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Compile Data Set for Download or QSAR

Found 1006 hits with Last Name = 'niizuma' and Initial = 's'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50121716
PNG
((3-methyl-4-(3-(pyridin-3-ylmethylamino)propoxy)be...)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1ccc(C)cn1
Show InChI InChI=1S/C25H25N3O3/c1-17-9-10-20(28-14-17)24(29)25-18(2)23-21(7-3-8-22(23)31-25)30-13-5-12-27-16-19-6-4-11-26-15-19/h3-4,6-11,14-15,27H,5,12-13,16H2,1-2H3
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n/an/a 0.390n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220561
PNG
(CHEMBL173370)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1nc2ccccc2n1C
Show InChI InChI=1S/C27H26N4O3/c1-18-24-22(33-15-7-14-29-17-19-8-6-13-28-16-19)11-5-12-23(24)34-26(18)25(32)27-30-20-9-3-4-10-21(20)31(27)2/h3-6,8-13,16,29H,7,14-15,17H2,1-2H3
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n/an/a 0.400n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220562
PNG
(CHEMBL171506)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1nc2ccccc2n1CC=C
Show InChI InChI=1S/C29H28N4O3/c1-3-16-33-23-11-5-4-10-22(23)32-29(33)27(34)28-20(2)26-24(12-6-13-25(26)36-28)35-17-8-15-31-19-21-9-7-14-30-18-21/h3-7,9-14,18,31H,1,8,15-17,19H2,2H3
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n/an/a 0.580n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220565
PNG
(CHEMBL170524)
Show SMILES Cc1nc(sc1C)C(=O)c1oc2cccc(OCCCNCc3cccnc3)c2c1C
Show InChI InChI=1S/C24H25N3O3S/c1-15-21-19(29-12-6-11-26-14-18-7-5-10-25-13-18)8-4-9-20(21)30-23(15)22(28)24-27-16(2)17(3)31-24/h4-5,7-10,13,26H,6,11-12,14H2,1-3H3
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n/an/a 0.710n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220569
PNG
(CHEMBL422896)
Show SMILES CC(C)n1c(nc2ccccc12)C(=O)c1oc2cccc(OCCCNCc3cccnc3)c2c1C
Show InChI InChI=1S/C29H30N4O3/c1-19(2)33-23-11-5-4-10-22(23)32-29(33)27(34)28-20(3)26-24(12-6-13-25(26)36-28)35-16-8-15-31-18-21-9-7-14-30-17-21/h4-7,9-14,17,19,31H,8,15-16,18H2,1-3H3
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n/an/a 1.30n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50121720
PNG
((1-METHYL-1H-IMIDAZOL-2-YL)-(3-METHYL-4-{3-[(PYRID...)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1nccn1C
Show InChI InChI=1S/C23H24N4O3/c1-16-20-18(29-13-5-10-25-15-17-6-4-9-24-14-17)7-3-8-19(20)30-22(16)21(28)23-26-11-12-27(23)2/h3-4,6-9,11-12,14,25H,5,10,13,15H2,1-2H3
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n/an/a 1.30n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220559
PNG
(CHEMBL422746)
Show SMILES Cc1csc(n1)C(=O)c1oc2cccc(OCCCNCc3cccnc3)c2c1C
Show InChI InChI=1S/C23H23N3O3S/c1-15-14-30-23(26-15)21(27)22-16(2)20-18(7-3-8-19(20)29-22)28-11-5-10-25-13-17-6-4-9-24-12-17/h3-4,6-9,12,14,25H,5,10-11,13H2,1-2H3
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n/an/a 2n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50220571
PNG
(CHEMBL355250)
Show SMILES Cc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1ccccn1
Show InChI InChI=1S/C24H23N3O3/c1-17-22-20(29-14-6-12-26-16-18-7-5-11-25-15-18)9-4-10-21(22)30-24(17)23(28)19-8-2-3-13-27-19/h2-5,7-11,13,15,26H,6,12,14,16H2,1H3
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n/an/a 3.5n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM88314
PNG
(US9695118, 202)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CC[C@@H](CNC)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H28Cl2F3N3O3S/c1-3-36(34,35)22-5-4-18(25)8-17(22)12-31-23(33)16-9-20(24(27,28)29)19(21(26)10-16)14-32-7-6-15(13-32)11-30-2/h4-5,8-10,15,30H,3,6-7,11-14H2,1-2H3,(H,31,33)/t15-/m0/s1
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US Patent
n/an/a 4.60n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Peptide N-myristoyltransferase


(Homo sapiens (Human))
BDBM50109882
PNG
(3-(3-methyl-2-((2,3,4-trifluorophenoxy)methyl)benz...)
Show SMILES Cc1c(COc2ccc(F)c(F)c2F)oc2cccc(OCCCNCc3cccnc3)c12
Show InChI InChI=1S/C25H23F3N2O3/c1-16-22(15-32-21-9-8-18(26)24(27)25(21)28)33-20-7-2-6-19(23(16)20)31-12-4-11-30-14-17-5-3-10-29-13-17/h2-3,5-10,13,30H,4,11-12,14-15H2,1H3
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n/an/a 5.60n/an/an/an/an/an/a



Nippon Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against Candida albicans Nmt (CaNmt)


Bioorg Med Chem Lett 13: 87-91 (2003)


Article DOI: 10.1016/s0960-894x(02)00844-2
BindingDB Entry DOI: 10.7270/Q25D8V2K
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM77638
PNG
(US9695118, 161)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CCC[C@H](N)C2)c(OC(F)(F)F)c1
Show InChI InChI=1S/C23H27ClF3N3O4S/c1-2-35(32,33)21-8-7-18(24)10-17(21)12-29-22(31)15-5-6-16(20(11-15)34-23(25,26)27)13-30-9-3-4-19(28)14-30/h5-8,10-11,19H,2-4,9,12-14,28H2,1H3,(H,29,31)/t19-/m0/s1
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n/an/a 6.5n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM88312
PNG
(US9695118, 200)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@@H](C2)NC)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H28Cl2F3N3O3S/c1-3-36(34,35)22-7-6-17(25)9-16(22)12-31-23(33)15-10-20(24(27,28)29)19(21(26)11-15)14-32-8-4-5-18(13-32)30-2/h6-7,9-11,18,30H,3-5,8,12-14H2,1-2H3,(H,31,33)/t18-/m0/s1
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n/an/a 6.70n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM88311
PNG
(US9695118, 199)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@H](N)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H26Cl2F3N3O3S/c1-2-35(33,34)21-6-5-16(24)8-15(21)11-30-22(32)14-9-19(23(26,27)28)18(20(25)10-14)13-31-7-3-4-17(29)12-31/h5-6,8-10,17H,2-4,7,11-13,29H2,1H3,(H,30,32)/t17-/m0/s1
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n/an/a 7.40n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM286684
PNG
(7-((R)-3-Amino-pyrrolidin-1-ylmethyl)-3-(5-chloro-...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2cc(CN3CC[C@@H](N)C3)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C23H24ClF3N4O4S/c1-2-36(34,35)20-4-3-15(24)7-14(20)11-31-21(32)17-9-18(23(25,26)27)13(8-19(17)29-22(31)33)10-30-6-5-16(28)12-30/h3-4,7-9,16H,2,5-6,10-12,28H2,1H3,(H,29,33)/t16-/m1/s1
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n/an/a 7.90n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen(Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporatio...


US Patent US9567304 (2017)


BindingDB Entry DOI: 10.7270/Q2FN1871
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM77182
PNG
(US9695118, 22)
Show SMILES CCSc1ccc(F)cc1NNC(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H14F4N2OS/c1-2-24-14-7-6-12(17)9-13(14)21-22-15(23)10-4-3-5-11(8-10)16(18,19)20/h3-9,21H,2H2,1H3,(H,22,23)
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n/an/a 9n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM88242
PNG
(US9695118, 633)
Show SMILES CCS(=O)(=O)c1c(C)cc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@@H](C2)NC)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H30Cl2F3N3O3S/c1-4-37(35,36)23-15(2)8-18(26)9-17(23)12-32-24(34)16-10-21(25(28,29)30)20(22(27)11-16)14-33-7-5-6-19(13-33)31-3/h8-11,19,31H,4-7,12-14H2,1-3H3,(H,32,34)/t19-/m0/s1
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n/an/a 9.10n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM88316
PNG
(US9695118, 222)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Br)c(CN2CCC[C@H](N)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H26BrClF3N3O3S/c1-2-35(33,34)21-6-5-16(25)8-15(21)11-30-22(32)14-9-19(23(26,27)28)18(20(24)10-14)13-31-7-3-4-17(29)12-31/h5-6,8-10,17H,2-4,7,11-13,29H2,1H3,(H,30,32)/t17-/m0/s1
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n/an/a 9.20n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM50080409
PNG
(CHEMBL3422020 | US9695118, 43)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CCN(C)CC2)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H27ClF3N3O3S/c1-3-34(32,33)21-7-6-19(24)12-18(21)14-28-22(31)16-4-5-17(20(13-16)23(25,26)27)15-30-10-8-29(2)9-11-30/h4-7,12-13H,3,8-11,14-15H2,1-2H3,(H,28,31)
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n/an/a 9.70n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM286640
PNG
(7-((R)-3-Amino-pyrrolidin-1-ylmethyl)-8-bromo-3-(5...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2c(Br)c(CN3CC[C@@H](N)C3)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C23H23BrClF3N4O4S/c1-2-37(35,36)18-4-3-13(25)7-12(18)9-32-21(33)15-8-17(23(26,27)28)16(11-31-6-5-14(29)10-31)19(24)20(15)30-22(32)34/h3-4,7-8,14H,2,5-6,9-11,29H2,1H3,(H,30,34)/t14-/m1/s1
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n/an/a 9.80n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen(Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporatio...


US Patent US9567304 (2017)


BindingDB Entry DOI: 10.7270/Q2FN1871
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM88309
PNG
(US9695118, 197)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@@H](N)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H26Cl2F3N3O3S/c1-2-35(33,34)21-6-5-16(24)8-15(21)11-30-22(32)14-9-19(23(26,27)28)18(20(25)10-14)13-31-7-3-4-17(29)12-31/h5-6,8-10,17H,2-4,7,11-13,29H2,1H3,(H,30,32)/t17-/m1/s1
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n/an/a 9.90n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM88310
PNG
(US9695118, 198)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@H](C2)NC)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H28Cl2F3N3O3S/c1-3-36(34,35)22-7-6-17(25)9-16(22)12-31-23(33)15-10-20(24(27,28)29)19(21(26)11-15)14-32-8-4-5-18(13-32)30-2/h6-7,9-11,18,30H,3-5,8,12-14H2,1-2H3,(H,31,33)/t18-/m1/s1
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n/an/a 9.90n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM77664
PNG
(US9695118, 192)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CC[C@H](C2)N(C)C)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H28Cl2F3N3O3S/c1-4-36(34,35)22-6-5-17(25)9-16(22)12-30-23(33)15-10-20(24(27,28)29)19(21(26)11-15)14-32-8-7-18(13-32)31(2)3/h5-6,9-11,18H,4,7-8,12-14H2,1-3H3,(H,30,33)/t18-/m1/s1
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n/an/a 9.90n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM88267
PNG
(US9695118, 683)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCOC3(CNC3)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H26Cl2F3N3O4S/c1-2-37(34,35)21-4-3-17(25)7-16(21)10-31-22(33)15-8-19(24(27,28)29)18(20(26)9-15)11-32-5-6-36-23(14-32)12-30-13-23/h3-4,7-9,30H,2,5-6,10-14H2,1H3,(H,31,33)
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n/an/a 10n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM88276
PNG
(US9695118, 707)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCCC3(CCCCN3)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C27H32Cl2F3N3O3S/c1-2-39(37,38)24-7-6-20(28)12-19(24)15-33-25(36)18-13-22(27(30,31)32)21(23(29)14-18)16-35-11-5-9-26(17-35)8-3-4-10-34-26/h6-7,12-14,34H,2-5,8-11,15-17H2,1H3,(H,33,36)
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n/an/a 10n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM77663
PNG
(US9695118, 191)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CC[C@@H](N)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C22H24Cl2F3N3O3S/c1-2-34(32,33)20-4-3-15(23)7-14(20)10-29-21(31)13-8-18(22(25,26)27)17(19(24)9-13)12-30-6-5-16(28)11-30/h3-4,7-9,16H,2,5-6,10-12,28H2,1H3,(H,29,31)/t16-/m1/s1
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n/an/a 10n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM77688
PNG
(US9695118, 220 | US9695118, 221)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Br)c(CN2CC[C@@H](CN)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H26BrClF3N3O3S/c1-2-35(33,34)21-4-3-17(25)7-16(21)11-30-22(32)15-8-19(23(26,27)28)18(20(24)9-15)13-31-6-5-14(10-29)12-31/h3-4,7-9,14H,2,5-6,10-13,29H2,1H3,(H,30,32)/t14-/m0/s1
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n/an/a 10n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM88317
PNG
(US9695118, 223 | US9695118, 229)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Br)c(CN2CC[C@@H](CNC)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H28BrClF3N3O3S/c1-3-36(34,35)22-5-4-18(26)8-17(22)12-31-23(33)16-9-20(24(27,28)29)19(21(25)10-16)14-32-7-6-15(13-32)11-30-2/h4-5,8-10,15,30H,3,6-7,11-14H2,1-2H3,(H,31,33)/t15-/m0/s1
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n/an/a 10n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM77680
PNG
(US9695118, 208)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@@H](C2)N(C)C)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H30Cl2F3N3O3S/c1-4-37(35,36)23-8-7-18(26)10-17(23)13-31-24(34)16-11-21(25(28,29)30)20(22(27)12-16)15-33-9-5-6-19(14-33)32(2)3/h7-8,10-12,19H,4-6,9,13-15H2,1-3H3,(H,31,34)/t19-/m0/s1
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n/an/a 10n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM88313
PNG
(US9695118, 201)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CC[C@@H](CN)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H26Cl2F3N3O3S/c1-2-35(33,34)21-4-3-17(24)7-16(21)11-30-22(32)15-8-19(23(26,27)28)18(20(25)9-15)13-31-6-5-14(10-29)12-31/h3-4,7-9,14H,2,5-6,10-13,29H2,1H3,(H,30,32)/t14-/m0/s1
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n/an/a 10n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401184
PNG
(8-Chloro-3-[(5-chloro-2-ethylsulfonylphenyl)methyl...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CC[C@@H](CNC)C3)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C25H27Cl2F3N4O3S/c1-3-38(36,37)21-5-4-17(26)8-16(21)12-34-14-32-23-18(24(34)35)9-20(25(28,29)30)19(22(23)27)13-33-7-6-15(11-33)10-31-2/h4-5,8-9,14-15,31H,3,6-7,10-13H2,1-2H3/t15-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)


BindingDB Entry DOI: 10.7270/Q2Z03BGV
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM286685
PNG
(3-(5-Chloro-2-ethanesulfonyl-benzyl)-7-((R)-3-dime...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2cc(CN3CC[C@H](C3)N(C)C)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C25H28ClF3N4O4S/c1-4-38(36,37)22-6-5-17(26)9-16(22)13-33-23(34)19-11-20(25(27,28)29)15(10-21(19)30-24(33)35)12-32-8-7-18(14-32)31(2)3/h5-6,9-11,18H,4,7-8,12-14H2,1-3H3,(H,30,35)/t18-/m1/s1
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n/an/a 11n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen(Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporatio...


US Patent US9567304 (2017)


BindingDB Entry DOI: 10.7270/Q2FN1871
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM88308
PNG
(US9695118, 196)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CC[C@H](C2)NC)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H26Cl2F3N3O3S/c1-3-35(33,34)21-5-4-16(24)8-15(21)11-30-22(32)14-9-19(23(26,27)28)18(20(25)10-14)13-31-7-6-17(12-31)29-2/h4-5,8-10,17,29H,3,6-7,11-13H2,1-2H3,(H,30,32)/t17-/m1/s1
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n/an/a 11n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM88151
PNG
(US9695118, 410)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@@H](C2)NCCN)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H31Cl2F3N4O3S/c1-2-38(36,37)23-6-5-18(26)10-17(23)13-33-24(35)16-11-21(25(28,29)30)20(22(27)12-16)15-34-9-3-4-19(14-34)32-8-7-31/h5-6,10-12,19,32H,2-4,7-9,13-15,31H2,1H3,(H,33,35)/t19-/m0/s1
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n/an/a 11n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM88272
PNG
(US9695118, 702)
Show SMILES CCS(=O)(=O)c1ccc(C)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@@H](C2)NC)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H31ClF3N3O3S/c1-4-36(34,35)23-8-7-16(2)10-18(23)13-31-24(33)17-11-21(25(27,28)29)20(22(26)12-17)15-32-9-5-6-19(14-32)30-3/h7-8,10-12,19,30H,4-6,9,13-15H2,1-3H3,(H,31,33)/t19-/m0/s1
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n/an/a 11n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401038
PNG
(A-12 | US10005739, Example 164)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Nn1cnc2c(Cl)cc(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C17H12Cl2F3N3O3S/c1-2-29(27,28)14-4-3-10(18)7-13(14)24-25-8-23-15-11(16(25)26)5-9(6-12(15)19)17(20,21)22/h3-8,24H,2H2,1H3
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n/an/a 12n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)


BindingDB Entry DOI: 10.7270/Q2Z03BGV
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM286718
PNG
(7-((R)-3-Amino-pyrrolidin-1-ylmethyl)-6-bromo-3-(5...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2cc(CN3CC[C@@H](N)C3)c(Br)cc2c1=O
Show InChI InChI=1S/C22H24BrClN4O4S/c1-2-33(31,32)20-4-3-15(24)7-14(20)11-28-21(29)17-9-18(23)13(8-19(17)26-22(28)30)10-27-6-5-16(25)12-27/h3-4,7-9,16H,2,5-6,10-12,25H2,1H3,(H,26,30)/t16-/m1/s1
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n/an/a 12n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen(Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporatio...


US Patent US9567304 (2017)


BindingDB Entry DOI: 10.7270/Q2FN1871
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM286724
PNG
(7-((S)-3- Aminomethyl- pyrrolidin-1- ylmethyl)-6-b...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2cc(CN3CC[C@@H](CN)C3)c(Br)cc2c1=O
Show InChI InChI=1S/C23H26BrClN4O4S/c1-2-34(32,33)21-4-3-17(25)7-16(21)13-29-22(30)18-9-19(24)15(8-20(18)27-23(29)31)12-28-6-5-14(10-26)11-28/h3-4,7-9,14H,2,5-6,10-13,26H2,1H3,(H,27,31)/t14-/m0/s1
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n/an/a 12n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen(Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporatio...


US Patent US9567304 (2017)


BindingDB Entry DOI: 10.7270/Q2FN1871
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM88299
PNG
(US9695118, 86)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CCCC[C@@H]2NC(=O)CNC)c(c1)C(F)(F)F
Show InChI InChI=1S/C26H32ClF3N4O4S/c1-3-39(37,38)22-10-9-20(27)12-19(22)14-32-25(36)17-7-8-18(21(13-17)26(28,29)30)16-34-11-5-4-6-23(34)33-24(35)15-31-2/h7-10,12-13,23,31H,3-6,11,14-16H2,1-2H3,(H,32,36)(H,33,35)/t23-/m1/s1
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n/an/a 12n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM88158
PNG
(US9695118, 428)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCCC[C@@H]2CN)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H28Cl2F3N3O3S/c1-2-36(34,35)22-7-6-17(25)9-16(22)13-31-23(33)15-10-20(24(27,28)29)19(21(26)11-15)14-32-8-4-3-5-18(32)12-30/h6-7,9-11,18H,2-5,8,12-14,30H2,1H3,(H,31,33)/t18-/m1/s1
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n/an/a 12n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM77364
PNG
(US9695118, 92)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CCC[C@@H](C2)NC)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H29ClF3N3O3S/c1-3-35(33,34)22-9-8-19(25)11-18(22)13-30-23(32)16-6-7-17(21(12-16)24(26,27)28)14-31-10-4-5-20(15-31)29-2/h6-9,11-12,20,29H,3-5,10,13-15H2,1-2H3,(H,30,32)/t20-/m0/s1
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Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM77248
PNG
(US9695118, 44)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CCN(CC2)C(C)C)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H31ClF3N3O3S/c1-4-36(34,35)23-8-7-21(26)13-20(23)15-30-24(33)18-5-6-19(22(14-18)25(27,28)29)16-31-9-11-32(12-10-31)17(2)3/h5-8,13-14,17H,4,9-12,15-16H2,1-3H3,(H,30,33)
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n/an/a 12n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM286641
PNG
(7-((S)-3-Aminomethyl-pyrrolidin-1-ylmethyl)-8-brom...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2c(Br)c(CN3CC[C@@H](CN)C3)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C24H25BrClF3N4O4S/c1-2-38(36,37)19-4-3-15(26)7-14(19)11-33-22(34)16-8-18(24(27,28)29)17(20(25)21(16)31-23(33)35)12-32-6-5-13(9-30)10-32/h3-4,7-8,13H,2,5-6,9-12,30H2,1H3,(H,31,35)/t13-/m0/s1
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n/an/a 12n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen(Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporatio...


US Patent US9567304 (2017)


BindingDB Entry DOI: 10.7270/Q2FN1871
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401230
PNG
(7-[[(3S)-3-Aminopiperidin-1-yl]methyl]-3-[(5-chlor...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2cc(CN3CCC[C@H](N)C3)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C24H26ClF3N4O3S/c1-2-36(34,35)22-6-5-17(25)8-16(22)12-32-14-30-21-9-15(11-31-7-3-4-18(29)13-31)20(24(26,27)28)10-19(21)23(32)33/h5-6,8-10,14,18H,2-4,7,11-13,29H2,1H3/t18-/m0/s1
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Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)


BindingDB Entry DOI: 10.7270/Q2Z03BGV
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401041
PNG
(8-Chloro-3-(5-chloro-2-ethylsulfonylanilino)-6-(tr...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Nn1cnc2c(Cl)cc(OC(F)(F)F)cc2c1=O
Show InChI InChI=1S/C17H12Cl2F3N3O4S/c1-2-30(27,28)14-4-3-9(18)5-13(14)24-25-8-23-15-11(16(25)26)6-10(7-12(15)19)29-17(20,21)22/h3-8,24H,2H2,1H3
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Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)


BindingDB Entry DOI: 10.7270/Q2Z03BGV
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM77255
PNG
(US9695118, 52)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CC[C@@H](N)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C22H25ClF3N3O3S/c1-2-33(31,32)20-6-5-17(23)9-16(20)11-28-21(30)14-3-4-15(19(10-14)22(24,25)26)12-29-8-7-18(27)13-29/h3-6,9-10,18H,2,7-8,11-13,27H2,1H3,(H,28,30)/t18-/m1/s1
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Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM88155
PNG
(US9695118, 423)
Show SMILES CCN[C@H]1CCCN(Cc2c(Cl)cc(cc2C(F)(F)F)C(=O)NCc2cc(Cl)ccc2S(=O)(=O)CC)C1
Show InChI InChI=1S/C25H30Cl2F3N3O3S/c1-3-31-19-6-5-9-33(14-19)15-20-21(25(28,29)30)11-16(12-22(20)27)24(34)32-13-17-10-18(26)7-8-23(17)37(35,36)4-2/h7-8,10-12,19,31H,3-6,9,13-15H2,1-2H3,(H,32,34)/t19-/m0/s1
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Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM286721
PNG
(N-{(R)-1-[6-Bromo-3-(5-chloro-2-ethanesulfonyl-ben...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2cc(CN3CC[C@H](C3)NS(C)(=O)=O)c(Br)cc2c1=O
Show InChI InChI=1S/C23H26BrClN4O6S2/c1-3-37(34,35)21-5-4-16(25)8-15(21)12-29-22(30)18-10-19(24)14(9-20(18)26-23(29)31)11-28-7-6-17(13-28)27-36(2,32)33/h4-5,8-10,17,27H,3,6-7,11-13H2,1-2H3,(H,26,31)/t17-/m1/s1
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Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen(Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporatio...


US Patent US9567304 (2017)


BindingDB Entry DOI: 10.7270/Q2FN1871
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401187
PNG
(8-Chloro-3-[(5-chloro-2-ethylsulfonylphenyl)methyl...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CCC[C@H](C3)N(C)C)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C26H29Cl2F3N4O3S/c1-4-39(37,38)22-8-7-17(27)10-16(22)12-35-15-32-24-19(25(35)36)11-21(26(29,30)31)20(23(24)28)14-34-9-5-6-18(13-34)33(2)3/h7-8,10-11,15,18H,4-6,9,12-14H2,1-3H3/t18-/m1/s1
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Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)


BindingDB Entry DOI: 10.7270/Q2Z03BGV
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM401197
PNG
(7-[[(3R)-3-(Aminomethyl)pyrrolidin-1-yl]methyl]-8-...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CC[C@H](CN)C3)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C24H25Cl2F3N4O3S/c1-2-37(35,36)20-4-3-16(25)7-15(20)11-33-13-31-22-17(23(33)34)8-19(24(27,28)29)18(21(22)26)12-32-6-5-14(9-30)10-32/h3-4,7-8,13-14H,2,5-6,9-12,30H2,1H3/t14-/m1/s1
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Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporati...


US Patent US10005739 (2018)


BindingDB Entry DOI: 10.7270/Q2Z03BGV
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM286912
PNG
(8-Bromo-3-(5-chloro-2-ethanesulfonyl-benzyl)-7-((R...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2c(Br)c(CN3CC[C@H](C3)N(C)C)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C25H27BrClF3N4O4S/c1-4-39(37,38)20-6-5-15(27)9-14(20)11-34-23(35)17-10-19(25(28,29)30)18(21(26)22(17)31-24(34)36)13-33-8-7-16(12-33)32(2)3/h5-6,9-10,16H,4,7-8,11-13H2,1-3H3,(H,31,36)/t16-/m1/s1
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Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen(Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporatio...


US Patent US9567304 (2017)


BindingDB Entry DOI: 10.7270/Q2FN1871
More data for this
Ligand-Target Pair
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