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Compile Data Set for Download or QSAR

Found 802 hits with Last Name = 'olhava' and Initial = 'ej'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone-lysine N-methyltransferase, H3 lysine-79 specific


(Homo sapiens (Human))
BDBM92649
PNG
(EPZ004777)
Show SMILES CC(C)N(CCCNC(=O)Nc1ccc(cc1)C(C)(C)C)CC1OC([C@H](O)[C@@H]1O)n1ccc2c(N)ncnc12
Show InChI InChI=1S/C28H41N7O4/c1-17(2)34(13-6-12-30-27(38)33-19-9-7-18(8-10-19)28(3,4)5)15-21-22(36)23(37)26(39-21)35-14-11-20-24(29)31-16-32-25(20)35/h7-11,14,16-17,21-23,26,36-37H,6,12-13,15H2,1-5H3,(H2,29,31,32)(H2,30,33,38)/t21?,22-,23-,26?/m1/s1
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0.300n/an/a 0.100n/an/an/an/an/a



Epizyme Inc



Assay Description
Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.


Chem Biol Drug Des 80: 971-80 (2012)


Article DOI: 10.1111/cbdd.12050
BindingDB Entry DOI: 10.7270/Q2Z89B12
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase, H3 lysine-79 specific


(Homo sapiens (Human))
BDBM297395
PNG
(US10112968, Compound D16)
Show SMILES CC(C)N(CCCNC(=O)Nc1ccc(cc1)C(C)(C)C)C[C@H]1OC(C(O)[C@@H]1O)n1ccc2c(N)ncnc12
Show InChI InChI=1S/C28H41N7O4/c1-17(2)34(13-6-12-30-27(38)33-19-9-7-18(8-10-19)28(3,4)5)15-21-22(36)23(37)26(39-21)35-14-11-20-24(29)31-16-32-25(20)35/h7-11,14,16-17,21-23,26,36-37H,6,12-13,15H2,1-5H3,(H2,29,31,32)(H2,30,33,38)/t21-,22-,23?,26?/m1/s1
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0.300n/an/a 0.0100n/a 0.000300 3.00E+6n/an/a



Epizyme Inc

US Patent


Assay Description
Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...


US Patent US10112968 (2018)


Article DOI: 10.1016/j.bmcl.2005.03.024
BindingDB Entry DOI: 10.7270/Q20R9RFJ
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase, H3 lysine-79 specific


(Homo sapiens (Human))
BDBM92648
PNG
(EPZ004450)
Show SMILES CN(CCCNC(=O)Nc1ccc(cc1)C(C)(C)C)CC1OC([C@H](O)[C@@H]1O)n1ccc2c(N)ncnc12
Show InChI InChI=1S/C26H37N7O4/c1-26(2,3)16-6-8-17(9-7-16)31-25(36)28-11-5-12-32(4)14-19-20(34)21(35)24(37-19)33-13-10-18-22(27)29-15-30-23(18)33/h6-10,13,15,19-21,24,34-35H,5,11-12,14H2,1-4H3,(H2,27,29,30)(H2,28,31,36)/t19?,20-,21-,24?/m1/s1
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4n/an/an/an/an/an/an/an/a



Epizyme Inc



Assay Description
Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.


Chem Biol Drug Des 80: 971-80 (2012)


Article DOI: 10.1111/cbdd.12050
BindingDB Entry DOI: 10.7270/Q2Z89B12
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase, H3 lysine-79 specific


(Homo sapiens (Human))
BDBM92647
PNG
(EPZ003696)
Show SMILES CN(CCCNC(=O)Nc1ccc(cc1)C(C)(C)C)CC1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C25H36N8O4/c1-25(2,3)15-6-8-16(9-7-15)31-24(36)27-10-5-11-32(4)12-17-19(34)20(35)23(37-17)33-14-30-18-21(26)28-13-29-22(18)33/h6-9,13-14,17,19-20,23,34-35H,5,10-12H2,1-4H3,(H2,26,28,29)(H2,27,31,36)/t17?,19-,20-,23?/m1/s1
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13n/an/an/an/an/an/an/an/a



Epizyme Inc



Assay Description
Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.


Chem Biol Drug Des 80: 971-80 (2012)


Article DOI: 10.1111/cbdd.12050
BindingDB Entry DOI: 10.7270/Q2Z89B12
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase, H3 lysine-79 specific


(Homo sapiens (Human))
BDBM297394
PNG
(US10112968, Compound C118)
Show SMILES CN(CCCNC(=O)Nc1ccc(cc1)C(C)(C)C)C[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C25H36N8O4/c1-25(2,3)15-6-8-16(9-7-15)31-24(36)27-10-5-11-32(4)12-17-19(34)20(35)23(37-17)33-14-30-18-21(26)28-13-29-22(18)33/h6-9,13-14,17,19-20,23,34-35H,5,10-12H2,1-4H3,(H2,26,28,29)(H2,27,31,36)/t17-,19-,20-,23?/m1/s1
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13n/an/a 1.70n/a 0.0200 1.20E+7n/an/a



Epizyme Inc

US Patent


Assay Description
Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...


US Patent US10112968 (2018)


Article DOI: 10.1016/j.bmcl.2005.03.024
BindingDB Entry DOI: 10.7270/Q20R9RFJ
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase, H3 lysine-79 specific


(Homo sapiens (Human))
BDBM92642
PNG
(SAH)
Show SMILES NC(CCSCC1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6?,7?,9-,10-,13?/m1/s1
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320n/an/a 71n/an/an/an/an/a



Epizyme Inc



Assay Description
Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.


Chem Biol Drug Des 80: 971-80 (2012)


Article DOI: 10.1111/cbdd.12050
BindingDB Entry DOI: 10.7270/Q2Z89B12
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase, H3 lysine-79 specific


(Homo sapiens (Human))
BDBM297392
PNG
(US10112968, Compound SAH)
Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)OC=O
Show InChI InChI=1S/C14H20N6O5S/c15-8(24-6-21)1-2-26-3-7-10(22)11(23)14(25-7)20-5-19-9-12(16)17-4-18-13(9)20/h4-8,10-11,14,22-23H,1-3,15H2,(H2,16,17,18)/t7-,8-,10-,11-,14-/m1/s1
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320n/an/a 71n/a 0.100 1.40E+6n/an/a



Epizyme Inc

US Patent


Assay Description
Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...


US Patent US10112968 (2018)


Article DOI: 10.1016/j.bmcl.2005.03.024
BindingDB Entry DOI: 10.7270/Q20R9RFJ
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase, H3 lysine-79 specific


(Homo sapiens (Human))
BDBM297393
PNG
(US10112968, Compound C94)
Show SMILES CN(CCNC(=O)Nc1ccc(cc1)C(C)(C)C)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C24H34N8O4/c1-24(2,3)14-5-7-15(8-6-14)30-23(35)26-9-10-31(4)11-16-18(33)19(34)22(36-16)32-13-29-17-20(25)27-12-28-21(17)32/h5-8,12-13,16,18-19,22,33-34H,9-11H2,1-4H3,(H2,25,27,28)(H2,26,30,35)/t16-,18-,19-,22-/m1/s1
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845n/an/a 167n/a 0.200 1.20E+6n/an/a



Epizyme Inc

US Patent


Assay Description
Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...


US Patent US10112968 (2018)


Article DOI: 10.1016/j.bmcl.2005.03.024
BindingDB Entry DOI: 10.7270/Q20R9RFJ
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase, H3 lysine-79 specific


(Homo sapiens (Human))
BDBM92646
PNG
(EPZ003647)
Show SMILES CN(CCNC(=O)Nc1ccc(cc1)C(C)(C)C)CC1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C24H34N8O4/c1-24(2,3)14-5-7-15(8-6-14)30-23(35)26-9-10-31(4)11-16-18(33)19(34)22(36-16)32-13-29-17-20(25)27-12-28-21(17)32/h5-8,12-13,16,18-19,22,33-34H,9-11H2,1-4H3,(H2,25,27,28)(H2,26,30,35)/t16?,18-,19-,22?/m1/s1
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845n/an/a 167n/an/an/an/an/a



Epizyme Inc



Assay Description
Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.


Chem Biol Drug Des 80: 971-80 (2012)


Article DOI: 10.1111/cbdd.12050
BindingDB Entry DOI: 10.7270/Q2Z89B12
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase, H3 lysine-79 specific


(Homo sapiens (Human))
BDBM92644
PNG
(EPZ002446)
Show SMILES CC(C)N(C)CC1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C14H22N6O3/c1-7(2)19(3)4-8-10(21)11(22)14(23-8)20-6-18-9-12(15)16-5-17-13(9)20/h5-8,10-11,14,21-22H,4H2,1-3H3,(H2,15,16,17)/t8?,10-,11-,14?/m1/s1
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1.20E+4n/an/an/an/an/an/an/an/a



Epizyme Inc



Assay Description
Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.


Chem Biol Drug Des 80: 971-80 (2012)


Article DOI: 10.1111/cbdd.12050
BindingDB Entry DOI: 10.7270/Q2Z89B12
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase, H3 lysine-79 specific


(Homo sapiens (Human))
BDBM92645
PNG
(EPZ003144)
Show SMILES CN(CCNC(=O)OCC1c2ccccc2-c2ccccc12)CC1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C28H31N7O5/c1-34(12-21-23(36)24(37)27(40-21)35-15-33-22-25(29)31-14-32-26(22)35)11-10-30-28(38)39-13-20-18-8-4-2-6-16(18)17-7-3-5-9-19(17)20/h2-9,14-15,20-21,23-24,27,36-37H,10-13H2,1H3,(H,30,38)(H2,29,31,32)/t21?,23-,24-,27?/m1/s1
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2.00E+4n/an/an/an/an/an/an/an/a



Epizyme Inc



Assay Description
Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.


Chem Biol Drug Des 80: 971-80 (2012)


Article DOI: 10.1111/cbdd.12050
BindingDB Entry DOI: 10.7270/Q2Z89B12
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase, H3 lysine-79 specific


(Homo sapiens (Human))
BDBM92643
PNG
(EPZ000004)
Show SMILES CN(C)CC1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C12H18N6O3/c1-17(2)3-6-8(19)9(20)12(21-6)18-5-16-7-10(13)14-4-15-11(7)18/h4-6,8-9,12,19-20H,3H2,1-2H3,(H2,13,14,15)/t6?,8-,9-,12?/m1/s1
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3.80E+4n/an/an/an/an/an/an/an/a



Epizyme Inc



Assay Description
Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.


Chem Biol Drug Des 80: 971-80 (2012)


Article DOI: 10.1111/cbdd.12050
BindingDB Entry DOI: 10.7270/Q2Z89B12
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase, H3 lysine-79 specific


(Homo sapiens (Human))
BDBM297391
PNG
((2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3...)
Show SMILES CC(C)N(CC1OC([C@@H](O)C1O)n1cnc2c(N)ncnc12)C1CC(CCc2nc3cc(c(Cl)cc3[nH]2)C(F)(F)F)C1
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n/an/a 0.590n/an/an/an/an/an/a



Epizyme Inc

US Patent


Assay Description
Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...


US Patent US10112968 (2018)


Article DOI: 10.1016/j.bmcl.2005.03.024
BindingDB Entry DOI: 10.7270/Q20R9RFJ
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase, H3 lysine-79 specific


(Homo sapiens (Human))
BDBM297390
PNG
((2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1s,3...)
Show SMILES CC(C)N(CC1OC([C@H](O)C1O)n1cnc2c(N)ncnc12)C1CC(CCc2nc3ccc(cc3[nH]2)C(C)(C)C)C1
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n/an/a 0.730n/an/an/an/an/an/a



Epizyme Inc

US Patent


Assay Description
Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...


US Patent US10112968 (2018)


Article DOI: 10.1016/j.bmcl.2005.03.024
BindingDB Entry DOI: 10.7270/Q20R9RFJ
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase, H3 lysine-79 specific


(Homo sapiens (Human))
BDBM297389
PNG
((2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3...)
Show SMILES CC(C)N(CC1OC([C@@H](O)C1O)n1cnc2c(N)ncnc12)C1CC(CCc2nc3ccc(cc3[nH]2)C(C)(C)C)C1
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n/an/a 0.740n/an/an/an/an/an/a



Epizyme Inc

US Patent


Assay Description
Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...


US Patent US10112968 (2018)


Article DOI: 10.1016/j.bmcl.2005.03.024
BindingDB Entry DOI: 10.7270/Q20R9RFJ
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase, H3 lysine-79 specific


(Homo sapiens (Human))
BDBM121392
PNG
(US8722877, 17)
Show SMILES CC(C)N(CCCNC(=O)Nc1ccc(cc1)C(C)(C)C)CC1O[C@H]([C@H](O)[C@@H]1O)n1ccc2c(N)ncnc12
Show InChI InChI=1S/C28H41N7O4/c1-17(2)34(13-6-12-30-27(38)33-19-9-7-18(8-10-19)28(3,4)5)15-21-22(36)23(37)26(39-21)35-14-11-20-24(29)31-16-32-25(20)35/h7-11,14,16-17,21-23,26,36-37H,6,12-13,15H2,1-5H3,(H2,29,31,32)(H2,30,33,38)/t21?,22-,23-,26-/m1/s1
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n/an/a<1n/an/an/an/a8.025



Epizyme Inc

US Patent


Assay Description
Compound was serially diluted 3 fold in DMSO for 10 points and 1 μl was plated in a 384 well microtiter plate. Positive control (100% inhibition...


US Patent US8722877 (2014)


BindingDB Entry DOI: 10.7270/Q2X63KKV
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase, H3 lysine-79 specific


(Homo sapiens (Human))
BDBM121391
PNG
(US8722877, 9)
Show SMILES CN(CCCNC(=O)Nc1ccc(cc1)C(C)(C)C)CC1O[C@H]([C@H](O)[C@@H]1O)n1ccc2c(N)ncnc12
Show InChI InChI=1S/C26H37N7O4/c1-26(2,3)16-6-8-17(9-7-16)31-25(36)28-11-5-12-32(4)14-19-20(34)21(35)24(37-19)33-13-10-18-22(27)29-15-30-23(18)33/h6-10,13,15,19-21,24,34-35H,5,11-12,14H2,1-4H3,(H2,27,29,30)(H2,28,31,36)/t19?,20-,21-,24-/m1/s1
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n/an/a 6n/an/an/an/a8.025



Epizyme Inc

US Patent


Assay Description
Compound was serially diluted 3 fold in DMSO for 10 points and 1 μl was plated in a 384 well microtiter plate. Positive control (100% inhibition...


US Patent US8722877 (2014)


BindingDB Entry DOI: 10.7270/Q2X63KKV
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase, H3 lysine-79 specific


(Homo sapiens (Human))
BDBM121393
PNG
(US8722877, 18)
Show SMILES CC(C)N(CCCNC(=O)Nc1nc2ccc(cc2[nH]1)C(C)(C)C)CC1O[C@H]([C@H](O)[C@@H]1O)n1ccc2c(N)ncnc12
Show InChI InChI=1S/C29H41N9O4/c1-16(2)37(14-21-22(39)23(40)26(42-21)38-12-9-18-24(30)32-15-33-25(18)38)11-6-10-31-28(41)36-27-34-19-8-7-17(29(3,4)5)13-20(19)35-27/h7-9,12-13,15-16,21-23,26,39-40H,6,10-11,14H2,1-5H3,(H2,30,32,33)(H3,31,34,35,36,41)/t21?,22-,23-,26-/m1/s1
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n/an/a<10n/an/an/an/a8.025



Epizyme Inc

US Patent


Assay Description
Compound was serially diluted 3 fold in DMSO for 10 points and 1 μl was plated in a 384 well microtiter plate. Positive control (100% inhibition...


US Patent US8722877 (2014)


BindingDB Entry DOI: 10.7270/Q2X63KKV
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM325938
PNG
(US10273223, Compound B-32 | US9637472, Compound B-...)
Show SMILES CC(C)n1ncc2c(cc(nc12)C1=CCN(CC1)C(=O)C1CCCN(C)C1)C(=O)NCc1c(C)cc(C)[nH]c1=O
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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM325939
PNG
(US10273223, Compound B-33 | US9637472, Compound B-...)
Show SMILES CC(C)n1ncc2c(cc(nc12)C1=CCN(CC1)C1CCN(CCS(C)(=O)=O)CC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C31H43N7O4S/c1-20(2)38-29-27(19-33-38)25(30(39)32-18-26-21(3)16-22(4)34-31(26)40)17-28(35-29)23-6-12-37(13-7-23)24-8-10-36(11-9-24)14-15-43(5,41)42/h6,16-17,19-20,24H,7-15,18H2,1-5H3,(H,32,39)(H,34,40)
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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM325940
PNG
(US10273223, Compound B-34 | US9637472, Compound B-...)
Show SMILES CC(C)n1ncc2c(cc(nc12)C1=CCN(CC1)C(=O)C1CCN(C)CC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C30H39N7O3/c1-18(2)37-27-25(17-32-37)23(28(38)31-16-24-19(3)14-20(4)33-29(24)39)15-26(34-27)21-8-12-36(13-9-21)30(40)22-6-10-35(5)11-7-22/h8,14-15,17-18,22H,6-7,9-13,16H2,1-5H3,(H,31,38)(H,33,39)
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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM325941
PNG
(US10273223, Compound B-35 | US9637472, Compound B-...)
Show SMILES CC(C)n1ncc2c(cc(nc12)C1CCN(CC1)C1CCN(CC1)S(C)(=O)=O)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C29H41N7O4S/c1-18(2)36-27-25(17-31-36)23(28(37)30-16-24-19(3)14-20(4)32-29(24)38)15-26(33-27)21-6-10-34(11-7-21)22-8-12-35(13-9-22)41(5,39)40/h14-15,17-18,21-22H,6-13,16H2,1-5H3,(H,30,37)(H,32,38)
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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326097
PNG
(US10273223, Compound C-30 | US9637472, Compound C-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2cnc(N)nc2)c(=O)[nH]1
Show InChI InChI=1S/C25H27N7O2/c1-14-7-15(2)31-24(34)20(14)12-27-23(33)19-8-16(17-10-28-25(26)29-11-17)9-22-21(19)13-30-32(22)18-5-3-4-6-18/h7-11,13,18H,3-6,12H2,1-2H3,(H,27,33)(H,31,34)(H2,26,28,29)
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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326098
PNG
(US10273223, Compound C-31 | US9637472, Compound C-...)
Show SMILES CN(C)Cc1ccc(cc1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCN(CC3)C(=O)C(C)(C)C)c2c1
Show InChI InChI=1S/C35H44N6O3/c1-22-16-23(2)38-33(43)29(22)19-36-32(42)28-17-26(25-10-8-24(9-11-25)21-39(6)7)18-31-30(28)20-37-41(31)27-12-14-40(15-13-27)34(44)35(3,4)5/h8-11,16-18,20,27H,12-15,19,21H2,1-7H3,(H,36,42)(H,38,43)
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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326099
PNG
(US10273223, Compound C-32 | US9637472, Compound C-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2ccc(CN3CCOCC3)cc2Cl)c(=O)[nH]1
Show InChI InChI=1S/C32H36ClN5O3/c1-20-13-21(2)36-32(40)27(20)17-34-31(39)26-15-23(16-30-28(26)18-35-38(30)24-5-3-4-6-24)25-8-7-22(14-29(25)33)19-37-9-11-41-12-10-37/h7-8,13-16,18,24H,3-6,9-12,17,19H2,1-2H3,(H,34,39)(H,36,40)
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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326100
PNG
(US10273223, Compound C-33 | US9637472, Compound C-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2cnn(CCN3CCOCC3)c2)c(=O)[nH]1
Show InChI InChI=1S/C30H37N7O3/c1-20-13-21(2)34-30(39)26(20)17-31-29(38)25-14-22(15-28-27(25)18-33-37(28)24-5-3-4-6-24)23-16-32-36(19-23)8-7-35-9-11-40-12-10-35/h13-16,18-19,24H,3-12,17H2,1-2H3,(H,31,38)(H,34,39)
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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326101
PNG
(US10273223, Compound C-34 | US9637472, Compound C-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCN(CC2)C(=O)C(C)(C)C)-c2cnn(CCN3CCOCC3)c2)c(=O)[nH]1
Show InChI InChI=1S/C35H46N8O4/c1-23-16-24(2)39-33(45)29(23)20-36-32(44)28-17-25(26-19-37-42(22-26)11-10-40-12-14-47-15-13-40)18-31-30(28)21-38-43(31)27-6-8-41(9-7-27)34(46)35(3,4)5/h16-19,21-22,27H,6-15,20H2,1-5H3,(H,36,44)(H,39,45)
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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326102
PNG
(US10273223, Compound C-35 | US9637472, Compound C-...)
Show SMILES CN(C)CCCOc1ccc(cc1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C32H39N5O3/c1-21-16-22(2)35-32(39)28(21)19-33-31(38)27-17-24(18-30-29(27)20-34-37(30)25-8-5-6-9-25)23-10-12-26(13-11-23)40-15-7-14-36(3)4/h10-13,16-18,20,25H,5-9,14-15,19H2,1-4H3,(H,33,38)(H,35,39)
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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326104
PNG
(US10273223, Compound D-2 | US9637472, Compound D-2)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)C2=CC(C)(C)NC(C)(C)C2)c(=O)[nH]1
Show InChI InChI=1S/C30H39N5O2/c1-18-11-19(2)33-28(37)24(18)16-31-27(36)23-12-20(21-14-29(3,4)34-30(5,6)15-21)13-26-25(23)17-32-35(26)22-9-7-8-10-22/h11-14,17,22,34H,7-10,15-16H2,1-6H3,(H,31,36)(H,33,37)
PDB

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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326105
PNG
(US10273223, Compound D-3 | US9637472, Compound D-3)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)C2CC(C)(C)NC(C)(C)C2)c(=O)[nH]1
Show InChI InChI=1S/C30H41N5O2/c1-18-11-19(2)33-28(37)24(18)16-31-27(36)23-12-20(21-14-29(3,4)34-30(5,6)15-21)13-26-25(23)17-32-35(26)22-9-7-8-10-22/h11-13,17,21-22,34H,7-10,14-16H2,1-6H3,(H,31,36)(H,33,37)
PDB

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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326106
PNG
(US10273223, Compound D-4 | US9637472, Compound D-4)
Show SMILES CC(=O)N1CCC(=CC1)c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C28H33N5O3/c1-17-12-18(2)31-28(36)24(17)15-29-27(35)23-13-21(20-8-10-32(11-9-20)19(3)34)14-26-25(23)16-30-33(26)22-6-4-5-7-22/h8,12-14,16,22H,4-7,9-11,15H2,1-3H3,(H,29,35)(H,31,36)
PDB

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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326107
PNG
(US10273223, Compound D-5 | US9637472, Compound D-5)
Show SMILES CN1CCC(CC1)C(=O)N1CCC(=CC1)c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C33H42N6O3/c1-21-16-22(2)36-32(41)28(21)19-34-31(40)27-17-25(18-30-29(27)20-35-39(30)26-6-4-5-7-26)23-10-14-38(15-11-23)33(42)24-8-12-37(3)13-9-24/h10,16-18,20,24,26H,4-9,11-15,19H2,1-3H3,(H,34,40)(H,36,41)
PDB

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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326108
PNG
(US10273223, Compound D-6 | US9637472, Compound D-6)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)C2CCN(CC2)C2CCNCC2)c(=O)[nH]1
Show InChI InChI=1S/C31H42N6O2/c1-20-15-21(2)35-31(39)27(20)18-33-30(38)26-16-23(17-29-28(26)19-34-37(29)25-5-3-4-6-25)22-9-13-36(14-10-22)24-7-11-32-12-8-24/h15-17,19,22,24-25,32H,3-14,18H2,1-2H3,(H,33,38)(H,35,39)
PDB

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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326109
PNG
(US10273223, Compound D-7 | US9637472, Compound D-7)
Show SMILES CN1CCN(Cc2cc(C(=O)NCc3c(C)cc(C)[nH]c3=O)c3cnn(C4CCCC4)c3c2)CC1
Show InChI InChI=1S/C27H36N6O2/c1-18-12-19(2)30-27(35)23(18)15-28-26(34)22-13-20(17-32-10-8-31(3)9-11-32)14-25-24(22)16-29-33(25)21-6-4-5-7-21/h12-14,16,21H,4-11,15,17H2,1-3H3,(H,28,34)(H,30,35)
PDB

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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326112
PNG
(US10273223, Compound D-10 | US9637472, Compound D-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(Cl)cc3n(ncc23)C2CCCC2)c(=O)[nH]1
Show InChI InChI=1S/C21H23ClN4O2/c1-12-7-13(2)25-21(28)17(12)10-23-20(27)16-8-14(22)9-19-18(16)11-24-26(19)15-5-3-4-6-15/h7-9,11,15H,3-6,10H2,1-2H3,(H,23,27)(H,25,28)
PDB

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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326114
PNG
(US10273223, Compound D-12 | US9637472, Compound D-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(Br)cc3n(ncc23)C2CCN(CC2)C(=O)OC(C)(C)C)c(=O)[nH]1
Show InChI InChI=1S/C26H32BrN5O4/c1-15-10-16(2)30-24(34)20(15)13-28-23(33)19-11-17(27)12-22-21(19)14-29-32(22)18-6-8-31(9-7-18)25(35)36-26(3,4)5/h10-12,14,18H,6-9,13H2,1-5H3,(H,28,33)(H,30,34)
PDB

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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326115
PNG
(US10273223, Compound D-13 | US9637472, Compound D-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(Br)cc3n(ncc23)C2CCN(CC2)C(=O)C(C)(C)C)c(=O)[nH]1
Show InChI InChI=1S/C26H32BrN5O3/c1-15-10-16(2)30-24(34)20(15)13-28-23(33)19-11-17(27)12-22-21(19)14-29-32(22)18-6-8-31(9-7-18)25(35)26(3,4)5/h10-12,14,18H,6-9,13H2,1-5H3,(H,28,33)(H,30,34)
PDB

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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326116
PNG
(US10273223, Compound D-14 | US9637472, Compound D-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(Br)cc3n(ncc23)C2CCN(CC2)C(=O)C2CNC2)c(=O)[nH]1
Show InChI InChI=1S/C25H29BrN6O3/c1-14-7-15(2)30-24(34)20(14)12-28-23(33)19-8-17(26)9-22-21(19)13-29-32(22)18-3-5-31(6-4-18)25(35)16-10-27-11-16/h7-9,13,16,18,27H,3-6,10-12H2,1-2H3,(H,28,33)(H,30,34)
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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326118
PNG
(US10273223, Compound D-16 | US9637472, Compound D-...)
Show SMILES CN1CCC(CC1)N1CCC(CC1)n1ncc2c(cc(Br)cc12)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C27H35BrN6O2/c1-17-12-18(2)31-27(36)23(17)15-29-26(35)22-13-19(28)14-25-24(22)16-30-34(25)21-6-10-33(11-7-21)20-4-8-32(3)9-5-20/h12-14,16,20-21H,4-11,15H2,1-3H3,(H,29,35)(H,31,36)
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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326119
PNG
(US10273223, Compound D-17 | US9637472, Compound D-...)
Show SMILES CN(C)Cc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(Br)cc2n(ncc12)C1CCCC1
Show InChI InChI=1S/C23H28BrN5O2/c1-14-8-15(13-28(2)3)19(23(31)27-14)11-25-22(30)18-9-16(24)10-21-20(18)12-26-29(21)17-6-4-5-7-17/h8-10,12,17H,4-7,11,13H2,1-3H3,(H,25,30)(H,27,31)
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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326120
PNG
(US10273223, Compound D-18 | US9637472, Compound D-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)N2CCN(CC2)C(=O)C2CCNCC2)c(=O)[nH]1
Show InChI InChI=1S/C31H41N7O3/c1-20-15-21(2)35-30(40)26(20)18-33-29(39)25-16-24(17-28-27(25)19-34-38(28)23-5-3-4-6-23)36-11-13-37(14-12-36)31(41)22-7-9-32-10-8-22/h15-17,19,22-23,32H,3-14,18H2,1-2H3,(H,33,39)(H,35,40)
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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326125
PNG
(US10273223, Compound D-23 | US9637472, Compound D-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCN(CC2)C(=O)C(C)(C)C)C(F)(F)F)c(=O)[nH]1
Show InChI InChI=1S/C27H32F3N5O3/c1-15-10-16(2)33-24(37)20(15)13-31-23(36)19-11-17(27(28,29)30)12-22-21(19)14-32-35(22)18-6-8-34(9-7-18)25(38)26(3,4)5/h10-12,14,18H,6-9,13H2,1-5H3,(H,31,36)(H,33,37)
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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326126
PNG
(US10273223, Compound D-24 | US9637472, Compound D-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(Cl)cc3n(ncc23)C2CCN(CC2)C(=O)C(C)(C)C)c(=O)[nH]1
Show InChI InChI=1S/C26H32ClN5O3/c1-15-10-16(2)30-24(34)20(15)13-28-23(33)19-11-17(27)12-22-21(19)14-29-32(22)18-6-8-31(9-7-18)25(35)26(3,4)5/h10-12,14,18H,6-9,13H2,1-5H3,(H,28,33)(H,30,34)
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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326127
PNG
(US10273223, Compound D-25 | US9637472, Compound D-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCN(CC2)C(=O)C(C)(C)C)C2=CC(C)(C)NC(C)(C)C2)c(=O)[nH]1
Show InChI InChI=1S/C35H48N6O3/c1-21-14-22(2)38-31(43)27(21)19-36-30(42)26-15-23(24-17-34(6,7)39-35(8,9)18-24)16-29-28(26)20-37-41(29)25-10-12-40(13-11-25)32(44)33(3,4)5/h14-17,20,25,39H,10-13,18-19H2,1-9H3,(H,36,42)(H,38,43)
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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326132
PNG
(US10273223, Compound D-30 | US9637472, Compound D-...)
Show SMILES CN(C)CCCN1CCC(CC1)c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C31H44N6O2/c1-21-16-22(2)34-31(39)27(21)19-32-30(38)26-17-24(23-10-14-36(15-11-23)13-7-12-35(3)4)18-29-28(26)20-33-37(29)25-8-5-6-9-25/h16-18,20,23,25H,5-15,19H2,1-4H3,(H,32,38)(H,34,39)
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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326135
PNG
(US10273223, Compound D-33 | US9637472, Compound D-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(Br)cc3n(ncc23)C2CCN(C2)C(=O)C(C)(C)C)c(=O)[nH]1
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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326139
PNG
(US10273223, Compound D-37 | US9637472, Compound D-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)C2=CCN(CC2)C(=O)C2CNC2)c(=O)[nH]1
Show InChI InChI=1S/C30H36N6O3/c1-18-11-19(2)34-29(38)25(18)16-32-28(37)24-12-21(13-27-26(24)17-33-36(27)23-5-3-4-6-23)20-7-9-35(10-8-20)30(39)22-14-31-15-22/h7,11-13,17,22-23,31H,3-6,8-10,14-16H2,1-2H3,(H,32,37)(H,34,38)
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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326140
PNG
(US10273223, Compound D-38 | US9637472, Compound D-...)
Show SMILES CN(C)CC(=O)N1CCC(=CC1)c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C30H38N6O3/c1-19-13-20(2)33-30(39)25(19)16-31-29(38)24-14-22(21-9-11-35(12-10-21)28(37)18-34(3)4)15-27-26(24)17-32-36(27)23-7-5-6-8-23/h9,13-15,17,23H,5-8,10-12,16,18H2,1-4H3,(H,31,38)(H,33,39)
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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326141
PNG
(US10273223, Compound D-39 | US9637472, Compound D-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)C2=CCN(CC2)C(=O)C2CCNCC2)c(=O)[nH]1
Show InChI InChI=1S/C32H40N6O3/c1-20-15-21(2)36-31(40)27(20)18-34-30(39)26-16-24(17-29-28(26)19-35-38(29)25-5-3-4-6-25)22-9-13-37(14-10-22)32(41)23-7-11-33-12-8-23/h9,15-17,19,23,25,33H,3-8,10-14,18H2,1-2H3,(H,34,39)(H,36,40)
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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326103
PNG
(US10273223, Compound D-40 | US9637472, Compound D-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(Br)cc3n(ncc23)C2CCCC2)c(=O)[nH]1
Show InChI InChI=1S/C21H23BrN4O2/c1-12-7-13(2)25-21(28)17(12)10-23-20(27)16-8-14(22)9-19-18(16)11-24-26(19)15-5-3-4-6-15/h7-9,11,15H,3-6,10H2,1-2H3,(H,23,27)(H,25,28)
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Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
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