BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 128 hits with Last Name = 'panarese' and Initial = 'jd'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 1A


(Homo sapiens (human))
BDBM50166956
PNG
(CHEMBL3798517)
Show SMILES CCc1cnc(Oc2ccc(NC(=O)c3ncccc3N)cc2Cl)nc1
Show InChI InChI=1S/C18H16ClN5O2/c1-2-11-9-22-18(23-10-11)26-15-6-5-12(8-13(15)19)24-17(25)16-14(20)4-3-7-21-16/h3-10H,2,20H2,1H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.60E+3n/an/an/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2 in human liver microsomes using acetaminophen as substrate


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (human))
BDBM50166968
PNG
(CHEMBL3798234)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H13ClN4O3/c21-14-10-11(24-18(26)17-15(22)6-3-9-23-17)7-8-16(14)25-19(27)12-4-1-2-5-13(12)20(25)28/h1-10H,22H2,(H,24,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 7.20E+3n/an/an/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9 in human liver microsomes using 4-hydroxydiclofenac as substrate


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (human))
BDBM50166956
PNG
(CHEMBL3798517)
Show SMILES CCc1cnc(Oc2ccc(NC(=O)c3ncccc3N)cc2Cl)nc1
Show InChI InChI=1S/C18H16ClN5O2/c1-2-11-9-22-18(23-10-11)26-15-6-5-12(8-13(15)19)24-17(25)16-14(20)4-3-7-21-16/h3-10H,2,20H2,1H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.11E+4n/an/an/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4 in human liver microsomes using 1-hydroxymidazolam as substrate


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (human))
BDBM50166968
PNG
(CHEMBL3798234)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H13ClN4O3/c21-14-10-11(24-18(26)17-15(22)6-3-9-23-17)7-8-16(14)25-19(27)12-4-1-2-5-13(12)20(25)28/h1-10H,22H2,(H,24,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4 in human liver microsomes using 1-hydroxymidazolam as substrate


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (human))
BDBM50166968
PNG
(CHEMBL3798234)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H13ClN4O3/c21-14-10-11(24-18(26)17-15(22)6-3-9-23-17)7-8-16(14)25-19(27)12-4-1-2-5-13(12)20(25)28/h1-10H,22H2,(H,24,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2 in human liver microsomes using acetaminophen as substrate


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50166968
PNG
(CHEMBL3798234)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H13ClN4O3/c21-14-10-11(24-18(26)17-15(22)6-3-9-23-17)7-8-16(14)25-19(27)12-4-1-2-5-13(12)20(25)28/h1-10H,22H2,(H,24,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6 in human liver microsomes using dextrophan tartarate as substrate


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50166956
PNG
(CHEMBL3798517)
Show SMILES CCc1cnc(Oc2ccc(NC(=O)c3ncccc3N)cc2Cl)nc1
Show InChI InChI=1S/C18H16ClN5O2/c1-2-11-9-22-18(23-10-11)26-15-6-5-12(8-13(15)19)24-17(25)16-14(20)4-3-7-21-16/h3-10H,2,20H2,1H3,(H,24,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6 in human liver microsomes using dextrophan tartarate as substrate


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (human))
BDBM50166956
PNG
(CHEMBL3798517)
Show SMILES CCc1cnc(Oc2ccc(NC(=O)c3ncccc3N)cc2Cl)nc1
Show InChI InChI=1S/C18H16ClN5O2/c1-2-11-9-22-18(23-10-11)26-15-6-5-12(8-13(15)19)24-17(25)16-14(20)4-3-7-21-16/h3-10H,2,20H2,1H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9 in human liver microsomes using 4-hydroxydiclofenac as substrate


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034650
PNG
(CHEMBL3360957)
Show SMILES Cc1ccc(C)c(Cn2nc3c(c[nH]c4ccccc34)c2=O)c1
Show InChI InChI=1S/C19H17N3O/c1-12-7-8-13(2)14(9-12)11-22-19(23)16-10-20-17-6-4-3-5-15(17)18(16)21-22/h3-10,20H,11H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034652
PNG
(CHEMBL3360958)
Show SMILES Cn1nc2c(cn(Cc3ccc(cc3)-n3cccn3)c3ccccc23)c1=O
Show InChI InChI=1S/C21H17N5O/c1-24-21(27)18-14-25(19-6-3-2-5-17(19)20(18)23-24)13-15-7-9-16(10-8-15)26-12-4-11-22-26/h2-12,14H,13H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 2.43E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034653
PNG
(CHEMBL3360959)
Show SMILES O=c1n(Cc2ccccc2)nc2c1cn(Cc1ccc(cc1)-n1cccn1)c1ccccc21
Show InChI InChI=1S/C27H21N5O/c33-27-24-19-30(17-21-11-13-22(14-12-21)31-16-6-15-28-31)25-10-5-4-9-23(25)26(24)29-32(27)18-20-7-2-1-3-8-20/h1-16,19H,17-18H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>10n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034654
PNG
(CHEMBL3360956)
Show SMILES O=C1N(Cc2ccc(cc2)-n2cccn2)c2ccccc2C1=O
Show InChI InChI=1S/C18H13N3O2/c22-17-15-4-1-2-5-16(15)20(18(17)23)12-13-6-8-14(9-7-13)21-11-3-10-19-21/h1-11H,12H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 10n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM22794
PNG
(1-benzyl-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Show SMILES O=C1N(Cc2ccccc2)c2ccccc2C1=O
Show InChI InChI=1S/C15H11NO2/c17-14-12-8-4-5-9-13(12)16(15(14)18)10-11-6-2-1-3-7-11/h1-9H,10H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 10n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034655
PNG
(CHEMBL3360955)
Show SMILES O=c1[nH]nc2c1cn(Cc1ccc(cc1)-n1cccn1)c1ccccc21
Show InChI InChI=1S/C20H15N5O/c26-20-17-13-24(18-5-2-1-4-16(18)19(17)22-23-20)12-14-6-8-15(9-7-14)25-11-3-10-21-25/h1-11,13H,12H2,(H,23,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.20n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034656
PNG
(CHEMBL3360954)
Show SMILES Cn1cc(cn1)-c1ccc(Cn2cc3c(n[nH]c3=O)c3ccccc23)c(F)c1
Show InChI InChI=1S/C21H16FN5O/c1-26-10-15(9-23-26)13-6-7-14(18(22)8-13)11-27-12-17-20(24-25-21(17)28)16-4-2-3-5-19(16)27/h2-10,12H,11H2,1H3,(H,25,28)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 0.600n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034657
PNG
(CHEMBL3360950)
Show SMILES Cc1ccc(Cn2nc3c(cn(Cc4ccc(cc4)-n4cccn4)c4ccccc34)c2=O)c(C)c1
Show InChI InChI=1S/C29H25N5O/c1-20-8-11-23(21(2)16-20)18-34-29(35)26-19-32(27-7-4-3-6-25(27)28(26)31-34)17-22-9-12-24(13-10-22)33-15-5-14-30-33/h3-16,19H,17-18H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.15E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034658
PNG
(CHEMBL3360949)
Show SMILES Cc1ccc(Cn2nc3c(cn(Cc4ccc(cc4F)-c4cnn(C)c4)c4ccccc34)c2=O)c(C)c1
Show InChI InChI=1S/C30H26FN5O/c1-19-8-9-22(20(2)12-19)17-36-30(37)26-18-35(28-7-5-4-6-25(28)29(26)33-36)16-23-11-10-21(13-27(23)31)24-14-32-34(3)15-24/h4-15,18H,16-17H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.94E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034659
PNG
(CHEMBL3360947)
Show SMILES COc1ccc(Cn2cc3c(nn(Cc4ccc(C)cc4C)c3=O)c3ccccc23)cc1
Show InChI InChI=1S/C27H25N3O2/c1-18-8-11-21(19(2)14-18)16-30-27(31)24-17-29(15-20-9-12-22(32-3)13-10-20)25-7-5-4-6-23(25)26(24)28-30/h4-14,17H,15-16H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 821n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034660
PNG
(CHEMBL3360946)
Show SMILES Cc1ccc(Cn2nc3c(cn(Cc4ccncc4)c4ccccc34)c2=O)c(C)c1
Show InChI InChI=1S/C25H22N4O/c1-17-7-8-20(18(2)13-17)15-29-25(30)22-16-28(14-19-9-11-26-12-10-19)23-6-4-3-5-21(23)24(22)27-29/h3-13,16H,14-15H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.55E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034661
PNG
(CHEMBL3360945)
Show SMILES Cc1ccc(Cn2nc3c(cn(Cc4cccnc4)c4ccccc34)c2=O)c(C)c1
Show InChI InChI=1S/C25H22N4O/c1-17-9-10-20(18(2)12-17)15-29-25(30)22-16-28(14-19-6-5-11-26-13-19)23-8-4-3-7-21(23)24(22)27-29/h3-13,16H,14-15H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 3.66E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034662
PNG
(CHEMBL3360944)
Show SMILES Cc1ccc(Cn2nc3c(cn(Cc4ccccn4)c4ccccc34)c2=O)c(C)c1
Show InChI InChI=1S/C25H22N4O/c1-17-10-11-19(18(2)13-17)14-29-25(30)22-16-28(15-20-7-5-6-12-26-20)23-9-4-3-8-21(23)24(22)27-29/h3-13,16H,14-15H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 3.79E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034663
PNG
(CHEMBL3360940)
Show SMILES Cc1ccc(Cn2nc3c(cn(Cc4ccc(F)cc4)c4ccccc34)c2=O)c(C)c1
Show InChI InChI=1S/C26H22FN3O/c1-17-7-10-20(18(2)13-17)15-30-26(31)23-16-29(14-19-8-11-21(27)12-9-19)24-6-4-3-5-22(24)25(23)28-30/h3-13,16H,14-15H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.02E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034664
PNG
(CHEMBL3360939)
Show SMILES Cc1ccc(Cn2nc3c(cn(Cc4cccc(F)c4)c4ccccc34)c2=O)c(C)c1
Show InChI InChI=1S/C26H22FN3O/c1-17-10-11-20(18(2)12-17)15-30-26(31)23-16-29(14-19-6-5-7-21(27)13-19)24-9-4-3-8-22(24)25(23)28-30/h3-13,16H,14-15H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.42E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034665
PNG
(CHEMBL3360938)
Show SMILES Cc1ccc(Cn2nc3c(cn(Cc4ccccc4F)c4ccccc34)c2=O)c(C)c1
Show InChI InChI=1S/C26H22FN3O/c1-17-11-12-19(18(2)13-17)15-30-26(31)22-16-29(14-20-7-3-5-9-23(20)27)24-10-6-4-8-21(24)25(22)28-30/h3-13,16H,14-15H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 656n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034666
PNG
(CHEMBL3360936)
Show SMILES O=c1n(Cc2ccncc2)nc2c1cn(Cc1ccccc1)c1ccccc21
Show InChI InChI=1S/C23H18N4O/c28-23-20-16-26(14-17-6-2-1-3-7-17)21-9-5-4-8-19(21)22(20)25-27(23)15-18-10-12-24-13-11-18/h1-13,16H,14-15H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034667
PNG
(CHEMBL3360935)
Show SMILES O=c1n(Cc2cccnc2)nc2c1cn(Cc1ccccc1)c1ccccc21
Show InChI InChI=1S/C23H18N4O/c28-23-20-16-26(14-17-7-2-1-3-8-17)21-11-5-4-10-19(21)22(20)25-27(23)15-18-9-6-12-24-13-18/h1-13,16H,14-15H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 6.31E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034679
PNG
(CHEMBL3360934)
Show SMILES O=c1n(Cc2ccccn2)nc2c1cn(Cc1ccccc1)c1ccccc21
Show InChI InChI=1S/C23H18N4O/c28-23-20-16-26(14-17-8-2-1-3-9-17)21-12-5-4-11-19(21)22(20)25-27(23)15-18-10-6-7-13-24-18/h1-13,16H,14-15H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034680
PNG
(CHEMBL3360931)
Show SMILES Cc1ccccc1Cn1nc2c(cn(Cc3ccccc3)c3ccccc23)c1=O
Show InChI InChI=1S/C25H21N3O/c1-18-9-5-6-12-20(18)16-28-25(29)22-17-27(15-19-10-3-2-4-11-19)23-14-8-7-13-21(23)24(22)26-28/h2-14,17H,15-16H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 783n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034771
PNG
(CHEMBL3360928)
Show SMILES Fc1ccccc1Cn1nc2c(cn(Cc3ccccc3)c3ccccc23)c1=O
Show InChI InChI=1S/C24H18FN3O/c25-21-12-6-4-10-18(21)15-28-24(29)20-16-27(14-17-8-2-1-3-9-17)22-13-7-5-11-19(22)23(20)26-28/h1-13,16H,14-15H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.01E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034772
PNG
(CHEMBL89202)
Show SMILES Cn1nc2c(cn(Cc3ccccc3)c3ccccc23)c1=O
Show InChI InChI=1S/C18H15N3O/c1-20-18(22)15-12-21(11-13-7-3-2-4-8-13)16-10-6-5-9-14(16)17(15)19-20/h2-10,12H,11H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034657
PNG
(CHEMBL3360950)
Show SMILES Cc1ccc(Cn2nc3c(cn(Cc4ccc(cc4)-n4cccn4)c4ccccc34)c2=O)c(C)c1
Show InChI InChI=1S/C29H25N5O/c1-20-8-11-23(21(2)16-20)18-34-29(35)26-19-32(27-7-4-3-6-25(27)28(26)31-34)17-22-9-12-24(13-10-22)33-15-5-14-30-33/h3-16,19H,17-18H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.15E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034658
PNG
(CHEMBL3360949)
Show SMILES Cc1ccc(Cn2nc3c(cn(Cc4ccc(cc4F)-c4cnn(C)c4)c4ccccc34)c2=O)c(C)c1
Show InChI InChI=1S/C30H26FN5O/c1-19-8-9-22(20(2)12-19)17-36-30(37)26-18-35(28-7-5-4-6-25(28)29(26)33-36)16-23-11-10-21(13-27(23)31)24-14-32-34(3)15-24/h4-15,18H,16-17H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.95E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034659
PNG
(CHEMBL3360947)
Show SMILES COc1ccc(Cn2cc3c(nn(Cc4ccc(C)cc4C)c3=O)c3ccccc23)cc1
Show InChI InChI=1S/C27H25N3O2/c1-18-8-11-21(19(2)14-18)16-30-27(31)24-17-29(15-20-9-12-22(32-3)13-10-20)25-7-5-4-6-23(25)26(24)28-30/h4-14,17H,15-16H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 813n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034660
PNG
(CHEMBL3360946)
Show SMILES Cc1ccc(Cn2nc3c(cn(Cc4ccncc4)c4ccccc34)c2=O)c(C)c1
Show InChI InChI=1S/C25H22N4O/c1-17-7-8-20(18(2)13-17)15-29-25(30)22-16-28(14-19-9-11-26-12-10-19)23-6-4-3-5-21(23)24(22)27-29/h3-13,16H,14-15H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.55E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034661
PNG
(CHEMBL3360945)
Show SMILES Cc1ccc(Cn2nc3c(cn(Cc4cccnc4)c4ccccc34)c2=O)c(C)c1
Show InChI InChI=1S/C25H22N4O/c1-17-9-10-20(18(2)12-17)15-29-25(30)22-16-28(14-19-6-5-11-26-13-19)23-8-4-3-7-21(23)24(22)27-29/h3-13,16H,14-15H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 3.63E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034662
PNG
(CHEMBL3360944)
Show SMILES Cc1ccc(Cn2nc3c(cn(Cc4ccccn4)c4ccccc34)c2=O)c(C)c1
Show InChI InChI=1S/C25H22N4O/c1-17-10-11-19(18(2)13-17)14-29-25(30)22-16-28(15-20-7-5-6-12-26-20)23-9-4-3-8-21(23)24(22)27-29/h3-13,16H,14-15H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 3.80E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034663
PNG
(CHEMBL3360940)
Show SMILES Cc1ccc(Cn2nc3c(cn(Cc4ccc(F)cc4)c4ccccc34)c2=O)c(C)c1
Show InChI InChI=1S/C26H22FN3O/c1-17-7-10-20(18(2)13-17)15-30-26(31)23-16-29(14-19-8-11-21(27)12-9-19)24-6-4-3-5-22(24)25(23)28-30/h3-13,16H,14-15H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.04E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034664
PNG
(CHEMBL3360939)
Show SMILES Cc1ccc(Cn2nc3c(cn(Cc4cccc(F)c4)c4ccccc34)c2=O)c(C)c1
Show InChI InChI=1S/C26H22FN3O/c1-17-10-11-20(18(2)12-17)15-30-26(31)23-16-29(14-19-6-5-7-21(27)13-19)24-9-4-3-8-22(24)25(23)28-30/h3-13,16H,14-15H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.41E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034665
PNG
(CHEMBL3360938)
Show SMILES Cc1ccc(Cn2nc3c(cn(Cc4ccccc4F)c4ccccc34)c2=O)c(C)c1
Show InChI InChI=1S/C26H22FN3O/c1-17-11-12-19(18(2)13-17)15-30-26(31)22-16-29(14-20-7-3-5-9-23(20)27)24-10-6-4-8-21(24)25(22)28-30/h3-13,16H,14-15H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 661n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034666
PNG
(CHEMBL3360936)
Show SMILES O=c1n(Cc2ccncc2)nc2c1cn(Cc1ccccc1)c1ccccc21
Show InChI InChI=1S/C23H18N4O/c28-23-20-16-26(14-17-6-2-1-3-7-17)21-9-5-4-8-19(21)22(20)25-27(23)15-18-10-12-24-13-11-18/h1-13,16H,14-15H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a<1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034667
PNG
(CHEMBL3360935)
Show SMILES O=c1n(Cc2cccnc2)nc2c1cn(Cc1ccccc1)c1ccccc21
Show InChI InChI=1S/C23H18N4O/c28-23-20-16-26(14-17-7-2-1-3-8-17)21-11-5-4-10-19(21)22(20)25-27(23)15-18-9-6-12-24-13-18/h1-13,16H,14-15H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 6.31E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034679
PNG
(CHEMBL3360934)
Show SMILES O=c1n(Cc2ccccn2)nc2c1cn(Cc1ccccc1)c1ccccc21
Show InChI InChI=1S/C23H18N4O/c28-23-20-16-26(14-17-8-2-1-3-9-17)21-12-5-4-11-19(21)22(20)25-27(23)15-18-10-6-7-13-24-18/h1-13,16H,14-15H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a<1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034680
PNG
(CHEMBL3360931)
Show SMILES Cc1ccccc1Cn1nc2c(cn(Cc3ccccc3)c3ccccc23)c1=O
Show InChI InChI=1S/C25H21N3O/c1-18-9-5-6-12-20(18)16-28-25(29)22-17-27(15-19-10-3-2-4-11-19)23-14-8-7-13-21(23)24(22)26-28/h2-14,17H,15-16H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 776n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034771
PNG
(CHEMBL3360928)
Show SMILES Fc1ccccc1Cn1nc2c(cn(Cc3ccccc3)c3ccccc23)c1=O
Show InChI InChI=1S/C24H18FN3O/c25-21-12-6-4-10-18(21)15-28-24(29)20-16-27(14-17-8-2-1-3-9-17)22-13-7-5-11-19(22)23(20)26-28/h1-13,16H,14-15H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.00E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034772
PNG
(CHEMBL89202)
Show SMILES Cn1nc2c(cn(Cc3ccccc3)c3ccccc23)c1=O
Show InChI InChI=1S/C18H15N3O/c1-20-18(22)15-12-21(11-13-7-3-2-4-8-13)16-10-6-5-9-14(16)17(15)19-20/h2-10,12H,11H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a<1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034773
PNG
(CHEMBL1556989)
Show SMILES Cc1ccc(C)c(Cn2nc3c(cn(Cc4ccccc4)c4ccccc34)c2=O)c1
Show InChI InChI=1S/C26H23N3O/c1-18-12-13-19(2)21(14-18)16-29-26(30)23-17-28(15-20-8-4-3-5-9-20)24-11-7-6-10-22(24)25(23)27-29/h3-14,17H,15-16H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 473n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034774
PNG
(CHEMBL3360927)
Show SMILES Cc1cc(NC(=O)CS(=O)(=O)c2cn(Cc3ccc(nc3)-c3cnn(C)c3)c3cc(F)cc(F)c23)no1
Show InChI InChI=1S/C24H20F2N6O4S/c1-14-5-22(30-36-14)29-23(33)13-37(34,35)21-12-32(20-7-17(25)6-18(26)24(20)21)10-15-3-4-19(27-8-15)16-9-28-31(2)11-16/h3-9,11-12H,10,13H2,1-2H3,(H,29,30,33)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 845n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50313633
PNG
(1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)ind...)
Show SMILES Cn1cc(cn1)-c1ccc(CN2C(=O)C(=O)c3ccccc23)c(F)c1
Show InChI InChI=1S/C19H14FN3O2/c1-22-10-14(9-21-22)12-6-7-13(16(20)8-12)11-23-17-5-3-2-4-15(17)18(24)19(23)25/h2-10H,11H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 830n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay


Bioorg Med Chem Lett 25: 384-8 (2014)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166951
PNG
(CHEMBL3797449)
Show SMILES Nc1cccnc1C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C12H10ClN3O/c13-8-3-1-4-9(7-8)16-12(17)11-10(14)5-2-6-15-11/h1-7H,14H2,(H,16,17)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 575n/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM186216
PNG
(US9163015, 2)
Show SMILES Fc1ccc(Nc2n[nH]c3cccnc23)cc1Cl
Show InChI InChI=1S/C12H8ClFN4/c13-8-6-7(3-4-9(8)14)16-12-11-10(17-18-12)2-1-5-15-11/h1-6H,(H2,16,17,18)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 68n/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 128 total )  |  Next  |  Last  >>
Jump to: