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Compile Data Set for Download or QSAR

Found 421 hits with Last Name = 'rice' and Initial = 'wg'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50384714
PNG
(CHEMBL2037200)
Show SMILES CN1CCCN(CC1)C(=O)c1cccc(c1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1
Show InChI InChI=1S/C26H24ClN3O3/c1-29-10-3-11-30(13-12-29)26(32)18-5-2-4-17(14-18)24-9-7-20(33-24)16-22-21-15-19(27)6-8-23(21)28-25(22)31/h2,4-9,14-16H,3,10-13H2,1H3,(H,28,31)/b22-16+
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TBA

Curated by ChEMBL


Assay Description
Reversible inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate


ACS Med Chem Lett 3: 135-139 (2012)

More data for this
Ligand-Target Pair
Casein Kinase II


(Homo sapiens (human))
BDBM50335638
PNG
(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Show SMILES OC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc21
Show InChI InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H,(H,22,23)(H,24,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CK2alpha by radiometric assay


J Med Chem 54: 635-54 (2011)

More data for this
Ligand-Target Pair
Casein Kinase II


(Homo sapiens (human))
BDBM50335638
PNG
(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Show SMILES OC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc21
Show InChI InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H,(H,22,23)(H,24,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CK2alpha at enzyme-substrate complex by radiometric assay


J Med Chem 54: 635-54 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381040
PNG
(CHEMBL2017348)
Show SMILES Fc1ccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)c(F)c1
Show InChI InChI=1S/C19H11F2N5S/c20-10-4-5-15(14(21)8-10)24-19-13-6-7-27-17(13)11-2-1-3-12(16(11)25-19)18-22-9-23-26-18/h1-9H,(H,24,25)(H,22,23,26)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50381040
PNG
(CHEMBL2017348)
Show SMILES Fc1ccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)c(F)c1
Show InChI InChI=1S/C19H11F2N5S/c20-10-4-5-15(14(21)8-10)24-19-13-6-7-27-17(13)11-2-1-3-12(16(11)25-19)18-22-9-23-26-18/h1-9H,(H,24,25)(H,22,23,26)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate and 5 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50381054
PNG
(CHEMBL2017323)
Show SMILES Clc1ccccc1Nc1nc2c(cccc2c2sccc12)-c1nnc[nH]1
Show InChI InChI=1S/C19H12ClN5S/c20-14-6-1-2-7-15(14)23-19-13-8-9-26-17(13)11-4-3-5-12(16(11)24-19)18-21-10-22-25-18/h1-10H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate and 5 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50381055
PNG
(CHEMBL2017324)
Show SMILES Fc1ccccc1Nc1nc2c(cccc2c2sccc12)-c1nnc[nH]1
Show InChI InChI=1S/C19H12FN5S/c20-14-6-1-2-7-15(14)23-19-13-8-9-26-17(13)11-4-3-5-12(16(11)24-19)18-21-10-22-25-18/h1-10H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate and 5 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381055
PNG
(CHEMBL2017324)
Show SMILES Fc1ccccc1Nc1nc2c(cccc2c2sccc12)-c1nnc[nH]1
Show InChI InChI=1S/C19H12FN5S/c20-14-6-1-2-7-15(14)23-19-13-8-9-26-17(13)11-4-3-5-12(16(11)24-19)18-21-10-22-25-18/h1-10H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381038
PNG
(CHEMBL2017346)
Show SMILES Fc1cccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)c1
Show InChI InChI=1S/C19H12FN5S/c20-11-3-1-4-12(9-11)23-19-15-7-8-26-17(15)13-5-2-6-14(16(13)24-19)18-21-10-22-25-18/h1-10H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50384706
PNG
(CHEMBL2037204)
Show SMILES CN1CCCN(CC1)C(=O)c1ccc(F)c(c1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1
Show InChI InChI=1S/C26H23ClFN3O3/c1-30-9-2-10-31(12-11-30)26(33)16-3-6-22(28)21(13-16)24-8-5-18(34-24)15-20-19-14-17(27)4-7-23(19)29-25(20)32/h3-8,13-15H,2,9-12H2,1H3,(H,29,32)/b20-15+
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay


ACS Med Chem Lett 3: 135-139 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381054
PNG
(CHEMBL2017323)
Show SMILES Clc1ccccc1Nc1nc2c(cccc2c2sccc12)-c1nnc[nH]1
Show InChI InChI=1S/C19H12ClN5S/c20-14-6-1-2-7-15(14)23-19-13-8-9-26-17(13)11-4-3-5-12(16(11)24-19)18-21-10-22-25-18/h1-10H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381039
PNG
(CHEMBL2017347)
Show SMILES Fc1ccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)cc1
Show InChI InChI=1S/C19H12FN5S/c20-11-4-6-12(7-5-11)23-19-15-8-9-26-17(15)13-2-1-3-14(16(13)24-19)18-21-10-22-25-18/h1-10H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381045
PNG
(CHEMBL2017352)
Show SMILES COc1ccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)cc1
Show InChI InChI=1S/C20H15N5OS/c1-26-13-7-5-12(6-8-13)23-20-16-9-10-27-18(16)14-3-2-4-15(17(14)24-20)19-21-11-22-25-19/h2-11H,1H3,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50381071
PNG
(CHEMBL2017341)
Show SMILES Oc1ccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)c(Cl)c1
Show InChI InChI=1S/C19H12ClN5OS/c20-14-8-10(26)4-5-15(14)23-19-13-6-7-27-17(13)11-2-1-3-12(16(11)24-19)18-21-9-22-25-18/h1-9,26H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate and 5 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381053
PNG
(CHEMBL2017322)
Show SMILES N(c1ccccc1)c1nc2c(cccc2c2sccc12)-c1nnc[nH]1
Show InChI InChI=1S/C19H13N5S/c1-2-5-12(6-3-1)22-19-15-9-10-25-17(15)13-7-4-8-14(16(13)23-19)18-20-11-21-24-18/h1-11H,(H,22,23)(H,20,21,24)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381059
PNG
(CHEMBL2017328)
Show SMILES Clc1ccccc1Nc1nc2c(cccc2c2ccsc12)-c1nnc[nH]1
Show InChI InChI=1S/C19H12ClN5S/c20-14-6-1-2-7-15(14)23-19-17-12(8-9-26-17)11-4-3-5-13(16(11)24-19)18-21-10-22-25-18/h1-10H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381066
PNG
(CHEMBL2017336)
Show SMILES C(Nc1nc2c(cccc2c2sccc12)-c1nnc[nH]1)c1ccccc1
Show InChI InChI=1S/C20H15N5S/c1-2-5-13(6-3-1)11-21-19-16-9-10-26-18(16)14-7-4-8-15(17(14)24-19)20-22-12-23-25-20/h1-10,12H,11H2,(H,21,24)(H,22,23,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381073
PNG
(CHEMBL2017343)
Show SMILES COc1cccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)c1Cl
Show InChI InChI=1S/C20H14ClN5OS/c1-27-15-7-3-6-14(16(15)21)24-20-13-8-9-28-18(13)11-4-2-5-12(17(11)25-20)19-22-10-23-26-19/h2-10H,1H3,(H,24,25)(H,22,23,26)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50384706
PNG
(CHEMBL2037204)
Show SMILES CN1CCCN(CC1)C(=O)c1ccc(F)c(c1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1
Show InChI InChI=1S/C26H23ClFN3O3/c1-30-9-2-10-31(12-11-30)26(33)16-3-6-22(28)21(13-16)24-8-5-18(34-24)15-20-19-14-17(27)4-7-23(19)29-25(20)32/h3-8,13-15H,2,9-12H2,1H3,(H,29,32)/b20-15+
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay


ACS Med Chem Lett 3: 135-139 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50384714
PNG
(CHEMBL2037200)
Show SMILES CN1CCCN(CC1)C(=O)c1cccc(c1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1
Show InChI InChI=1S/C26H24ClN3O3/c1-29-10-3-11-30(13-12-29)26(32)18-5-2-4-17(14-18)24-9-7-20(33-24)16-22-21-15-19(27)6-8-23(21)28-25(22)31/h2,4-9,14-16H,3,10-13H2,1H3,(H,28,31)/b22-16+
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay


ACS Med Chem Lett 3: 135-139 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50384715
PNG
(CHEMBL2037201)
Show SMILES Clc1ccc2NC(=O)\C(=C\c3ccc(o3)-c3cccc(c3)C(=O)N3CCCNCC3)c2c1
Show InChI InChI=1S/C25H22ClN3O3/c26-18-5-7-22-20(14-18)21(24(30)28-22)15-19-6-8-23(32-19)16-3-1-4-17(13-16)25(31)29-11-2-9-27-10-12-29/h1,3-8,13-15,27H,2,9-12H2,(H,28,30)/b21-15+
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay


ACS Med Chem Lett 3: 135-139 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50381038
PNG
(CHEMBL2017346)
Show SMILES Fc1cccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)c1
Show InChI InChI=1S/C19H12FN5S/c20-11-3-1-4-12(9-11)23-19-15-7-8-26-17(15)13-5-2-6-14(16(13)24-19)18-21-10-22-25-18/h1-10H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate and 5 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50381048
PNG
(CHEMBL2017356)
Show SMILES C#Cc1cccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)c1
Show InChI InChI=1S/C21H13N5S/c1-2-13-5-3-6-14(11-13)24-21-17-9-10-27-19(17)15-7-4-8-16(18(15)25-21)20-22-12-23-26-20/h1,3-12H,(H,24,25)(H,22,23,26)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate and 5 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381051
PNG
(CHEMBL2017359)
Show SMILES NC(=O)c1cccc2c3sccc3c(Nc3ccccc3Cl)nc12
Show InChI InChI=1S/C18H12ClN3OS/c19-13-6-1-2-7-14(13)21-18-12-8-9-24-16(12)10-4-3-5-11(17(20)23)15(10)22-18/h1-9H,(H2,20,23)(H,21,22)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381052
PNG
(CHEMBL2017360)
Show SMILES CNC(=O)c1cccc2c3sccc3c(Nc3ccccc3Cl)nc12
Show InChI InChI=1S/C19H14ClN3OS/c1-21-19(24)12-6-4-5-11-16(12)23-18(13-9-10-25-17(11)13)22-15-8-3-2-7-14(15)20/h2-10H,1H3,(H,21,24)(H,22,23)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381069
PNG
(CHEMBL2017339)
Show SMILES Clc1cccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)c1
Show InChI InChI=1S/C19H12ClN5S/c20-11-3-1-4-12(9-11)23-19-15-7-8-26-17(15)13-5-2-6-14(16(13)24-19)18-21-10-22-25-18/h1-10H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50381045
PNG
(CHEMBL2017352)
Show SMILES COc1ccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)cc1
Show InChI InChI=1S/C20H15N5OS/c1-26-13-7-5-12(6-8-13)23-20-16-9-10-27-18(16)14-3-2-4-15(17(14)24-20)19-21-11-22-25-19/h2-11H,1H3,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate and 5 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381048
PNG
(CHEMBL2017356)
Show SMILES C#Cc1cccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)c1
Show InChI InChI=1S/C21H13N5S/c1-2-13-5-3-6-14(11-13)24-21-17-9-10-27-19(17)15-7-4-8-16(18(15)25-21)20-22-12-23-26-20/h1,3-12H,(H,24,25)(H,22,23,26)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50381059
PNG
(CHEMBL2017328)
Show SMILES Clc1ccccc1Nc1nc2c(cccc2c2ccsc12)-c1nnc[nH]1
Show InChI InChI=1S/C19H12ClN5S/c20-14-6-1-2-7-15(14)23-19-17-12(8-9-26-17)11-4-3-5-13(16(11)24-19)18-21-10-22-25-18/h1-10H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate and 5 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50381069
PNG
(CHEMBL2017339)
Show SMILES Clc1cccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)c1
Show InChI InChI=1S/C19H12ClN5S/c20-11-3-1-4-12(9-11)23-19-15-7-8-26-17(15)13-5-2-6-14(16(13)24-19)18-21-10-22-25-18/h1-10H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate and 5 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50381074
PNG
(CHEMBL2017361)
Show SMILES Cc1cc2c(Nc3ccccc3F)nc3c(cccc3c2s1)-c1nnc[nH]1
Show InChI InChI=1S/C20H14FN5S/c1-11-9-14-18(27-11)12-5-4-6-13(19-22-10-23-26-19)17(12)25-20(14)24-16-8-3-2-7-15(16)21/h2-10H,1H3,(H,24,25)(H,22,23,26)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate and 5 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50381039
PNG
(CHEMBL2017347)
Show SMILES Fc1ccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)cc1
Show InChI InChI=1S/C19H12FN5S/c20-11-4-6-12(7-5-11)23-19-15-8-9-26-17(15)13-2-1-3-14(16(13)24-19)18-21-10-22-25-18/h1-10H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate and 5 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381043
PNG
(CHEMBL2017350)
Show SMILES COc1ccccc1Nc1nc2c(cccc2c2sccc12)-c1nnc[nH]1
Show InChI InChI=1S/C20H15N5OS/c1-26-16-8-3-2-7-15(16)23-20-14-9-10-27-18(14)12-5-4-6-13(17(12)24-20)19-21-11-22-25-19/h2-11H,1H3,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381057
PNG
(CHEMBL2017326)
Show SMILES Clc1ccccc1Nc1nc2c(cccc2c2cscc12)-c1nnc[nH]1
Show InChI InChI=1S/C19H12ClN5S/c20-15-6-1-2-7-16(15)23-19-14-9-26-8-13(14)11-4-3-5-12(17(11)24-19)18-21-10-22-25-18/h1-10H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50381057
PNG
(CHEMBL2017326)
Show SMILES Clc1ccccc1Nc1nc2c(cccc2c2cscc12)-c1nnc[nH]1
Show InChI InChI=1S/C19H12ClN5S/c20-15-6-1-2-7-16(15)23-19-14-9-26-8-13(14)11-4-3-5-12(17(11)24-19)18-21-10-22-25-18/h1-10H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate and 5 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381060
PNG
(CHEMBL2017329)
Show SMILES Clc1ccccc1Nc1nc2c(cccc2c2scnc12)-c1nnc[nH]1
Show InChI InChI=1S/C18H11ClN6S/c19-12-6-1-2-7-13(12)23-18-15-16(26-9-21-15)10-4-3-5-11(14(10)24-18)17-20-8-22-25-17/h1-9H,(H,23,24)(H,20,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381063
PNG
(CHEMBL2017332)
Show SMILES Fc1ccccc1Nc1nc2c(cccc2n2cccc12)-c1nnc[nH]1
Show InChI InChI=1S/C19H13FN6/c20-13-6-1-2-7-14(13)23-19-16-9-4-10-26(16)15-8-3-5-12(17(15)24-19)18-21-11-22-25-18/h1-11H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381072
PNG
(CHEMBL2017342)
Show SMILES Fc1ccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)c(Cl)c1
Show InChI InChI=1S/C19H11ClFN5S/c20-14-8-10(21)4-5-15(14)24-19-13-6-7-27-17(13)11-2-1-3-12(16(11)25-19)18-22-9-23-26-18/h1-9H,(H,24,25)(H,22,23,26)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381041
PNG
(CHEMBL2017349)
Show SMILES Fc1ccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)cc1F
Show InChI InChI=1S/C19H11F2N5S/c20-14-5-4-10(8-15(14)21)24-19-13-6-7-27-17(13)11-2-1-3-12(16(11)25-19)18-22-9-23-26-18/h1-9H,(H,24,25)(H,22,23,26)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381042
PNG
(CHEMBL2017344)
Show SMILES Fc1cc(F)cc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)c1
Show InChI InChI=1S/C19H11F2N5S/c20-10-6-11(21)8-12(7-10)24-19-15-4-5-27-17(15)13-2-1-3-14(16(13)25-19)18-22-9-23-26-18/h1-9H,(H,24,25)(H,22,23,26)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50381060
PNG
(CHEMBL2017329)
Show SMILES Clc1ccccc1Nc1nc2c(cccc2c2scnc12)-c1nnc[nH]1
Show InChI InChI=1S/C18H11ClN6S/c19-12-6-1-2-7-13(12)23-18-15-16(26-9-21-15)10-4-3-5-11(14(10)24-18)17-20-8-22-25-17/h1-9H,(H,23,24)(H,20,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate and 5 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50381072
PNG
(CHEMBL2017342)
Show SMILES Fc1ccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)c(Cl)c1
Show InChI InChI=1S/C19H11ClFN5S/c20-14-8-10(21)4-5-15(14)24-19-13-6-7-27-17(13)11-2-1-3-12(16(11)25-19)18-22-9-23-26-18/h1-9H,(H,24,25)(H,22,23,26)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate and 5 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381047
PNG
(CHEMBL2017355)
Show SMILES N#Cc1cccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)c1
Show InChI InChI=1S/C20H12N6S/c21-10-12-3-1-4-13(9-12)24-20-16-7-8-27-18(16)14-5-2-6-15(17(14)25-20)19-22-11-23-26-19/h1-9,11H,(H,24,25)(H,22,23,26)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50381065
PNG
(CHEMBL2017335)
Show SMILES C1CN(CCO1)c1nc2c(cccc2c2sccc12)-c1nnc[nH]1
Show InChI InChI=1S/C17H15N5OS/c1-2-11-14(12(3-1)16-18-10-19-21-16)20-17(13-4-9-24-15(11)13)22-5-7-23-8-6-22/h1-4,9-10H,5-8H2,(H,18,19,21)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate and 5 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381044
PNG
(CHEMBL2017351)
Show SMILES COc1cccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)c1
Show InChI InChI=1S/C20H15N5OS/c1-26-13-5-2-4-12(10-13)23-20-16-8-9-27-18(16)14-6-3-7-15(17(14)24-20)19-21-11-22-25-19/h2-11H,1H3,(H,23,24)(H,21,22,25)
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n/an/a 11n/an/an/an/an/an/a



Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50381047
PNG
(CHEMBL2017355)
Show SMILES N#Cc1cccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)c1
Show InChI InChI=1S/C20H12N6S/c21-10-12-3-1-4-13(9-12)24-20-16-7-8-27-18(16)14-5-2-6-15(17(14)25-20)19-22-11-23-26-19/h1-9,11H,(H,24,25)(H,22,23,26)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate and 5 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50381051
PNG
(CHEMBL2017359)
Show SMILES NC(=O)c1cccc2c3sccc3c(Nc3ccccc3Cl)nc12
Show InChI InChI=1S/C18H12ClN3OS/c19-13-6-1-2-7-14(13)21-18-12-8-9-24-16(12)10-4-3-5-11(17(20)23)15(10)22-18/h1-9H,(H2,20,23)(H,21,22)
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n/an/a 12n/an/an/an/an/an/a



Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate and 5 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
poly-ADP-ribose polymerase 1 (PARP1)


(Homo sapiens (human))
BDBM50335639
PNG
(7-((1H-tetrazol-5-yl)methyl)indolo[1,2-a]quinazoli...)
Show SMILES O=c1[nH]c2c(Cc3nnn[nH]3)c3ccccc3n2c2ccccc12
Show InChI InChI=1S/C17H12N6O/c24-17-11-6-2-4-8-14(11)23-13-7-3-1-5-10(13)12(16(23)18-17)9-15-19-21-22-20-15/h1-8H,9H2,(H,18,24)(H,19,20,21,22)
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n/an/a 12n/an/an/an/an/an/a



Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of PARP1 at 1 uM by chemiluminescence assay


J Med Chem 54: 635-54 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381062
PNG
(CHEMBL2017331)
Show SMILES Clc1ccccc1Nc1nc2c(cccc2n2cccc12)-c1nnc[nH]1
Show InChI InChI=1S/C19H13ClN6/c20-13-6-1-2-7-14(13)23-19-16-9-4-10-26(16)15-8-3-5-12(17(15)24-19)18-21-11-22-25-18/h1-11H,(H,23,24)(H,21,22,25)
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n/an/a 12n/an/an/an/an/an/a



Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381070
PNG
(CHEMBL2017340)
Show SMILES Clc1ccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)cc1
Show InChI InChI=1S/C19H12ClN5S/c20-11-4-6-12(7-5-11)23-19-15-8-9-26-17(15)13-2-1-3-14(16(13)24-19)18-21-10-22-25-18/h1-10H,(H,23,24)(H,21,22,25)
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n/an/a 14n/an/an/an/an/an/a



Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
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