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Compile Data Set for Download or QSAR

Found 174 hits with Last Name = 'kang' and Initial = 'kw'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sialidase


(Clostridium perfringens)
BDBM50311581
PNG
(CHEMBL1086764 | erysubin E)
Show SMILES CC(C)=CCc1cc2[C@@H]3Oc4c(ccc5OC(C)(C)C=Cc45)[C@]3(O)COc2cc1O
Show InChI InChI=1S/C25H26O5/c1-14(2)5-6-15-11-17-21(12-19(15)26)28-13-25(27)18-7-8-20-16(22(18)29-23(17)25)9-10-24(3,4)30-20/h5,7-12,23,26-27H,6,13H2,1-4H3/t23-,25+/m0/s1
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240n/an/an/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of Clostridium perfringens neuraminidase


Bioorg Med Chem 18: 3335-44 (2010)


Article DOI: 10.1016/j.bmc.2010.03.005
BindingDB Entry DOI: 10.7270/Q2MW2HBM
More data for this
Ligand-Target Pair
Sialidase


(Clostridium perfringens)
BDBM50317430
PNG
(CHEMBL454849 | Erythrabyssin I | cristacarpin | cr...)
Show SMILES COc1ccc2c(O[C@H]3c4ccc(O)cc4OC[C@@]23O)c1CC=C(C)C
Show InChI InChI=1S/C21H22O5/c1-12(2)4-6-14-17(24-3)9-8-16-19(14)26-20-15-7-5-13(22)10-18(15)25-11-21(16,20)23/h4-5,7-10,20,22-23H,6,11H2,1-3H3/t20-,21+/m0/s1
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310n/an/an/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of Clostridium perfringens neuraminidase


Bioorg Med Chem 18: 3335-44 (2010)


Article DOI: 10.1016/j.bmc.2010.03.005
BindingDB Entry DOI: 10.7270/Q2MW2HBM
More data for this
Ligand-Target Pair
Sialidase


(Clostridium perfringens)
BDBM50317435
PNG
(CHEMBL1096406 | Erythribyssin O)
Show SMILES CC(C)=CCc1c(O)ccc2c3COc4cc(O)c(C=O)cc4-c3oc12
Show InChI InChI=1S/C21H18O5/c1-11(2)3-4-14-17(23)6-5-13-16-10-25-19-8-18(24)12(9-22)7-15(19)21(16)26-20(13)14/h3,5-9,23-24H,4,10H2,1-2H3
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1.21E+3n/an/an/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of Clostridium perfringens neuraminidase


Bioorg Med Chem 18: 3335-44 (2010)


Article DOI: 10.1016/j.bmc.2010.03.005
BindingDB Entry DOI: 10.7270/Q2MW2HBM
More data for this
Ligand-Target Pair
Sialidase


(Clostridium perfringens)
BDBM50311583
PNG
(Abyssinone II | CHEMBL508534 | phaseolidin | phase...)
Show SMILES CC(C)=CCc1c2O[C@@H]3[C@@H](COc4cc(O)ccc34)c2ccc1O
Show InChI InChI=1S/C20H20O4/c1-11(2)3-5-14-17(22)8-7-13-16-10-23-18-9-12(21)4-6-15(18)20(16)24-19(13)14/h3-4,6-9,16,20-22H,5,10H2,1-2H3/t16-,20-/m0/s1
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1.78E+3n/an/an/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of Clostridium perfringens neuraminidase


Bioorg Med Chem 18: 3335-44 (2010)


Article DOI: 10.1016/j.bmc.2010.03.005
BindingDB Entry DOI: 10.7270/Q2MW2HBM
More data for this
Ligand-Target Pair
Sialidase


(Clostridium perfringens)
BDBM50311586
PNG
(CHEMBL1088462 | erystagallin A)
Show SMILES COc1ccc2c(O[C@H]3c4cc(CC=C(C)C)c(O)cc4OC[C@@]23O)c1CC=C(C)C
Show InChI InChI=1S/C26H30O5/c1-15(2)6-8-17-12-19-23(13-21(17)27)30-14-26(28)20-10-11-22(29-5)18(9-7-16(3)4)24(20)31-25(19)26/h6-7,10-13,25,27-28H,8-9,14H2,1-5H3/t25-,26+/m0/s1
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1.80E+3n/an/an/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of Clostridium perfringens neuraminidase


Bioorg Med Chem 18: 3335-44 (2010)


Article DOI: 10.1016/j.bmc.2010.03.005
BindingDB Entry DOI: 10.7270/Q2MW2HBM
More data for this
Ligand-Target Pair
Sialidase


(Clostridium perfringens)
BDBM50317436
PNG
(CHEMBL1096407 | calopocarpin)
Show SMILES CC(C)=CCc1cc2[C@@H]3Oc4cc(O)ccc4[C@@H]3COc2cc1O
Show InChI InChI=1S/C20H20O4/c1-11(2)3-4-12-7-15-18(9-17(12)22)23-10-16-14-6-5-13(21)8-19(14)24-20(15)16/h3,5-9,16,20-22H,4,10H2,1-2H3/t16-,20-/m0/s1
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2.09E+3n/an/an/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of Clostridium perfringens neuraminidase


Bioorg Med Chem 18: 3335-44 (2010)


Article DOI: 10.1016/j.bmc.2010.03.005
BindingDB Entry DOI: 10.7270/Q2MW2HBM
More data for this
Ligand-Target Pair
Sialidase


(Clostridium perfringens)
BDBM50317434
PNG
(CHEMBL1097045 | eryvarin D)
Show SMILES COc1ccc2c3COc4cc(O)ccc4-c3oc2c1CC=C(C)C
Show InChI InChI=1S/C21H20O4/c1-12(2)4-6-15-18(23-3)9-8-14-17-11-24-19-10-13(22)5-7-16(19)21(17)25-20(14)15/h4-5,7-10,22H,6,11H2,1-3H3
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2.55E+3n/an/an/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of Clostridium perfringens neuraminidase


Bioorg Med Chem 18: 3335-44 (2010)


Article DOI: 10.1016/j.bmc.2010.03.005
BindingDB Entry DOI: 10.7270/Q2MW2HBM
More data for this
Ligand-Target Pair
Sialidase


(Clostridium perfringens)
BDBM50317431
PNG
(CHEMBL1098413 | demethylmedicarpin)
Show SMILES Oc1ccc2[C@@H]3COc4cc(O)ccc4[C@@H]3Oc2c1
Show InChI InChI=1S/C15H12O4/c16-8-2-4-11-13(5-8)18-7-12-10-3-1-9(17)6-14(10)19-15(11)12/h1-6,12,15-17H,7H2/t12-,15-/m0/s1
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3.83E+3n/an/an/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of Clostridium perfringens neuraminidase


Bioorg Med Chem 18: 3335-44 (2010)


Article DOI: 10.1016/j.bmc.2010.03.005
BindingDB Entry DOI: 10.7270/Q2MW2HBM
More data for this
Ligand-Target Pair
Sialidase


(Clostridium perfringens)
BDBM50317437
PNG
(CHEMBL1096408 | Erythribyssin L)
Show SMILES CC(C)=CCc1c2O[C@@H]3[C@@H](COc4cc5OC(C)(C)C(O)Cc5cc34)c2ccc1O
Show InChI InChI=1S/C25H28O5/c1-13(2)5-6-16-19(26)8-7-15-18-12-28-21-11-20-14(10-22(27)25(3,4)30-20)9-17(21)24(18)29-23(15)16/h5,7-9,11,18,22,24,26-27H,6,10,12H2,1-4H3/t18-,22?,24-/m0/s1
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4.13E+3n/an/an/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of Clostridium perfringens neuraminidase


Bioorg Med Chem 18: 3335-44 (2010)


Article DOI: 10.1016/j.bmc.2010.03.005
BindingDB Entry DOI: 10.7270/Q2MW2HBM
More data for this
Ligand-Target Pair
Sialidase


(Clostridium perfringens)
BDBM50317438
PNG
(Abyssinone I | CHEMBL448350 | phaseollin)
Show SMILES CC1(C)Oc2ccc3[C@@H]4COc5cc(O)ccc5[C@@H]4Oc3c2C=C1
Show InChI InChI=1S/C20H18O4/c1-20(2)8-7-14-16(24-20)6-5-12-15-10-22-17-9-11(21)3-4-13(17)19(15)23-18(12)14/h3-9,15,19,21H,10H2,1-2H3/t15-,19-/m0/s1
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4.84E+3n/an/an/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Competitive inhibition of Clostridium perfringens neuraminidase


Bioorg Med Chem 18: 3335-44 (2010)


Article DOI: 10.1016/j.bmc.2010.03.005
BindingDB Entry DOI: 10.7270/Q2MW2HBM
More data for this
Ligand-Target Pair
Sialidase


(Clostridium perfringens)
BDBM50317433
PNG
(CHEMBL1098729 | isoneorautenol)
Show SMILES CC1(C)Oc2cc3O[C@@H]4[C@@H](COc5cc(O)ccc45)c3cc2C=C1
Show InChI InChI=1S/C20H18O4/c1-20(2)6-5-11-7-14-15-10-22-17-8-12(21)3-4-13(17)19(15)23-18(14)9-16(11)24-20/h3-9,15,19,21H,10H2,1-2H3/t15-,19-/m0/s1
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1.10E+4n/an/an/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of Clostridium perfringens neuraminidase


Bioorg Med Chem 18: 3335-44 (2010)


Article DOI: 10.1016/j.bmc.2010.03.005
BindingDB Entry DOI: 10.7270/Q2MW2HBM
More data for this
Ligand-Target Pair
Sialidase


(Clostridium perfringens)
BDBM50317439
PNG
(CHEMBL1095422 | erysubin D)
Show SMILES CC(C)=CCc1cc2[C@@H]3Oc4c(ccc5OC(C)(C)C(O)Cc45)[C@@H]3COc2cc1O
Show InChI InChI=1S/C25H28O5/c1-13(2)5-6-14-9-16-21(11-19(14)26)28-12-18-15-7-8-20-17(23(15)29-24(16)18)10-22(27)25(3,4)30-20/h5,7-9,11,18,22,24,26-27H,6,10,12H2,1-4H3/t18-,22?,24-/m0/s1
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1.52E+4n/an/an/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Competitive inhibition of Clostridium perfringens neuraminidase


Bioorg Med Chem 18: 3335-44 (2010)


Article DOI: 10.1016/j.bmc.2010.03.005
BindingDB Entry DOI: 10.7270/Q2MW2HBM
More data for this
Ligand-Target Pair
Sialidase


(Clostridium perfringens)
BDBM50317432
PNG
(CHEMBL1098728 | NEORAUTENOL)
Show SMILES CC1(C)Oc2cc3OC[C@@H]4[C@@H](Oc5cc(O)ccc45)c3cc2C=C1
Show InChI InChI=1S/C20H18O4/c1-20(2)6-5-11-7-14-17(9-16(11)24-20)22-10-15-13-4-3-12(21)8-18(13)23-19(14)15/h3-9,15,19,21H,10H2,1-2H3/t15-,19-/m0/s1
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2.17E+4n/an/an/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of Clostridium perfringens neuraminidase


Bioorg Med Chem 18: 3335-44 (2010)


Article DOI: 10.1016/j.bmc.2010.03.005
BindingDB Entry DOI: 10.7270/Q2MW2HBM
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50386567
PNG
(CHEMBL2048437)
Show SMILES Clc1cncc(Cl)c1NNC(=O)C1C2CC3CC(C2)C(Br)C1C3
Show InChI InChI=1S/C16H18BrCl2N3O/c17-14-9-2-7-1-8(4-9)13(10(14)3-7)16(23)22-21-15-11(18)5-20-6-12(15)19/h5-10,13-14H,1-4H2,(H,20,21)(H,22,23)
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n/an/a 1.30n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced IL8 release pretreated for 30 mins before bzAT...


J Med Chem 55: 3687-98 (2012)


Article DOI: 10.1021/jm2012326
BindingDB Entry DOI: 10.7270/Q21G0NB3
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50386567
PNG
(CHEMBL2048437)
Show SMILES Clc1cncc(Cl)c1NNC(=O)C1C2CC3CC(C2)C(Br)C1C3
Show InChI InChI=1S/C16H18BrCl2N3O/c17-14-9-2-7-1-8(4-9)13(10(14)3-7)16(23)22-21-15-11(18)5-20-6-12(15)19/h5-10,13-14H,1-4H2,(H,20,21)(H,22,23)
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n/an/a 4.90n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced ethidium bromide uptake after 2 hrs by f...


J Med Chem 55: 3687-98 (2012)


Article DOI: 10.1021/jm2012326
BindingDB Entry DOI: 10.7270/Q21G0NB3
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50386566
PNG
(CHEMBL2048438)
Show SMILES CC12CC3CC(C)(C1)CC(C3)(C2)C(=O)NNc1c(Cl)cncc1Cl
Show InChI InChI=1S/C18H23Cl2N3O/c1-16-3-11-4-17(2,8-16)10-18(5-11,9-16)15(24)23-22-14-12(19)6-21-7-13(14)20/h6-7,11H,3-5,8-10H2,1-2H3,(H,21,22)(H,23,24)
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n/an/a 9.20n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced IL8 release pretreated for 30 mins before bzAT...


J Med Chem 55: 3687-98 (2012)


Article DOI: 10.1021/jm2012326
BindingDB Entry DOI: 10.7270/Q21G0NB3
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50087267
PNG
((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)
Show SMILES CN([C@@H](Cc1ccc(OS(=O)(=O)c2cccc3cnccc23)cc1)C(=O)N1CCN(CC1)c1ccccc1)S(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at P2X7 receptor in LPS/IFN-gamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preinc...


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50386566
PNG
(CHEMBL2048438)
Show SMILES CC12CC3CC(C)(C1)CC(C3)(C2)C(=O)NNc1c(Cl)cncc1Cl
Show InChI InChI=1S/C18H23Cl2N3O/c1-16-3-11-4-17(2,8-16)10-18(5-11,9-16)15(24)23-22-14-12(19)6-21-7-13(14)20/h6-7,11H,3-5,8-10H2,1-2H3,(H,21,22)(H,23,24)
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n/an/a 13n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced ethidium bromide uptake after 2 hrs by f...


J Med Chem 55: 3687-98 (2012)


Article DOI: 10.1021/jm2012326
BindingDB Entry DOI: 10.7270/Q21G0NB3
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50075452
PNG
(CHEMBL3415315)
Show SMILES O=C(N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C35H38N4O6S/c40-32-30(17-22-4-6-28(7-5-22)45-46(43,44)31-3-1-2-26-21-36-11-8-29(26)31)39(34(42)37-32)27-9-12-38(13-10-27)33(41)35-18-23-14-24(19-35)16-25(15-23)20-35/h1-8,11,21,23-25,27,30H,9-10,12-20H2,(H,37,40,42)
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n/an/a 14n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at P2X7 receptor in LPS/IFN-gamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preinc...


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50075454
PNG
(CHEMBL3415330)
Show SMILES O=C(CC12CC3CC(CC(C3)C1)C2)N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O
Show InChI InChI=1S/C36H40N4O6S/c41-33(21-36-18-24-14-25(19-36)16-26(15-24)20-36)39-12-9-28(10-13-39)40-31(34(42)38-35(40)43)17-23-4-6-29(7-5-23)46-47(44,45)32-3-1-2-27-22-37-11-8-30(27)32/h1-8,11,22,24-26,28,31H,9-10,12-21H2,(H,38,42,43)
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n/an/a 15n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at P2X7 receptor in LPS/IFN-gamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preinc...


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50075452
PNG
(CHEMBL3415315)
Show SMILES O=C(N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C35H38N4O6S/c40-32-30(17-22-4-6-28(7-5-22)45-46(43,44)31-3-1-2-26-21-36-11-8-29(26)31)39(34(42)37-32)27-9-12-38(13-10-27)33(41)35-18-23-14-24(19-35)16-25(15-23)20-35/h1-8,11,21,23-25,27,30H,9-10,12-20H2,(H,37,40,42)
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n/an/a 23n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced intracellular ethidium bromi...


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50075455
PNG
(CHEMBL3415331)
Show SMILES BrC12CC3CC(C1)CC(C3)(C2)C(=O)N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O
Show InChI InChI=1S/C35H37BrN4O6S/c36-35-18-23-14-24(19-35)17-34(16-23,21-35)32(42)39-12-9-26(10-13-39)40-29(31(41)38-33(40)43)15-22-4-6-27(7-5-22)46-47(44,45)30-3-1-2-25-20-37-11-8-28(25)30/h1-8,11,20,23-24,26,29H,9-10,12-19,21H2,(H,38,41,43)
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n/an/a 27n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at P2X7 receptor in LPS/IFN-gamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preinc...


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50075458
PNG
(CHEMBL3415334)
Show SMILES O=C(CC1CC2CCC1C2)N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O
Show InChI InChI=1S/C33H36N4O6S/c38-31(19-25-17-22-4-7-23(25)16-22)36-14-11-26(12-15-36)37-29(32(39)35-33(37)40)18-21-5-8-27(9-6-21)43-44(41,42)30-3-1-2-24-20-34-13-10-28(24)30/h1-3,5-6,8-10,13,20,22-23,25-26,29H,4,7,11-12,14-19H2,(H,35,39,40)
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n/an/a 29n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at P2X7 receptor in LPS/IFN-gamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preinc...


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50075455
PNG
(CHEMBL3415331)
Show SMILES BrC12CC3CC(C1)CC(C3)(C2)C(=O)N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O
Show InChI InChI=1S/C35H37BrN4O6S/c36-35-18-23-14-24(19-35)17-34(16-23,21-35)32(42)39-12-9-26(10-13-39)40-29(31(41)38-33(40)43)15-22-4-6-27(7-5-22)46-47(44,45)30-3-1-2-25-20-37-11-8-28(25)30/h1-8,11,20,23-24,26,29H,9-10,12-19,21H2,(H,38,41,43)
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n/an/a 30n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced intracellular ethidium bromi...


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50230061
PNG
((S)-4-(3-(4-benzoylpiperazin-1-yl)-2-(benzyloxycar...)
Show SMILES [O-][N+](=O)c1ccc(cc1)S(=O)(=O)Oc1ccc(C[C@H](NC(=O)OCc2ccccc2)C(=O)N2CCN(CC2)C(=O)c2ccccc2)cc1
Show InChI InChI=1S/C34H32N4O9S/c39-32(27-9-5-2-6-10-27)36-19-21-37(22-20-36)33(40)31(35-34(41)46-24-26-7-3-1-4-8-26)23-25-11-15-29(16-12-25)47-48(44,45)30-17-13-28(14-18-30)38(42)43/h1-18,31H,19-24H2,(H,35,41)/t31-/m0/s1
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n/an/a 34n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X7 receptor


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50230072
PNG
((S)-tert-butyl 4-(3-(4-(isoquinolin-5-ylsulfonylox...)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)C(=O)[C@H](Cc1ccc(OS(=O)(=O)c2cccc3cnccc23)cc1)NS(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C36H37N5O8S2/c1-36(2,3)48-35(43)41-20-18-40(19-21-41)34(42)31(39-50(44,45)32-8-4-6-26-23-37-16-14-29(26)32)22-25-10-12-28(13-11-25)49-51(46,47)33-9-5-7-27-24-38-17-15-30(27)33/h4-17,23-24,31,39H,18-22H2,1-3H3/t31-/m0/s1
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n/an/a 41n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X7 receptor


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50386572
PNG
(CHEMBL2048286)
Show SMILES Clc1cncc(Cl)c1NNC(=O)CC1CCCCCC1
Show InChI InChI=1S/C14H19Cl2N3O/c15-11-8-17-9-12(16)14(11)19-18-13(20)7-10-5-3-1-2-4-6-10/h8-10H,1-7H2,(H,17,19)(H,18,20)
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n/an/a 42n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced IL8 release pretreated for 30 mins before bzAT...


J Med Chem 55: 3687-98 (2012)


Article DOI: 10.1021/jm2012326
BindingDB Entry DOI: 10.7270/Q21G0NB3
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50075457
PNG
(CHEMBL3415333)
Show SMILES O=C(N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O)C12CC3CC1CC(C2)C3
Show InChI InChI=1S/C34H36N4O6S/c39-31-29(17-21-4-6-27(7-5-21)44-45(42,43)30-3-1-2-24-20-35-11-8-28(24)30)38(33(41)36-31)26-9-12-37(13-10-26)32(40)34-18-22-14-23(19-34)16-25(34)15-22/h1-8,11,20,22-23,25-26,29H,9-10,12-19H2,(H,36,39,41)
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n/an/a 49n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at P2X7 receptor in LPS/IFN-gamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preinc...


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50075467
PNG
(CHEMBL3415342)
Show SMILES FC(F)(F)c1cc(ccc1Cl)C(=O)N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O
Show InChI InChI=1S/C32H26ClF3N4O6S/c33-26-9-6-20(17-25(26)32(34,35)36)30(42)39-14-11-22(12-15-39)40-27(29(41)38-31(40)43)16-19-4-7-23(8-5-19)46-47(44,45)28-3-1-2-21-18-37-13-10-24(21)28/h1-10,13,17-18,22,27H,11-12,14-16H2,(H,38,41,43)
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n/an/a 50n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at P2X7 receptor in LPS/IFN-gamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preinc...


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50087267
PNG
((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)
Show SMILES CN([C@@H](Cc1ccc(OS(=O)(=O)c2cccc3cnccc23)cc1)C(=O)N1CCN(CC1)c1ccccc1)S(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1
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n/an/a 51n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X7 receptor


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50386573
PNG
(CHEMBL2048285)
Show SMILES Clc1cncc(Cl)c1NNC(=O)CCC1CCCCC1
Show InChI InChI=1S/C14H19Cl2N3O/c15-11-8-17-9-12(16)14(11)19-18-13(20)7-6-10-4-2-1-3-5-10/h8-10H,1-7H2,(H,17,19)(H,18,20)
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n/an/a 56n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced IL8 release pretreated for 30 mins before bzAT...


J Med Chem 55: 3687-98 (2012)


Article DOI: 10.1021/jm2012326
BindingDB Entry DOI: 10.7270/Q21G0NB3
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50075457
PNG
(CHEMBL3415333)
Show SMILES O=C(N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O)C12CC3CC1CC(C2)C3
Show InChI InChI=1S/C34H36N4O6S/c39-31-29(17-21-4-6-27(7-5-21)44-45(42,43)30-3-1-2-24-20-35-11-8-28(24)30)38(33(41)36-31)26-9-12-37(13-10-26)32(40)34-18-22-14-23(19-34)16-25(34)15-22/h1-8,11,20,22-23,25-26,29H,9-10,12-19H2,(H,36,39,41)
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n/an/a 69n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced intracellular ethidium bromi...


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50075467
PNG
(CHEMBL3415342)
Show SMILES FC(F)(F)c1cc(ccc1Cl)C(=O)N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O
Show InChI InChI=1S/C32H26ClF3N4O6S/c33-26-9-6-20(17-25(26)32(34,35)36)30(42)39-14-11-22(12-15-39)40-27(29(41)38-31(40)43)16-19-4-7-23(8-5-19)46-47(44,45)28-3-1-2-21-18-37-13-10-24(21)28/h1-10,13,17-18,22,27H,11-12,14-16H2,(H,38,41,43)
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n/an/a 70n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced intracellular ethidium bromi...


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50075466
PNG
(CHEMBL3415341)
Show SMILES Clc1ccc(cc1Cl)C(=O)N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O
Show InChI InChI=1S/C31H26Cl2N4O6S/c32-25-9-6-20(17-26(25)33)30(39)36-14-11-22(12-15-36)37-27(29(38)35-31(37)40)16-19-4-7-23(8-5-19)43-44(41,42)28-3-1-2-21-18-34-13-10-24(21)28/h1-10,13,17-18,22,27H,11-12,14-16H2,(H,35,38,40)
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n/an/a 72n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at P2X7 receptor in LPS/IFN-gamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preinc...


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50075466
PNG
(CHEMBL3415341)
Show SMILES Clc1ccc(cc1Cl)C(=O)N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O
Show InChI InChI=1S/C31H26Cl2N4O6S/c32-25-9-6-20(17-26(25)33)30(39)36-14-11-22(12-15-36)37-27(29(38)35-31(37)40)16-19-4-7-23(8-5-19)43-44(41,42)28-3-1-2-21-18-34-13-10-24(21)28/h1-10,13,17-18,22,27H,11-12,14-16H2,(H,35,38,40)
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n/an/a 73n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced intracellular ethidium bromi...


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50386568
PNG
(CHEMBL2048436)
Show SMILES Clc1cncc(Cl)c1NNC(=O)C1C2CC3CC(C2)CC1C3
Show InChI InChI=1S/C16H19Cl2N3O/c17-12-6-19-7-13(18)15(12)20-21-16(22)14-10-2-8-1-9(4-10)5-11(14)3-8/h6-11,14H,1-5H2,(H,19,20)(H,21,22)
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n/an/a 77n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced ethidium bromide uptake after 2 hrs by f...


J Med Chem 55: 3687-98 (2012)


Article DOI: 10.1021/jm2012326
BindingDB Entry DOI: 10.7270/Q21G0NB3
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50075451
PNG
(CHEMBL3415314)
Show SMILES O=C(C1CCCCC1)N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O
Show InChI InChI=1S/C31H34N4O6S/c36-29-27(35(31(38)33-29)24-14-17-34(18-15-24)30(37)22-5-2-1-3-6-22)19-21-9-11-25(12-10-21)41-42(39,40)28-8-4-7-23-20-32-16-13-26(23)28/h4,7-13,16,20,22,24,27H,1-3,5-6,14-15,17-19H2,(H,33,36,38)
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n/an/a 80n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at P2X7 receptor in LPS/IFN-gamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preinc...


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50075456
PNG
(CHEMBL3415332)
Show SMILES CC12CC3CC(C)(C1)CC(C3)(C2)C(=O)N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O
Show InChI InChI=1S/C37H42N4O6S/c1-35-17-25-18-36(2,21-35)23-37(19-25,22-35)33(43)40-14-11-27(12-15-40)41-30(32(42)39-34(41)44)16-24-6-8-28(9-7-24)47-48(45,46)31-5-3-4-26-20-38-13-10-29(26)31/h3-10,13,20,25,27,30H,11-12,14-19,21-23H2,1-2H3,(H,39,42,44)
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n/an/a 81n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at P2X7 receptor in LPS/IFN-gamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preinc...


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50075465
PNG
(CHEMBL3415340)
Show SMILES Fc1ccc(cc1F)C(=O)N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O
Show InChI InChI=1S/C31H26F2N4O6S/c32-25-9-6-20(17-26(25)33)30(39)36-14-11-22(12-15-36)37-27(29(38)35-31(37)40)16-19-4-7-23(8-5-19)43-44(41,42)28-3-1-2-21-18-34-13-10-24(21)28/h1-10,13,17-18,22,27H,11-12,14-16H2,(H,35,38,40)
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n/an/a 81n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at P2X7 receptor in LPS/IFN-gamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preinc...


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50075454
PNG
(CHEMBL3415330)
Show SMILES O=C(CC12CC3CC(CC(C3)C1)C2)N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O
Show InChI InChI=1S/C36H40N4O6S/c41-33(21-36-18-24-14-25(19-36)16-26(15-24)20-36)39-12-9-28(10-13-39)40-31(34(42)38-35(40)43)17-23-4-6-29(7-5-23)46-47(44,45)32-3-1-2-27-22-37-11-8-30(27)32/h1-8,11,22,24-26,28,31H,9-10,12-21H2,(H,38,42,43)
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n/an/a 84n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced intracellular ethidium bromi...


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50075456
PNG
(CHEMBL3415332)
Show SMILES CC12CC3CC(C)(C1)CC(C3)(C2)C(=O)N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O
Show InChI InChI=1S/C37H42N4O6S/c1-35-17-25-18-36(2,21-35)23-37(19-25,22-35)33(43)40-14-11-27(12-15-40)41-30(32(42)39-34(41)44)16-24-6-8-28(9-7-24)47-48(45,46)31-5-3-4-26-20-38-13-10-29(26)31/h3-10,13,20,25,27,30H,11-12,14-19,21-23H2,1-2H3,(H,39,42,44)
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n/an/a 99n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced intracellular ethidium bromi...


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50075458
PNG
(CHEMBL3415334)
Show SMILES O=C(CC1CC2CCC1C2)N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O
Show InChI InChI=1S/C33H36N4O6S/c38-31(19-25-17-22-4-7-23(25)16-22)36-14-11-26(12-15-36)37-29(32(39)35-33(37)40)18-21-5-8-27(9-6-21)43-44(41,42)30-3-1-2-24-20-34-13-10-28(24)30/h1-3,5-6,8-10,13,20,22-23,25-26,29H,4,7,11-12,14-19H2,(H,35,39,40)
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n/an/a 109n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced intracellular ethidium bromi...


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50087267
PNG
((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)
Show SMILES CN([C@@H](Cc1ccc(OS(=O)(=O)c2cccc3cnccc23)cc1)C(=O)N1CCN(CC1)c1ccccc1)S(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1
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n/an/a 120n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced IL8 release pretreated for 30 mins before bzAT...


J Med Chem 55: 3687-98 (2012)


Article DOI: 10.1021/jm2012326
BindingDB Entry DOI: 10.7270/Q21G0NB3
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50386568
PNG
(CHEMBL2048436)
Show SMILES Clc1cncc(Cl)c1NNC(=O)C1C2CC3CC(C2)CC1C3
Show InChI InChI=1S/C16H19Cl2N3O/c17-12-6-19-7-13(18)15(12)20-21-16(22)14-10-2-8-1-9(4-10)5-11(14)3-8/h6-11,14H,1-5H2,(H,19,20)(H,21,22)
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n/an/a 130n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced IL8 release pretreated for 30 mins before bzAT...


J Med Chem 55: 3687-98 (2012)


Article DOI: 10.1021/jm2012326
BindingDB Entry DOI: 10.7270/Q21G0NB3
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50386573
PNG
(CHEMBL2048285)
Show SMILES Clc1cncc(Cl)c1NNC(=O)CCC1CCCCC1
Show InChI InChI=1S/C14H19Cl2N3O/c15-11-8-17-9-12(16)14(11)19-18-13(20)7-6-10-4-2-1-3-5-10/h8-10H,1-7H2,(H,17,19)(H,18,20)
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n/an/a 130n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced ethidium bromide uptake after 2 hrs by f...


J Med Chem 55: 3687-98 (2012)


Article DOI: 10.1021/jm2012326
BindingDB Entry DOI: 10.7270/Q21G0NB3
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50075451
PNG
(CHEMBL3415314)
Show SMILES O=C(C1CCCCC1)N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O
Show InChI InChI=1S/C31H34N4O6S/c36-29-27(35(31(38)33-29)24-14-17-34(18-15-24)30(37)22-5-2-1-3-6-22)19-21-9-11-25(12-10-21)41-42(39,40)28-8-4-7-23-20-32-16-13-26(23)28/h4,7-13,16,20,22,24,27H,1-3,5-6,14-15,17-19H2,(H,33,36,38)
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n/an/a 133n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced intracellular ethidium bromi...


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50075462
PNG
(CHEMBL3415338)
Show SMILES Clc1ccc(cc1)C(=O)N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O
Show InChI InChI=1S/C31H27ClN4O6S/c32-23-8-6-21(7-9-23)30(38)35-16-13-24(14-17-35)36-27(29(37)34-31(36)39)18-20-4-10-25(11-5-20)42-43(40,41)28-3-1-2-22-19-33-15-12-26(22)28/h1-12,15,19,24,27H,13-14,16-18H2,(H,34,37,39)
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n/an/a 133n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced intracellular ethidium bromi...


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50087267
PNG
((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)
Show SMILES CN([C@@H](Cc1ccc(OS(=O)(=O)c2cccc3cnccc23)cc1)C(=O)N1CCN(CC1)c1ccccc1)S(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1
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n/an/a 143n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at P2X7 receptor in LPS/IFN-gamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preinc...


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50087267
PNG
((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)
Show SMILES CN([C@@H](Cc1ccc(OS(=O)(=O)c2cccc3cnccc23)cc1)C(=O)N1CCN(CC1)c1ccccc1)S(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1
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n/an/a 158n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced intracellular ethidium bromi...


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50075462
PNG
(CHEMBL3415338)
Show SMILES Clc1ccc(cc1)C(=O)N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O
Show InChI InChI=1S/C31H27ClN4O6S/c32-23-8-6-21(7-9-23)30(38)35-16-13-24(14-17-35)36-27(29(37)34-31(36)39)18-20-4-10-25(11-5-20)42-43(40,41)28-3-1-2-22-19-33-15-12-26(22)28/h1-12,15,19,24,27H,13-14,16-18H2,(H,34,37,39)
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n/an/a 192n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Antagonist activity at P2X7 receptor in LPS/IFN-gamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preinc...


J Med Chem 58: 2114-34 (2015)


Article DOI: 10.1021/jm500324g
BindingDB Entry DOI: 10.7270/Q2H133QD
More data for this
Ligand-Target Pair
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