c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C23H25BrN4O2/c24-19-6-8-22(27-11-9-16(15-29)10-12-27)26-23(19)30-18-13-28(14-18)21-7-5-17-3-1-2-4-20(17)25-21/h1-8,16,18,29H,9-15H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.229n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).


US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124450
PNG
(US8759532, 107 | US8759532, 187)
Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2[C@@H]2CCOC2)cc1
Show InChI InChI=1S/C23H19N3O3/c27-21(22-25-19-5-1-2-6-20(19)26-22)15-7-9-17(10-8-15)29-23-18(4-3-12-24-23)16-11-13-28-14-16/h1-10,12,16H,11,13-14H2,(H,25,26)/t16-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.232n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124430
PNG
(US8759532, 83)
Show SMILES Cn1c(Nc2ccc(Oc3ncccc3-c3cccnc3)cc2)nc2ccccc12
Show InChI InChI=1S/C24H19N5O/c1-29-22-9-3-2-8-21(22)28-24(29)27-18-10-12-19(13-11-18)30-23-20(7-5-15-26-23)17-6-4-14-25-16-17/h2-16H,1H3,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.249n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124355
PNG
(US8759532, 6)
Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2-c2ccncc2)cc1
Show InChI InChI=1S/C24H16N4O2/c29-22(23-27-20-5-1-2-6-21(20)28-23)17-7-9-18(10-8-17)30-24-19(4-3-13-26-24)16-11-14-25-15-12-16/h1-15H,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.256n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124393
PNG
(US8759532, 45)
Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2-c2cccnc2)cc1
Show InChI InChI=1S/C24H16N4O2/c29-22(23-27-20-7-1-2-8-21(20)28-23)16-9-11-18(12-10-16)30-24-19(6-4-14-26-24)17-5-3-13-25-15-17/h1-15H,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.260n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124565
PNG
(US8759532, 247)
Show SMILES COc1cnccc1-c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C25H18N4O3/c1-31-22-15-26-14-12-18(22)19-5-4-13-27-25(19)32-17-10-8-16(9-11-17)23(30)24-28-20-6-2-3-7-21(20)29-24/h2-15H,1H3,(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.261n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124437
PNG
(US8759532, 90)
Show SMILES C1CC(CCO1)c1cccnc1Oc1ccc(Nc2nc3ccccc3[nH]2)cc1
Show InChI InChI=1S/C23H22N4O2/c1-2-6-21-20(5-1)26-23(27-21)25-17-7-9-18(10-8-17)29-22-19(4-3-13-24-22)16-11-14-28-15-12-16/h1-10,13,16H,11-12,14-15H2,(H2,25,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.267n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124496
PNG
(US8759532, 170)
Show SMILES CC(=O)N1CCC[C@H](C1)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1
Show InChI InChI=1S/C25H24N4O2S/c1-17(30)29-15-5-6-18(16-29)21-7-4-14-26-24(21)31-20-12-10-19(11-13-20)27-25-28-22-8-2-3-9-23(22)32-25/h2-4,7-14,18H,5-6,15-16H2,1H3,(H,27,28)/t18-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.268n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 2328 total )  |  Next  |  Last  >>
Jump to: