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Compile Data Set for Download or QSAR

Found 658 hits with Last Name = 'masse' and Initial = 'c'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332777
PNG
(US10196390, Compound I-13)
Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(CC(=O)NCC3CCNCC3)cc2)n1
Show InChI InChI=1S/C26H26F2N6O2/c27-18-2-1-3-19(28)22(18)24-33-20-14-31-26(36)23(20)25(34-24)32-17-6-4-15(5-7-17)12-21(35)30-13-16-8-10-29-11-9-16/h1-7,16,29H,8-14H2,(H,30,35)(H,31,36)(H,32,33,34)
PDB

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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332778
PNG
(US10196390, Compound I-14)
Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(CC(=O)NC3CC4(CNC4)C3)cc2)n1
Show InChI InChI=1S/C26H24F2N6O2/c27-17-2-1-3-18(28)21(17)23-33-19-11-30-25(36)22(19)24(34-23)32-15-6-4-14(5-7-15)8-20(35)31-16-9-26(10-16)12-29-13-26/h1-7,16,29H,8-13H2,(H,30,36)(H,31,35)(H,32,33,34)
PDB

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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332779
PNG
(US10196390, Compound I-15)
Show SMILES OC[C@H]1CCCN1C(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C25H23F2N5O3/c26-17-4-1-5-18(27)21(17)23-30-19-12-28-25(35)22(19)24(31-23)29-15-8-6-14(7-9-15)11-20(34)32-10-2-3-16(32)13-33/h1,4-9,16,33H,2-3,10-13H2,(H,28,35)(H,29,30,31)/t16-/m1/s1
PDB

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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332780
PNG
(US10196390, Compound I-16)
Show SMILES OC[C@@H]1CCCN1C(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C25H23F2N5O3/c26-17-4-1-5-18(27)21(17)23-30-19-12-28-25(35)22(19)24(31-23)29-15-8-6-14(7-9-15)11-20(34)32-10-2-3-16(32)13-33/h1,4-9,16,33H,2-3,10-13H2,(H,28,35)(H,29,30,31)/t16-/m0/s1
PDB

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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332785
PNG
(US10196390, Compound I-21)
Show SMILES Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C19H14F2N4O/c1-10-5-7-11(8-6-10)23-18-16-14(9-22-19(16)26)24-17(25-18)15-12(20)3-2-4-13(15)21/h2-8H,9H2,1H3,(H,22,26)(H,23,24,25)
PDB

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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332786
PNG
(US10196390, Compound I-22)
Show SMILES CN(C1CCNCC1)C(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C26H26F2N6O2/c1-34(17-9-11-29-12-10-17)21(35)13-15-5-7-16(8-6-15)31-25-23-20(14-30-26(23)36)32-24(33-25)22-18(27)3-2-4-19(22)28/h2-8,17,29H,9-14H2,1H3,(H,30,36)(H,31,32,33)
PDB

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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332788
PNG
(US10196390, Compound I-61)
Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(CC(=O)N[C@@H]3CCCNC3)cc2)n1
Show InChI InChI=1S/C25H24F2N6O2/c26-17-4-1-5-18(27)21(17)23-32-19-13-29-25(35)22(19)24(33-23)31-15-8-6-14(7-9-15)11-20(34)30-16-3-2-10-28-12-16/h1,4-9,16,28H,2-3,10-13H2,(H,29,35)(H,30,34)(H,31,32,33)/t16-/m1/s1
PDB

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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332789
PNG
(US10196390, Compound I-62)
Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(CC(=O)N3CC4(COC4)C3)cc2)n1
Show InChI InChI=1S/C25H21F2N5O3/c26-16-2-1-3-17(27)20(16)22-30-18-9-28-24(34)21(18)23(31-22)29-15-6-4-14(5-7-15)8-19(33)32-10-25(11-32)12-35-13-25/h1-7H,8-13H2,(H,28,34)(H,29,30,31)
PDB

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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332790
PNG
(US10196390, Compound I-63)
Show SMILES C[C@H](CO)NC(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C23H21F2N5O3/c1-12(11-31)27-18(32)9-13-5-7-14(8-6-13)28-22-20-17(10-26-23(20)33)29-21(30-22)19-15(24)3-2-4-16(19)25/h2-8,12,31H,9-11H2,1H3,(H,26,33)(H,27,32)(H,28,29,30)/t12-/m1/s1
PDB

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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332791
PNG
(US10196390, Compound I-64)
Show SMILES C[C@H]1COCCN1C(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C25H23F2N5O3/c1-14-13-35-10-9-32(14)20(33)11-15-5-7-16(8-6-15)29-24-22-19(12-28-25(22)34)30-23(31-24)21-17(26)3-2-4-18(21)27/h2-8,14H,9-13H2,1H3,(H,28,34)(H,29,30,31)/t14-/m0/s1
PDB

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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332792
PNG
(US10196390, Compound I-65)
Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(CC(=O)NC3CCOCC3)cc2)n1
Show InChI InChI=1S/C25H23F2N5O3/c26-17-2-1-3-18(27)21(17)23-31-19-13-28-25(34)22(19)24(32-23)30-15-6-4-14(5-7-15)12-20(33)29-16-8-10-35-11-9-16/h1-7,16H,8-13H2,(H,28,34)(H,29,33)(H,30,31,32)
PDB

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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332793
PNG
(US10196390, Compound I-66)
Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(CC(=O)N3CCOCC3)cc2)n1
Show InChI InChI=1S/C24H21F2N5O3/c25-16-2-1-3-17(26)20(16)22-29-18-13-27-24(33)21(18)23(30-22)28-15-6-4-14(5-7-15)12-19(32)31-8-10-34-11-9-31/h1-7H,8-13H2,(H,27,33)(H,28,29,30)
PDB

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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332794
PNG
(US10196390, Compound I-67)
Show SMILES CN1CCN(CC1)C(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C25H24F2N6O2/c1-32-9-11-33(12-10-32)20(34)13-15-5-7-16(8-6-15)29-24-22-19(14-28-25(22)35)30-23(31-24)21-17(26)3-2-4-18(21)27/h2-8H,9-14H2,1H3,(H,28,35)(H,29,30,31)
PDB

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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332799
PNG
(US10196390, Compound I-72)
Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(CC(=O)NCC3CNC3)cc2)n1
Show InChI InChI=1S/C24H22F2N6O2/c25-16-2-1-3-17(26)20(16)22-31-18-12-29-24(34)21(18)23(32-22)30-15-6-4-13(5-7-15)8-19(33)28-11-14-9-27-10-14/h1-7,14,27H,8-12H2,(H,28,33)(H,29,34)(H,30,31,32)
PDB

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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332800
PNG
(US10196390, Compound I-73 | US10196390, Compound I...)
Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(CC(=O)N[C@@H]3CCNC3)cc2)n1
Show InChI InChI=1S/C24H22F2N6O2/c25-16-2-1-3-17(26)20(16)22-31-18-12-28-24(34)21(18)23(32-22)30-14-6-4-13(5-7-14)10-19(33)29-15-8-9-27-11-15/h1-7,15,27H,8-12H2,(H,28,34)(H,29,33)(H,30,31,32)/t15-/m1/s1
PDB

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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332801
PNG
(US10196390, Compound I-74)
Show SMILES C[C@@H](CO)NC(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C23H21F2N5O3/c1-12(11-31)27-18(32)9-13-5-7-14(8-6-13)28-22-20-17(10-26-23(20)33)29-21(30-22)19-15(24)3-2-4-16(19)25/h2-8,12,31H,9-11H2,1H3,(H,26,33)(H,27,32)(H,28,29,30)/t12-/m0/s1
PDB

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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332802
PNG
(US10196390, Compound I-75)
Show SMILES C[C@H](O)CNC(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C23H21F2N5O3/c1-12(31)10-26-18(32)9-13-5-7-14(8-6-13)28-22-20-17(11-27-23(20)33)29-21(30-22)19-15(24)3-2-4-16(19)25/h2-8,12,31H,9-11H2,1H3,(H,26,32)(H,27,33)(H,28,29,30)/t12-/m0/s1
PDB

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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332803
PNG
(US10196390, Compound I-76)
Show SMILES CC(C)(O)CNC(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C24H23F2N5O3/c1-24(2,34)12-28-18(32)10-13-6-8-14(9-7-13)29-22-20-17(11-27-23(20)33)30-21(31-22)19-15(25)4-3-5-16(19)26/h3-9,34H,10-12H2,1-2H3,(H,27,33)(H,28,32)(H,29,30,31)
PDB

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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332804
PNG
(US10196390, Compound I-77)
Show SMILES C[C@@H](O)CNC(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C23H21F2N5O3/c1-12(31)10-26-18(32)9-13-5-7-14(8-6-13)28-22-20-17(11-27-23(20)33)29-21(30-22)19-15(24)3-2-4-16(19)25/h2-8,12,31H,9-11H2,1H3,(H,26,32)(H,27,33)(H,28,29,30)/t12-/m1/s1
PDB

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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332805
PNG
(US10196390, Compound I-78)
Show SMILES FC(F)CN1CCN(CC1)C(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C26H24F4N6O2/c27-17-2-1-3-18(28)22(17)24-33-19-13-31-26(38)23(19)25(34-24)32-16-6-4-15(5-7-16)12-21(37)36-10-8-35(9-11-36)14-20(29)30/h1-7,20H,8-14H2,(H,31,38)(H,32,33,34)
PDB

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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332806
PNG
(US10196390, Compound I-79)
Show SMILES OCCNC(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C22H19F2N5O3/c23-14-2-1-3-15(24)18(14)20-28-16-11-26-22(32)19(16)21(29-20)27-13-6-4-12(5-7-13)10-17(31)25-8-9-30/h1-7,30H,8-11H2,(H,25,31)(H,26,32)(H,27,28,29)
PDB

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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332807
PNG
(US10196390, Compound I-80)
Show SMILES CCNC(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C22H19F2N5O2/c1-2-25-17(30)10-12-6-8-13(9-7-12)27-21-19-16(11-26-22(19)31)28-20(29-21)18-14(23)4-3-5-15(18)24/h3-9H,2,10-11H2,1H3,(H,25,30)(H,26,31)(H,27,28,29)
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332800
PNG
(US10196390, Compound I-73 | US10196390, Compound I...)
Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(CC(=O)N[C@@H]3CCNC3)cc2)n1
Show InChI InChI=1S/C24H22F2N6O2/c25-16-2-1-3-17(26)20(16)22-31-18-12-28-24(34)21(18)23(32-22)30-14-6-4-13(5-7-14)10-19(33)29-15-8-9-27-11-15/h1-7,15,27H,8-12H2,(H,28,34)(H,29,33)(H,30,31,32)/t15-/m1/s1
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332812
PNG
(US10196390, Compound I-84)
Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(CC(=O)N3CCS(=O)(=O)CC3)cc2)n1
Show InChI InChI=1S/C24H21F2N5O4S/c25-16-2-1-3-17(26)20(16)22-29-18-13-27-24(33)21(18)23(30-22)28-15-6-4-14(5-7-15)12-19(32)31-8-10-36(34,35)11-9-31/h1-7H,8-13H2,(H,27,33)(H,28,29,30)
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332814
PNG
(US10196390, Compound I-86)
Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(cc2)[C@H]2CCNC2=O)n1
Show InChI InChI=1S/C22H17F2N5O2/c23-14-2-1-3-15(24)17(14)19-28-16-10-26-22(31)18(16)20(29-19)27-12-6-4-11(5-7-12)13-8-9-25-21(13)30/h1-7,13H,8-10H2,(H,25,30)(H,26,31)(H,27,28,29)/t13-/m1/s1
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332815
PNG
(US10196390, Compound I-87)
Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(cc2)[C@@H]2CCNC2=O)n1
Show InChI InChI=1S/C22H17F2N5O2/c23-14-2-1-3-15(24)17(14)19-28-16-10-26-22(31)18(16)20(29-19)27-12-6-4-11(5-7-12)13-8-9-25-21(13)30/h1-7,13H,8-10H2,(H,25,30)(H,26,31)(H,27,28,29)/t13-/m0/s1
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332817
PNG
(US10196390, Compound I-91)
Show SMILES Fc1cccc(F)c1-c1cc(Nc2ccc(cn2)[C@H]2CCNC2=O)c2C(=O)NCc2n1
Show InChI InChI=1S/C22H17F2N5O2/c23-13-2-1-3-14(24)19(13)15-8-16(20-17(28-15)10-27-22(20)31)29-18-5-4-11(9-26-18)12-6-7-25-21(12)30/h1-5,8-9,12H,6-7,10H2,(H,25,30)(H,27,31)(H,26,28,29)/t12-/m1/s1
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332818
PNG
(US10196390, Compound I-92)
Show SMILES Fc1cccc(F)c1-c1cc(Nc2ccc(cn2)[C@@H]2CCNC2=O)c2C(=O)NCc2n1
Show InChI InChI=1S/C22H17F2N5O2/c23-13-2-1-3-14(24)19(13)15-8-16(20-17(28-15)10-27-22(20)31)29-18-5-4-11(9-26-18)12-6-7-25-21(12)30/h1-5,8-9,12H,6-7,10H2,(H,25,30)(H,27,31)(H,26,28,29)/t12-/m0/s1
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332819
PNG
(US10196390, Compound I-109)
Show SMILES CC(C)(C(O)=O)c1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C22H18F2N4O3/c1-22(2,21(30)31)11-6-8-12(9-7-11)26-19-17-15(10-25-20(17)29)27-18(28-19)16-13(23)4-3-5-14(16)24/h3-9H,10H2,1-2H3,(H,25,29)(H,30,31)(H,26,27,28)
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332820
PNG
(US10196390, Compound I-110)
Show SMILES COc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C19H14F2N4O2/c1-27-11-7-5-10(6-8-11)23-18-16-14(9-22-19(16)26)24-17(25-18)15-12(20)3-2-4-13(15)21/h2-8H,9H2,1H3,(H,22,26)(H,23,24,25)
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332822
PNG
(US10196390, Compound I-112)
Show SMILES OC(=O)[C@@H]1COCCN1C(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C25H21F2N5O5/c26-15-2-1-3-16(27)20(15)22-30-17-11-28-24(34)21(17)23(31-22)29-14-6-4-13(5-7-14)10-19(33)32-8-9-37-12-18(32)25(35)36/h1-7,18H,8-12H2,(H,28,34)(H,35,36)(H,29,30,31)/t18-/m0/s1
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332823
PNG
(US10196390, Compound I-113)
Show SMILES Fc1cccc(Cl)c1-c1nc2CNC(=O)c2c(Nc2ccc(cc2)C2CCNC2=O)n1
Show InChI InChI=1S/C22H17ClFN5O2/c23-14-2-1-3-15(24)17(14)19-28-16-10-26-22(31)18(16)20(29-19)27-12-6-4-11(5-7-12)13-8-9-25-21(13)30/h1-7,13H,8-10H2,(H,25,30)(H,26,31)(H,27,28,29)
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332900
PNG
(US10196390, Compound I-189)
Show SMILES CC(C(O)=O)c1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C21H16F2N4O3/c1-10(21(29)30)11-5-7-12(8-6-11)25-19-17-15(9-24-20(17)28)26-18(27-19)16-13(22)3-2-4-14(16)23/h2-8,10H,9H2,1H3,(H,24,28)(H,29,30)(H,25,26,27)
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332901
PNG
(US10196390, Compound I-190)
Show SMILES C[C@@H](C(O)=O)c1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C21H16F2N4O3/c1-10(21(29)30)11-5-7-12(8-6-11)25-19-17-15(9-24-20(17)28)26-18(27-19)16-13(22)3-2-4-14(16)23/h2-8,10H,9H2,1H3,(H,24,28)(H,29,30)(H,25,26,27)/t10-/m1/s1
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332902
PNG
(US10196390, Compound I-191)
Show SMILES C[C@H](C(O)=O)c1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C21H16F2N4O3/c1-10(21(29)30)11-5-7-12(8-6-11)25-19-17-15(9-24-20(17)28)26-18(27-19)16-13(22)3-2-4-14(16)23/h2-8,10H,9H2,1H3,(H,24,28)(H,29,30)(H,25,26,27)/t10-/m0/s1
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332903
PNG
(US10196390, Compound I-192)
Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(cc2)C2SC(=O)NC2=O)n1
Show InChI InChI=1S/C21H13F2N5O3S/c22-11-2-1-3-12(23)14(11)17-26-13-8-24-19(29)15(13)18(27-17)25-10-6-4-9(5-7-10)16-20(30)28-21(31)32-16/h1-7,16H,8H2,(H,24,29)(H,25,26,27)(H,28,30,31)
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332904
PNG
(US10196390, Compound I-193)
Show SMILES CN(CC(C)(C)O)C(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C25H25F2N5O3/c1-25(2,35)13-32(3)19(33)11-14-7-9-15(10-8-14)29-23-21-18(12-28-24(21)34)30-22(31-23)20-16(26)5-4-6-17(20)27/h4-10,35H,11-13H2,1-3H3,(H,28,34)(H,29,30,31)
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332906
PNG
(US10196390, Compound I-195)
Show SMILES CCNC(=O)c1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C21H17F2N5O2/c1-2-24-20(29)11-6-8-12(9-7-11)26-19-17-15(10-25-21(17)30)27-18(28-19)16-13(22)4-3-5-14(16)23/h3-9H,2,10H2,1H3,(H,24,29)(H,25,30)(H,26,27,28)
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332907
PNG
(US10196390, Compound I-196)
Show SMILES CC(C)(C(=O)N1CCCC1)c1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C26H25F2N5O2/c1-26(2,25(35)33-12-3-4-13-33)15-8-10-16(11-9-15)30-23-21-19(14-29-24(21)34)31-22(32-23)20-17(27)6-5-7-18(20)28/h5-11H,3-4,12-14H2,1-2H3,(H,29,34)(H,30,31,32)
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332909
PNG
(US10196390, Compound I-198)
Show SMILES CC(C(=O)N1CCCCC1)c1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C26H25F2N5O2/c1-15(26(35)33-12-3-2-4-13-33)16-8-10-17(11-9-16)30-24-22-20(14-29-25(22)34)31-23(32-24)21-18(27)6-5-7-19(21)28/h5-11,15H,2-4,12-14H2,1H3,(H,29,34)(H,30,31,32)
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332910
PNG
(US10196390, Compound I-199)
Show SMILES CCNC(=O)Cc1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2Cl)nc1
Show InChI InChI=1S/C22H19ClFN5O2/c1-2-25-19(30)8-12-6-7-18(26-10-12)29-16-9-15(20-13(23)4-3-5-14(20)24)28-17-11-27-22(31)21(16)17/h3-7,9-10H,2,8,11H2,1H3,(H,25,30)(H,27,31)(H,26,28,29)
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332911
PNG
(US10196390, Compound I-200)
Show SMILES COC(=O)Cc1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2Cl)nc1
Show InChI InChI=1S/C21H16ClFN4O3/c1-30-18(28)7-11-5-6-17(24-9-11)27-15-8-14(19-12(22)3-2-4-13(19)23)26-16-10-25-21(29)20(15)16/h2-6,8-9H,7,10H2,1H3,(H,25,29)(H,24,26,27)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332912
PNG
(US10196390, Compound I-201)
Show SMILES COC(=O)C1COCCN1C(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C26H23F2N5O5/c1-37-26(36)19-13-38-10-9-33(19)20(34)11-14-5-7-15(8-6-14)30-24-22-18(12-29-25(22)35)31-23(32-24)21-16(27)3-2-4-17(21)28/h2-8,19H,9-13H2,1H3,(H,29,35)(H,30,31,32)
PDB

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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332913
PNG
(US10196390, Compound I-202)
Show SMILES OC(=O)C1COCCN1C(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C25H21F2N5O5/c26-15-2-1-3-16(27)20(15)22-30-17-11-28-24(34)21(17)23(31-22)29-14-6-4-13(5-7-14)10-19(33)32-8-9-37-12-18(32)25(35)36/h1-7,18H,8-12H2,(H,28,34)(H,35,36)(H,29,30,31)
PDB

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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332915
PNG
(US10196390, Compound I-204)
Show SMILES Fc1cccc(Cl)c1-c1cc(Nc2ccc(cn2)N2CCCC2)c2C(=O)NCc2n1
Show InChI InChI=1S/C22H19ClFN5O/c23-14-4-3-5-15(24)20(14)16-10-17(21-18(27-16)12-26-22(21)30)28-19-7-6-13(11-25-19)29-8-1-2-9-29/h3-7,10-11H,1-2,8-9,12H2,(H,26,30)(H,25,27,28)
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332916
PNG
(US10196390, Compound I-205)
Show SMILES Fc1cccc(F)c1-c1cc(Nc2ccc(cn2)N2CCCC2)c2C(=O)NCc2n1
Show InChI InChI=1S/C22H19F2N5O/c23-14-4-3-5-15(24)20(14)16-10-17(21-18(27-16)12-26-22(21)30)28-19-7-6-13(11-25-19)29-8-1-2-9-29/h3-7,10-11H,1-2,8-9,12H2,(H,26,30)(H,25,27,28)
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332824
PNG
(US10196390, Compound I-114)
Show SMILES Fc1cccc(Cl)c1-c1nc2CNC(=O)c2c(Nc2ccc(cc2)[C@H]2CCNC2=O)n1
Show InChI InChI=1S/C22H17ClFN5O2/c23-14-2-1-3-15(24)17(14)19-28-16-10-26-22(31)18(16)20(29-19)27-12-6-4-11(5-7-12)13-8-9-25-21(13)30/h1-7,13H,8-10H2,(H,25,30)(H,26,31)(H,27,28,29)/t13-/m1/s1
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332826
PNG
(US10196390, Compound I-116)
Show SMILES COCCC1(CCNC1=O)c1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1
Show InChI InChI=1S/C25H23F2N5O3/c1-35-12-10-25(9-11-28-24(25)34)14-5-7-15(8-6-14)30-22-20-18(13-29-23(20)33)31-21(32-22)19-16(26)3-2-4-17(19)27/h2-8H,9-13H2,1H3,(H,28,34)(H,29,33)(H,30,31,32)
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332827
PNG
(US10196390, Compound I-117)
Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(cc2)C2CCN(C3CCC3)C2=O)n1
Show InChI InChI=1S/C26H23F2N5O2/c27-18-5-2-6-19(28)21(18)23-31-20-13-29-25(34)22(20)24(32-23)30-15-9-7-14(8-10-15)17-11-12-33(26(17)35)16-3-1-4-16/h2,5-10,16-17H,1,3-4,11-13H2,(H,29,34)(H,30,31,32)
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM332828
PNG
(US10196390, Compound I-118)
Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(cc2)[C@H]2CCN(C3CCC3)C2=O)n1
Show InChI InChI=1S/C26H23F2N5O2/c27-18-5-2-6-19(28)21(18)23-31-20-13-29-25(34)22(20)24(32-23)30-15-9-7-14(8-10-15)17-11-12-33(26(17)35)16-3-1-4-16/h2,5-10,16-17H,1,3-4,11-13H2,(H,29,34)(H,30,31,32)/t17-/m1/s1
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<10n/an/an/an/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...


US Patent US10196390 (2019)

More data for this
Ligand-Target Pair
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