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Compile Data Set for Download or QSAR

Found 960 hits with Last Name = 'park' and Initial = 'hj'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50015639
PNG
(CHEMBL3260567 | USRE47141, Example 2)
Show SMILES Cc1cccc(n1)-c1[nH]c(CNc2ccccc2F)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C22H18FN7/c1-14-5-4-8-18(27-14)22-21(15-9-10-20-25-13-26-30(20)12-15)28-19(29-22)11-24-17-7-3-2-6-16(17)23/h2-10,12-13,24H,11H2,1H3,(H,28,29)
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6.30n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Competitive inhibition of ALK5 (unknown origin) assessed as enzyme/ATP complex by Michaelis-Menten plot analysis in presence of ATP


J Med Chem 57: 4213-38 (2014)


Article DOI: 10.1021/jm500115w
BindingDB Entry DOI: 10.7270/Q2DV1MFM
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50015639
PNG
(CHEMBL3260567 | USRE47141, Example 2)
Show SMILES Cc1cccc(n1)-c1[nH]c(CNc2ccccc2F)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C22H18FN7/c1-14-5-4-8-18(27-14)22-21(15-9-10-20-25-13-26-30(20)12-15)28-19(29-22)11-24-17-7-3-2-6-16(17)23/h2-10,12-13,24H,11H2,1H3,(H,28,29)
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21n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Competitive inhibition of ALK5 (unknown origin) by Michaelis-Menten plot analysis in presence of ATP


J Med Chem 57: 4213-38 (2014)


Article DOI: 10.1021/jm500115w
BindingDB Entry DOI: 10.7270/Q2DV1MFM
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50027770
PNG
(CHEMBL245388)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCC(CCC(O)=O)CC1
Show InChI InChI=1S/C26H35N5O6S/c1-4-6-20-23-24(30(3)29-20)26(34)28-25(27-23)19-16-18(8-9-21(19)37-15-5-2)38(35,36)31-13-11-17(12-14-31)7-10-22(32)33/h8-9,16-17H,4-7,10-15H2,1-3H3,(H,32,33)(H,27,28,34)
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n/an/a 0.0500n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50027767
PNG
(CHEMBL246988)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCC(CC(O)=O)CC1
Show InChI InChI=1S/C25H33N5O6S/c1-4-6-19-22-23(29(3)28-19)25(33)27-24(26-22)18-15-17(7-8-20(18)36-13-5-2)37(34,35)30-11-9-16(10-12-30)14-21(31)32/h7-8,15-16H,4-6,9-14H2,1-3H3,(H,31,32)(H,26,27,33)
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n/an/a 0.110n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50027728
PNG
(CHEMBL394886)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCC(CC1)C(O)=O
Show InChI InChI=1S/C24H31N5O6S/c1-4-6-18-20-21(28(3)27-18)23(30)26-22(25-20)17-14-16(7-8-19(17)35-13-5-2)36(33,34)29-11-9-15(10-12-29)24(31)32/h7-8,14-15H,4-6,9-13H2,1-3H3,(H,31,32)(H,25,26,30)
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n/an/a 0.151n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50027766
PNG
(CHEMBL391333)
Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCC(CCC(O)=O)CC1
Show InChI InChI=1S/C25H33N5O6S/c1-4-6-19-22-23(29(3)28-19)25(33)27-24(26-22)18-15-17(8-9-20(18)36-5-2)37(34,35)30-13-11-16(12-14-30)7-10-21(31)32/h8-9,15-16H,4-7,10-14H2,1-3H3,(H,31,32)(H,26,27,33)
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n/an/a 0.151n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50241303
PNG
(CHEMBL245317 | ethyl hydrogen (1-(3-(1-methyl-7-ox...)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCC(CP(O)(=O)OCC)CC1
Show InChI InChI=1S/C26H38N5O7PS/c1-5-8-21-23-24(30(4)29-21)26(32)28-25(27-23)20-16-19(9-10-22(20)37-15-6-2)40(35,36)31-13-11-18(12-14-31)17-39(33,34)38-7-3/h9-10,16,18H,5-8,11-15,17H2,1-4H3,(H,33,34)(H,27,28,32)
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n/an/a 0.170n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 5 of rabbit platelets


Bioorg Med Chem Lett 14: 2099-103 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.040
BindingDB Entry DOI: 10.7270/Q290237J
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50241303
PNG
(CHEMBL245317 | ethyl hydrogen (1-(3-(1-methyl-7-ox...)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCC(CP(O)(=O)OCC)CC1
Show InChI InChI=1S/C26H38N5O7PS/c1-5-8-21-23-24(30(4)29-21)26(32)28-25(27-23)20-16-19(9-10-22(20)37-15-6-2)40(35,36)31-13-11-18(12-14-31)17-39(33,34)38-7-3/h9-10,16,18H,5-8,11-15,17H2,1-4H3,(H,33,34)(H,27,28,32)
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n/an/a 0.170n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50241300
PNG
(CHEMBL245517 | ethyl hydrogen (4-(3-(1-methyl-7-ox...)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCN(CP(O)(=O)OCC)CC1
Show InChI InChI=1S/C25H37N6O7PS/c1-5-8-20-22-23(29(4)28-20)25(32)27-24(26-22)19-16-18(9-10-21(19)37-15-6-2)40(35,36)31-13-11-30(12-14-31)17-39(33,34)38-7-3/h9-10,16H,5-8,11-15,17H2,1-4H3,(H,33,34)(H,26,27,32)
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n/an/a 0.180n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 5 of rabbit platelets


Bioorg Med Chem Lett 14: 2099-103 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.040
BindingDB Entry DOI: 10.7270/Q290237J
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50241300
PNG
(CHEMBL245517 | ethyl hydrogen (4-(3-(1-methyl-7-ox...)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCN(CP(O)(=O)OCC)CC1
Show InChI InChI=1S/C25H37N6O7PS/c1-5-8-20-22-23(29(4)28-20)25(32)27-24(26-22)19-16-18(9-10-21(19)37-15-6-2)40(35,36)31-13-11-30(12-14-31)17-39(33,34)38-7-3/h9-10,16H,5-8,11-15,17H2,1-4H3,(H,33,34)(H,26,27,32)
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n/an/a 0.182n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50027773
PNG
(CHEMBL264319)
Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCC(CCCC(O)=O)CC1
Show InChI InChI=1S/C26H35N5O6S/c1-4-7-20-23-24(30(3)29-20)26(34)28-25(27-23)19-16-18(10-11-21(19)37-5-2)38(35,36)31-14-12-17(13-15-31)8-6-9-22(32)33/h10-11,16-17H,4-9,12-15H2,1-3H3,(H,32,33)(H,27,28,34)
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n/an/a 0.219n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50027771
PNG
(CHEMBL246329)
Show SMILES CCCOc1ccc(NC(=O)CCC)cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1
Show InChI InChI=1S/C22H29N5O3/c1-5-8-16-19-20(27(4)26-16)22(29)25-21(24-19)15-13-14(23-18(28)9-6-2)10-11-17(15)30-12-7-3/h10-11,13H,5-9,12H2,1-4H3,(H,23,28)(H,24,25,29)
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n/an/a 0.269n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50144215
PNG
(CHEMBL63548 | {4-[3-(1-Methyl-7-oxo-3-propyl-6,7-d...)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCN(CP(O)(O)=O)CC1
Show InChI InChI=1S/C23H33N6O7PS/c1-4-6-18-20-21(27(3)26-18)23(30)25-22(24-20)17-14-16(7-8-19(17)36-13-5-2)38(34,35)29-11-9-28(10-12-29)15-37(31,32)33/h7-8,14H,4-6,9-13,15H2,1-3H3,(H,24,25,30)(H2,31,32,33)
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n/an/a 0.280n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 5 of rabbit platelets


Bioorg Med Chem Lett 14: 2099-103 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.040
BindingDB Entry DOI: 10.7270/Q290237J
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50241301
PNG
((2-{4-[3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-p...)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCN(CCP(O)(=O)OCC)CC1
Show InChI InChI=1S/C26H39N6O7PS/c1-5-8-21-23-24(30(4)29-21)26(33)28-25(27-23)20-18-19(9-10-22(20)38-16-6-2)41(36,37)32-13-11-31(12-14-32)15-17-40(34,35)39-7-3/h9-10,18H,5-8,11-17H2,1-4H3,(H,34,35)(H,27,28,33)
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n/an/a 0.280n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 5 of rabbit platelets


Bioorg Med Chem Lett 14: 2099-103 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.040
BindingDB Entry DOI: 10.7270/Q290237J
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50241301
PNG
((2-{4-[3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-p...)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCN(CCP(O)(=O)OCC)CC1
Show InChI InChI=1S/C26H39N6O7PS/c1-5-8-21-23-24(30(4)29-21)26(33)28-25(27-23)20-18-19(9-10-22(20)38-16-6-2)41(36,37)32-13-11-31(12-14-32)15-17-40(34,35)39-7-3/h9-10,18H,5-8,11-17H2,1-4H3,(H,34,35)(H,27,28,33)
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n/an/a 0.282n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50144213
PNG
((2-{1-[3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-p...)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCC(CCP(O)(=O)OCC)CC1
Show InChI InChI=1S/C27H40N5O7PS/c1-5-8-22-24-25(31(4)30-22)27(33)29-26(28-24)21-18-20(9-10-23(21)38-16-6-2)41(36,37)32-14-11-19(12-15-32)13-17-40(34,35)39-7-3/h9-10,18-19H,5-8,11-17H2,1-4H3,(H,34,35)(H,28,29,33)
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n/an/a 0.290n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 5 of rabbit platelets


Bioorg Med Chem Lett 14: 2099-103 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.040
BindingDB Entry DOI: 10.7270/Q290237J
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50241302
PNG
(CHEMBL245315 | ethyl hydrogen 1-(3-(1-methyl-7-oxo...)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCC(CC1)P(O)(=O)OCC
Show InChI InChI=1S/C25H36N5O7PS/c1-5-8-20-22-23(29(4)28-20)25(31)27-24(26-22)19-16-18(9-10-21(19)36-15-6-2)39(34,35)30-13-11-17(12-14-30)38(32,33)37-7-3/h9-10,16-17H,5-8,11-15H2,1-4H3,(H,32,33)(H,26,27,31)
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n/an/a 0.300n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 5 of rabbit platelets


Bioorg Med Chem Lett 14: 2099-103 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.040
BindingDB Entry DOI: 10.7270/Q290237J
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50241302
PNG
(CHEMBL245315 | ethyl hydrogen 1-(3-(1-methyl-7-oxo...)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCC(CC1)P(O)(=O)OCC
Show InChI InChI=1S/C25H36N5O7PS/c1-5-8-20-22-23(29(4)28-20)25(31)27-24(26-22)19-16-18(9-10-21(19)36-15-6-2)39(34,35)30-13-11-17(12-14-30)38(32,33)37-7-3/h9-10,16-17H,5-8,11-15H2,1-4H3,(H,32,33)(H,26,27,31)
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n/an/a 0.302n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50241310
PNG
((1-(3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyra...)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCC(CP(O)(O)=O)CC1
Show InChI InChI=1S/C24H34N5O7PS/c1-4-6-19-21-22(28(3)27-19)24(30)26-23(25-21)18-14-17(7-8-20(18)36-13-5-2)38(34,35)29-11-9-16(10-12-29)15-37(31,32)33/h7-8,14,16H,4-6,9-13,15H2,1-3H3,(H,25,26,30)(H2,31,32,33)
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n/an/a 0.320n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 5 of rabbit platelets


Bioorg Med Chem Lett 14: 2099-103 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.040
BindingDB Entry DOI: 10.7270/Q290237J
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50241310
PNG
((1-(3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyra...)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCC(CP(O)(O)=O)CC1
Show InChI InChI=1S/C24H34N5O7PS/c1-4-6-19-21-22(28(3)27-19)24(30)26-23(25-21)18-14-17(7-8-20(18)36-13-5-2)38(34,35)29-11-9-16(10-12-29)15-37(31,32)33/h7-8,14,16H,4-6,9-13,15H2,1-3H3,(H,25,26,30)(H2,31,32,33)
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n/an/a 0.324n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50027734
PNG
(CHEMBL246136)
Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCC(CC(O)=O)CC1
Show InChI InChI=1S/C24H31N5O6S/c1-4-6-18-21-22(28(3)27-18)24(32)26-23(25-21)17-14-16(7-8-19(17)35-5-2)36(33,34)29-11-9-15(10-12-29)13-20(30)31/h7-8,14-15H,4-6,9-13H2,1-3H3,(H,30,31)(H,25,26,32)
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n/an/a 0.331n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50241307
PNG
(CHEMBL394040 | diethyl (1-(3-(1-methyl-7-oxo-3-pro...)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCC(CP(=O)(OCC)OCC)CC1
Show InChI InChI=1S/C28H42N5O7PS/c1-6-10-23-25-26(32(5)31-23)28(34)30-27(29-25)22-18-21(11-12-24(22)38-17-7-2)42(36,37)33-15-13-20(14-16-33)19-41(35,39-8-3)40-9-4/h11-12,18,20H,6-10,13-17,19H2,1-5H3,(H,29,30,34)
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n/an/a 0.339n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50241307
PNG
(CHEMBL394040 | diethyl (1-(3-(1-methyl-7-oxo-3-pro...)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCC(CP(=O)(OCC)OCC)CC1
Show InChI InChI=1S/C28H42N5O7PS/c1-6-10-23-25-26(32(5)31-23)28(34)30-27(29-25)22-18-21(11-12-24(22)38-17-7-2)42(36,37)33-15-13-20(14-16-33)19-41(35,39-8-3)40-9-4/h11-12,18,20H,6-10,13-17,19H2,1-5H3,(H,29,30,34)
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n/an/a 0.340n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 5 of rabbit platelets


Bioorg Med Chem Lett 14: 2099-103 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.040
BindingDB Entry DOI: 10.7270/Q290237J
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50027727
PNG
(CHEMBL246743)
Show SMILES CCCOc1ccc(NC(=O)C(C)C)cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1
Show InChI InChI=1S/C22H29N5O3/c1-6-8-16-18-19(27(5)26-16)22(29)25-20(24-18)15-12-14(23-21(28)13(3)4)9-10-17(15)30-11-7-2/h9-10,12-13H,6-8,11H2,1-5H3,(H,23,28)(H,24,25,29)
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n/an/a 0.347n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50027768
PNG
(CHEMBL392182)
Show SMILES CCCOc1ccc(NC(=O)CC)cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1
Show InChI InChI=1S/C21H27N5O3/c1-5-8-15-18-19(26(4)25-15)21(28)24-20(23-18)14-12-13(22-17(27)7-3)9-10-16(14)29-11-6-2/h9-10,12H,5-8,11H2,1-4H3,(H,22,27)(H,23,24,28)
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n/an/a 0.380n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50027774
PNG
(CHEMBL246337)
Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CCC(O)=O)CC1
Show InChI InChI=1S/C24H32N6O6S/c1-4-6-18-21-22(28(3)27-18)24(33)26-23(25-21)17-15-16(7-8-19(17)36-5-2)37(34,35)30-13-11-29(12-14-30)10-9-20(31)32/h7-8,15H,4-6,9-14H2,1-3H3,(H,31,32)(H,25,26,33)
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n/an/a 0.407n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50241306
PNG
(CHEMBL245522 | diethyl 1-(3-(1-methyl-7-oxo-3-prop...)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCC(CC1)P(=O)(OCC)OCC
Show InChI InChI=1S/C27H40N5O7PS/c1-6-10-22-24-25(31(5)30-22)27(33)29-26(28-24)21-18-20(11-12-23(21)37-17-7-2)41(35,36)32-15-13-19(14-16-32)40(34,38-8-3)39-9-4/h11-12,18-19H,6-10,13-17H2,1-5H3,(H,28,29,33)
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n/an/a 0.407n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50241306
PNG
(CHEMBL245522 | diethyl 1-(3-(1-methyl-7-oxo-3-prop...)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCC(CC1)P(=O)(OCC)OCC
Show InChI InChI=1S/C27H40N5O7PS/c1-6-10-22-24-25(31(5)30-22)27(33)29-26(28-24)21-18-20(11-12-23(21)37-17-7-2)41(35,36)32-15-13-19(14-16-32)40(34,38-8-3)39-9-4/h11-12,18-19H,6-10,13-17H2,1-5H3,(H,28,29,33)
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n/an/a 0.410n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 5 of rabbit platelets


Bioorg Med Chem Lett 14: 2099-103 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.040
BindingDB Entry DOI: 10.7270/Q290237J
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50027730
PNG
(CHEMBL396610)
Show SMILES CCCOc1ccc(NC(=O)C2CCCCC2)cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1
Show InChI InChI=1S/C25H33N5O3/c1-4-9-19-21-22(30(3)29-19)25(32)28-23(27-21)18-15-17(12-13-20(18)33-14-5-2)26-24(31)16-10-7-6-8-11-16/h12-13,15-16H,4-11,14H2,1-3H3,(H,26,31)(H,27,28,32)
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n/an/a 0.417n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/a 0.490n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counting


Bioorg Med Chem 19: 5813-32 (2011)


Article DOI: 10.1016/j.bmc.2011.08.014
BindingDB Entry DOI: 10.7270/Q2FB53BQ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/a 0.490n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50027769
PNG
(CHEMBL395660)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCC(CCCC(O)=O)CC1
Show InChI InChI=1S/C27H37N5O6S/c1-4-7-21-24-25(31(3)30-21)27(35)29-26(28-24)20-17-19(10-11-22(20)38-16-5-2)39(36,37)32-14-12-18(13-15-32)8-6-9-23(33)34/h10-11,17-18H,4-9,12-16H2,1-3H3,(H,33,34)(H,28,29,35)
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n/an/a 0.501n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50027738
PNG
(CHEMBL246135)
Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCC(CC1)C(O)=O
Show InChI InChI=1S/C23H29N5O6S/c1-4-6-17-19-20(27(3)26-17)22(29)25-21(24-19)16-13-15(7-8-18(16)34-5-2)35(32,33)28-11-9-14(10-12-28)23(30)31/h7-8,13-14H,4-6,9-12H2,1-3H3,(H,30,31)(H,24,25,29)
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n/an/a 0.513n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50275414
PNG
(2-(4-((1H-1,2,4-Triazol-1-yl)methyl)-5-(4-bromophe...)
Show SMILES Clc1ccc(cc1)C1(CC1)c1nnc(o1)-c1nn(c(c1Cn1cncn1)-c1ccc(Br)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C29H19BrCl3N7O/c30-19-5-1-17(2-6-19)26-22(14-39-16-34-15-35-39)25(38-40(26)24-10-9-21(32)13-23(24)33)27-36-37-28(41-27)29(11-12-29)18-3-7-20(31)8-4-18/h1-10,13,15-16H,11-12,14H2
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n/an/a 0.570n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from CB1 receptor in Sprague-Dawley rat cerebellum by liquid scintillation spectrometry


J Med Chem 51: 7216-33 (2009)


Article DOI: 10.1021/jm800843r
BindingDB Entry DOI: 10.7270/Q2PK0G0G
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50027772
PNG
(CHEMBL63686)
Show SMILES CCCOc1ccc(cc1-c1nc(O)c2n(C)nc(CCC)c2n1)S(=O)(=O)N1CCN(CP(=O)(OCC)OCC)CC1
Show InChI InChI=1S/C27H41N6O7PS/c1-6-10-22-24-25(31(5)30-22)27(34)29-26(28-24)21-18-20(11-12-23(21)38-17-7-2)42(36,37)33-15-13-32(14-16-33)19-41(35,39-8-3)40-9-4/h11-12,18H,6-10,13-17,19H2,1-5H3,(H,28,29,34)
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n/an/a 0.575n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50144220
PNG
(CHEMBL63686 | diethyl (4-(3-(1-methyl-7-oxo-3-prop...)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCN(CP(=O)(OCC)OCC)CC1
Show InChI InChI=1S/C27H41N6O7PS/c1-6-10-22-24-25(31(5)30-22)27(34)29-26(28-24)21-18-20(11-12-23(21)38-17-7-2)42(36,37)33-15-13-32(14-16-33)19-41(35,39-8-3)40-9-4/h11-12,18H,6-10,13-17,19H2,1-5H3,(H,28,29,34)
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n/an/a 0.580n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 5 of rabbit platelets


Bioorg Med Chem Lett 14: 2099-103 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.040
BindingDB Entry DOI: 10.7270/Q290237J
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50241309
PNG
(1-(3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyraz...)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCC(CC1)P(O)(O)=O
Show InChI InChI=1S/C23H32N5O7PS/c1-4-6-18-20-21(27(3)26-18)23(29)25-22(24-20)17-14-16(7-8-19(17)35-13-5-2)37(33,34)28-11-9-15(10-12-28)36(30,31)32/h7-8,14-15H,4-6,9-13H2,1-3H3,(H,24,25,29)(H2,30,31,32)
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n/an/a 0.700n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 5 of rabbit platelets


Bioorg Med Chem Lett 14: 2099-103 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.040
BindingDB Entry DOI: 10.7270/Q290237J
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50241309
PNG
(1-(3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyraz...)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCC(CC1)P(O)(O)=O
Show InChI InChI=1S/C23H32N5O7PS/c1-4-6-18-20-21(27(3)26-18)23(29)25-22(24-20)17-14-16(7-8-19(17)35-13-5-2)37(33,34)28-11-9-15(10-12-28)36(30,31)32/h7-8,14-15H,4-6,9-13H2,1-3H3,(H,24,25,29)(H2,30,31,32)
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n/an/a 0.708n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345359
PNG
((2S,3R,4R,5S,6R)-2-(4-chloro-5-((5-(furan-2-yl)thi...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccco2)c(Cl)cc1O
Show InChI InChI=1S/C20H20ClNO7S/c21-11-6-12(24)10(20-19(27)18(26)17(25)14(8-23)29-20)4-9(11)5-16-22-7-15(30-16)13-2-1-3-28-13/h1-4,6-7,14,17-20,23-27H,5,8H2/t14-,17-,18+,19-,20+/m1/s1
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n/an/a 0.797n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50027733
PNG
(CHEMBL248165)
Show SMILES CCCOc1ccc(NC(C)=O)cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1
Show InChI InChI=1S/C20H25N5O3/c1-5-7-15-17-18(25(4)24-15)20(27)23-19(22-17)14-11-13(21-12(3)26)8-9-16(14)28-10-6-2/h8-9,11H,5-7,10H2,1-4H3,(H,21,26)(H,22,23,27)
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n/an/a 0.813n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50200841
PNG
(CHEMBL220360 | MK-0364 | MK-0634 | N-((2S,3S)-4-(4...)
Show SMILES C[C@H](NC(=O)C(C)(C)Oc1ccc(cn1)C(F)(F)F)[C@@H](Cc1ccc(Cl)cc1)c1cccc(c1)C#N
Show InChI InChI=1S/C27H25ClF3N3O2/c1-17(34-25(35)26(2,3)36-24-12-9-21(16-33-24)27(29,30)31)23(14-18-7-10-22(28)11-8-18)20-6-4-5-19(13-20)15-32/h4-13,16-17,23H,14H2,1-3H3,(H,34,35)/t17-,23+/m0/s1
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Article
PubMed
n/an/a 0.860n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from CB1 receptor in Sprague-Dawley rat cerebellum by liquid scintillation spectrometry


J Med Chem 51: 7216-33 (2009)


Article DOI: 10.1021/jm800843r
BindingDB Entry DOI: 10.7270/Q2PK0G0G
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50275368
PNG
(2-(4-((1H-1,2,4-Triazol-1-yl)methyl)-5-(4-bromophe...)
Show SMILES FC(F)(F)C1(CC1)c1nnc(o1)-c1nn(c(c1Cn1cncn1)-c1ccc(Br)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C24H15BrCl2F3N7O/c25-14-3-1-13(2-4-14)20-16(10-36-12-31-11-32-36)19(35-37(20)18-6-5-15(26)9-17(18)27)21-33-34-22(38-21)23(7-8-23)24(28,29)30/h1-6,9,11-12H,7-8,10H2
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n/an/a 0.930n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from CB1 receptor in Sprague-Dawley rat cerebellum by liquid scintillation spectrometry


J Med Chem 51: 7216-33 (2009)


Article DOI: 10.1021/jm800843r
BindingDB Entry DOI: 10.7270/Q2PK0G0G
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50241308
PNG
((2-{4-[3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-p...)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCN(CCP(O)(O)=O)CC1
Show InChI InChI=1S/C24H35N6O7PS/c1-4-6-19-21-22(28(3)27-19)24(31)26-23(25-21)18-16-17(7-8-20(18)37-14-5-2)39(35,36)30-11-9-29(10-12-30)13-15-38(32,33)34/h7-8,16H,4-6,9-15H2,1-3H3,(H,25,26,31)(H2,32,33,34)
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n/an/a 0.933n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345356
PNG
((2S,3R,4R,5S,6R)-2-(2-(Allyloxy)-4-chloro-5-((5-(t...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccsc2)c(Cl)cc1OCC=C
Show InChI InChI=1S/C23H24ClNO6S2/c1-2-4-30-16-8-15(24)13(7-19-25-9-18(33-19)12-3-5-32-11-12)6-14(16)23-22(29)21(28)20(27)17(10-26)31-23/h2-3,5-6,8-9,11,17,20-23,26-29H,1,4,7,10H2/t17-,20-,21+,22-,23+/m1/s1
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n/an/a 0.934n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50241308
PNG
((2-{4-[3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-p...)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCN(CCP(O)(O)=O)CC1
Show InChI InChI=1S/C24H35N6O7PS/c1-4-6-19-21-22(28(3)27-19)24(31)26-23(25-21)18-16-17(7-8-20(18)37-14-5-2)39(35,36)30-11-9-29(10-12-30)13-15-38(32,33)34/h7-8,16H,4-6,9-15H2,1-3H3,(H,25,26,31)(H2,32,33,34)
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n/an/a 0.940n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 5 of rabbit platelets


Bioorg Med Chem Lett 14: 2099-103 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.040
BindingDB Entry DOI: 10.7270/Q290237J
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50275412
PNG
(2-(4-((1H-1,2,4-Triazol-1-yl)methyl)-5-(4-bromophe...)
Show SMILES Clc1ccc(c(Cl)c1)-n1nc(c(Cn2cncn2)c1-c1ccc(Br)cc1)-c1nnc(o1)C1(CC1)c1ccccc1
Show InChI InChI=1S/C29H20BrCl2N7O/c30-20-8-6-18(7-9-20)26-22(15-38-17-33-16-34-38)25(37-39(26)24-11-10-21(31)14-23(24)32)27-35-36-28(40-27)29(12-13-29)19-4-2-1-3-5-19/h1-11,14,16-17H,12-13,15H2
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n/an/a 0.960n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from CB1 receptor in Sprague-Dawley rat cerebellum by liquid scintillation spectrometry


J Med Chem 51: 7216-33 (2009)


Article DOI: 10.1021/jm800843r
BindingDB Entry DOI: 10.7270/Q2PK0G0G
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM50156678
PNG
(CHEMBL3792392)
Show SMILES ONC(=O)CCCc1csc(\C=C\c2ccccc2)n1
Show InChI InChI=1S/C15H16N2O2S/c18-14(17-19)8-4-7-13-11-20-15(16-13)10-9-12-5-2-1-3-6-12/h1-3,5-6,9-11,19H,4,7-8H2,(H,17,18)/b10-9+
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n/an/a>1n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant C-terminal GST-tagged HDAC2 (1 to 488 residues) expressed in insect cells using RHK-K(Ac)-AMC as substrat...


Eur J Med Chem 116: 126-135 (2016)


Article DOI: 10.1016/j.ejmech.2016.03.046
BindingDB Entry DOI: 10.7270/Q2057HTZ
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50156678
PNG
(CHEMBL3792392)
Show SMILES ONC(=O)CCCc1csc(\C=C\c2ccccc2)n1
Show InChI InChI=1S/C15H16N2O2S/c18-14(17-19)8-4-7-13-11-20-15(16-13)10-9-12-5-2-1-3-6-12/h1-3,5-6,9-11,19H,4,7-8H2,(H,17,18)/b10-9+
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n/an/a>1n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant C-terminal FLAG-His-tagged HDAC1 (1 to 482 residues) expressed in Sf21 cells using RHK-K(Ac)-AMC as subst...


Eur J Med Chem 116: 126-135 (2016)


Article DOI: 10.1016/j.ejmech.2016.03.046
BindingDB Entry DOI: 10.7270/Q2057HTZ
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50241305
PNG
((2-{4-[3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-p...)
Show SMILES CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCN(CCP(=O)(OCC)OCC)CC1
Show InChI InChI=1S/C28H43N6O7PS/c1-6-10-23-25-26(32(5)31-23)28(35)30-27(29-25)22-20-21(11-12-24(22)39-18-7-2)43(37,38)34-15-13-33(14-16-34)17-19-42(36,40-8-3)41-9-4/h11-12,20H,6-10,13-19H2,1-5H3,(H,29,30,35)
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n/an/a 1.05n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 17: 4271-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.064
BindingDB Entry DOI: 10.7270/Q289172C
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50275482
PNG
(2-(4-((1H-1,2,4-Triazol-1-yl)methyl)-5-(4-chloroph...)
Show SMILES Cc1ccc(cc1)C1(CC1)c1nnc(o1)-c1nn(c(c1Cn1cncn1)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C30H22Cl3N7O/c1-18-2-6-20(7-3-18)30(12-13-30)29-37-36-28(41-29)26-23(15-39-17-34-16-35-39)27(19-4-8-21(31)9-5-19)40(38-26)25-11-10-22(32)14-24(25)33/h2-11,14,16-17H,12-13,15H2,1H3
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n/an/a 1.09n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from CB1 receptor in Sprague-Dawley rat cerebellum by liquid scintillation spectrometry


J Med Chem 51: 7216-33 (2009)


Article DOI: 10.1021/jm800843r
BindingDB Entry DOI: 10.7270/Q2PK0G0G
More data for this
Ligand-Target Pair
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