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Compile Data Set for Download or QSAR

Found 1703 hits with Last Name = 'kerr' and Initial = 'j'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM29568
PNG
(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)
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0.200n/an/an/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards mu-specific opiate receptor from combinatorial peptoid library


J Med Chem 37: 2678-85 (1994)


Article DOI: 10.1021/jm00043a007
BindingDB Entry DOI: 10.7270/Q2P26ZSP
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50000092
PNG
((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5O
Show InChI InChI=1/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/s2
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2n/an/an/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards mu-specific opiate receptor from combinatorial peptoid library


J Med Chem 37: 2678-85 (1994)


Article DOI: 10.1021/jm00043a007
BindingDB Entry DOI: 10.7270/Q2P26ZSP
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM21015
PNG
((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Show SMILES C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)NCCO
Show InChI InChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1
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4n/an/an/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards mu-specific opiate receptor from combinatorial peptoid library


J Med Chem 37: 2678-85 (1994)


Article DOI: 10.1021/jm00043a007
BindingDB Entry DOI: 10.7270/Q2P26ZSP
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50039664
PNG
(CHEMBL91890 | N-Biphenyl-4-yl-N-[(carbamoylmethyl-...)
Show SMILES NC(=O)CN(CCc1ccccc1)C(=O)CN(C(=O)CNCCc1ccccc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C34H36N4O3/c35-32(39)25-37(23-21-28-12-6-2-7-13-28)34(41)26-38(33(40)24-36-22-20-27-10-4-1-5-11-27)31-18-16-30(17-19-31)29-14-8-3-9-15-29/h1-19,36H,20-26H2,(H2,35,39)
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4n/an/an/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards mu-specific opiate receptor from combinatorial peptoid library


J Med Chem 37: 2678-85 (1994)


Article DOI: 10.1021/jm00043a007
BindingDB Entry DOI: 10.7270/Q2P26ZSP
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50039665
PNG
(CHEMBL90649 | CHIR-4531 | N-Benzo[1,3]dioxol-5-ylm...)
Show SMILES NC(=O)CN(CCc1ccc(O)cc1)C(=O)CN(Cc1ccc2OCOc2c1)C(=O)CNCC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C36H38N4O6/c37-34(42)23-39(18-17-26-11-14-30(41)15-12-26)36(44)24-40(22-27-13-16-32-33(19-27)46-25-45-32)35(43)21-38-20-31(28-7-3-1-4-8-28)29-9-5-2-6-10-29/h1-16,19,31,38,41H,17-18,20-25H2,(H2,37,42)
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6n/an/an/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards mu-specific opiate receptor from rat brain membrane using [3H]DAMGO


J Med Chem 37: 2678-85 (1994)


Article DOI: 10.1021/jm00043a007
BindingDB Entry DOI: 10.7270/Q2P26ZSP
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50229128
PNG
(CHEMBL401401 | N-((S)-1-oxo-1-((S)-5-phenyl-1-(phe...)
Show SMILES Cc1ccc(C[C@H](NC(=O)c2ccc3OCCOc3c2)C(=O)N[C@@H](CCc2ccccc2)\C=C\S(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C36H36N2O6S/c1-26-12-14-28(15-13-26)24-32(38-35(39)29-17-19-33-34(25-29)44-22-21-43-33)36(40)37-30(18-16-27-8-4-2-5-9-27)20-23-45(41,42)31-10-6-3-7-11-31/h2-15,17,19-20,23,25,30,32H,16,18,21-22,24H2,1H3,(H,37,40)(H,38,39)/b23-20+/t30-,32-/m0/s1
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19n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi cruzain


Bioorg Med Chem Lett 18: 624-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.070
BindingDB Entry DOI: 10.7270/Q2DN44SC
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50019056
PNG
((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C27H35N5O7S/c1-40-12-11-21(27(38)39)32-26(37)22(14-17-5-3-2-4-6-17)31-24(35)16-29-23(34)15-30-25(36)20(28)13-18-7-9-19(33)10-8-18/h2-10,20-22,33H,11-16,28H2,1H3,(H,29,34)(H,30,36)(H,31,35)(H,32,37)(H,38,39)/t20-,21-,22-/m0/s1
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20n/an/an/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards mu-specific opiate receptor from combinatorial peptoid library


J Med Chem 37: 2678-85 (1994)


Article DOI: 10.1021/jm00043a007
BindingDB Entry DOI: 10.7270/Q2P26ZSP
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50039661
PNG
(CHEMBL327549 | CHIR-4537 | N-({Carbamoylmethyl-[2-...)
Show SMILES COc1ccc(CN(CC(=O)N(CCc2ccc(O)cc2)CC(N)=O)C(=O)CNCC(c2ccccc2)c2ccccc2)cc1OC
Show InChI InChI=1S/C37H42N4O6/c1-46-33-18-15-28(21-34(33)47-2)24-41(26-37(45)40(25-35(38)43)20-19-27-13-16-31(42)17-14-27)36(44)23-39-22-32(29-9-5-3-6-10-29)30-11-7-4-8-12-30/h3-18,21,32,39,42H,19-20,22-26H2,1-2H3,(H2,38,43)
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31n/an/an/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards mu-specific opiate receptor from rat brain membrane using [3H]DAMGO


J Med Chem 37: 2678-85 (1994)


Article DOI: 10.1021/jm00043a007
BindingDB Entry DOI: 10.7270/Q2P26ZSP
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50229117
PNG
(CHEMBL399181 | N-((S)-1-oxo-1-((S)-5-phenyl-1-(phe...)
Show SMILES Cc1ccc(C[C@H](NC(=O)c2ccc(cc2)C(F)(F)F)C(=O)N[C@@H](CCc2ccccc2)\C=C\S(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C35H33F3N2O4S/c1-25-12-14-27(15-13-25)24-32(40-33(41)28-17-19-29(20-18-28)35(36,37)38)34(42)39-30(21-16-26-8-4-2-5-9-26)22-23-45(43,44)31-10-6-3-7-11-31/h2-15,17-20,22-23,30,32H,16,21,24H2,1H3,(H,39,42)(H,40,41)/b23-22+/t30-,32-/m0/s1
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45n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi cruzain


Bioorg Med Chem Lett 18: 624-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.070
BindingDB Entry DOI: 10.7270/Q2DN44SC
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50039663
PNG
(CHEMBL89378 | CHIR-4534 | N-({Carbamoylmethyl-[2-(...)
Show SMILES CCCCCN(CC(=O)N(CCc1ccc(O)cc1)CC(N)=O)C(=O)CNCC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C33H42N4O4/c1-2-3-10-20-36(25-33(41)37(24-31(34)39)21-19-26-15-17-29(38)18-16-26)32(40)23-35-22-30(27-11-6-4-7-12-27)28-13-8-5-9-14-28/h4-9,11-18,30,35,38H,2-3,10,19-25H2,1H3,(H2,34,39)
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46n/an/an/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards mu-specific opiate receptor from rat brain membrane using [3H]DAMGO


J Med Chem 37: 2678-85 (1994)


Article DOI: 10.1021/jm00043a007
BindingDB Entry DOI: 10.7270/Q2P26ZSP
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50229124
PNG
(3,5-difluoro-N-((S)-1-oxo-1-((S)-5-phenyl-1-(pheny...)
Show SMILES Cc1cccc(C[C@H](NC(=O)c2cc(F)cc(F)c2)C(=O)N[C@@H](CCc2ccccc2)\C=C\S(=O)(=O)c2ccccc2)c1
Show InChI InChI=1S/C34H32F2N2O4S/c1-24-9-8-12-26(19-24)20-32(38-33(39)27-21-28(35)23-29(36)22-27)34(40)37-30(16-15-25-10-4-2-5-11-25)17-18-43(41,42)31-13-6-3-7-14-31/h2-14,17-19,21-23,30,32H,15-16,20H2,1H3,(H,37,40)(H,38,39)/b18-17+/t30-,32-/m0/s1
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50n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi cruzain


Bioorg Med Chem Lett 18: 624-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.070
BindingDB Entry DOI: 10.7270/Q2DN44SC
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50091554
PNG
(CHEMBL3582308)
Show SMILES Fc1ccc(cc1)-c1c[nH]c(n1)[C@@H]1CCc2[nH]c3ccccc3c2C1
Show InChI InChI=1/C21H18FN3/c22-15-8-5-13(6-9-15)20-12-23-21(25-20)14-7-10-19-17(11-14)16-3-1-2-4-18(16)24-19/h1-6,8-9,12,14,24H,7,10-11H2,(H,23,25)/t14-/s2
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50n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of MK499 binding to human ERG


ACS Med Chem Lett 6: 513-7 (2015)


Article DOI: 10.1021/ml500514w
BindingDB Entry DOI: 10.7270/Q2M61N0H
More data for this
Ligand-Target Pair
Peptide Deformylase


(Streptococcus pneumoniae (strain ATCC BAA-255 / R6...)
BDBM92766
PNG
(PDF inhibitor, compound 8)
Show SMILES Cc1ccccc1Nc1nc(nc(n1)N1CCN(CC1)c1ccccc1Cl)N1CSC[C@H]1COCC(=O)NO
Show InChI InChI=1/C26H31ClN8O3S/c1-18-6-2-4-8-21(18)28-24-29-25(34-12-10-33(11-13-34)22-9-5-3-7-20(22)27)31-26(30-24)35-17-39-16-19(35)14-38-15-23(36)32-37/h2-9,19,37H,10-17H2,1H3,(H,32,36)(H,28,29,30,31)/t19-/s2
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53.7n/an/an/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
Binding assay using PDF inhibitors.


Biochemistry 50: 6642-54 (2011)


Article DOI: 10.1021/bi200655g
BindingDB Entry DOI: 10.7270/Q2MS3RBV
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Cruzipain


(Trypanosoma cruzi)
BDBM50322737
PNG
(2-(2-chloro-5-(trifluoromethyl)phenylamino)-2-oxo-...)
Show SMILES FC(F)(F)c1ccc(Cl)c(NC(=O)C(OC(=O)CNC(=O)c2ccccc2)c2ccccc2)c1
Show InChI InChI=1/C24H18ClF3N2O4/c25-18-12-11-17(24(26,27)28)13-19(18)30-23(33)21(15-7-3-1-4-8-15)34-20(31)14-29-22(32)16-9-5-2-6-10-16/h1-13,21H,14H2,(H,29,32)(H,30,33)
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70n/an/an/an/an/an/an/an/a



University of California San Francisco

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi cruzain assessed as Z-Phe-Arg-aminomethylcoumarin cleavage by competetive binding assay


J Med Chem 53: 4891-905 (2010)


Article DOI: 10.1021/jm100488w
BindingDB Entry DOI: 10.7270/Q2BG2P68
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50229118
PNG
(CHEMBL254903 | N-((S)-1-oxo-1-((S)-5-phenyl-1-(phe...)
Show SMILES Cc1cccc(C[C@H](NC(=O)c2ccc3OCCOc3c2)C(=O)N[C@@H](CCc2ccccc2)\C=C\S(=O)(=O)c2ccccc2)c1
Show InChI InChI=1S/C36H36N2O6S/c1-26-9-8-12-28(23-26)24-32(38-35(39)29-16-18-33-34(25-29)44-21-20-43-33)36(40)37-30(17-15-27-10-4-2-5-11-27)19-22-45(41,42)31-13-6-3-7-14-31/h2-14,16,18-19,22-23,25,30,32H,15,17,20-21,24H2,1H3,(H,37,40)(H,38,39)/b22-19+/t30-,32-/m0/s1
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71n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi cruzain


Bioorg Med Chem Lett 18: 624-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.070
BindingDB Entry DOI: 10.7270/Q2DN44SC
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50389592
PNG
(CHEMBL2069500)
Show SMILES C1CCC(CC1)C1N[C@H](Cc2c1[nH]c1ccccc21)c1nc(c[nH]1)-c1ccccc1
Show InChI InChI=1/C26H28N4/c1-3-9-17(10-4-1)23-16-27-26(30-23)22-15-20-19-13-7-8-14-21(19)28-25(20)24(29-22)18-11-5-2-6-12-18/h1,3-4,7-10,13-14,16,18,22,24,28-29H,2,5-6,11-12,15H2,(H,27,30)/t22-,24?/s2
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80n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of MK499 binding to human ERG


ACS Med Chem Lett 6: 513-7 (2015)


Article DOI: 10.1021/ml500514w
BindingDB Entry DOI: 10.7270/Q2M61N0H
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50229127
PNG
(CHEMBL399676 | N-((S)-1-oxo-3-phenyl-1-((S)-5-phen...)
Show SMILES O=C(N[C@@H](CCc1ccccc1)\C=C\S(=O)(=O)c1ccccc1)[C@H](Cc1ccccc1)NC(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C35H34N2O6S/c38-34(28-17-19-32-33(25-28)43-22-21-42-32)37-31(24-27-12-6-2-7-13-27)35(39)36-29(18-16-26-10-4-1-5-11-26)20-23-44(40,41)30-14-8-3-9-15-30/h1-15,17,19-20,23,25,29,31H,16,18,21-22,24H2,(H,36,39)(H,37,38)/b23-20+/t29-,31-/m0/s1
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80n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi cruzain


Bioorg Med Chem Lett 18: 624-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.070
BindingDB Entry DOI: 10.7270/Q2DN44SC
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50229132
PNG
(CHEMBL254066 | N-((S)-1-oxo-1-((S)-5-phenyl-1-(phe...)
Show SMILES Cc1cccc(C[C@H](NC(=O)c2ccc(cc2)C(F)(F)F)C(=O)N[C@@H](CCc2ccccc2)\C=C\S(=O)(=O)c2ccccc2)c1
Show InChI InChI=1S/C35H33F3N2O4S/c1-25-9-8-12-27(23-25)24-32(40-33(41)28-16-18-29(19-17-28)35(36,37)38)34(42)39-30(20-15-26-10-4-2-5-11-26)21-22-45(43,44)31-13-6-3-7-14-31/h2-14,16-19,21-23,30,32H,15,20,24H2,1H3,(H,39,42)(H,40,41)/b22-21+/t30-,32-/m0/s1
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92n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi cruzain


Bioorg Med Chem Lett 18: 624-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.070
BindingDB Entry DOI: 10.7270/Q2DN44SC
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50229123
PNG
(CHEMBL254687 | N-((S)-1-oxo-3-phenyl-1-((S)-5-phen...)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCc1ccccc1)\C=C\S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C34H31F3N2O4S/c35-34(36,37)28-19-17-27(18-20-28)32(40)39-31(24-26-12-6-2-7-13-26)33(41)38-29(21-16-25-10-4-1-5-11-25)22-23-44(42,43)30-14-8-3-9-15-30/h1-15,17-20,22-23,29,31H,16,21,24H2,(H,38,41)(H,39,40)/b23-22+/t29-,31-/m0/s1
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97n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi cruzain


Bioorg Med Chem Lett 18: 624-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.070
BindingDB Entry DOI: 10.7270/Q2DN44SC
More data for this
Ligand-Target Pair
Rhodesain


(Trypanosoma brucei rhodesiense)
BDBM50183768
PNG
((2S,3S)-1-((S)-2-((R)-2-(tert-butoxycarbonyl)-3-ph...)
Show SMILES C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N1[C@@H]([C@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C21H27N3O8/c1-11(17(26)24-14(18(27)28)15(24)19(29)30)22-16(25)13(10-12-8-6-5-7-9-12)23-20(31)32-21(2,3)4/h5-9,11,13-15H,10H2,1-4H3,(H,22,25)(H,23,31)(H,27,28)(H,29,30)/t11-,13+,14-,15-/m0/s1
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100n/an/an/an/an/an/an/an/a



University of Wuerzburg

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei rhodesiense rhodesain


Bioorg Med Chem Lett 16: 2753-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.026
BindingDB Entry DOI: 10.7270/Q2PK0FRX
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50306596
PNG
(3-(4-((S)-4-methyl-2-(quinolin-6-ylmethylamino)pen...)
Show SMILES CCCCC(C(=O)COc1c(F)c(F)cc(F)c1F)n1cc(nn1)[C@](C)(CC(C)C)NCc1ccc2ncccc2c1
Show InChI InChI=1/C31H35F4N5O2/c1-5-6-9-25(26(41)18-42-30-28(34)22(32)14-23(33)29(30)35)40-17-27(38-39-40)31(4,15-19(2)3)37-16-20-10-11-24-21(13-20)8-7-12-36-24/h7-8,10-14,17,19,25,37H,5-6,9,15-16,18H2,1-4H3/t25?,31-/s2
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100n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi cruzain


J Med Chem 53: 1763-73 (2010)


Article DOI: 10.1021/jm901633v
BindingDB Entry DOI: 10.7270/Q21N8172
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50306600
PNG
(3-(4-((S)-1-cyclopentyl-1-(quinolin-6-ylmethylamin...)
Show SMILES CCCCC(C(=O)COc1c(F)c(F)cc(F)c1F)n1cc(nn1)[C@@](C)(NCc1ccc2ncccc2c1)C1CCCC1
Show InChI InChI=1/C32H35F4N5O2/c1-3-4-11-26(27(42)19-43-31-29(35)23(33)16-24(34)30(31)36)41-18-28(39-40-41)32(2,22-9-5-6-10-22)38-17-20-12-13-25-21(15-20)8-7-14-37-25/h7-8,12-16,18,22,26,38H,3-6,9-11,17,19H2,1-2H3/t26?,32-/s2
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110n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi cruzain


J Med Chem 53: 1763-73 (2010)


Article DOI: 10.1021/jm901633v
BindingDB Entry DOI: 10.7270/Q21N8172
More data for this
Ligand-Target Pair
Peptide Deformylase


(Streptococcus pneumoniae (strain ATCC BAA-255 / R6...)
BDBM92761
PNG
(PDF inhibitor, compound 3)
Show SMILES CNC(=O)[C@@H]1CSCN1c1nc(Nc2c(C)cccc2C(=O)NC)nc(n1)N1CCN(CC1)c1ccccc1Cl
Show InChI InChI=1/C27H32ClN9O2S/c1-17-7-6-8-18(23(38)29-2)22(17)31-25-32-26(34-27(33-25)37-16-40-15-21(37)24(39)30-3)36-13-11-35(12-14-36)20-10-5-4-9-19(20)28/h4-10,21H,11-16H2,1-3H3,(H,29,38)(H,30,39)(H,31,32,33,34)/t21-/s2
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117n/an/an/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
Binding assay using PDF inhibitors.


Biochemistry 50: 6642-54 (2011)


Article DOI: 10.1021/bi200655g
BindingDB Entry DOI: 10.7270/Q2MS3RBV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50328879
PNG
(CHEMBL1234898 | N-benzyl-3-(2-cyano-6-propylpyrimi...)
Show SMILES CCCc1cc(nc(n1)C#N)-c1cc(cc(c1)C(F)(F)F)C(=O)N(CCN(C)C)Cc1ccccc1
Show InChI InChI=1S/C27H28F3N5O/c1-4-8-23-16-24(33-25(17-31)32-23)20-13-21(15-22(14-20)27(28,29)30)26(36)35(12-11-34(2)3)18-19-9-6-5-7-10-19/h5-7,9-10,13-16H,4,8,11-12,18H2,1-3H3
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120n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cells


Bioorg Med Chem Lett 20: 6237-41 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.101
BindingDB Entry DOI: 10.7270/Q2RR1ZFT
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50306598
PNG
(3-(4-((S)-1-cyclobutyl-1-(quinolin-6-ylmethylamino...)
Show SMILES CCCCC(C(=O)COc1c(F)c(F)cc(F)c1F)n1cc(nn1)[C@@](C)(NCc1ccc2ncccc2c1)C1CCC1
Show InChI InChI=1/C31H33F4N5O2/c1-3-4-10-25(26(41)18-42-30-28(34)22(32)15-23(33)29(30)35)40-17-27(38-39-40)31(2,21-8-5-9-21)37-16-19-11-12-24-20(14-19)7-6-13-36-24/h6-7,11-15,17,21,25,37H,3-5,8-10,16,18H2,1-2H3/t25?,31-/s2
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130n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi cruzain


J Med Chem 53: 1763-73 (2010)


Article DOI: 10.1021/jm901633v
BindingDB Entry DOI: 10.7270/Q21N8172
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50229135
PNG
(CHEMBL253015 | N-((S)-1-oxo-1-((S)-5-phenyl-1-(phe...)
Show SMILES FC(F)(F)c1cccc(C[C@H](NC(=O)c2ccccn2)C(=O)N[C@@H](CCc2ccccc2)\C=C\S(=O)(=O)c2ccccc2)c1
Show InChI InChI=1S/C33H30F3N3O4S/c34-33(35,36)26-13-9-12-25(22-26)23-30(39-31(40)29-16-7-8-20-37-29)32(41)38-27(18-17-24-10-3-1-4-11-24)19-21-44(42,43)28-14-5-2-6-15-28/h1-16,19-22,27,30H,17-18,23H2,(H,38,41)(H,39,40)/b21-19+/t27-,30-/m0/s1
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150n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi cruzain


Bioorg Med Chem Lett 18: 624-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.070
BindingDB Entry DOI: 10.7270/Q2DN44SC
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50313476
PNG
(4-(3-(piperidin-1-yl)propyl)-6-(3-(trifluoromethyl...)
Show SMILES FC(F)(F)c1cccc(c1)-c1cc(CCCN2CCCCC2)nc(n1)C#N
Show InChI InChI=1S/C20H21F3N4/c21-20(22,23)16-7-4-6-15(12-16)18-13-17(25-19(14-24)26-18)8-5-11-27-9-2-1-3-10-27/h4,6-7,12-13H,1-3,5,8-11H2
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160n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cells


Bioorg Med Chem Lett 20: 6237-41 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.101
BindingDB Entry DOI: 10.7270/Q2RR1ZFT
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50229122
PNG
(4-methyl-N-((S)-1-oxo-1-((S)-5-phenyl-1-(phenylsul...)
Show SMILES CN1CCN(CC1)C(=O)N[C@@H](Cc1cccc(c1)C(F)(F)F)C(=O)N[C@@H](CCc1ccccc1)C=CS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C33H37F3N4O4S/c1-39-18-20-40(21-19-39)32(42)38-30(24-26-11-8-12-27(23-26)33(34,35)36)31(41)37-28(16-15-25-9-4-2-5-10-25)17-22-45(43,44)29-13-6-3-7-14-29/h2-14,17,22-23,28,30H,15-16,18-21,24H2,1H3,(H,37,41)(H,38,42)/b22-17+/t28-,30-/m0/s1
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170n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi cruzain


Bioorg Med Chem Lett 18: 624-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.070
BindingDB Entry DOI: 10.7270/Q2DN44SC
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50303409
PNG
(4-amino-6-(diphenylamino)-1,3,5-triazine-2-carboni...)
Show SMILES Nc1nc(nc(n1)N(c1ccccc1)c1ccccc1)C#N
Show InChI InChI=1S/C16H12N6/c17-11-14-19-15(18)21-16(20-14)22(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10H,(H2,18,19,20,21)
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180n/an/an/an/an/an/an/an/a



National Human Genome Research Institute

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant Trypanosoma cruzi cruzain by Lineweaver-Burk plot analysis


J Med Chem 53: 52-60 (2010)


Article DOI: 10.1021/jm901069a
BindingDB Entry DOI: 10.7270/Q2TX3FG5
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50306597
PNG
(3-(4-((S)-4-methyl-2-(quinolin-6-ylmethylamino)pen...)
Show SMILES CCC(C(=O)COc1c(F)c(F)cc(F)c1F)n1cc(nn1)[C@](C)(CC(C)C)NCc1ccc2ncccc2c1
Show InChI InChI=1/C29H31F4N5O2/c1-5-23(24(39)16-40-28-26(32)20(30)12-21(31)27(28)33)38-15-25(36-37-38)29(4,13-17(2)3)35-14-18-8-9-22-19(11-18)7-6-10-34-22/h6-12,15,17,23,35H,5,13-14,16H2,1-4H3/t23?,29-/s2
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190n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi cruzain


J Med Chem 53: 1763-73 (2010)


Article DOI: 10.1021/jm901633v
BindingDB Entry DOI: 10.7270/Q21N8172
More data for this
Ligand-Target Pair
Peptide Deformylase


(Streptococcus pneumoniae (strain ATCC BAA-255 / R6...)
BDBM92764
PNG
(PDF inhibitor, compound 6)
Show SMILES CNC(=O)c1cccc(C)c1Nc1nc(nc(n1)N1CCN(CC1)c1ccccc1Cl)N1CSC[C@H]1COCC(=O)NO
Show InChI InChI=1/C28H34ClN9O4S/c1-18-6-5-7-20(25(40)30-2)24(18)31-26-32-27(37-12-10-36(11-13-37)22-9-4-3-8-21(22)29)34-28(33-26)38-17-43-16-19(38)14-42-15-23(39)35-41/h3-9,19,41H,10-17H2,1-2H3,(H,30,40)(H,35,39)(H,31,32,33,34)/t19-/s2
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213n/an/an/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
Binding assay using PDF inhibitors.


Biochemistry 50: 6642-54 (2011)


Article DOI: 10.1021/bi200655g
BindingDB Entry DOI: 10.7270/Q2MS3RBV
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Cruzipain


(Trypanosoma cruzi)
BDBM50229129
PNG
(4-Methyl-piperazine-1-carboxylic acid [(S)-1-((E)-...)
Show SMILES CN1CCN(CC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCc1ccccc1)C=CS(=O)(=O)c1ccccc1
Show InChI InChI=1/C32H38N4O4S/c1-35-20-22-36(23-21-35)32(38)34-30(25-27-13-7-3-8-14-27)31(37)33-28(18-17-26-11-5-2-6-12-26)19-24-41(39,40)29-15-9-4-10-16-29/h2-16,19,24,28,30H,17-18,20-23,25H2,1H3,(H,33,37)(H,34,38)/b24-19+/t28-,30-/s2
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220n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi cruzain


Bioorg Med Chem Lett 18: 624-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.070
BindingDB Entry DOI: 10.7270/Q2DN44SC
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50229133
PNG
(CHEMBL399591 | N-((S)-1-oxo-3-phenyl-1-((S)-5-phen...)
Show SMILES O=C(N[C@@H](CCc1ccccc1)\C=C\S(=O)(=O)c1ccccc1)[C@H](Cc1ccccc1)NC(=O)c1ccccn1
Show InChI InChI=1S/C32H31N3O4S/c36-31(29-18-10-11-22-33-29)35-30(24-26-14-6-2-7-15-26)32(37)34-27(20-19-25-12-4-1-5-13-25)21-23-40(38,39)28-16-8-3-9-17-28/h1-18,21-23,27,30H,19-20,24H2,(H,34,37)(H,35,36)/b23-21+/t27-,30-/m0/s1
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250n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi cruzain


Bioorg Med Chem Lett 18: 624-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.070
BindingDB Entry DOI: 10.7270/Q2DN44SC
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50229125
PNG
(CHEMBL442284 | N-((S)-1-oxo-1-((S)-5-phenyl-1-(phe...)
Show SMILES Cc1cccc(C[C@H](NC(=O)c2ccccn2)C(=O)N[C@@H](CCc2ccccc2)\C=C\S(=O)(=O)c2ccccc2)c1
Show InChI InChI=1S/C33H33N3O4S/c1-25-11-10-14-27(23-25)24-31(36-32(37)30-17-8-9-21-34-30)33(38)35-28(19-18-26-12-4-2-5-13-26)20-22-41(39,40)29-15-6-3-7-16-29/h2-17,20-23,28,31H,18-19,24H2,1H3,(H,35,38)(H,36,37)/b22-20+/t28-,31-/m0/s1
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280n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi cruzain


Bioorg Med Chem Lett 18: 624-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.070
BindingDB Entry DOI: 10.7270/Q2DN44SC
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50091555
PNG
(CHEMBL3582307)
Show SMILES Fc1ccc(cc1)-c1c[nH]c(n1)[C@H]1Cc2c(CN1)[nH]c1ccccc21
Show InChI InChI=1/C20H17FN4/c21-13-7-5-12(6-8-13)18-10-23-20(25-18)17-9-15-14-3-1-2-4-16(14)24-19(15)11-22-17/h1-8,10,17,22,24H,9,11H2,(H,23,25)/t17-/s2
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290n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of MK499 binding to human ERG


ACS Med Chem Lett 6: 513-7 (2015)


Article DOI: 10.1021/ml500514w
BindingDB Entry DOI: 10.7270/Q2M61N0H
More data for this
Ligand-Target Pair
Rhodesain


(Trypanosoma brucei rhodesiense)
BDBM50183749
PNG
((2S,3S)-diethyl 1-((S)-1-((S)-2-(tert-butoxycarbon...)
Show SMILES CCOC(=O)[C@@H]1[C@H](N1C(=O)[C@@H]1CN1C(=O)[C@H](CC(C)C)NC(=O)OC(C)(C)C)C(=O)OCC
Show InChI InChI=1S/C22H35N3O8/c1-8-31-19(28)15-16(20(29)32-9-2)25(15)18(27)14-11-24(14)17(26)13(10-12(3)4)23-21(30)33-22(5,6)7/h12-16H,8-11H2,1-7H3,(H,23,30)/t13-,14-,15-,16-,24?/m0/s1
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300n/an/an/an/an/an/an/an/a



University of Wuerzburg

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei rhodesiense rhodesain


Bioorg Med Chem Lett 16: 2753-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.026
BindingDB Entry DOI: 10.7270/Q2PK0FRX
More data for this
Ligand-Target Pair
Rhodesain


(Trypanosoma brucei rhodesiense)
BDBM50311245
PNG
((S)-4-methyl-2-phenyl-N-(5-phenyl-1-(phenylsulfony...)
Show SMILES Cc1nc(sc1C(=O)N[C@@H](CCc1ccccc1)\C=C\S(=O)(=O)c1ccccc1)-c1ccccc1
Show InChI InChI=1/C28H26N2O3S2/c1-21-26(34-28(29-21)23-13-7-3-8-14-23)27(31)30-24(18-17-22-11-5-2-6-12-22)19-20-35(32,33)25-15-9-4-10-16-25/h2-16,19-20,24H,17-18H2,1H3,(H,30,31)/b20-19+/t24-/s2
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320n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei rhodesiense rhodesain preincubated after 5 mins


Bioorg Med Chem Lett 19: 6218-21 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.098
BindingDB Entry DOI: 10.7270/Q26973PF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50328887
PNG
(4-(3-morpholinopropyl)-6-(3-(trifluoromethyl)pheny...)
Show SMILES FC(F)(F)c1cccc(c1)-c1cc(CCCN2CCOCC2)nc(n1)C#N
Show InChI InChI=1S/C19H19F3N4O/c20-19(21,22)15-4-1-3-14(11-15)17-12-16(24-18(13-23)25-17)5-2-6-26-7-9-27-10-8-26/h1,3-4,11-12H,2,5-10H2
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320n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cells


Bioorg Med Chem Lett 20: 6237-41 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.101
BindingDB Entry DOI: 10.7270/Q2RR1ZFT
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50313477
PNG
(4-(3-(pentan-3-ylamino)propyl)-6-(3-(trifluorometh...)
Show SMILES CCC(CC)NCCCc1cc(nc(n1)C#N)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H23F3N4/c1-3-16(4-2)25-10-6-9-17-12-18(27-19(13-24)26-17)14-7-5-8-15(11-14)20(21,22)23/h5,7-8,11-12,16,25H,3-4,6,9-10H2,1-2H3
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320n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cells


Bioorg Med Chem Lett 20: 6237-41 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.101
BindingDB Entry DOI: 10.7270/Q2RR1ZFT
More data for this
Ligand-Target Pair
Peptide Deformylase


(Streptococcus pneumoniae (strain ATCC BAA-255 / R6...)
BDBM92760
PNG
(PDF inhibitor, compound 2)
Show SMILES CNC(=O)c1cccc(C)c1Nc1nc(nc(n1)N1CCN(CC1)c1ccccc1Cl)N1CSC[C@H]1C(=O)NCC(=O)NO
Show InChI InChI=1/C28H33ClN10O4S/c1-17-6-5-7-18(24(41)30-2)23(17)32-26-33-27(38-12-10-37(11-13-38)20-9-4-3-8-19(20)29)35-28(34-26)39-16-44-15-21(39)25(42)31-14-22(40)36-43/h3-9,21,43H,10-16H2,1-2H3,(H,30,41)(H,31,42)(H,36,40)(H,32,33,34,35)/t21-/s2
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334n/an/an/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
Binding assay using PDF inhibitors.


Biochemistry 50: 6642-54 (2011)


Article DOI: 10.1021/bi200655g
BindingDB Entry DOI: 10.7270/Q2MS3RBV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cruzipain


(Trypanosoma cruzi)
BDBM50306599
PNG
(3-(4-((S)-1-cyclobutyl-1-(quinolin-6-ylmethylamino...)
Show SMILES CCC(C(=O)COc1c(F)c(F)cc(F)c1F)n1cc(nn1)[C@@](C)(NCc1ccc2ncccc2c1)C1CCC1
Show InChI InChI=1/C29H29F4N5O2/c1-3-23(24(39)16-40-28-26(32)20(30)13-21(31)27(28)33)38-15-25(36-37-38)29(2,19-7-4-8-19)35-14-17-9-10-22-18(12-17)6-5-11-34-22/h5-6,9-13,15,19,23,35H,3-4,7-8,14,16H2,1-2H3/t23?,29-/s2
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350n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi cruzain


J Med Chem 53: 1763-73 (2010)


Article DOI: 10.1021/jm901633v
BindingDB Entry DOI: 10.7270/Q21N8172
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50229119
PNG
(3,5-difluoro-N-((S)-1-oxo-1-((S)-5-phenyl-1-(pheny...)
Show SMILES Cc1ccc(C[C@H](NC(=O)c2cc(F)cc(F)c2)C(=O)N[C@@H](CCc2ccccc2)\C=C\S(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C34H32F2N2O4S/c1-24-12-14-26(15-13-24)20-32(38-33(39)27-21-28(35)23-29(36)22-27)34(40)37-30(17-16-25-8-4-2-5-9-25)18-19-43(41,42)31-10-6-3-7-11-31/h2-15,18-19,21-23,30,32H,16-17,20H2,1H3,(H,37,40)(H,38,39)/b19-18+/t30-,32-/m0/s1
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350n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi cruzain


Bioorg Med Chem Lett 18: 624-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.070
BindingDB Entry DOI: 10.7270/Q2DN44SC
More data for this
Ligand-Target Pair
Rhodesain


(Trypanosoma brucei rhodesiense)
BDBM50183749
PNG
((2S,3S)-diethyl 1-((S)-1-((S)-2-(tert-butoxycarbon...)
Show SMILES CCOC(=O)[C@@H]1[C@H](N1C(=O)[C@@H]1CN1C(=O)[C@H](CC(C)C)NC(=O)OC(C)(C)C)C(=O)OCC
Show InChI InChI=1S/C22H35N3O8/c1-8-31-19(28)15-16(20(29)32-9-2)25(15)18(27)14-11-24(14)17(26)13(10-12(3)4)23-21(30)33-22(5,6)7/h12-16H,8-11H2,1-7H3,(H,23,30)/t13-,14-,15-,16-,24?/m0/s1
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360n/an/an/an/an/an/an/an/a



University of Wuerzburg

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei rhodesiense rhodesain in presence of 31.6 uM substrate Cbz-Phe-Arg-AMC


Bioorg Med Chem Lett 16: 2753-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.026
BindingDB Entry DOI: 10.7270/Q2PK0FRX
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50328880
PNG
(CHEMBL1271174 | N-benzyl-3-(2-cyano-6-propylpyrimi...)
Show SMILES CCCc1cc(nc(n1)C#N)-c1cc(cc(c1)C(F)(F)F)C(=O)N(C)Cc1ccccc1
Show InChI InChI=1S/C24H21F3N4O/c1-3-7-20-13-21(30-22(14-28)29-20)17-10-18(12-19(11-17)24(25,26)27)23(32)31(2)15-16-8-5-4-6-9-16/h4-6,8-13H,3,7,15H2,1-2H3
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370n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cells


Bioorg Med Chem Lett 20: 6237-41 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.101
BindingDB Entry DOI: 10.7270/Q2RR1ZFT
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50328890
PNG
(4-(3-(pyridin-2-ylamino)propyl)-6-(3-(trifluoromet...)
Show SMILES FC(F)(F)c1cccc(c1)-c1cc(CCCNc2ccccn2)nc(n1)C#N
Show InChI InChI=1S/C20H16F3N5/c21-20(22,23)15-6-3-5-14(11-15)17-12-16(27-19(13-24)28-17)7-4-10-26-18-8-1-2-9-25-18/h1-3,5-6,8-9,11-12H,4,7,10H2,(H,25,26)
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400n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cells


Bioorg Med Chem Lett 20: 6237-41 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.101
BindingDB Entry DOI: 10.7270/Q2RR1ZFT
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50091553
PNG
(CHEMBL3582309)
Show SMILES C1CCC(CC1)C1O[C@H](Cc2c1[nH]c1ccccc21)c1nc(c[nH]1)-c1ccccc1
Show InChI InChI=1/C26H27N3O/c1-3-9-17(10-4-1)22-16-27-26(29-22)23-15-20-19-13-7-8-14-21(19)28-24(20)25(30-23)18-11-5-2-6-12-18/h1,3-4,7-10,13-14,16,18,23,25,28H,2,5-6,11-12,15H2,(H,27,29)/t23-,25?/s2
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440n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of MK499 binding to human ERG


ACS Med Chem Lett 6: 513-7 (2015)


Article DOI: 10.1021/ml500514w
BindingDB Entry DOI: 10.7270/Q2M61N0H
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50306592
PNG
(3-(4-((S)-3-methyl-2-(quinolin-6-ylmethylamino)but...)
Show SMILES CCCCC(C(=O)COc1c(F)c(F)cc(F)c1F)n1cc(nn1)[C@@](C)(NCc1ccc2ncccc2c1)C(C)C
Show InChI InChI=1/C30H33F4N5O2/c1-5-6-9-24(25(40)17-41-29-27(33)21(31)14-22(32)28(29)34)39-16-26(37-38-39)30(4,18(2)3)36-15-19-10-11-23-20(13-19)8-7-12-35-23/h7-8,10-14,16,18,24,36H,5-6,9,15,17H2,1-4H3/t24?,30-/s2
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460n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi cruzain


J Med Chem 53: 1763-73 (2010)


Article DOI: 10.1021/jm901633v
BindingDB Entry DOI: 10.7270/Q21N8172
More data for this
Ligand-Target Pair
Rhodesain


(Trypanosoma brucei rhodesiense)
BDBM50183779
PNG
((2S,3S)-1-((S)-2-((S)-2-(tert-butoxycarbonyl)-3-ph...)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N1[C@@H]([C@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C21H27N3O8/c1-11(17(26)24-14(18(27)28)15(24)19(29)30)22-16(25)13(10-12-8-6-5-7-9-12)23-20(31)32-21(2,3)4/h5-9,11,13-15H,10H2,1-4H3,(H,22,25)(H,23,31)(H,27,28)(H,29,30)/t11-,13-,14-,15-/m0/s1
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500n/an/an/an/an/an/an/an/a



University of Wuerzburg

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei rhodesiense rhodesain


Bioorg Med Chem Lett 16: 2753-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.026
BindingDB Entry DOI: 10.7270/Q2PK0FRX
More data for this
Ligand-Target Pair
Rhodesain


(Trypanosoma brucei rhodesiense)
BDBM50183767
PNG
((2R,3R)-dibenzyl 1-((S)-1-((S)-2-(tert-butoxycarbo...)
Show SMILES CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)N1[C@H]([C@@H]1C(=O)OCc1ccccc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C34H43N3O8/c1-22(2)19-25(35-33(42)45-34(3,4)5)29(38)36-18-12-17-26(36)30(39)37-27(31(40)43-20-23-13-8-6-9-14-23)28(37)32(41)44-21-24-15-10-7-11-16-24/h6-11,13-16,22,25-28H,12,17-21H2,1-5H3,(H,35,42)/t25-,26-,27+,28+/m0/s1
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500n/an/an/an/an/an/an/an/a



University of Wuerzburg

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei rhodesiense rhodesain


Bioorg Med Chem Lett 16: 2753-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.026
BindingDB Entry DOI: 10.7270/Q2PK0FRX
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50328885
PNG
(4-(3-(2,2,2-trifluoroethylamino)propyl)-6-(3-(trif...)
Show SMILES FC(F)(F)CNCCCc1cc(nc(n1)C#N)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C17H14F6N4/c18-16(19,20)10-25-6-2-5-13-8-14(27-15(9-24)26-13)11-3-1-4-12(7-11)17(21,22)23/h1,3-4,7-8,25H,2,5-6,10H2
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500n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cells


Bioorg Med Chem Lett 20: 6237-41 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.101
BindingDB Entry DOI: 10.7270/Q2RR1ZFT
More data for this
Ligand-Target Pair
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