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Found 67 hits with Last Name = 'okabe' and Initial = 'm'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Solute carrier organic anion transporter family member 1A4


(Rattus norvegicus)
BDBM18957
PNG
((2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-2,6-di...)
Show SMILES CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1
Show InChI InChI=1S/C25H29I2NO3/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3
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PubMed
1.80E+3n/an/an/an/an/an/an/an/a



Tohoku University School of Medicine

Curated by ChEMBL


Assay Description
TP_TRANSPORTER: inhibition of Digoxin uptake in Xenopus laevis oocytes


Endocrinology 142: 2005-12 (2001)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM327443
PNG
(N-{3-[(1R,5S)-6-ethyl-3-azabicyclo[3.1.0]hexan-6-y...)
Show SMILES CCC1([C@H]2CNC[C@@H]12)c1cccc(NS(=O)(=O)C2CC2)c1
Show InChI InChI=1S/C16H22N2O2S/c1-2-16(14-9-17-10-15(14)16)11-4-3-5-12(8-11)18-21(19,20)13-6-7-13/h3-5,8,13-15,17-18H,2,6-7,9-10H2,1H3/t14-,15+,16?
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n/an/a 1.30n/an/an/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

US Patent


Assay Description
The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...


US Patent US9663463 (2017)


BindingDB Entry DOI: 10.7270/Q27946RR
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM327436
PNG
(N-(3-{(1R,5S,6r)-3-[3-(1-ethoxy-4,4-difluorocycloh...)
Show SMILES CCOC1(CCCN2C[C@H]3[C@@H](C2)C3(CC)c2cccc(NS(=O)(=O)C3CC3)c2)CCC(F)(F)CC1
Show InChI InChI=1S/C27H40F2N2O3S/c1-3-27(20-7-5-8-21(17-20)30-35(32,33)22-9-10-22)23-18-31(19-24(23)27)16-6-11-25(34-4-2)12-14-26(28,29)15-13-25/h5,7-8,17,22-24,30H,3-4,6,9-16,18-19H2,1-2H3/t23-,24+,27?
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n/an/a 1.30n/an/an/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

US Patent


Assay Description
The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...


US Patent US9663463 (2017)


BindingDB Entry DOI: 10.7270/Q27946RR
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM327428
PNG
( N-(3-{(1R,5S,6r)-3-[3-(4,4-difluoro-1-methoxycycl...)
Show SMILES CCC1([C@H]2CN(CCCC3(CCC(F)(F)CC3)OC)C[C@@H]12)c1cccc(NS(=O)(=O)C2CC2)c1
Show InChI InChI=1S/C26H38F2N2O3S/c1-3-26(19-6-4-7-20(16-19)29-34(31,32)21-8-9-21)22-17-30(18-23(22)26)15-5-10-24(33-2)11-13-25(27,28)14-12-24/h4,6-7,16,21-23,29H,3,5,8-15,17-18H2,1-2H3/t22-,23+,26?
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Sanwa Kagaku Kenkyusho Co., Ltd

US Patent


Assay Description
The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...


US Patent US9663463 (2017)


BindingDB Entry DOI: 10.7270/Q27946RR
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM327429
PNG
(N-(3-{(1R,5S,6r)-3-[3-(4,4-difluoropiperidin-1-yl)...)
Show SMILES CCC1([C@H]2CN(CCCN3CCC(F)(F)CC3)C[C@@H]12)c1cccc(NS(=O)(=O)C2CC2)c1
Show InChI InChI=1S/C24H35F2N3O2S/c1-2-24(18-5-3-6-19(15-18)27-32(30,31)20-7-8-20)21-16-29(17-22(21)24)12-4-11-28-13-9-23(25,26)10-14-28/h3,5-6,15,20-22,27H,2,4,7-14,16-17H2,1H3/t21-,22+,24?
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n/an/a 1.40n/an/an/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

US Patent


Assay Description
The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...


US Patent US9663463 (2017)


BindingDB Entry DOI: 10.7270/Q27946RR
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM327423
PNG
( N-(3-{(1R,5S,6r)-6-ethyl-3-[(2-hydroxy-2,3-dihydr...)
Show SMILES CCC1([C@H]2CN(CC3(O)Cc4ccccc4C3)C[C@@H]12)c1cccc(NS(=O)(=O)C2CC2)c1
Show InChI InChI=1S/C26H32N2O3S/c1-2-26(20-8-5-9-21(12-20)27-32(30,31)22-10-11-22)23-15-28(16-24(23)26)17-25(29)13-18-6-3-4-7-19(18)14-25/h3-9,12,22-24,27,29H,2,10-11,13-17H2,1H3/t23-,24+,26?
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Sanwa Kagaku Kenkyusho Co., Ltd

US Patent


Assay Description
The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...


US Patent US9663463 (2017)


BindingDB Entry DOI: 10.7270/Q27946RR
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM327426
PNG
(N-(3-{(1R,5S,6r)-3-[3-(4,4-difluorocyclohexyl)prop...)
Show SMILES CCC1([C@H]2CN(CCCC3CCC(F)(F)CC3)C[C@@H]12)c1cccc(NS(=O)(=O)C2CC2)c1
Show InChI InChI=1S/C25H36F2N2O2S/c1-2-25(19-6-3-7-20(15-19)28-32(30,31)21-8-9-21)22-16-29(17-23(22)25)14-4-5-18-10-12-24(26,27)13-11-18/h3,6-7,15,18,21-23,28H,2,4-5,8-14,16-17H2,1H3/t22-,23+,25?
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Sanwa Kagaku Kenkyusho Co., Ltd

US Patent


Assay Description
The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...


US Patent US9663463 (2017)


BindingDB Entry DOI: 10.7270/Q27946RR
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM327427
PNG
(N-(3-{(1R,5S,6r)-3-[3-(4,4-difluorocyclohexyl)prop...)
Show SMILES CCC1([C@H]2CN(CCCC3CCC(F)(F)CC3)C[C@@H]12)c1cc(NS(=O)(=O)C2CC2)ccc1F
Show InChI InChI=1S/C25H35F3N2O2S/c1-2-25(20-14-18(5-8-23(20)26)29-33(31,32)19-6-7-19)21-15-30(16-22(21)25)13-3-4-17-9-11-24(27,28)12-10-17/h5,8,14,17,19,21-22,29H,2-4,6-7,9-13,15-16H2,1H3/t21-,22+,25?
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Sanwa Kagaku Kenkyusho Co., Ltd

US Patent


Assay Description
The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...


US Patent US9663463 (2017)


BindingDB Entry DOI: 10.7270/Q27946RR
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM327437
PNG
(N-(3-{(1R,5S,6r)-3-[3-(4,4-difluoropiperidin-1-yl)...)
Show SMILES CCC1([C@H]2CN(CCCN3CCC(F)(F)CC3)C[C@@H]12)c1cc(NS(=O)(=O)C2CC2)ccc1F
Show InChI InChI=1S/C24H34F3N3O2S/c1-2-24(19-14-17(4-7-22(19)25)28-33(31,32)18-5-6-18)20-15-30(16-21(20)24)11-3-10-29-12-8-23(26,27)9-13-29/h4,7,14,18,20-21,28H,2-3,5-6,8-13,15-16H2,1H3/t20-,21+,24?
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n/an/a 1.70n/an/an/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

US Patent


Assay Description
The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...


US Patent US9663463 (2017)


BindingDB Entry DOI: 10.7270/Q27946RR
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM327424
PNG
(N-(3-{(1R,5S,6r)-6-ethyl-3-[(2-hydroxy-2,3-dihydro...)
Show SMILES CCC1([C@H]2CN(CC3(O)Cc4ccccc4C3)C[C@@H]12)c1cc(NS(=O)(=O)C2CC2)ccc1F
Show InChI InChI=1S/C26H31FN2O3S/c1-2-26(21-11-19(7-10-24(21)27)28-33(31,32)20-8-9-20)22-14-29(15-23(22)26)16-25(30)12-17-5-3-4-6-18(17)13-25/h3-7,10-11,20,22-23,28,30H,2,8-9,12-16H2,1H3/t22-,23+,26?
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n/an/a 2n/an/an/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

US Patent


Assay Description
The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...


US Patent US9663463 (2017)


BindingDB Entry DOI: 10.7270/Q27946RR
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM327431
PNG
(N-(3-{(1R,5S,6r)-3-[3-(3,3-difluoropyrrolidin-1-yl...)
Show SMILES CCC1([C@H]2CN(CCCN3CCC(F)(F)C3)C[C@@H]12)c1cc(NS(=O)(=O)C2CC2)ccc1F
Show InChI InChI=1S/C23H32F3N3O2S/c1-2-23(18-12-16(4-7-21(18)24)27-32(30,31)17-5-6-17)19-13-29(14-20(19)23)10-3-9-28-11-8-22(25,26)15-28/h4,7,12,17,19-20,27H,2-3,5-6,8-11,13-15H2,1H3/t19-,20+,23?
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n/an/a 2.5n/an/an/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

US Patent


Assay Description
The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...


US Patent US9663463 (2017)


BindingDB Entry DOI: 10.7270/Q27946RR
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM327433
PNG
(N-(3-{(1R,5S,6r)-6-ethyl-3-[(2-methoxy-2,3-dihydro...)
Show SMILES CCC1([C@H]2CN(CC3(Cc4ccccc4C3)OC)C[C@@H]12)c1cc(NS(=O)(=O)C2CC2)ccc1F
Show InChI InChI=1S/C27H33FN2O3S/c1-3-27(22-12-20(8-11-25(22)28)29-34(31,32)21-9-10-21)23-15-30(16-24(23)27)17-26(33-2)13-18-6-4-5-7-19(18)14-26/h4-8,11-12,21,23-24,29H,3,9-10,13-17H2,1-2H3/t23-,24+,27?
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n/an/a 2.80n/an/an/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

US Patent


Assay Description
The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...


US Patent US9663463 (2017)


BindingDB Entry DOI: 10.7270/Q27946RR
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM327430
PNG
(N-(3-{(1R,5S,6r)-3-[3-(3,3-difluoropyrrolidin-1-yl...)
Show SMILES CCC1([C@H]2CN(CCCN3CCC(F)(F)C3)C[C@@H]12)c1cccc(NS(=O)(=O)C2CC2)c1
Show InChI InChI=1S/C23H33F2N3O2S/c1-2-23(17-5-3-6-18(13-17)26-31(29,30)19-7-8-19)20-14-28(15-21(20)23)11-4-10-27-12-9-22(24,25)16-27/h3,5-6,13,19-21,26H,2,4,7-12,14-16H2,1H3/t20-,21+,23?
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n/an/a 2.90n/an/an/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

US Patent


Assay Description
The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...


US Patent US9663463 (2017)


BindingDB Entry DOI: 10.7270/Q27946RR
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM327438
PNG
(N-(3-{(1R,5S,6r)-3-[3-(3,3-difluoropiperidin-1-yl)...)
Show SMILES CCC1([C@H]2CN(CCCN3CCCC(F)(F)C3)C[C@@H]12)c1cccc(NS(=O)(=O)C2CC2)c1
Show InChI InChI=1S/C24H35F2N3O2S/c1-2-24(18-6-3-7-19(14-18)27-32(30,31)20-8-9-20)21-15-29(16-22(21)24)13-5-12-28-11-4-10-23(25,26)17-28/h3,6-7,14,20-22,27H,2,4-5,8-13,15-17H2,1H3/t21-,22+,24?
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Sanwa Kagaku Kenkyusho Co., Ltd

US Patent


Assay Description
The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...


US Patent US9663463 (2017)


BindingDB Entry DOI: 10.7270/Q27946RR
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM327432
PNG
(N-(3-{(1R,5S,6r)-6-ethyl-3-[(2-hydroxy-2,3-dihydro...)
Show SMILES CCC1([C@H]2CN(CC3(O)Cc4ccccc4C3)C[C@@H]12)c1cc(F)cc(NS(=O)(=O)C2CC2)c1
Show InChI InChI=1S/C26H31FN2O3S/c1-2-26(19-9-20(27)11-21(10-19)28-33(31,32)22-7-8-22)23-14-29(15-24(23)26)16-25(30)12-17-5-3-4-6-18(17)13-25/h3-6,9-11,22-24,28,30H,2,7-8,12-16H2,1H3/t23-,24+,26?
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Sanwa Kagaku Kenkyusho Co., Ltd

US Patent


Assay Description
The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...


US Patent US9663463 (2017)


BindingDB Entry DOI: 10.7270/Q27946RR
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM327425
PNG
(N-(3-{(1R,5S,6r)-6-ethyl-3-[(2-methoxy-2,3-dihydro...)
Show SMILES CCC1([C@H]2CN(CC3(Cc4ccccc4C3)OC)C[C@@H]12)c1cccc(NS(=O)(=O)C2CC2)c1
Show InChI InChI=1S/C27H34N2O3S/c1-3-27(21-9-6-10-22(13-21)28-33(30,31)23-11-12-23)24-16-29(17-25(24)27)18-26(32-2)14-19-7-4-5-8-20(19)15-26/h4-10,13,23-25,28H,3,11-12,14-18H2,1-2H3/t24-,25+,27?
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Sanwa Kagaku Kenkyusho Co., Ltd

US Patent


Assay Description
The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...


US Patent US9663463 (2017)


BindingDB Entry DOI: 10.7270/Q27946RR
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM327442
PNG
(N-(3-{(1R,5S,6r)-3-[(5,6-difluoro-2-hydroxy-2,3-di...)
Show SMILES CCC1([C@H]2CN(CC3(O)Cc4cc(F)c(F)cc4C3)C[C@@H]12)c1cccc(NS(=O)(=O)C2CC2)c1
Show InChI InChI=1S/C26H30F2N2O3S/c1-2-26(18-4-3-5-19(10-18)29-34(32,33)20-6-7-20)21-13-30(14-22(21)26)15-25(31)11-16-8-23(27)24(28)9-17(16)12-25/h3-5,8-10,20-22,29,31H,2,6-7,11-15H2,1H3/t21-,22+,26?
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Sanwa Kagaku Kenkyusho Co., Ltd

US Patent


Assay Description
The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...


US Patent US9663463 (2017)


BindingDB Entry DOI: 10.7270/Q27946RR
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM327435
PNG
(N-(3-{(1R,5S,6r)-3-[(2-ethoxy-2,3-dihydro-1H-inden...)
Show SMILES CCOC1(CN2C[C@H]3[C@@H](C2)C3(CC)c2cccc(NS(=O)(=O)C3CC3)c2)Cc2ccccc2C1
Show InChI InChI=1S/C28H36N2O3S/c1-3-28(22-10-7-11-23(14-22)29-34(31,32)24-12-13-24)25-17-30(18-26(25)28)19-27(33-4-2)15-20-8-5-6-9-21(20)16-27/h5-11,14,24-26,29H,3-4,12-13,15-19H2,1-2H3/t25-,26+,28?
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n/an/a 4.10n/an/an/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

US Patent


Assay Description
The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...


US Patent US9663463 (2017)


BindingDB Entry DOI: 10.7270/Q27946RR
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM327441
PNG
(N-(3-{(1R,5S,6r)-3-[(2-hydroxy-2,3-dihydro-1H-inde...)
Show SMILES OC1(CN2C[C@H]3[C@@H](C2)C3(C=C)c2cccc(NS(=O)(=O)C3CC3)c2)Cc2ccccc2C1
Show InChI InChI=1S/C26H30N2O3S/c1-2-26(20-8-5-9-21(12-20)27-32(30,31)22-10-11-22)23-15-28(16-24(23)26)17-25(29)13-18-6-3-4-7-19(18)14-25/h2-9,12,22-24,27,29H,1,10-11,13-17H2/t23-,24+,26?
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n/an/a 4.5n/an/an/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

US Patent


Assay Description
The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...


US Patent US9663463 (2017)


BindingDB Entry DOI: 10.7270/Q27946RR
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM327439
PNG
(N-(3-{(1R,5S,6r)-3-[(2-hydroxy-2,3-dihydro-1H-inde...)
Show SMILES CC1([C@H]2CN(CC3(O)Cc4ccccc4C3)C[C@@H]12)c1cccc(NS(=O)(=O)C2CC2)c1
Show InChI InChI=1S/C25H30N2O3S/c1-24(19-7-4-8-20(11-19)26-31(29,30)21-9-10-21)22-14-27(15-23(22)24)16-25(28)12-17-5-2-3-6-18(17)13-25/h2-8,11,21-23,26,28H,9-10,12-16H2,1H3/t22-,23+,24?
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n/an/a 5.40n/an/an/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

US Patent


Assay Description
The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...


US Patent US9663463 (2017)


BindingDB Entry DOI: 10.7270/Q27946RR
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM327434
PNG
(N-(3-{(1R,5S,6r)-6-ethyl-3-[(2-methoxy-2,3-dihydro...)
Show SMILES CCC1([C@H]2CN(CC3(Cc4ccccc4C3)OC)C[C@@H]12)c1cc(F)cc(NS(=O)(=O)C2CC2)c1
Show InChI InChI=1S/C27H33FN2O3S/c1-3-27(20-10-21(28)12-22(11-20)29-34(31,32)23-8-9-23)24-15-30(16-25(24)27)17-26(33-2)13-18-6-4-5-7-19(18)14-26/h4-7,10-12,23-25,29H,3,8-9,13-17H2,1-2H3/t24-,25+,27?
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n/an/a 12n/an/an/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

US Patent


Assay Description
The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...


US Patent US9663463 (2017)


BindingDB Entry DOI: 10.7270/Q27946RR
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM327440
PNG
(N-(3-{(1R,5S,6r)-3-[(2-methoxy-2,3-dihydro-1H-inde...)
Show SMILES COC1(CN2C[C@H]3[C@@H](C2)C3(C)c2cccc(NS(=O)(=O)C3CC3)c2)Cc2ccccc2C1
Show InChI InChI=1S/C26H32N2O3S/c1-25(20-8-5-9-21(12-20)27-32(29,30)22-10-11-22)23-15-28(16-24(23)25)17-26(31-2)13-18-6-3-4-7-19(18)14-26/h3-9,12,22-24,27H,10-11,13-17H2,1-2H3/t23-,24+,25?
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n/an/a 16n/an/an/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

US Patent


Assay Description
The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...


US Patent US9663463 (2017)


BindingDB Entry DOI: 10.7270/Q27946RR
More data for this
Ligand-Target Pair
Solute carrier organic anion transporter family member 2B1


(Rattus norvegicus)
BDBM50101853
PNG
((11alpha,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O
Show InChI InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
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n/an/a 36n/an/an/an/an/an/a



Tohoku University School of Medicine

Curated by ChEMBL


Assay Description
TP_TRANSPORTER: inhibition of PGD2 uptake in Xenopus laevis oocytes


Biochem Biophys Res Commun 275: 831-8 (2000)


Article DOI: 10.1006/bbrc.2000.3377
BindingDB Entry DOI: 10.7270/Q2DN46J2
More data for this
Ligand-Target Pair
Solute carrier organic anion transporter family member 2B1


(Rattus norvegicus)
BDBM50035622
PNG
((5Z,13E,15S)-9alpha,11alpha,15-trihydroxyprosta-5,...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1
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n/an/a 287n/an/an/an/an/an/a



Tohoku University School of Medicine

Curated by ChEMBL


Assay Description
TP_TRANSPORTER: inhibition of PGD2 uptake in Xenopus laevis oocytes


Biochem Biophys Res Commun 275: 831-8 (2000)


Article DOI: 10.1006/bbrc.2000.3377
BindingDB Entry DOI: 10.7270/Q2DN46J2
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50387889
PNG
(CHEMBL2058666)
Show SMILES CCc1cnc(nc1)N1CCC(CCCNc2ccc3c(O)coc3c2)CC1
Show InChI InChI=1S/C22H28N4O2/c1-2-16-13-24-22(25-14-16)26-10-7-17(8-11-26)4-3-9-23-18-5-6-19-20(27)15-28-21(19)12-18/h5-6,12-15,17,23,27H,2-4,7-11H2,1H3
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n/an/an/an/a 159n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50387890
PNG
(CHEMBL2058388)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCC(=O)Nc2ccc3c(CCS3(=O)=O)c2)CC1
Show InChI InChI=1S/C22H32N2O5S/c1-22(2,3)29-21(26)24-12-9-16(10-13-24)5-4-6-20(25)23-18-7-8-19-17(15-18)11-14-30(19,27)28/h7-8,15-16H,4-6,9-14H2,1-3H3,(H,23,25)
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n/an/an/an/a 2.61E+3n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50387891
PNG
(CHEMBL2058389)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCCNc2ccc3c(CCS3(=O)=O)c2)CC1
Show InChI InChI=1S/C22H34N2O4S/c1-22(2,3)28-21(25)24-13-9-17(10-14-24)6-4-5-12-23-19-7-8-20-18(16-19)11-15-29(20,26)27/h7-8,16-17,23H,4-6,9-15H2,1-3H3
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n/an/an/an/a 210n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50387892
PNG
(CHEMBL2058390)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCCCNc2ccc3c(CCS3(=O)=O)c2)CC1
Show InChI InChI=1S/C23H36N2O4S/c1-23(2,3)29-22(26)25-14-10-18(11-15-25)7-5-4-6-13-24-20-8-9-21-19(17-20)12-16-30(21,27)28/h8-9,17-18,24H,4-7,10-16H2,1-3H3
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n/an/an/an/a 145n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50387893
PNG
(CHEMBL2058391)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3c(CCS3(=O)=O)c2)CC1
Show InChI InChI=1S/C21H32N2O4S/c1-21(2,3)27-20(24)23-12-8-16(9-13-23)5-4-11-22-18-6-7-19-17(15-18)10-14-28(19,25)26/h6-7,15-16,22H,4-5,8-14H2,1-3H3
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n/an/an/an/a 270n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50387894
PNG
(CHEMBL2058394)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCOc2ccc3c(CCS3(=O)=O)c2)CC1
Show InChI InChI=1S/C21H31NO5S/c1-21(2,3)27-20(23)22-11-8-16(9-12-22)5-4-13-26-18-6-7-19-17(15-18)10-14-28(19,24)25/h6-7,15-16H,4-5,8-14H2,1-3H3
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n/an/an/an/a 736n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50387895
PNG
(CHEMBL2058395)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3c(OCS3(=O)=O)c2)CC1
Show InChI InChI=1S/C20H30N2O5S/c1-20(2,3)27-19(23)22-11-8-15(9-12-22)5-4-10-21-16-6-7-18-17(13-16)26-14-28(18,24)25/h6-7,13,15,21H,4-5,8-12,14H2,1-3H3
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n/an/an/an/a 254n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50387896
PNG
(CHEMBL2058396)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3c(OCCS3(=O)=O)c2)CC1
Show InChI InChI=1S/C21H32N2O5S/c1-21(2,3)28-20(24)23-11-8-16(9-12-23)5-4-10-22-17-6-7-19-18(15-17)27-13-14-29(19,25)26/h6-7,15-16,22H,4-5,8-14H2,1-3H3
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n/an/an/an/a 511n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50387897
PNG
(CHEMBL2058397)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3c(NNS3(=O)=O)c2)CC1
Show InChI InChI=1S/C19H30N4O4S/c1-19(2,3)27-18(24)23-11-8-14(9-12-23)5-4-10-20-15-6-7-17-16(13-15)21-22-28(17,25)26/h6-7,13-14,20-22H,4-5,8-12H2,1-3H3
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n/an/an/an/a 268n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50387898
PNG
(CHEMBL2058399)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3c(CCCCC3=O)c2)CC1
Show InChI InChI=1S/C24H36N2O3/c1-24(2,3)29-23(28)26-15-12-18(13-16-26)7-6-14-25-20-10-11-21-19(17-20)8-4-5-9-22(21)27/h10-11,17-18,25H,4-9,12-16H2,1-3H3
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n/an/an/an/a 770n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50387899
PNG
(CHEMBL2058400)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3c(O)coc3c2)CC1
Show InChI InChI=1S/C21H30N2O4/c1-21(2,3)27-20(25)23-11-8-15(9-12-23)5-4-10-22-16-6-7-17-18(24)14-26-19(17)13-16/h6-7,13-15,22,24H,4-5,8-12H2,1-3H3
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n/an/an/an/a 52n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50387902
PNG
(CHEMBL2058403)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3CCC(=O)c3c2)CC1
Show InChI InChI=1S/C22H32N2O3/c1-22(2,3)27-21(26)24-13-10-16(11-14-24)5-4-12-23-18-8-6-17-7-9-20(25)19(17)15-18/h6,8,15-16,23H,4-5,7,9-14H2,1-3H3
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n/an/an/an/a 46n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50387903
PNG
(CHEMBL2058404)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3occ(O)c3c2)CC1
Show InChI InChI=1S/C21H30N2O4/c1-21(2,3)27-20(25)23-11-8-15(9-12-23)5-4-10-22-16-6-7-19-17(13-16)18(24)14-26-19/h6-7,13-15,22,24H,4-5,8-12H2,1-3H3
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n/an/an/an/a 88n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50387904
PNG
(CHEMBL2058405)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3OCCC(=O)c3c2)CC1
Show InChI InChI=1S/C22H32N2O4/c1-22(2,3)28-21(26)24-12-8-16(9-13-24)5-4-11-23-17-6-7-20-18(15-17)19(25)10-14-27-20/h6-7,15-16,23H,4-5,8-14H2,1-3H3
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n/an/an/an/a 272n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50387905
PNG
(CHEMBL2058406)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3CNC(=O)c3c2)CC1
Show InChI InChI=1S/C21H31N3O3/c1-21(2,3)27-20(26)24-11-8-15(9-12-24)5-4-10-22-17-7-6-16-14-23-19(25)18(16)13-17/h6-7,13,15,22H,4-5,8-12,14H2,1-3H3,(H,23,25)
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n/an/an/an/a 734n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50387889
PNG
(CHEMBL2058666)
Show SMILES CCc1cnc(nc1)N1CCC(CCCNc2ccc3c(O)coc3c2)CC1
Show InChI InChI=1S/C22H28N4O2/c1-2-16-13-24-22(25-14-16)26-10-7-17(8-11-26)4-3-9-23-18-5-6-19-20(27)15-28-21(19)12-18/h5-6,12-15,17,23,27H,2-4,7-11H2,1H3
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n/an/an/an/a 117n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50387906
PNG
(CHEMBL2058667)
Show SMILES COc1cnc(nc1)N1CCC(CCCNc2ccc3c(O)coc3c2)CC1
Show InChI InChI=1S/C21H26N4O3/c1-27-17-12-23-21(24-13-17)25-9-6-15(7-10-25)3-2-8-22-16-4-5-18-19(26)14-28-20(18)11-16/h4-5,11-15,22,26H,2-3,6-10H2,1H3
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n/an/an/an/a 115n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50387907
PNG
(CHEMBL2058668)
Show SMILES COC(=O)c1cnc(nc1)N1CCC(CCCNc2ccc3c(O)coc3c2)CC1
Show InChI InChI=1S/C22H26N4O4/c1-29-21(28)16-12-24-22(25-13-16)26-9-6-15(7-10-26)3-2-8-23-17-4-5-18-19(27)14-30-20(18)11-17/h4-5,11-15,23,27H,2-3,6-10H2,1H3
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n/an/an/an/a 149n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50387908
PNG
(CHEMBL2058669)
Show SMILES CC(C)c1noc(n1)N1CCC(CCCNc2ccc3c(O)coc3c2)CC1
Show InChI InChI=1S/C21H28N4O3/c1-14(2)20-23-21(28-24-20)25-10-7-15(8-11-25)4-3-9-22-16-5-6-17-18(26)13-27-19(17)12-16/h5-6,12-15,22,26H,3-4,7-11H2,1-2H3
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n/an/an/an/a 73n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50387909
PNG
(CHEMBL2058670)
Show SMILES CC(C)c1nc(no1)N1CCC(CCCNc2ccc3c(O)coc3c2)CC1
Show InChI InChI=1S/C21H28N4O3/c1-14(2)20-23-21(24-28-20)25-10-7-15(8-11-25)4-3-9-22-16-5-6-17-18(26)13-27-19(17)12-16/h5-6,12-15,22,26H,3-4,7-11H2,1-2H3
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n/an/an/an/a 161n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50387910
PNG
(CHEMBL2058671)
Show SMILES CC(C)c1nnc(o1)N1CCC(CCCNc2ccc3c(O)coc3c2)CC1
Show InChI InChI=1S/C21H28N4O3/c1-14(2)20-23-24-21(28-20)25-10-7-15(8-11-25)4-3-9-22-16-5-6-17-18(26)13-27-19(17)12-16/h5-6,12-15,22,26H,3-4,7-11H2,1-2H3
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n/an/an/an/a 704n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50387911
PNG
(CHEMBL2058672)
Show SMILES CC(C)c1nsc(n1)N1CCC(CCCNc2ccc3c(O)coc3c2)CC1
Show InChI InChI=1S/C21H28N4O2S/c1-14(2)20-23-21(28-24-20)25-10-7-15(8-11-25)4-3-9-22-16-5-6-17-18(26)13-27-19(17)12-16/h5-6,12-15,22,26H,3-4,7-11H2,1-2H3
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n/an/an/an/a 121n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50387912
PNG
(CHEMBL2058673)
Show SMILES CCc1cnc(nc1)N1CCC(CCCNc2ccc3CCC(=O)c3c2)CC1
Show InChI InChI=1S/C23H30N4O/c1-2-17-15-25-23(26-16-17)27-12-9-18(10-13-27)4-3-11-24-20-7-5-19-6-8-22(28)21(19)14-20/h5,7,14-16,18,24H,2-4,6,8-13H2,1H3
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n/an/an/an/a 51n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50387913
PNG
(CHEMBL2058674)
Show SMILES CC(C)c1noc(n1)N1CCC(CCCNc2ccc3CCC(=O)c3c2)CC1
Show InChI InChI=1S/C22H30N4O2/c1-15(2)21-24-22(28-25-21)26-12-9-16(10-13-26)4-3-11-23-18-7-5-17-6-8-20(27)19(17)14-18/h5,7,14-16,23H,3-4,6,8-13H2,1-2H3
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n/an/an/an/a 58n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50387893
PNG
(CHEMBL2058391)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3c(CCS3(=O)=O)c2)CC1
Show InChI InChI=1S/C21H32N2O4S/c1-21(2,3)27-20(24)23-12-8-16(9-13-23)5-4-11-22-18-6-7-19-17(15-18)10-14-28(19,25)26/h6-7,15-16,22H,4-5,8-14H2,1-3H3
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n/an/an/an/a 224n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50387895
PNG
(CHEMBL2058395)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3c(OCS3(=O)=O)c2)CC1
Show InChI InChI=1S/C20H30N2O5S/c1-20(2,3)27-19(23)22-11-8-15(9-12-22)5-4-10-21-16-6-7-18-17(13-16)26-14-28(18,24)25/h6-7,13,15,21H,4-5,8-12,14H2,1-3H3
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n/an/an/an/a 266n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
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