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Compile Data Set for Download or QSAR

Found 297 hits with Last Name = 'min' and Initial = 'kh'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM20330
PNG
(3-[(4-tert-butylphenyl)methyl]-1-[(4-methanesulfon...)
Show SMILES COc1cc(CNC(=S)NCc2ccc(cc2)C(C)(C)C)ccc1NS(C)(=O)=O
Show InChI InChI=1S/C21H29N3O3S2/c1-21(2,3)17-9-6-15(7-10-17)13-22-20(28)23-14-16-8-11-18(19(12-16)27-4)24-29(5,25)26/h6-12,24H,13-14H2,1-5H3,(H2,22,23,28)
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3.40n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity for rat TRPV1 expressed in CHO cells


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM20321
PNG
(3-[(4-tert-butylphenyl)methyl]-1-[(3-fluoro-4-meth...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1
Show InChI InChI=1S/C20H26FN3O2S2/c1-20(2,3)16-8-5-14(6-9-16)12-22-19(27)23-13-15-7-10-18(17(21)11-15)24-28(4,25)26/h5-11,24H,12-13H2,1-4H3,(H2,22,23,27)
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9.16n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity for rat TRPV1 expressed in CHO cells


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170266
PNG
(CHEMBL363267 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)cc2F)cc1
Show InChI InChI=1S/C20H26FN3O2S2/c1-20(2,3)16-8-5-14(6-9-16)12-22-19(27)23-13-15-7-10-17(11-18(15)21)24-28(4,25)26/h5-11,24H,12-13H2,1-4H3,(H2,22,23,27)
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27.3n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity for rat TRPV1 expressed in CHO cells


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170262
PNG
(CHEMBL190637 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)cc2Cl)cc1
Show InChI InChI=1S/C20H26ClN3O2S2/c1-20(2,3)16-8-5-14(6-9-16)12-22-19(27)23-13-15-7-10-17(11-18(15)21)24-28(4,25)26/h5-11,24H,12-13H2,1-4H3,(H2,22,23,27)
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45.5n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity for rat TRPV1 expressed in CHO cells


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM20330
PNG
(3-[(4-tert-butylphenyl)methyl]-1-[(4-methanesulfon...)
Show SMILES COc1cc(CNC(=S)NCc2ccc(cc2)C(C)(C)C)ccc1NS(C)(=O)=O
Show InChI InChI=1S/C21H29N3O3S2/c1-21(2,3)17-9-6-15(7-10-17)13-22-20(28)23-14-16-8-11-18(19(12-16)27-4)24-29(5,25)26/h6-12,24H,13-14H2,1-5H3,(H2,22,23,28)
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50.4n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM20321
PNG
(3-[(4-tert-butylphenyl)methyl]-1-[(3-fluoro-4-meth...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1
Show InChI InChI=1S/C20H26FN3O2S2/c1-20(2,3)16-8-5-14(6-9-16)12-22-19(27)23-13-15-7-10-18(17(21)11-15)24-28(4,25)26/h5-11,24H,12-13H2,1-4H3,(H2,22,23,27)
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53.5n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM20315
PNG
(3-[(4-tert-butylphenyl)methyl]-1-[(4-methanesulfon...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)cc2)cc1
Show InChI InChI=1S/C20H27N3O2S2/c1-20(2,3)17-9-5-15(6-10-17)13-21-19(26)22-14-16-7-11-18(12-8-16)23-27(4,24)25/h5-12,23H,13-14H2,1-4H3,(H2,21,22,26)
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54n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity for rat TRPV1 expressed in CHO cells


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM20315
PNG
(3-[(4-tert-butylphenyl)methyl]-1-[(4-methanesulfon...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)cc2)cc1
Show InChI InChI=1S/C20H27N3O2S2/c1-20(2,3)17-9-5-15(6-10-17)13-21-19(26)22-14-16-7-11-18(12-8-16)23-27(4,24)25/h5-12,23H,13-14H2,1-4H3,(H2,21,22,26)
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63n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170253
PNG
(CHEMBL365213 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)cc2C(F)(F)F)cc1
Show InChI InChI=1S/C21H26F3N3O2S2/c1-20(2,3)16-8-5-14(6-9-16)12-25-19(30)26-13-15-7-10-17(27-31(4,28)29)11-18(15)21(22,23)24/h5-11,27H,12-13H2,1-4H3,(H2,25,26,30)
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119n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity for rat TRPV1 expressed in CHO cells


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170262
PNG
(CHEMBL190637 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)cc2Cl)cc1
Show InChI InChI=1S/C20H26ClN3O2S2/c1-20(2,3)16-8-5-14(6-9-16)12-22-19(27)23-13-15-7-10-17(11-18(15)21)24-28(4,25)26/h5-11,24H,12-13H2,1-4H3,(H2,22,23,27)
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144n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170251
PNG
(2-Azido-ethanesulfonic acid {4-[3-(4-tert-butyl-be...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(=O)(=O)CCN=[N+]=[N-])cc2)cc1
Show InChI InChI=1S/C21H28N6O2S2/c1-21(2,3)18-8-4-16(5-9-18)14-23-20(30)24-15-17-6-10-19(11-7-17)26-31(28,29)13-12-25-27-22/h4-11,26H,12-15H2,1-3H3,(H2,23,24,30)
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145n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170252
PNG
(CHEMBL425180 | N-{5-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)nc2)cc1
Show InChI InChI=1S/C19H26N4O2S2/c1-19(2,3)16-8-5-14(6-9-16)11-21-18(26)22-13-15-7-10-17(20-12-15)23-27(4,24)25/h5-10,12H,11,13H2,1-4H3,(H,20,23)(H2,21,22,26)
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177n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity for rat TRPV1 expressed in CHO cells


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170266
PNG
(CHEMBL363267 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)cc2F)cc1
Show InChI InChI=1S/C20H26FN3O2S2/c1-20(2,3)16-8-5-14(6-9-16)12-22-19(27)23-13-15-7-10-17(11-18(15)21)24-28(4,25)26/h5-11,24H,12-13H2,1-4H3,(H2,22,23,27)
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215n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170256
PNG
(CHEMBL426266 | Ethenesulfonic acid {4-[3-(4-tert-b...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(=O)(=O)C=C)cc2)cc1
Show InChI InChI=1S/C21H27N3O2S2/c1-5-28(25,26)24-19-12-8-17(9-13-19)15-23-20(27)22-14-16-6-10-18(11-7-16)21(2,3)4/h5-13,24H,1,14-15H2,2-4H3,(H2,22,23,27)
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231n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170251
PNG
(2-Azido-ethanesulfonic acid {4-[3-(4-tert-butyl-be...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(=O)(=O)CCN=[N+]=[N-])cc2)cc1
Show InChI InChI=1S/C21H28N6O2S2/c1-21(2,3)18-8-4-16(5-9-18)14-23-20(30)24-15-17-6-10-19(11-7-17)26-31(28,29)13-12-25-27-22/h4-11,26H,12-15H2,1-3H3,(H2,23,24,30)
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231n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity for rat TRPV1 expressed in CHO cells


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170264
PNG
(CHEMBL361931 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(Cl)c2)cc1
Show InChI InChI=1S/C20H26ClN3O2S2/c1-20(2,3)16-8-5-14(6-9-16)12-22-19(27)23-13-15-7-10-18(17(21)11-15)24-28(4,25)26/h5-11,24H,12-13H2,1-4H3,(H2,22,23,27)
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400n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity for rat TRPV1 expressed in CHO cells


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170253
PNG
(CHEMBL365213 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)cc2C(F)(F)F)cc1
Show InChI InChI=1S/C21H26F3N3O2S2/c1-20(2,3)16-8-5-14(6-9-16)12-25-19(30)26-13-15-7-10-17(27-31(4,28)29)11-18(15)21(22,23)24/h5-11,27H,12-13H2,1-4H3,(H2,25,26,30)
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440n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM20284
PNG
(CHEMBL391997 | CPZ | Capsazepine | N-[2-(4-chlorop...)
Show SMILES Oc1cc2CCCN(Cc2cc1O)C(=S)NCCc1ccc(Cl)cc1
Show InChI InChI=1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)
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520n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity for rat TRPV1 expressed in CHO cells


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170255
PNG
(1-(4-tert-Butyl-benzyl)-3-(3-methylsulfanyl-benzyl...)
Show SMILES CSc1cccc(CNC(=S)NCc2ccc(cc2)C(C)(C)C)c1
Show InChI InChI=1S/C20H26N2S2/c1-20(2,3)17-10-8-15(9-11-17)13-21-19(23)22-14-16-6-5-7-18(12-16)24-4/h5-12H,13-14H2,1-4H3,(H2,21,22,23)
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580n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170263
PNG
(CHEMBL189418 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(C[N-]C(=[SH+])NCc2ccc(NS(C)(=O)=O)c(c2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C20H26N4O4S2/c1-20(2,3)16-8-5-14(6-9-16)12-21-19(29)22-13-15-7-10-17(23-30(4,27)28)18(11-15)24(25)26/h5-11,23H,12-13H2,1-4H3,(H2,21,22,29)
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610n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity for rat TRPV1 expressed in CHO cells


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50139640
PNG
(CHEMBL165272 | N-4-Substituted-benzyl-N'-tert-buty...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(N)(=O)=O)cc2)cc1
Show InChI InChI=1S/C19H26N4O2S2/c1-19(2,3)16-8-4-14(5-9-16)12-21-18(26)22-13-15-6-10-17(11-7-15)23-27(20,24)25/h4-11,23H,12-13H2,1-3H3,(H2,20,24,25)(H2,21,22,26)
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650n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170258
PNG
(CHEMBL187735 | N-(4-{2-[3-(4-tert-Butyl-benzyl)-th...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCCc2ccc(NS(C)(=O)=O)cc2)cc1
Show InChI InChI=1S/C21H29N3O2S2/c1-21(2,3)18-9-5-17(6-10-18)15-23-20(27)22-14-13-16-7-11-19(12-8-16)24-28(4,25)26/h5-12,24H,13-15H2,1-4H3,(H2,22,23,27)
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699n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity for rat TRPV1 expressed in CHO cells


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170267
PNG
(CHEMBL188024 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(O)c2)cc1
Show InChI InChI=1S/C20H27N3O3S2/c1-20(2,3)16-8-5-14(6-9-16)12-21-19(27)22-13-15-7-10-17(18(24)11-15)23-28(4,25)26/h5-11,23-24H,12-13H2,1-4H3,(H2,21,22,27)
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750n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170257
PNG
(1-(4-tert-Butyl-benzyl)-3-(3-methanesulfonyl-benzy...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2cccc(c2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C20H26N2O2S2/c1-20(2,3)17-10-8-15(9-11-17)13-21-19(25)22-14-16-6-5-7-18(12-16)26(4,23)24/h5-12H,13-14H2,1-4H3,(H2,21,22,25)
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1.00E+3n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170264
PNG
(CHEMBL361931 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(Cl)c2)cc1
Show InChI InChI=1S/C20H26ClN3O2S2/c1-20(2,3)16-8-5-14(6-9-16)12-22-19(27)23-13-15-7-10-18(17(21)11-15)24-28(4,25)26/h5-11,24H,12-13H2,1-4H3,(H2,22,23,27)
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1.16E+3n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM20284
PNG
(CHEMBL391997 | CPZ | Capsazepine | N-[2-(4-chlorop...)
Show SMILES Oc1cc2CCCN(Cc2cc1O)C(=S)NCCc1ccc(Cl)cc1
Show InChI InChI=1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)
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1.30E+3n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170263
PNG
(CHEMBL189418 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(C[N-]C(=[SH+])NCc2ccc(NS(C)(=O)=O)c(c2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C20H26N4O4S2/c1-20(2,3)16-8-5-14(6-9-16)12-21-19(29)22-13-15-7-10-17(23-30(4,27)28)18(11-15)24(25)26/h5-11,23H,12-13H2,1-4H3,(H2,21,22,29)
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1.30E+3n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170254
PNG
(1-(4-tert-Butyl-benzyl)-3-(3-methanesulfinyl-benzy...)
Show SMILES CS(=O)c1cccc(CNC(=S)NCc2ccc(cc2)C(C)(C)C)c1
Show InChI InChI=1S/C20H26N2OS2/c1-20(2,3)17-10-8-15(9-11-17)13-21-19(24)22-14-16-6-5-7-18(12-16)25(4)23/h5-12H,13-14H2,1-4H3,(H2,21,22,24)
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3.60E+3n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170265
PNG
(CHEMBL191024 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)Oc1cc(CNC(=S)NCc2ccc(cc2)C(C)(C)C)ccc1NS(C)(=O)=O
Show InChI InChI=1S/C23H33N3O3S2/c1-16(2)29-21-13-18(9-12-20(21)26-31(6,27)28)15-25-22(30)24-14-17-7-10-19(11-8-17)23(3,4)5/h7-13,16,26H,14-15H2,1-6H3,(H2,24,25,30)
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3.60E+3n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity for rat TRPV1 expressed in CHO cells


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170258
PNG
(CHEMBL187735 | N-(4-{2-[3-(4-tert-Butyl-benzyl)-th...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCCc2ccc(NS(C)(=O)=O)cc2)cc1
Show InChI InChI=1S/C21H29N3O2S2/c1-21(2,3)18-9-5-17(6-10-18)15-23-20(27)22-14-13-16-7-11-19(12-8-16)24-28(4,25)26/h5-12,24H,13-15H2,1-4H3,(H2,22,23,27)
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3.90E+3n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170260
PNG
(CHEMBL187838 | N-{6-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)cn2)cc1
Show InChI InChI=1S/C19H26N4O2S2/c1-19(2,3)15-7-5-14(6-8-15)11-21-18(26)22-12-16-9-10-17(13-20-16)23-27(4,24)25/h5-10,13,23H,11-12H2,1-4H3,(H2,21,22,26)
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4.10E+3n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity for rat TRPV1 expressed in CHO cells


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170252
PNG
(CHEMBL425180 | N-{5-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)nc2)cc1
Show InChI InChI=1S/C19H26N4O2S2/c1-19(2,3)16-8-5-14(6-9-16)11-21-18(26)22-13-15-7-10-17(20-12-15)23-27(4,24)25/h5-10,12H,11,13H2,1-4H3,(H,20,23)(H2,21,22,26)
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4.10E+3n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170268
PNG
(2-Amino-ethanesulfonic acid {4-[3-(4-tert-butyl-be...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(=O)(=O)CCN)cc2)cc1
Show InChI InChI=1S/C21H30N4O2S2/c1-21(2,3)18-8-4-16(5-9-18)14-23-20(28)24-15-17-6-10-19(11-7-17)25-29(26,27)13-12-22/h4-11,25H,12-15,22H2,1-3H3,(H2,23,24,28)
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4.64E+3n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170259
PNG
(CHEMBL189507 | N-{3-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2cccc(NS(C)(=O)=O)c2)cc1
Show InChI InChI=1S/C20H27N3O2S2/c1-20(2,3)17-10-8-15(9-11-17)13-21-19(26)22-14-16-6-5-7-18(12-16)23-27(4,24)25/h5-12,23H,13-14H2,1-4H3,(H2,21,22,26)
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6.00E+3n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170261
PNG
(CHEMBL188264 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(CNS(C)(=O)=O)cc2)cc1
Show InChI InChI=1S/C21H29N3O2S2/c1-21(2,3)19-11-9-17(10-12-19)14-23-20(27)22-13-16-5-7-18(8-6-16)15-24-28(4,25)26/h5-12,24H,13-15H2,1-4H3,(H2,22,23,27)
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6.12E+3n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170250
PNG
(CHEMBL189640 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)Nc2ccc(NS(C)(=O)=O)cc2)cc1
Show InChI InChI=1S/C19H25N3O2S2/c1-19(2,3)15-7-5-14(6-8-15)13-20-18(25)21-16-9-11-17(12-10-16)22-26(4,23)24/h5-12,22H,13H2,1-4H3,(H2,20,21,25)
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6.80E+3n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity for rat TRPV1 expressed in CHO cells


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170265
PNG
(CHEMBL191024 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)Oc1cc(CNC(=S)NCc2ccc(cc2)C(C)(C)C)ccc1NS(C)(=O)=O
Show InChI InChI=1S/C23H33N3O3S2/c1-16(2)29-21-13-18(9-12-20(21)26-31(6,27)28)15-25-22(30)24-14-17-7-10-19(11-8-17)23(3,4)5/h7-13,16,26H,14-15H2,1-6H3,(H2,24,25,30)
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8.07E+3n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170250
PNG
(CHEMBL189640 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)Nc2ccc(NS(C)(=O)=O)cc2)cc1
Show InChI InChI=1S/C19H25N3O2S2/c1-19(2,3)15-7-5-14(6-8-15)13-20-18(25)21-16-9-11-17(12-10-16)22-26(4,23)24/h5-12,22H,13H2,1-4H3,(H2,20,21,25)
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9.56E+3n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170260
PNG
(CHEMBL187838 | N-{6-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)cn2)cc1
Show InChI InChI=1S/C19H26N4O2S2/c1-19(2,3)15-7-5-14(6-8-15)11-21-18(26)22-12-16-9-10-17(13-20-16)23-27(4,24)25/h5-10,13,23H,11-12H2,1-4H3,(H2,21,22,26)
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1.19E+4n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro binding affinity for rat TRPV1 expressed in CHO cells using [3H]-RTX


Bioorg Med Chem Lett 15: 4136-42 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.009
BindingDB Entry DOI: 10.7270/Q23B5ZN0
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM30130
PNG
(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)
Show SMILES CNCCC(Oc1ccc(cc1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3
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n/an/a 3.10n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells


Bioorg Med Chem Lett 20: 5567-71 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.021
BindingDB Entry DOI: 10.7270/Q24F1RQ7
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50121975
PNG
((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Show SMILES COc1ccc2nccc([C@H](O)[C@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1
Show InChI InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1
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n/an/a<6n/an/an/an/an/an/a



Chung-Ang University

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6 in human liver microsome


Bioorg Med Chem Lett 24: 4271-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.026
BindingDB Entry DOI: 10.7270/Q261122X
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50170264
PNG
(CHEMBL361931 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(Cl)c2)cc1
Show InChI InChI=1S/C20H26ClN3O2S2/c1-20(2,3)16-8-5-14(6-9-16)12-22-19(27)23-13-15-7-10-18(17(21)11-15)24-28(4,25)26/h5-11,24H,12-13H2,1-4H3,(H2,22,23,27)
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n/an/a 8.40n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes


J Med Chem 48: 5823-36 (2005)


Article DOI: 10.1021/jm0502790
BindingDB Entry DOI: 10.7270/Q2057FGN
More data for this
Ligand-Target Pair
Monoamine transporters; Norepinephrine & serotonin


(Rattus norvegicus (rat))
BDBM30130
PNG
(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)
Show SMILES CNCCC(Oc1ccc(cc1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3
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n/an/a 12.6n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]paroxetine from SERT in rat cerebral cortex


Bioorg Med Chem Lett 20: 5567-71 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.021
BindingDB Entry DOI: 10.7270/Q24F1RQ7
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))
BDBM50325937
PNG
(CHEMBL1224227 | rac-N-methyl-3-(naphthalen-2-yl)-3...)
Show SMILES CNCCC(c1ccc2ccccc2c1)n1ncnn1
Show InChI InChI=1S/C15H17N5/c1-16-9-8-15(20-18-11-17-19-20)14-7-6-12-4-2-3-5-13(12)10-14/h2-7,10-11,15-16H,8-9H2,1H3
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n/an/a 13.3n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of norepinephrine reuptake at human NET expressed in MDCK cells


Bioorg Med Chem Lett 20: 5567-71 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.021
BindingDB Entry DOI: 10.7270/Q24F1RQ7
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))
BDBM50325936
PNG
((S)-3-(5-(2H-1,2,3-triazol-2-yl)-2H-tetrazol-2-yl)...)
Show SMILES CNCC[C@@H](c1ccc(Cl)c(Cl)c1)n1nnc(n1)-n1nccn1
Show InChI InChI=1S/C13H14Cl2N8/c1-16-5-4-12(9-2-3-10(14)11(15)8-9)22-20-13(19-21-22)23-17-6-7-18-23/h2-3,6-8,12,16H,4-5H2,1H3/t12-/m0/s1
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n/an/a 14.7n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of norepinephrine reuptake at human NET expressed in MDCK cells


Bioorg Med Chem Lett 20: 5567-71 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.021
BindingDB Entry DOI: 10.7270/Q24F1RQ7
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))
BDBM50325933
PNG
((S)-3-(3,4-dichlorophenyl)-N-methyl-3-(5-methyl-2H...)
Show SMILES CNCC[C@@H](c1ccc(Cl)c(Cl)c1)n1nnc(C)n1
Show InChI InChI=1S/C12H15Cl2N5/c1-8-16-18-19(17-8)12(5-6-15-2)9-3-4-10(13)11(14)7-9/h3-4,7,12,15H,5-6H2,1-2H3/t12-/m0/s1
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n/an/a 19.8n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of norepinephrine reuptake at human NET expressed in MDCK cells


Bioorg Med Chem Lett 20: 5567-71 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.021
BindingDB Entry DOI: 10.7270/Q24F1RQ7
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50304771
PNG
(3-(4-tert-Butylphenyl)-N-[3-fluoro-4-(methylsulfon...)
Show SMILES CC(C)(C)c1ccc(CCC(=O)NCc2cc(F)c(NS(C)(=O)=O)c(C=C)c2)cc1
Show InChI InChI=1S/C23H29FN2O3S/c1-6-18-13-17(14-20(24)22(18)26-30(5,28)29)15-25-21(27)12-9-16-7-10-19(11-8-16)23(2,3)4/h6-8,10-11,13-14,26H,1,9,12,15H2,2-5H3,(H,25,27)
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n/an/a 25n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neurons assessed as inhibition of capsaicin-induced [45]Ca2+ uptake


Bioorg Med Chem 17: 8149-60 (2009)


Article DOI: 10.1016/j.bmc.2009.10.043
BindingDB Entry DOI: 10.7270/Q2NV9JBN
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50304776
PNG
(3-(4-tert-Butylphenyl)-N-[3-cyano-5-fluoro-4-(meth...)
Show SMILES CC(C)(C)c1ccc(CCC(=S)NCc2cc(F)c(NS(C)(=O)=O)c(c2)C#N)cc1
Show InChI InChI=1S/C22H26FN3O2S2/c1-22(2,3)18-8-5-15(6-9-18)7-10-20(29)25-14-16-11-17(13-24)21(19(23)12-16)26-30(4,27)28/h5-6,8-9,11-12,26H,7,10,14H2,1-4H3,(H,25,29)
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n/an/a 28n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neurons assessed as inhibition of capsaicin-induced [45]Ca2+ uptake


Bioorg Med Chem 17: 8149-60 (2009)


Article DOI: 10.1016/j.bmc.2009.10.043
BindingDB Entry DOI: 10.7270/Q2NV9JBN
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM50325937
PNG
(CHEMBL1224227 | rac-N-methyl-3-(naphthalen-2-yl)-3...)
Show SMILES CNCCC(c1ccc2ccccc2c1)n1ncnn1
Show InChI InChI=1S/C15H17N5/c1-16-9-8-15(20-18-11-17-19-20)14-7-6-12-4-2-3-5-13(12)10-14/h2-7,10-11,15-16H,8-9H2,1H3
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n/an/a 32n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells


Bioorg Med Chem Lett 20: 5567-71 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.021
BindingDB Entry DOI: 10.7270/Q24F1RQ7
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50304770
PNG
(3-(4-tert-Butylphenyl)-N-[3-fluoro-4-(methylsulfon...)
Show SMILES CC(C)(C)c1ccc(CCC(=S)NCc2cc(F)c(NS(C)(=O)=O)c(C=C)c2)cc1
Show InChI InChI=1S/C23H29FN2O2S2/c1-6-18-13-17(14-20(24)22(18)26-30(5,27)28)15-25-21(29)12-9-16-7-10-19(11-8-16)23(2,3)4/h6-8,10-11,13-14,26H,1,9,12,15H2,2-5H3,(H,25,29)
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n/an/a 32n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neurons assessed as inhibition of capsaicin-induced [45]Ca2+ uptake


Bioorg Med Chem 17: 8149-60 (2009)


Article DOI: 10.1016/j.bmc.2009.10.043
BindingDB Entry DOI: 10.7270/Q2NV9JBN
More data for this
Ligand-Target Pair
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