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Compile Data Set for Download or QSAR

Found 659 hits with Last Name = 'pangalos' and Initial = 'mn'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357868
PNG
(CHEMBL1916128)
Show SMILES COc1cc(OCc2ccccc2)cc2c1nc(C)c1c(C)nc(-c3cccnc3C)n21
Show InChI InChI=1S/C26H24N4O2/c1-16-21(11-8-12-27-16)26-29-18(3)25-17(2)28-24-22(30(25)26)13-20(14-23(24)31-4)32-15-19-9-6-5-7-10-19/h5-14H,15H2,1-4H3
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n/an/a 0.0500n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357869
PNG
(CHEMBL1916129)
Show SMILES COc1cc(OC(F)F)cc2c1nc(C)c1c(C)nc(-c3cccnc3C)n21
Show InChI InChI=1S/C20H18F2N4O2/c1-10-14(6-5-7-23-10)19-25-12(3)18-11(2)24-17-15(26(18)19)8-13(28-20(21)22)9-16(17)27-4/h5-9,20H,1-4H3
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n/an/a 0.0600n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357870
PNG
(CHEMBL1916130)
Show SMILES COc1cc(cc2c1nc(C)c1c(C)nc(-c3ccncc3C)n21)C(F)(F)F
Show InChI InChI=1S/C20H17F3N4O/c1-10-9-24-6-5-14(10)19-26-12(3)18-11(2)25-17-15(27(18)19)7-13(20(21,22)23)8-16(17)28-4/h5-9H,1-4H3
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n/an/a 0.0900n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357867
PNG
(CHEMBL1916127)
Show SMILES COc1cc(cc2c1nc(C)c1c(C)nc(-c3cccnc3C)n21)N1CCOCC1
Show InChI InChI=1S/C23H25N5O2/c1-14-18(6-5-7-24-14)23-26-16(3)22-15(2)25-21-19(28(22)23)12-17(13-20(21)29-4)27-8-10-30-11-9-27/h5-7,12-13H,8-11H2,1-4H3
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n/an/a 0.100n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357865
PNG
(CHEMBL1916125)
Show SMILES COc1cc(OC)c2nc(C)c3c(C)nc(-c4cccnc4C)n3c2c1
Show InChI InChI=1S/C20H20N4O2/c1-11-15(7-6-8-21-11)20-23-13(3)19-12(2)22-18-16(24(19)20)9-14(25-4)10-17(18)26-5/h6-10H,1-5H3
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n/an/a 0.140n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357864
PNG
(CHEMBL1916124)
Show SMILES COc1cc(OC)c2nc(C)c3c(C)nc(-c4ccncc4C)n3c2c1
Show InChI InChI=1S/C20H20N4O2/c1-11-10-21-7-6-15(11)20-23-13(3)19-12(2)22-18-16(24(19)20)8-14(25-4)9-17(18)26-5/h6-10H,1-5H3
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n/an/a 0.200n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50390812
PNG
(CHEMBL2069321)
Show SMILES COc1cc(OC)c2nnc3c(C)nc(-c4ccccc4Cl)n3c2c1
Show InChI InChI=1S/C18H15ClN4O2/c1-10-17-22-21-16-14(8-11(24-2)9-15(16)25-3)23(17)18(20-10)12-6-4-5-7-13(12)19/h4-9H,1-3H3
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n/an/a 0.280n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysis


Bioorg Med Chem Lett 22: 5876-84 (2012)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357857
PNG
(CHEMBL1916117)
Show SMILES COc1cc(F)cc2c1nc(C)c1c(C)nc(-c3ccccc3C)n21
Show InChI InChI=1S/C20H18FN3O/c1-11-7-5-6-8-15(11)20-23-13(3)19-12(2)22-18-16(24(19)20)9-14(21)10-17(18)25-4/h5-10H,1-4H3
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n/an/a 0.350n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357863
PNG
(CHEMBL1916123)
Show SMILES COc1cc(OC)c2nc(C)c3c(C)nc(-c4cnccc4C)n3c2c1
Show InChI InChI=1S/C20H20N4O2/c1-11-6-7-21-10-15(11)20-23-13(3)19-12(2)22-18-16(24(19)20)8-14(25-4)9-17(18)26-5/h6-10H,1-5H3
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n/an/a 0.5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357854
PNG
(CHEMBL1916114)
Show SMILES COc1cc(F)cc2c1nc(C)c1c(C)nc(-c3cccnc3C)n21
Show InChI InChI=1S/C19H17FN4O/c1-10-14(6-5-7-21-10)19-23-12(3)18-11(2)22-17-15(24(18)19)8-13(20)9-16(17)25-4/h5-9H,1-4H3
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n/an/a 0.550n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357803
PNG
(CHEMBL1916113)
Show SMILES COc1cc(F)cc2c1nc(C)c1c(C)nc(-c3ccncc3C)n21
Show InChI InChI=1S/C19H17FN4O/c1-10-9-21-6-5-14(10)19-23-12(3)18-11(2)22-17-15(24(18)19)7-13(20)8-16(17)25-4/h5-9H,1-4H3
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n/an/a 0.700n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357872
PNG
(CHEMBL1916132)
Show SMILES Cc1nc(-c2ccncc2C)n2c1c(C)nc1c(Cl)cc(cc21)C(F)(F)F
Show InChI InChI=1S/C19H14ClF3N4/c1-9-8-24-5-4-13(9)18-26-11(3)17-10(2)25-16-14(20)6-12(19(21,22)23)7-15(16)27(17)18/h4-8H,1-3H3
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n/an/a 0.700n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357871
PNG
(CHEMBL1916131)
Show SMILES COc1cc(Cl)c2nc(C)c3c(C)nc(-c4ccncc4C)n3c2c1
Show InChI InChI=1S/C19H17ClN4O/c1-10-9-21-6-5-14(10)19-23-12(3)18-11(2)22-17-15(20)7-13(25-4)8-16(17)24(18)19/h5-9H,1-4H3
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n/an/a 0.800n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357856
PNG
(CHEMBL1916116)
Show SMILES COc1cc(F)cc2c1nc(C)c1c(C)nc(-c3c(C)nn(C)c3C)n21
Show InChI InChI=1S/C19H20FN5O/c1-9-16(12(4)24(5)23-9)19-22-11(3)18-10(2)21-17-14(25(18)19)7-13(20)8-15(17)26-6/h7-8H,1-6H3
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n/an/a 0.850n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50390818
PNG
(CHEMBL2070655)
Show SMILES COc1cc(cc2c1nnc1c(C)nc(-c3ccccc3Cl)n21)N1CCOCC1
Show InChI InChI=1S/C21H20ClN5O2/c1-13-20-25-24-19-17(27(20)21(23-13)15-5-3-4-6-16(15)22)11-14(12-18(19)28-2)26-7-9-29-10-8-26/h3-6,11-12H,7-10H2,1-2H3
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n/an/a 0.850n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysis


Bioorg Med Chem Lett 22: 5876-84 (2012)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM31592
PNG
(PF-2545920 | US9138494, MP-10 | substituted pyraz...)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2ccc3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C25H20N4O/c1-29-16-23(18-12-14-26-15-13-18)25(28-29)20-7-10-22(11-8-20)30-17-21-9-6-19-4-2-3-5-24(19)27-21/h2-16H,17H2,1H3
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n/an/a 1.30n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319169
PNG
(3,4-Dimethoxy-1-isobutyl-8-methoxy-imidazo[1,5-a]p...)
Show SMILES COc1ccc2nc(C)c3c(C)nc(CC(C)C)n3c2n1
Show InChI InChI=1S/C16H20N4O/c1-9(2)8-13-18-11(4)15-10(3)17-12-6-7-14(21-5)19-16(12)20(13)15/h6-7,9H,8H2,1-5H3
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n/an/a 1.40n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50390829
PNG
(CHEMBL2070666)
Show SMILES COc1cc(cc2c1nnc1c(C)nc(-c3ccncc3C)n21)C(F)(F)F
Show InChI InChI=1S/C18H14F3N5O/c1-9-8-22-5-4-12(9)17-23-10(2)16-25-24-15-13(26(16)17)6-11(18(19,20)21)7-14(15)27-3/h4-8H,1-3H3
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n/an/a 1.48n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysis


Bioorg Med Chem Lett 22: 5876-84 (2012)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50390834
PNG
(CHEMBL2070651)
Show SMILES COc1cc(OC)c2nnc3c(C)nc(-c4cccnc4C)n3c2c1
Show InChI InChI=1S/C18H17N5O2/c1-10-13(6-5-7-19-10)18-20-11(2)17-22-21-16-14(23(17)18)8-12(24-3)9-15(16)25-4/h5-9H,1-4H3
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n/an/a 1.48n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysis


Bioorg Med Chem Lett 22: 5876-84 (2012)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357855
PNG
(CHEMBL1916115)
Show SMILES COc1cc(F)cc2c1nc(C)c1c(C)nc(-c3sc(C)nc3C)n21
Show InChI InChI=1S/C18H17FN4OS/c1-8-16-9(2)22-18(17-10(3)20-11(4)25-17)23(16)13-6-12(19)7-14(24-5)15(13)21-8/h6-7H,1-5H3
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n/an/a 1.5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357875
PNG
(CHEMBL1916135)
Show SMILES COc1cc(F)c2nc(C)c3c(C)nc(-c4cccnc4C)n3c2c1
Show InChI InChI=1S/C19H17FN4O/c1-10-14(6-5-7-21-10)19-23-12(3)18-11(2)22-17-15(20)8-13(25-4)9-16(17)24(18)19/h5-9H,1-4H3
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n/an/a 1.5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50390817
PNG
(CHEMBL2070654)
Show SMILES COc1cc(cc2c1nnc1c(C)nc(-c3ccccc3C)n21)N1CCOCC1
Show InChI InChI=1S/C22H23N5O2/c1-14-6-4-5-7-17(14)22-23-15(2)21-25-24-20-18(27(21)22)12-16(13-19(20)28-3)26-8-10-29-11-9-26/h4-7,12-13H,8-11H2,1-3H3
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n/an/a 1.53n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysis


Bioorg Med Chem Lett 22: 5876-84 (2012)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50390827
PNG
(CHEMBL2070664)
Show SMILES COc1cc(F)cc2c1nnc1c(C)nc(-c3sccc3C)n21
Show InChI InChI=1S/C16H13FN4OS/c1-8-4-5-23-14(8)16-18-9(2)15-20-19-13-11(21(15)16)6-10(17)7-12(13)22-3/h4-7H,1-3H3
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n/an/a 1.65n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysis


Bioorg Med Chem Lett 22: 5876-84 (2012)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357866
PNG
(CHEMBL1916126)
Show SMILES COc1cc(cc2c1nc(C)c1c(C)nc(-c3ccncc3C)n21)N1CCOCC1
Show InChI InChI=1S/C23H25N5O2/c1-14-13-24-6-5-18(14)23-26-16(3)22-15(2)25-21-19(28(22)23)11-17(12-20(21)29-4)27-7-9-30-10-8-27/h5-6,11-13H,7-10H2,1-4H3
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n/an/a 1.70n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357806
PNG
(CHEMBL1915896)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4cccc(c4)C(N)=O)n3c2n1
Show InChI InChI=1S/C19H17N5O2/c1-10-16-11(2)22-18(13-6-4-5-12(9-13)17(20)25)24(16)19-14(21-10)7-8-15(23-19)26-3/h4-9H,1-3H3,(H2,20,25)
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n/an/a 1.80n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50390831
PNG
(CHEMBL2070668)
Show SMILES COc1cc(cc2c1nnc1c(C)nc(-c3cccc(F)c3C)n21)C(F)(F)F
Show InChI InChI=1S/C19H14F4N4O/c1-9-12(5-4-6-13(9)20)18-24-10(2)17-26-25-16-14(27(17)18)7-11(19(21,22)23)8-15(16)28-3/h4-8H,1-3H3
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n/an/a 1.85n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysis


Bioorg Med Chem Lett 22: 5876-84 (2012)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357824
PNG
(CHEMBL1915890)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccccc4Cl)n3c2n1
Show InChI InChI=1S/C18H15ClN4O/c1-10-16-11(2)21-17(12-6-4-5-7-13(12)19)23(16)18-14(20-10)8-9-15(22-18)24-3/h4-9H,1-3H3
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n/an/a 1.90n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357858
PNG
(CHEMBL1916118)
Show SMILES Cc1nc(-c2ccccc2C)n2c1c(C)nc1c(OC(F)F)cc(F)cc21
Show InChI InChI=1S/C20H16F3N3O/c1-10-6-4-5-7-14(10)19-25-12(3)18-11(2)24-17-15(26(18)19)8-13(21)9-16(17)27-20(22)23/h4-9,20H,1-3H3
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n/an/a 1.90n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357853
PNG
(CHEMBL1916112)
Show SMILES COc1cc(F)cc2c1nc(C)c1c(C)nc(-c3cnccc3C)n21
Show InChI InChI=1S/C19H17FN4O/c1-10-5-6-21-9-14(10)19-23-12(3)18-11(2)22-17-15(24(18)19)7-13(20)8-16(17)25-4/h5-9H,1-4H3
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n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50390816
PNG
(CHEMBL2070653)
Show SMILES COc1cc(OC)c2nnc3c(C)nc(-c4ccncc4C)n3c2c1
Show InChI InChI=1S/C18H17N5O2/c1-10-9-19-6-5-13(10)18-20-11(2)17-22-21-16-14(23(17)18)7-12(24-3)8-15(16)25-4/h5-9H,1-4H3
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n/an/a 2.06n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysis


Bioorg Med Chem Lett 22: 5876-84 (2012)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50390811
PNG
(CHEMBL2070648)
Show SMILES COc1cccc2c1nnc1c(C)nc(-c3ccccc3Cl)n21
Show InChI InChI=1S/C17H13ClN4O/c1-10-16-21-20-15-13(8-5-9-14(15)23-2)22(16)17(19-10)11-6-3-4-7-12(11)18/h3-9H,1-2H3
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n/an/a 2.41n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysis


Bioorg Med Chem Lett 22: 5876-84 (2012)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357816
PNG
(CHEMBL1915906)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4sccc4C)n3c2n1
Show InChI InChI=1S/C17H16N4OS/c1-9-7-8-23-15(9)17-19-11(3)14-10(2)18-12-5-6-13(22-4)20-16(12)21(14)17/h5-8H,1-4H3
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n/an/a 2.80n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319168
PNG
(1-Cyclohexyl-3,4-dimethyl-8-methoxy-imidazo[1,5-a]...)
Show SMILES COc1ccc2nc(C)c3c(C)nc(C4CCCCC4)n3c2n1
Show InChI InChI=1S/C18H22N4O/c1-11-16-12(2)20-17(13-7-5-4-6-8-13)22(16)18-14(19-11)9-10-15(21-18)23-3/h9-10,13H,4-8H2,1-3H3
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n/an/a 2.80n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357879
PNG
(CHEMBL1916139)
Show SMILES COc1cc(F)c2nc(C)c3c(C)nc(-c4c(C)nn(C)c4C)n3c2c1
Show InChI InChI=1S/C19H20FN5O/c1-9-16(12(4)24(5)23-9)19-22-11(3)18-10(2)21-17-14(20)7-13(26-6)8-15(17)25(18)19/h7-8H,1-6H3
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n/an/a 2.90n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50390810
PNG
(CHEMBL2070647)
Show SMILES COc1cccc2c1nnc1c(C)nc(-c3ccccc3C)n21
Show InChI InChI=1S/C18H16N4O/c1-11-7-4-5-8-13(11)18-19-12(2)17-21-20-16-14(22(17)18)9-6-10-15(16)23-3/h4-10H,1-3H3
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n/an/a 3.30n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysis


Bioorg Med Chem Lett 22: 5876-84 (2012)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50390814
PNG
(CHEMBL2070650)
Show SMILES COc1cc(OC)c2nnc3c(C)nc(-c4ccccc4C(F)(F)F)n3c2c1
Show InChI InChI=1S/C19H15F3N4O2/c1-10-17-25-24-16-14(8-11(27-2)9-15(16)28-3)26(17)18(23-10)12-6-4-5-7-13(12)19(20,21)22/h4-9H,1-3H3
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n/an/a 3.35n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysis


Bioorg Med Chem Lett 22: 5876-84 (2012)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357876
PNG
(CHEMBL1916136)
Show SMILES Cc1nc(-c2ccncc2C)n2c1c(C)nc1c(F)cc(OC(F)F)cc21
Show InChI InChI=1S/C19H15F3N4O/c1-9-8-23-5-4-13(9)18-25-11(3)17-10(2)24-16-14(20)6-12(27-19(21)22)7-15(16)26(17)18/h4-8,19H,1-3H3
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n/an/a 3.5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50390822
PNG
(CHEMBL2070659)
Show SMILES COc1cc(F)cc2c1nnc1c(C)nc(-c3cccc(F)c3C)n21
Show InChI InChI=1S/C18H14F2N4O/c1-9-12(5-4-6-13(9)20)18-21-10(2)17-23-22-16-14(24(17)18)7-11(19)8-15(16)25-3/h4-8H,1-3H3
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n/an/a 3.55n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysis


Bioorg Med Chem Lett 22: 5876-84 (2012)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357836
PNG
(CHEMBL1916095)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccncc4Cl)n3c2n1
Show InChI InChI=1S/C17H14ClN5O/c1-9-15-10(2)21-16(11-6-7-19-8-12(11)18)23(15)17-13(20-9)4-5-14(22-17)24-3/h4-8H,1-3H3
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n/an/a 3.60n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357828
PNG
(CHEMBL1915912)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4sc(C)nc4C)n3c2n1
Show InChI InChI=1S/C17H17N5OS/c1-8-14-9(2)20-17(15-10(3)18-11(4)24-15)22(14)16-12(19-8)6-7-13(21-16)23-5/h6-7H,1-5H3
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n/an/a 3.70n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357874
PNG
(CHEMBL1916134)
Show SMILES COc1cc(F)c2nc(C)c3c(C)nc(-c4ccncc4C)n3c2c1
Show InChI InChI=1S/C19H17FN4O/c1-10-9-21-6-5-14(10)19-23-12(3)18-11(2)22-17-15(20)7-13(25-4)8-16(17)24(18)19/h5-9H,1-4H3
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n/an/a 3.90n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50390819
PNG
(CHEMBL2070656)
Show SMILES COc1cc(cc2c1nnc1c(C)nc(-c3ccncc3C)n21)N1CCOCC1
Show InChI InChI=1S/C21H22N6O2/c1-13-12-22-5-4-16(13)21-23-14(2)20-25-24-19-17(27(20)21)10-15(11-18(19)28-3)26-6-8-29-9-7-26/h4-5,10-12H,6-9H2,1-3H3
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n/an/a 3.99n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysis


Bioorg Med Chem Lett 22: 5876-84 (2012)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50390815
PNG
(CHEMBL2070652)
Show SMILES COc1cc(OC)c2nnc3c(C)nc(-c4cnccc4C)n3c2c1
Show InChI InChI=1S/C18H17N5O2/c1-10-5-6-19-9-13(10)18-20-11(2)17-22-21-16-14(23(17)18)7-12(24-3)8-15(16)25-4/h5-9H,1-4H3
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n/an/a 4.16n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysis


Bioorg Med Chem Lett 22: 5876-84 (2012)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357831
PNG
(CHEMBL1916090)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4cccnc4C)n3c2n1
Show InChI InChI=1S/C18H17N5O/c1-10-13(6-5-9-19-10)17-21-12(3)16-11(2)20-14-7-8-15(24-4)22-18(14)23(16)17/h5-9H,1-4H3
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n/an/a 4.20n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357826
PNG
(CHEMBL1915892)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccc(F)cc4Cl)n3c2n1
Show InChI InChI=1S/C18H14ClFN4O/c1-9-16-10(2)22-17(12-5-4-11(20)8-13(12)19)24(16)18-14(21-9)6-7-15(23-18)25-3/h4-8H,1-3H3
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n/an/a 4.30n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50390830
PNG
(CHEMBL2070667)
Show SMILES COc1cc(cc2c1nnc1c(C)nc(-c3cnccc3C)n21)C(F)(F)F
Show InChI InChI=1S/C18H14F3N5O/c1-9-4-5-22-8-12(9)17-23-10(2)16-25-24-15-13(26(16)17)6-11(18(19,20)21)7-14(15)27-3/h4-8H,1-3H3
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n/an/a 5.11n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysis


Bioorg Med Chem Lett 22: 5876-84 (2012)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50390813
PNG
(CHEMBL2070649)
Show SMILES COc1cc(OC)c2nnc3c(C)nc(-c4ccccc4C)n3c2c1
Show InChI InChI=1S/C19H18N4O2/c1-11-7-5-6-8-14(11)19-20-12(2)18-22-21-17-15(23(18)19)9-13(24-3)10-16(17)25-4/h5-10H,1-4H3
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n/an/a 5.13n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysis


Bioorg Med Chem Lett 22: 5876-84 (2012)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357835
PNG
(CHEMBL1916094)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccncc4C)n3c2n1
Show InChI InChI=1S/C18H17N5O/c1-10-9-19-8-7-13(10)17-21-12(3)16-11(2)20-14-5-6-15(24-4)22-18(14)23(16)17/h5-9H,1-4H3
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n/an/a 5.20n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50357814
PNG
(CHEMBL1915904)
Show SMILES COc1ccc2nc(C(F)F)c3c(C)nc(-c4ccccc4Cl)n3c2n1
Show InChI InChI=1S/C18H13ClF2N4O/c1-9-15-14(16(20)21)23-12-7-8-13(26-2)24-18(12)25(15)17(22-9)10-5-3-4-6-11(10)19/h3-8,16H,1-2H3
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n/an/a 5.40n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE2A using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50357877
PNG
(CHEMBL1916137)
Show SMILES Cc1nc(-c2ccncc2C)n2c1c(C)nc1c(F)cc(OCC(F)(F)F)cc21
Show InChI InChI=1S/C20H16F4N4O/c1-10-8-25-5-4-14(10)19-27-12(3)18-11(2)26-17-15(21)6-13(7-16(17)28(18)19)29-9-20(22,23)24/h4-8H,9H2,1-3H3
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n/an/a 5.5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)

More data for this
Ligand-Target Pair
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