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Compile Data Set for Download or QSAR

Found 465 hits with Last Name = 'mesangeau' and Initial = 'c'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50398057
PNG
(CHEMBL2181924)
Show SMILES FCCCc1ccc2n(CCN3CCCCCC3)c(=O)sc2c1
Show InChI InChI=1S/C18H25FN2OS/c19-9-5-6-15-7-8-16-17(14-15)23-18(22)21(16)13-12-20-10-3-1-2-4-11-20/h7-8,14H,1-6,9-13H2
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0.00250n/an/an/an/an/an/an/an/a



Stanford University

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from Sigma1 receptor in rat liver homogenate


J Med Chem 55: 8272-82 (2012)


Article DOI: 10.1021/jm300371c
BindingDB Entry DOI: 10.7270/Q2V40WB0
More data for this
Ligand-Target Pair
Sigma-2 receptor


(Rattus norvegicus (Rat))
BDBM330349
PNG
(US9724435, Compound CM-366)
Show SMILES Fc1ccc(cc1)-c1ccc2oc(=O)n(CCCCN3CCN(CC3)C3CCCCC3)c2c1
Show InChI InChI=1S/C27H34FN3O2/c28-23-11-8-21(9-12-23)22-10-13-26-25(20-22)31(27(32)33-26)15-5-4-14-29-16-18-30(19-17-29)24-6-2-1-3-7-24/h8-13,20,24H,1-7,14-19H2
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0.00600n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9724435 (2017)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2BZ6856
More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Mus musculus (Mouse))
BDBM312199
PNG
(US9604926, Compound CM-366)
Show SMILES Fc1ccc(cc1)-c1ccc2[nH]c(=O)n(CCCCN3CCN(CC3)C3CCCCC3)c2c1
Show InChI InChI=1S/C27H35FN4O/c28-23-11-8-21(9-12-23)22-10-13-25-26(20-22)32(27(33)29-25)15-5-4-14-30-16-18-31(19-17-30)24-6-2-1-3-7-24/h8-13,20,24H,1-7,14-19H2,(H,29,33)
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0.00600n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma-2 receptor


(Rattus norvegicus (Rat))
BDBM312198
PNG
(US9604926, Compound CM-365 | US9724435, Compound C...)
Show SMILES Brc1ccc2oc(=O)n(CCCCN3CCN(CC3)C3CCCCC3)c2c1
Show InChI InChI=1S/C21H30BrN3O2/c22-17-8-9-20-19(16-17)25(21(26)27-20)11-5-4-10-23-12-14-24(15-13-23)18-6-2-1-3-7-18/h8-9,16,18H,1-7,10-15H2
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0.0550n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9724435 (2017)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2BZ6856
More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Mus musculus (Mouse))
BDBM312198
PNG
(US9604926, Compound CM-365 | US9724435, Compound C...)
Show SMILES Brc1ccc2oc(=O)n(CCCCN3CCN(CC3)C3CCCCC3)c2c1
Show InChI InChI=1S/C21H30BrN3O2/c22-17-8-9-20-19(16-17)25(21(26)27-20)11-5-4-10-23-12-14-24(15-13-23)18-6-2-1-3-7-18/h8-9,16,18H,1-7,10-15H2
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0.0550n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma-2 receptor


(Rattus norvegicus (Rat))
BDBM50353847
PNG
(CHEMBL1831157 | US9604926, Compound CM-360 | US972...)
Show SMILES COc1cc2CCN(CCCCn3ccc4ccccc34)Cc2cc1OC
Show InChI InChI=1S/C23H28N2O2/c1-26-22-15-19-9-13-24(17-20(19)16-23(22)27-2)11-5-6-12-25-14-10-18-7-3-4-8-21(18)25/h3-4,7-8,10,14-16H,5-6,9,11-13,17H2,1-2H3
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0.210n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9724435 (2017)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2BZ6856
More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Mus musculus (Mouse))
BDBM50353847
PNG
(CHEMBL1831157 | US9604926, Compound CM-360 | US972...)
Show SMILES COc1cc2CCN(CCCCn3ccc4ccccc34)Cc2cc1OC
Show InChI InChI=1S/C23H28N2O2/c1-26-22-15-19-9-13-24(17-20(19)16-23(22)27-2)11-5-6-12-25-14-10-18-7-3-4-8-21(18)25/h3-4,7-8,10,14-16H,5-6,9,11-13,17H2,1-2H3
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0.210n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Mus musculus (Mouse))
BDBM312234
PNG
(US9604926, Compound AZ-68 | US9724435, Compound AZ...)
Show SMILES Fc1ccc2n(CCCCN3CCN(CC3)C3CCCCC3)c(=O)sc2c1
Show InChI InChI=1S/C21H30FN3OS/c22-17-8-9-19-20(16-17)27-21(26)25(19)11-5-4-10-23-12-14-24(15-13-23)18-6-2-1-3-7-18/h8-9,16,18H,1-7,10-15H2
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0.220n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma-2 receptor


(Rattus norvegicus (Rat))
BDBM312234
PNG
(US9604926, Compound AZ-68 | US9724435, Compound AZ...)
Show SMILES Fc1ccc2n(CCCCN3CCN(CC3)C3CCCCC3)c(=O)sc2c1
Show InChI InChI=1S/C21H30FN3OS/c22-17-8-9-19-20(16-17)27-21(26)25(19)11-5-4-10-23-12-14-24(15-13-23)18-6-2-1-3-7-18/h8-9,16,18H,1-7,10-15H2
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0.220n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9724435 (2017)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2BZ6856
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM312233
PNG
(US9604926, Compound AZ-66 | US9724435, Compound AZ...)
Show SMILES CC(CCCn1c2ccc(F)cc2sc1=O)N1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C22H32FN3OS/c1-17(24-12-14-25(15-13-24)19-7-3-2-4-8-19)6-5-11-26-20-10-9-18(23)16-21(20)28-22(26)27/h9-10,16-17,19H,2-8,11-15H2,1H3
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0.310n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9724435 (2017)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2BZ6856
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM312233
PNG
(US9604926, Compound AZ-66 | US9724435, Compound AZ...)
Show SMILES CC(CCCn1c2ccc(F)cc2sc1=O)N1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C22H32FN3OS/c1-17(24-12-14-25(15-13-24)19-7-3-2-4-8-19)6-5-11-26-20-10-9-18(23)16-21(20)28-22(26)27/h9-10,16-17,19H,2-8,11-15H2,1H3
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0.310n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Mus musculus (Mouse))
BDBM50353844
PNG
(CHEMBL270341 | US9604926, Compound CM-145 | US9724...)
Show SMILES O=c1sc2ccccc2n1CCCCN1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C21H31N3OS/c25-21-24(19-10-4-5-11-20(19)26-21)13-7-6-12-22-14-16-23(17-15-22)18-8-2-1-3-9-18/h4-5,10-11,18H,1-3,6-9,12-17H2
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0.390n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma-2 receptor


(Rattus norvegicus (Rat))
BDBM50353844
PNG
(CHEMBL270341 | US9604926, Compound CM-145 | US9724...)
Show SMILES O=c1sc2ccccc2n1CCCCN1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C21H31N3OS/c25-21-24(19-10-4-5-11-20(19)26-21)13-7-6-12-22-14-16-23(17-15-22)18-8-2-1-3-9-18/h4-5,10-11,18H,1-3,6-9,12-17H2
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0.390n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9724435 (2017)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2BZ6856
More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Mus musculus (Mouse))
BDBM50353844
PNG
(CHEMBL270341 | US9604926, Compound CM-145 | US9724...)
Show SMILES O=c1sc2ccccc2n1CCCCN1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C21H31N3OS/c25-21-24(19-10-4-5-11-20(19)26-21)13-7-6-12-22-14-16-23(17-15-22)18-8-2-1-3-9-18/h4-5,10-11,18H,1-3,6-9,12-17H2
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0.390n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma-2 receptor


(Rattus norvegicus (Rat))
BDBM50353844
PNG
(CHEMBL270341 | US9604926, Compound CM-145 | US9724...)
Show SMILES O=c1sc2ccccc2n1CCCCN1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C21H31N3OS/c25-21-24(19-10-4-5-11-20(19)26-21)13-7-6-12-22-14-16-23(17-15-22)18-8-2-1-3-9-18/h4-5,10-11,18H,1-3,6-9,12-17H2
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0.390n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9724435 (2017)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2BZ6856
More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Mus musculus (Mouse))
BDBM312202
PNG
(US9604926, Compound CM-397 | US9724435, Compound C...)
Show SMILES Cn1c2ccccc2n(CCCCN2CCN(CC2)c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C22H27FN4O/c1-24-20-6-2-3-7-21(20)27(22(24)28)13-5-4-12-25-14-16-26(17-15-25)19-10-8-18(23)9-11-19/h2-3,6-11H,4-5,12-17H2,1H3
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0.460n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma-2 receptor


(Rattus norvegicus (Rat))
BDBM312202
PNG
(US9604926, Compound CM-397 | US9724435, Compound C...)
Show SMILES Cn1c2ccccc2n(CCCCN2CCN(CC2)c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C22H27FN4O/c1-24-20-6-2-3-7-21(20)27(22(24)28)13-5-4-12-25-14-16-26(17-15-25)19-10-8-18(23)9-11-19/h2-3,6-11H,4-5,12-17H2,1H3
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0.460n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9724435 (2017)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2BZ6856
More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Mus musculus (Mouse))
BDBM312235
PNG
(US9604926, Compound AZ-78 | US9724435, Compound AZ...)
Show SMILES Fc1ccc2n(CCCCN3CCN(CC3)C3CCCCC3)c(=S)sc2c1
Show InChI InChI=1S/C21H30FN3S2/c22-17-8-9-19-20(16-17)27-21(26)25(19)11-5-4-10-23-12-14-24(15-13-23)18-6-2-1-3-7-18/h8-9,16,18H,1-7,10-15H2
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0.5n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma-2 receptor


(Rattus norvegicus (Rat))
BDBM312235
PNG
(US9604926, Compound AZ-78 | US9724435, Compound AZ...)
Show SMILES Fc1ccc2n(CCCCN3CCN(CC3)C3CCCCC3)c(=S)sc2c1
Show InChI InChI=1S/C21H30FN3S2/c22-17-8-9-19-20(16-17)27-21(26)25(19)11-5-4-10-23-12-14-24(15-13-23)18-6-2-1-3-7-18/h8-9,16,18H,1-7,10-15H2
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0.5n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9724435 (2017)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2BZ6856
More data for this
Ligand-Target Pair
Sigma-2 receptor


(Rattus norvegicus (Rat))
BDBM50374598
PNG
(CHEMBL272603 | US9604926, Compound CM-156 | US9724...)
Show SMILES S=c1sc2ccccc2n1CCCCN1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C21H31N3S2/c25-21-24(19-10-4-5-11-20(19)26-21)13-7-6-12-22-14-16-23(17-15-22)18-8-2-1-3-9-18/h4-5,10-11,18H,1-3,6-9,12-17H2
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0.550n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9724435 (2017)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2BZ6856
More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Mus musculus (Mouse))
BDBM50374598
PNG
(CHEMBL272603 | US9604926, Compound CM-156 | US9724...)
Show SMILES S=c1sc2ccccc2n1CCCCN1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C21H31N3S2/c25-21-24(19-10-4-5-11-20(19)26-21)13-7-6-12-22-14-16-23(17-15-22)18-8-2-1-3-9-18/h4-5,10-11,18H,1-3,6-9,12-17H2
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0.550n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50374600
PNG
(CHEMBL272899)
Show SMILES CCCc1ccc2n(CCN3CCCCCC3)c(=O)sc2c1
Show InChI InChI=1S/C18H26N2OS/c1-2-7-15-8-9-16-17(14-15)22-18(21)20(16)13-12-19-10-5-3-4-6-11-19/h8-9,14H,2-7,10-13H2,1H3
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0.560n/an/an/an/an/an/an/an/a



Stanford University

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from Sigma1 receptor in rat liver homogenate


J Med Chem 55: 8272-82 (2012)


Article DOI: 10.1021/jm300371c
BindingDB Entry DOI: 10.7270/Q2V40WB0
More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Mus musculus (Mouse))
BDBM312185
PNG
(US9604926, Compound CM-308 | US9724435, Compound C...)
Show SMILES COc1cc2CCN(CCCCn3c4ccccc4sc3=S)Cc2cc1OC
Show InChI InChI=1S/C22H26N2O2S2/c1-25-19-13-16-9-12-23(15-17(16)14-20(19)26-2)10-5-6-11-24-18-7-3-4-8-21(18)28-22(24)27/h3-4,7-8,13-14H,5-6,9-12,15H2,1-2H3
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0.560n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma-2 receptor


(Rattus norvegicus (Rat))
BDBM312185
PNG
(US9604926, Compound CM-308 | US9724435, Compound C...)
Show SMILES COc1cc2CCN(CCCCn3c4ccccc4sc3=S)Cc2cc1OC
Show InChI InChI=1S/C22H26N2O2S2/c1-25-19-13-16-9-12-23(15-17(16)14-20(19)26-2)10-5-6-11-24-18-7-3-4-8-21(18)28-22(24)27/h3-4,7-8,13-14H,5-6,9-12,15H2,1-2H3
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0.560n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9724435 (2017)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2BZ6856
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM312168
PNG
(US9604926, Compound CM-172 | US9724435, Compound C...)
Show SMILES O=c1oc2ccccc2n1CCCCN1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C22H26N2O2/c25-22-24(20-10-4-5-11-21(20)26-22)15-7-6-14-23-16-12-19(13-17-23)18-8-2-1-3-9-18/h1-5,8-11,19H,6-7,12-17H2
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0.580n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM312168
PNG
(US9604926, Compound CM-172 | US9724435, Compound C...)
Show SMILES O=c1oc2ccccc2n1CCCCN1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C22H26N2O2/c25-22-24(20-10-4-5-11-21(20)26-22)15-7-6-14-23-16-12-19(13-17-23)18-8-2-1-3-9-18/h1-5,8-11,19H,6-7,12-17H2
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0.580n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9724435 (2017)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2BZ6856
More data for this
Ligand-Target Pair
Sigma-2 receptor


(Rattus norvegicus (Rat))
BDBM312203
PNG
(US9604926, Compound CM-401 | US9724435, Compound C...)
Show SMILES CC(=O)c1ccc2n(CCCCN3CCC(=CC3)c3ccc(F)cc3)c(=O)oc2c1
Show InChI InChI=1S/C24H25FN2O3/c1-17(28)20-6-9-22-23(16-20)30-24(29)27(22)13-3-2-12-26-14-10-19(11-15-26)18-4-7-21(25)8-5-18/h4-10,16H,2-3,11-15H2,1H3
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0.660n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9724435 (2017)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2BZ6856
More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Mus musculus (Mouse))
BDBM312203
PNG
(US9604926, Compound CM-401 | US9724435, Compound C...)
Show SMILES CC(=O)c1ccc2n(CCCCN3CCC(=CC3)c3ccc(F)cc3)c(=O)oc2c1
Show InChI InChI=1S/C24H25FN2O3/c1-17(28)20-6-9-22-23(16-20)30-24(29)27(22)13-3-2-12-26-14-10-19(11-15-26)18-4-7-21(25)8-5-18/h4-10,16H,2-3,11-15H2,1H3
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0.660n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Mus musculus (Mouse))
BDBM312166
PNG
(US9604926, Compound CM-170 | US9724435, Compound C...)
Show SMILES Fc1ccc(cc1)N1CCN(CCCCn2c3ccccc3oc2=O)CC1
Show InChI InChI=1S/C21H24FN3O2/c22-17-7-9-18(10-8-17)24-15-13-23(14-16-24)11-3-4-12-25-19-5-1-2-6-20(19)27-21(25)26/h1-2,5-10H,3-4,11-16H2
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0.700n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma-2 receptor


(Rattus norvegicus (Rat))
BDBM312166
PNG
(US9604926, Compound CM-170 | US9724435, Compound C...)
Show SMILES Fc1ccc(cc1)N1CCN(CCCCn2c3ccccc3oc2=O)CC1
Show InChI InChI=1S/C21H24FN3O2/c22-17-7-9-18(10-8-17)24-15-13-23(14-16-24)11-3-4-12-25-19-5-1-2-6-20(19)27-21(25)26/h1-2,5-10H,3-4,11-16H2
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0.700n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9724435 (2017)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2BZ6856
More data for this
Ligand-Target Pair
Sigma-2 receptor


(Rattus norvegicus (Rat))
BDBM50374595
PNG
(CHEMBL272854 | US9604926, Compound CM-372 | US9724...)
Show SMILES S=c1oc2ccccc2n1CCCCN1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C21H31N3OS/c26-21-24(19-10-4-5-11-20(19)25-21)13-7-6-12-22-14-16-23(17-15-22)18-8-2-1-3-9-18/h4-5,10-11,18H,1-3,6-9,12-17H2
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0.770n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9724435 (2017)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2BZ6856
More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Mus musculus (Mouse))
BDBM50374595
PNG
(CHEMBL272854 | US9604926, Compound CM-372 | US9724...)
Show SMILES S=c1oc2ccccc2n1CCCCN1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C21H31N3OS/c26-21-24(19-10-4-5-11-20(19)25-21)13-7-6-12-22-14-16-23(17-15-22)18-8-2-1-3-9-18/h4-5,10-11,18H,1-3,6-9,12-17H2
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0.770n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM312167
PNG
(US9604926, Compound CM-171 | US9724435, Compound C...)
Show SMILES O=c1oc2ccccc2n1CCCCN1CCN(CC2CCCCC2)CC1
Show InChI InChI=1S/C22H33N3O2/c26-22-25(20-10-4-5-11-21(20)27-22)13-7-6-12-23-14-16-24(17-15-23)18-19-8-2-1-3-9-19/h4-5,10-11,19H,1-3,6-9,12-18H2
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0.940n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM312167
PNG
(US9604926, Compound CM-171 | US9724435, Compound C...)
Show SMILES O=c1oc2ccccc2n1CCCCN1CCN(CC2CCCCC2)CC1
Show InChI InChI=1S/C22H33N3O2/c26-22-25(20-10-4-5-11-21(20)27-22)13-7-6-12-23-14-16-24(17-15-23)18-19-8-2-1-3-9-19/h4-5,10-11,19H,1-3,6-9,12-18H2
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0.940n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9724435 (2017)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2BZ6856
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50398057
PNG
(CHEMBL2181924)
Show SMILES FCCCc1ccc2n(CCN3CCCCCC3)c(=O)sc2c1
Show InChI InChI=1S/C18H25FN2OS/c19-9-5-6-15-7-8-16-17(14-15)23-18(22)21(16)13-12-20-10-3-1-2-4-11-20/h7-8,14H,1-6,9-13H2
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0.960n/an/an/an/an/an/an/an/a



Stanford University

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from Sigma1 receptor in rat liver homogenate


J Med Chem 55: 8272-82 (2012)


Article DOI: 10.1021/jm300371c
BindingDB Entry DOI: 10.7270/Q2V40WB0
More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Mus musculus (Mouse))
BDBM312231
PNG
(US9604926, Compound AZ-59 | US9724435, Compound AZ...)
Show SMILES CC(CCCn1c2ccccc2sc1=S)N1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C22H33N3S2/c1-18(23-14-16-24(17-15-23)19-9-3-2-4-10-19)8-7-13-25-20-11-5-6-12-21(20)27-22(25)26/h5-6,11-12,18-19H,2-4,7-10,13-17H2,1H3
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0.990n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma-2 receptor


(Rattus norvegicus (Rat))
BDBM312231
PNG
(US9604926, Compound AZ-59 | US9724435, Compound AZ...)
Show SMILES CC(CCCn1c2ccccc2sc1=S)N1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C22H33N3S2/c1-18(23-14-16-24(17-15-23)19-9-3-2-4-10-19)8-7-13-25-20-11-5-6-12-21(20)27-22(25)26/h5-6,11-12,18-19H,2-4,7-10,13-17H2,1H3
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0.990n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9724435 (2017)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2BZ6856
More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Mus musculus (Mouse))
BDBM50353846
PNG
(CHEMBL1831156 | US9604926, Compound CM-338 | US972...)
Show SMILES Fc1ccc(cc1)N1CCN(CCCCn2ccc3ccccc23)CC1
Show InChI InChI=1S/C22H26FN3/c23-20-7-9-21(10-8-20)25-17-15-24(16-18-25)12-3-4-13-26-14-11-19-5-1-2-6-22(19)26/h1-2,5-11,14H,3-4,12-13,15-18H2
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1.09n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma-2 receptor


(Rattus norvegicus (Rat))
BDBM50353846
PNG
(CHEMBL1831156 | US9604926, Compound CM-338 | US972...)
Show SMILES Fc1ccc(cc1)N1CCN(CCCCn2ccc3ccccc23)CC1
Show InChI InChI=1S/C22H26FN3/c23-20-7-9-21(10-8-20)25-17-15-24(16-18-25)12-3-4-13-26-14-11-19-5-1-2-6-22(19)26/h1-2,5-11,14H,3-4,12-13,15-18H2
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1.09n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9724435 (2017)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2BZ6856
More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Mus musculus (Mouse))
BDBM312194
PNG
(US9604926, Compound CM-356)
Show SMILES CC(=O)c1ccc2[nH]c(=O)n(CCCCN3CCN(CC3)c3ccc(F)cc3)c2c1
Show InChI InChI=1S/C23H27FN4O2/c1-17(29)18-4-9-21-22(16-18)28(23(30)25-21)11-3-2-10-26-12-14-27(15-13-26)20-7-5-19(24)6-8-20/h4-9,16H,2-3,10-15H2,1H3,(H,25,30)
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1.21n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma-2 receptor


(Rattus norvegicus (Rat))
BDBM330344
PNG
(US9724435, Compound CM-356)
Show SMILES CC(=O)c1ccc2oc(=O)n(CCCCN3CCN(CC3)c3ccc(F)cc3)c2c1
Show InChI InChI=1S/C23H26FN3O3/c1-17(28)18-4-9-22-21(16-18)27(23(29)30-22)11-3-2-10-25-12-14-26(15-13-25)20-7-5-19(24)6-8-20/h4-9,16H,2-3,10-15H2,1H3
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1.21n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9724435 (2017)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2BZ6856
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM50374598
PNG
(CHEMBL272603 | US9604926, Compound CM-156 | US9724...)
Show SMILES S=c1sc2ccccc2n1CCCCN1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C21H31N3S2/c25-21-24(19-10-4-5-11-20(19)26-21)13-7-6-12-22-14-16-23(17-15-22)18-8-2-1-3-9-18/h4-5,10-11,18H,1-3,6-9,12-17H2
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1.28n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50374598
PNG
(CHEMBL272603 | US9604926, Compound CM-156 | US9724...)
Show SMILES S=c1sc2ccccc2n1CCCCN1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C21H31N3S2/c25-21-24(19-10-4-5-11-20(19)26-21)13-7-6-12-22-14-16-23(17-15-22)18-8-2-1-3-9-18/h4-5,10-11,18H,1-3,6-9,12-17H2
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1.28n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9724435 (2017)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2BZ6856
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Mus musculus (Mouse))
BDBM312174
PNG
(US9604926, Compound CM-176 | US9724435, Compound C...)
Show SMILES O=c1oc2ccccc2n1CCN1CCN(CCc2ccccc2)CC1
Show InChI InChI=1S/C21H25N3O2/c25-21-24(19-8-4-5-9-20(19)26-21)17-16-23-14-12-22(13-15-23)11-10-18-6-2-1-3-7-18/h1-9H,10-17H2
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1.43n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM312174
PNG
(US9604926, Compound CM-176 | US9724435, Compound C...)
Show SMILES O=c1oc2ccccc2n1CCN1CCN(CCc2ccccc2)CC1
Show InChI InChI=1S/C21H25N3O2/c25-21-24(19-8-4-5-9-20(19)26-21)17-16-23-14-12-22(13-15-23)11-10-18-6-2-1-3-7-18/h1-9H,10-17H2
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US Patent
1.43n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9724435 (2017)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2BZ6856
More data for this
Ligand-Target Pair
Sigma-2 receptor


(Rattus norvegicus (Rat))
BDBM50374602
PNG
(CHEMBL272608 | US9604926, Compound SN-102 | US9724...)
Show SMILES O=c1sc2ccccc2n1CCCCCCN1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C23H35N3OS/c27-23-26(21-12-6-7-13-22(21)28-23)15-9-2-1-8-14-24-16-18-25(19-17-24)20-10-4-3-5-11-20/h6-7,12-13,20H,1-5,8-11,14-19H2
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US Patent
1.49n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9724435 (2017)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2BZ6856
More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Mus musculus (Mouse))
BDBM50374602
PNG
(CHEMBL272608 | US9604926, Compound SN-102 | US9724...)
Show SMILES O=c1sc2ccccc2n1CCCCCCN1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C23H35N3OS/c27-23-26(21-12-6-7-13-22(21)28-23)15-9-2-1-8-14-24-16-18-25(19-17-24)20-10-4-3-5-11-20/h6-7,12-13,20H,1-5,8-11,14-19H2
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US Patent
1.49n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Mus musculus (Mouse))
BDBM50374602
PNG
(CHEMBL272608 | US9604926, Compound SN-102 | US9724...)
Show SMILES O=c1sc2ccccc2n1CCCCCCN1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C23H35N3OS/c27-23-26(21-12-6-7-13-22(21)28-23)15-9-2-1-8-14-24-16-18-25(19-17-24)20-10-4-3-5-11-20/h6-7,12-13,20H,1-5,8-11,14-19H2
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US Patent
1.49n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
Sigma-2 receptor


(Rattus norvegicus (Rat))
BDBM50374602
PNG
(CHEMBL272608 | US9604926, Compound SN-102 | US9724...)
Show SMILES O=c1sc2ccccc2n1CCCCCCN1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C23H35N3OS/c27-23-26(21-12-6-7-13-22(21)28-23)15-9-2-1-8-14-24-16-18-25(19-17-24)20-10-4-3-5-11-20/h6-7,12-13,20H,1-5,8-11,14-19H2
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US Patent
1.49n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9724435 (2017)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2BZ6856
More data for this
Ligand-Target Pair
Sigma intracellular receptor 2


(Mus musculus (Mouse))
BDBM312183
PNG
(US9604926, Compound CM-295 | US9724435, Compound C...)
Show SMILES COc1cc2CCN(CCCCn3c4ccccc4oc3=O)Cc2cc1OC
Show InChI InChI=1S/C22H26N2O4/c1-26-20-13-16-9-12-23(15-17(16)14-21(20)27-2)10-5-6-11-24-18-7-3-4-8-19(18)28-22(24)25/h3-4,7-8,13-14H,5-6,9-12,15H2,1-2H3
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1.52n/an/an/an/an/an/an/an/a



The University of Mississippi

US Patent


Assay Description
Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...


US Patent US9604926 (2017)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q27D2X6J
More data for this
Ligand-Target Pair
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