Compile Data Set for Download or QSAR

Found 4044 hits with Last Name = 'romero' and Initial = 'fa'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM394352 (N-[3-[2-(difluoromethoxy)-5- (difluoromethyl)pheny...) Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(ccc1OC(F)F)C(F)F Show InChI InChI=1S/C22H19F4N7O3/c1-31(2)17(34)11-32-10-15(29-21(35)14-9-28-33-7-3-6-27-20(14)33)18(30-32)13-8-12(19(23)24)4-5-16(13)36-22(25)26/h3-10,19,22H,11H2,1-2H3,(H,29,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM394350 (N-[3-[5-(1,2-difluoroethyl)-2- (difluoromethoxy)ph...) Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(ccc1OC(F)F)C(F)CF Show InChI InChI=1S/C23H21F4N7O3/c1-32(2)19(35)12-33-11-17(30-22(36)15-10-29-34-7-3-6-28-21(15)34)20(31-33)14-8-13(16(25)9-24)4-5-18(14)37-23(26)27/h3-8,10-11,16,23H,9,12H2,1-2H3,(H,30,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM394296 (N-[3-[2-(difluoromethoxy)-5-iodo- phenyl]-1-[2-(di...) Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(I)ccc1OC(F)F Show InChI InChI=1S/C21H18F2IN7O3/c1-29(2)17(32)11-30-10-15(27-20(33)14-9-26-31-7-3-6-25-19(14)31)18(28-30)13-8-12(24)4-5-16(13)34-21(22)23/h3-10,21H,11H2,1-2H3,(H,27,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Rattus norvegicus (rat))	BDBM50228837 (2-(3-(biphenyl-4-yl)propanoyl)oxazole-5-carbonitri...) Show SMILES O=C(CCc1ccc(cc1)-c1ccccc1)c1ncc(o1)C#N Show InChI InChI=1S/C19H14N2O2/c20-12-17-13-21-19(23-17)18(22)11-8-14-6-9-16(10-7-14)15-4-2-1-3-5-15/h1-7,9-10,13H,8,11H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of rat recombinant FAAH expressed in Escherichia coli				J Med Chem 51: 937-47 (2008) Article DOI: 10.1021/jm701210y BindingDB Entry DOI: 10.7270/Q2QV3NCP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM394352 (N-[3-[2-(difluoromethoxy)-5- (difluoromethyl)pheny...) Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(ccc1OC(F)F)C(F)F Show InChI InChI=1S/C22H19F4N7O3/c1-31(2)17(34)11-32-10-15(29-21(35)14-9-28-33-7-3-6-27-20(14)33)18(30-32)13-8-12(19(23)24)4-5-16(13)36-22(25)26/h3-10,19,22H,11H2,1-2H3,(H,29,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM394291 (N-[3-[2-(difluoromethoxy)-5-[rac- (1R,2R)-2-cyanoc...) Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(ccc1OC(F)F)[C@@H]1C[C@H]1C#N Show InChI InChI=1S/C25H22F2N8O3/c1-33(2)21(36)13-34-12-19(31-24(37)18-11-30-35-7-3-6-29-23(18)35)22(32-34)17-8-14(16-9-15(16)10-28)4-5-20(17)38-25(26)27/h3-8,11-12,15-16,25H,9,13H2,1-2H3,(H,31,37)/t15-,16-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM394296 (N-[3-[2-(difluoromethoxy)-5-iodo- phenyl]-1-[2-(di...) Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(I)ccc1OC(F)F Show InChI InChI=1S/C21H18F2IN7O3/c1-29(2)17(32)11-30-10-15(27-20(33)14-9-26-31-7-3-6-25-19(14)31)18(28-30)13-8-12(24)4-5-16(13)34-21(22)23/h3-10,21H,11H2,1-2H3,(H,27,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50228837 (2-(3-(biphenyl-4-yl)propanoyl)oxazole-5-carbonitri...) Show SMILES O=C(CCc1ccc(cc1)-c1ccccc1)c1ncc(o1)C#N Show InChI InChI=1S/C19H14N2O2/c20-12-17-13-21-19(23-17)18(22)11-8-14-6-9-16(10-7-14)15-4-2-1-3-5-15/h1-7,9-10,13H,8,11H2	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of human recombinant FAAH expressed COS7 cells				J Med Chem 51: 937-47 (2008) Article DOI: 10.1021/jm701210y BindingDB Entry DOI: 10.7270/Q2QV3NCP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM394375 (N-[3-[2,5- bis(difluoromethoxy)phenyl]-1-[2- (dime...) Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(OC(F)F)ccc1OC(F)F Show InChI InChI=1S/C22H19F4N7O4/c1-31(2)17(34)11-32-10-15(29-20(35)14-9-28-33-7-3-6-27-19(14)33)18(30-32)13-8-12(36-21(23)24)4-5-16(13)37-22(25)26/h3-10,21-22H,11H2,1-2H3,(H,29,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM394370 (N-[3-[2-(difluoromethoxy)-5-(1,2,3,4- tetrahydrois...) Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Oc2ccc3CCNCc3c2)ccc1OC(F)F Show InChI InChI=1S/C30H28F2N8O4/c1-38(2)26(41)17-39-16-24(36-29(42)23-15-35-40-11-3-9-34-28(23)40)27(37-39)22-13-21(6-7-25(22)44-30(31)32)43-20-5-4-18-8-10-33-14-19(18)12-20/h3-7,9,11-13,15-16,30,33H,8,10,14,17H2,1-2H3,(H,36,42)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM394373 (N-[3-[5-bromo-2- (difluoromethoxy)phenyl]-1-[2- (d...) Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Br)ccc1OC(F)F Show InChI InChI=1S/C21H18BrF2N7O3/c1-29(2)17(32)11-30-10-15(27-20(33)14-9-26-31-7-3-6-25-19(14)31)18(28-30)13-8-12(22)4-5-16(13)34-21(23)24/h3-10,21H,11H2,1-2H3,(H,27,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.320	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM394310 (2-amino-N-[3-[5-chloro-2- (difluoromethoxy)phenyl]...) Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F Show InChI InChI=1S/C21H19ClF2N8O3/c1-30(2)15(33)10-31-9-13(17(28-31)12-8-11(22)4-5-14(12)35-21(23)24)27-20(34)16-18(25)29-32-7-3-6-26-19(16)32/h3-9,21H,10H2,1-2H3,(H2,25,29)(H,27,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.340	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair
Fatty Acid Amide Hydrolase (Homo sapiens (Human))	BDBM23079 (3-[4-(benzyloxy)phenyl]-1-{pyrido[2,3-d][1,3]oxazo...) Show SMILES O=C(CCc1ccc(OCc2ccccc2)cc1)c1nc2ncccc2o1 Show InChI InChI=1S/C22H18N2O3/c25-19(22-24-21-20(27-22)7-4-14-23-21)13-10-16-8-11-18(12-9-16)26-15-17-5-2-1-3-6-17/h1-9,11-12,14H,10,13,15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem Patents Similars	Article PubMed	0.380	-53.8	0.300	n/a	n/a	n/a	n/a	n/a	25
The Scripps Research Institute					Assay Description The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...				J Med Chem 50: 3359-68 (2007) Article DOI: 10.1021/jm061414r BindingDB Entry DOI: 10.7270/Q2DR2SSH
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM394350 (N-[3-[5-(1,2-difluoroethyl)-2- (difluoromethoxy)ph...) Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(ccc1OC(F)F)C(F)CF Show InChI InChI=1S/C23H21F4N7O3/c1-32(2)19(35)12-33-11-17(30-22(36)15-10-29-34-7-3-6-28-21(15)34)20(31-33)14-8-13(16(25)9-24)4-5-18(14)37-23(26)27/h3-8,10-11,16,23H,9,12H2,1-2H3,(H,30,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.380	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50204512 (2-(7-phenylheptanoyl)oxazole-5-carbonitrile | CHEM...) Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)C#N Show InChI InChI=1S/C17H18N2O2/c18-12-15-13-19-17(21-15)16(20)11-7-2-1-4-8-14-9-5-3-6-10-14/h3,5-6,9-10,13H,1-2,4,7-8,11H2	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown				J Med Chem 50: 1058-68 (2007) Article DOI: 10.1021/jm0611509 BindingDB Entry DOI: 10.7270/Q26H4J6G
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Rattus norvegicus (rat))	BDBM50204512 (2-(7-phenylheptanoyl)oxazole-5-carbonitrile | CHEM...) Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)C#N Show InChI InChI=1S/C17H18N2O2/c18-12-15-13-19-17(21-15)16(20)11-7-2-1-4-8-14-9-5-3-6-10-14/h3,5-6,9-10,13H,1-2,4,7-8,11H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of rat recombinant FAAH expressed in Escherichia coli				J Med Chem 51: 937-47 (2008) Article DOI: 10.1021/jm701210y BindingDB Entry DOI: 10.7270/Q2QV3NCP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM394368 (N-[3-[5-chloro-2- (difluoromethoxy)phenyl]-1-[2- (...) Show SMILES CC(C(=O)N(C)C)n1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F Show InChI InChI=1S/C22H20ClF2N7O3/c1-12(21(34)30(2)3)32-11-16(28-20(33)15-10-27-31-8-4-7-26-19(15)31)18(29-32)14-9-13(23)5-6-17(14)35-22(24)25/h4-12,22H,1-3H3,(H,28,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.410	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM394373 (N-[3-[5-bromo-2- (difluoromethoxy)phenyl]-1-[2- (d...) Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Br)ccc1OC(F)F Show InChI InChI=1S/C21H18BrF2N7O3/c1-29(2)17(32)11-30-10-15(27-20(33)14-9-26-31-7-3-6-25-19(14)31)18(28-30)13-8-12(22)4-5-16(13)34-21(23)24/h3-10,21H,11H2,1-2H3,(H,27,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.430	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM23069 (3-[4-(benzyloxy)phenyl]-1-[5-(pyridin-2-yl)-1,3-ox...) Show SMILES O=C(CCc1ccc(OCc2ccccc2)cc1)c1ncc(o1)-c1ccccn1 Show InChI InChI=1S/C24H20N2O3/c27-22(24-26-16-23(29-24)21-8-4-5-15-25-21)14-11-18-9-12-20(13-10-18)28-17-19-6-2-1-3-7-19/h1-10,12-13,15-16H,11,14,17H2	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Patents Similars	Article PubMed	0.450	-53.3	n/a	n/a	n/a	n/a	n/a	n/a	25
The Scripps Research Institute					Assay Description The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...				J Med Chem 50: 3359-68 (2007) Article DOI: 10.1021/jm061414r BindingDB Entry DOI: 10.7270/Q2DR2SSH
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Rattus norvegicus (rat))	BDBM50372374 (CHEMBL258820) Show SMILES O=C(CCc1ccc(COc2ccccc2)cc1)c1ncc(o1)C#N Show InChI InChI=1S/C20H16N2O3/c21-12-18-13-22-20(25-18)19(23)11-10-15-6-8-16(9-7-15)14-24-17-4-2-1-3-5-17/h1-9,13H,10-11,14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of rat recombinant FAAH expressed in Escherichia coli				J Med Chem 51: 937-47 (2008) Article DOI: 10.1021/jm701210y BindingDB Entry DOI: 10.7270/Q2QV3NCP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM394371 (N-[3-[2-(difluoromethoxy)-5-vinyl- phenyl]-1-[2-(d...) Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(C=C)ccc1OC(F)F Show InChI InChI=1S/C23H21F2N7O3/c1-4-14-6-7-18(35-23(24)25)15(10-14)20-17(12-31(29-20)13-19(33)30(2)3)28-22(34)16-11-27-32-9-5-8-26-21(16)32/h4-12,23H,1,13H2,2-3H3,(H,28,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.510	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50372374 (CHEMBL258820) Show SMILES O=C(CCc1ccc(COc2ccccc2)cc1)c1ncc(o1)C#N Show InChI InChI=1S/C20H16N2O3/c21-12-18-13-22-20(25-18)19(23)11-10-15-6-8-16(9-7-15)14-24-17-4-2-1-3-5-17/h1-9,13H,10-11,14H2	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.510	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of human recombinant FAAH expressed COS7 cells				J Med Chem 51: 937-47 (2008) Article DOI: 10.1021/jm701210y BindingDB Entry DOI: 10.7270/Q2QV3NCP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM394365 (N-[3-[5-(2,2-difluoroethyl)-2- (difluoromethoxy)ph...) Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(CC(F)F)ccc1OC(F)F Show InChI InChI=1S/C23H21F4N7O3/c1-32(2)19(35)12-33-11-16(30-22(36)15-10-29-34-7-3-6-28-21(15)34)20(31-33)14-8-13(9-18(24)25)4-5-17(14)37-23(26)27/h3-8,10-11,18,23H,9,12H2,1-2H3,(H,30,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.520	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Rattus norvegicus (rat))	BDBM50372392 (CHEMBL405880) Show SMILES O=C(CCc1ccc(COc2ccccc2)cc1)c1ncc(o1)-c1cccc(n1)C#N Show InChI InChI=1S/C25H19N3O3/c26-15-20-5-4-8-22(28-20)24-16-27-25(31-24)23(29)14-13-18-9-11-19(12-10-18)17-30-21-6-2-1-3-7-21/h1-12,16H,13-14,17H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.560	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of rat recombinant FAAH expressed in Escherichia coli				J Med Chem 51: 937-47 (2008) Article DOI: 10.1021/jm701210y BindingDB Entry DOI: 10.7270/Q2QV3NCP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM394368 (N-[3-[5-chloro-2- (difluoromethoxy)phenyl]-1-[2- (...) Show SMILES CC(C(=O)N(C)C)n1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F Show InChI InChI=1S/C22H20ClF2N7O3/c1-12(21(34)30(2)3)32-11-16(28-20(33)15-10-27-31-8-4-7-26-19(15)31)18(29-32)14-9-13(23)5-6-17(14)35-22(24)25/h4-12,22H,1-3H3,(H,28,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.580	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM23079 (3-[4-(benzyloxy)phenyl]-1-{pyrido[2,3-d][1,3]oxazo...) Show SMILES O=C(CCc1ccc(OCc2ccccc2)cc1)c1nc2ncccc2o1 Show InChI InChI=1S/C22H18N2O3/c25-19(22-24-21-20(27-22)7-4-14-23-21)13-10-16-8-11-18(12-9-16)26-15-17-5-2-1-3-6-17/h1-9,11-12,14H,10,13,15H2	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Patents Similars	Article PubMed	0.600	-52.6	n/a	n/a	n/a	n/a	n/a	n/a	25
The Scripps Research Institute					Assay Description The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...				J Med Chem 50: 3359-68 (2007) Article DOI: 10.1021/jm061414r BindingDB Entry DOI: 10.7270/Q2DR2SSH
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50204478 (1-(5-(4-methylpyridin-2-yl)oxazol-2-yl)-7-phenylhe...) Show SMILES Cc1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1 Show InChI InChI=1S/C22H24N2O2/c1-17-13-14-23-19(15-17)21-16-24-22(26-21)20(25)12-8-3-2-5-9-18-10-6-4-7-11-18/h4,6-7,10-11,13-16H,2-3,5,8-9,12H2,1H3	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown				J Med Chem 50: 1058-68 (2007) Article DOI: 10.1021/jm0611509 BindingDB Entry DOI: 10.7270/Q26H4J6G
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Rattus norvegicus (rat))	BDBM50372380 (CHEMBL271745) Show SMILES COC(=O)c1ccc(cn1)-c1cnc(o1)C(=O)CCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C25H20N2O4/c1-30-25(29)21-13-12-20(15-26-21)23-16-27-24(31-23)22(28)14-9-17-7-10-19(11-8-17)18-5-3-2-4-6-18/h2-8,10-13,15-16H,9,14H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of rat recombinant FAAH expressed in Escherichia coli				J Med Chem 51: 937-47 (2008) Article DOI: 10.1021/jm701210y BindingDB Entry DOI: 10.7270/Q2QV3NCP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM394291 (N-[3-[2-(difluoromethoxy)-5-[rac- (1R,2R)-2-cyanoc...) Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(ccc1OC(F)F)[C@@H]1C[C@H]1C#N Show InChI InChI=1S/C25H22F2N8O3/c1-33(2)21(36)13-34-12-19(31-24(37)18-11-30-35-7-3-6-29-23(18)35)22(32-34)17-8-14(16-9-15(16)10-28)4-5-20(17)38-25(26)27/h3-8,11-12,15-16,25H,9,13H2,1-2H3,(H,31,37)/t15-,16-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.610	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM394374 (N-[3-[5-chloro-2- (difluoromethoxy)phenyl]-1-[2- (...) Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F Show InChI InChI=1S/C21H18ClF2N7O3/c1-29(2)17(32)11-30-10-15(27-20(33)14-9-26-31-7-3-6-25-19(14)31)18(28-30)13-8-12(22)4-5-16(13)34-21(23)24/h3-10,21H,11H2,1-2H3,(H,27,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.650	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50372399 (CHEMBL405604) Show SMILES FC(F)(F)c1cnc(o1)C(=O)CCc1ccc(COc2ccccc2)cc1 Show InChI InChI=1S/C20H16F3NO3/c21-20(22,23)18-12-24-19(27-18)17(25)11-10-14-6-8-15(9-7-14)13-26-16-4-2-1-3-5-16/h1-9,12H,10-11,13H2	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.670	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of human recombinant FAAH expressed COS7 cells				J Med Chem 51: 937-47 (2008) Article DOI: 10.1021/jm701210y BindingDB Entry DOI: 10.7270/Q2QV3NCP
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Rattus norvegicus (rat))	BDBM50372355 (CHEMBL272452) Show SMILES FC(F)(F)c1cnc(o1)C(=O)CCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C19H14F3NO2/c20-19(21,22)17-12-23-18(25-17)16(24)11-8-13-6-9-15(10-7-13)14-4-2-1-3-5-14/h1-7,9-10,12H,8,11H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of rat recombinant FAAH expressed in Escherichia coli				J Med Chem 51: 937-47 (2008) Article DOI: 10.1021/jm701210y BindingDB Entry DOI: 10.7270/Q2QV3NCP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM394375 (N-[3-[2,5- bis(difluoromethoxy)phenyl]-1-[2- (dime...) Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(OC(F)F)ccc1OC(F)F Show InChI InChI=1S/C22H19F4N7O4/c1-31(2)17(34)11-32-10-15(29-20(35)14-9-28-33-7-3-6-27-19(14)33)18(30-32)13-8-12(36-21(23)24)4-5-16(13)37-22(25)26/h3-10,21-22H,11H2,1-2H3,(H,29,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.720	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair
Fatty Acid Amide Hydrolase (Homo sapiens (Human))	BDBM23078 (3-(4-phenylphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-...) Show SMILES O=C(CCc1ccc(cc1)-c1ccccc1)c1ncc(o1)-c1ccccn1 Show InChI InChI=1S/C23H18N2O2/c26-21(23-25-16-22(27-23)20-8-4-5-15-24-20)14-11-17-9-12-19(13-10-17)18-6-2-1-3-7-18/h1-10,12-13,15-16H,11,14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.75	-52.1	0.700	n/a	n/a	n/a	n/a	n/a	25
The Scripps Research Institute					Assay Description The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...				J Med Chem 50: 3359-68 (2007) Article DOI: 10.1021/jm061414r BindingDB Entry DOI: 10.7270/Q2DR2SSH
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM394370 (N-[3-[2-(difluoromethoxy)-5-(1,2,3,4- tetrahydrois...) Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Oc2ccc3CCNCc3c2)ccc1OC(F)F Show InChI InChI=1S/C30H28F2N8O4/c1-38(2)26(41)17-39-16-24(36-29(42)23-15-35-40-11-3-9-34-28(23)40)27(37-39)22-13-21(6-7-25(22)44-30(31)32)43-20-5-4-18-8-10-33-14-19(18)12-20/h3-7,9,11-13,15-16,30,33H,8,10,14,17H2,1-2H3,(H,36,42)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.75	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Rattus norvegicus (rat))	BDBM23078 (3-(4-phenylphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-...) Show SMILES O=C(CCc1ccc(cc1)-c1ccccc1)c1ncc(o1)-c1ccccn1 Show InChI InChI=1S/C23H18N2O2/c26-21(23-25-16-22(27-23)20-8-4-5-15-24-20)14-11-17-9-12-19(13-10-17)18-6-2-1-3-7-18/h1-10,12-13,15-16H,11,14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.75	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of rat recombinant FAAH expressed in Escherichia coli				J Med Chem 51: 937-47 (2008) Article DOI: 10.1021/jm701210y BindingDB Entry DOI: 10.7270/Q2QV3NCP
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Rattus norvegicus (rat))	BDBM23078 (3-(4-phenylphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-...) Show SMILES O=C(CCc1ccc(cc1)-c1ccccc1)c1ncc(o1)-c1ccccn1 Show InChI InChI=1S/C23H18N2O2/c26-21(23-25-16-22(27-23)20-8-4-5-15-24-20)14-11-17-9-12-19(13-10-17)18-6-2-1-3-7-18/h1-10,12-13,15-16H,11,14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.75	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of rat recombinant FAAH expressed in Escherichia coli				J Med Chem 51: 937-47 (2008) Article DOI: 10.1021/jm701210y BindingDB Entry DOI: 10.7270/Q2QV3NCP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM394310 (2-amino-N-[3-[5-chloro-2- (difluoromethoxy)phenyl]...) Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F Show InChI InChI=1S/C21H19ClF2N8O3/c1-30(2)15(33)10-31-9-13(17(28-31)12-8-11(22)4-5-14(12)35-21(23)24)27-20(34)16-18(25)29-32-7-3-6-26-19(16)32/h3-9,21H,10H2,1-2H3,(H2,25,29)(H,27,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.770	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50204510 (1-(5-(4-methoxypyridin-2-yl)oxazol-2-yl)-7-phenylh...) Show SMILES COc1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1 Show InChI InChI=1S/C22H24N2O3/c1-26-18-13-14-23-19(15-18)21-16-24-22(27-21)20(25)12-8-3-2-5-9-17-10-6-4-7-11-17/h4,6-7,10-11,13-16H,2-3,5,8-9,12H2,1H3	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown				J Med Chem 50: 1058-68 (2007) Article DOI: 10.1021/jm0611509 BindingDB Entry DOI: 10.7270/Q26H4J6G
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM394372 (N-[3-[5-cyclopropyl-2- (difluoromethoxy)phenyl]-1-...) Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(ccc1OC(F)F)C1CC1 Show InChI InChI=1S/C24H23F2N7O3/c1-31(2)20(34)13-32-12-18(29-23(35)17-11-28-33-9-3-8-27-22(17)33)21(30-32)16-10-15(14-4-5-14)6-7-19(16)36-24(25)26/h3,6-12,14,24H,4-5,13H2,1-2H3,(H,29,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Rattus norvegicus (rat))	BDBM50372399 (CHEMBL405604) Show SMILES FC(F)(F)c1cnc(o1)C(=O)CCc1ccc(COc2ccccc2)cc1 Show InChI InChI=1S/C20H16F3NO3/c21-20(22,23)18-12-24-19(27-18)17(25)11-10-14-6-8-15(9-7-14)13-26-16-4-2-1-3-5-16/h1-9,12H,10-11,13H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of rat recombinant FAAH expressed in Escherichia coli				J Med Chem 51: 937-47 (2008) Article DOI: 10.1021/jm701210y BindingDB Entry DOI: 10.7270/Q2QV3NCP
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50204483 (7-phenyl-1-(5-(trifluoromethyl)oxazol-2-yl)heptan-...) Show SMILES FC(F)(F)c1cnc(o1)C(=O)CCCCCCc1ccccc1 Show InChI InChI=1S/C17H18F3NO2/c18-17(19,20)15-12-21-16(23-15)14(22)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown				J Med Chem 50: 1058-68 (2007) Article DOI: 10.1021/jm0611509 BindingDB Entry DOI: 10.7270/Q26H4J6G
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Rattus norvegicus (rat))	BDBM50372372 (CHEMBL272038) Show SMILES O=C(CCc1ccc(Oc2ccccc2)cc1)c1ncc(o1)C#N Show InChI InChI=1S/C19H14N2O3/c20-12-17-13-21-19(24-17)18(22)11-8-14-6-9-16(10-7-14)23-15-4-2-1-3-5-15/h1-7,9-10,13H,8,11H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of rat recombinant FAAH expressed in Escherichia coli				J Med Chem 51: 937-47 (2008) Article DOI: 10.1021/jm701210y BindingDB Entry DOI: 10.7270/Q2QV3NCP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM394368 (N-[3-[5-chloro-2- (difluoromethoxy)phenyl]-1-[2- (...) Show SMILES CC(C(=O)N(C)C)n1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F Show InChI InChI=1S/C22H20ClF2N7O3/c1-12(21(34)30(2)3)32-11-16(28-20(33)15-10-27-31-8-4-7-26-19(15)31)18(29-32)14-9-13(23)5-6-17(14)35-22(24)25/h4-12,22H,1-3H3,(H,28,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.830	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM394366 (N-[3-[2-(difluoromethoxy)-5-[4- (dimethylcarbamoyl...) Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Oc2ccc(cc2)C(=O)N(C)C)ccc1OC(F)F Show InChI InChI=1S/C30H28F2N8O5/c1-37(2)25(41)17-39-16-23(35-28(42)22-15-34-40-13-5-12-33-27(22)40)26(36-39)21-14-20(10-11-24(21)45-30(31)32)44-19-8-6-18(7-9-19)29(43)38(3)4/h5-16,30H,17H2,1-4H3,(H,35,42)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.830	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50372372 (CHEMBL272038) Show SMILES O=C(CCc1ccc(Oc2ccccc2)cc1)c1ncc(o1)C#N Show InChI InChI=1S/C19H14N2O3/c20-12-17-13-21-19(24-17)18(22)11-8-14-6-9-16(10-7-14)23-15-4-2-1-3-5-15/h1-7,9-10,13H,8,11H2	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.850	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of human recombinant FAAH expressed COS7 cells				J Med Chem 51: 937-47 (2008) Article DOI: 10.1021/jm701210y BindingDB Entry DOI: 10.7270/Q2QV3NCP
					More data for this Ligand-Target Pair
Fatty Acid Amide Hydrolase (Homo sapiens (Human))	BDBM23061 (7-(3-chlorophenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-...) Show SMILES Clc1cccc(CCCCCCC(=O)c2ncc(o2)-c2ccccn2)c1 Show InChI InChI=1S/C21H21ClN2O2/c22-17-10-7-9-16(14-17)8-3-1-2-4-12-19(25)21-24-15-20(26-21)18-11-5-6-13-23-18/h5-7,9-11,13-15H,1-4,8,12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.900	-51.6	2	n/a	n/a	n/a	n/a	n/a	25
The Scripps Research Institute					Assay Description The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...				J Med Chem 50: 3359-68 (2007) Article DOI: 10.1021/jm061414r BindingDB Entry DOI: 10.7270/Q2DR2SSH
					More data for this Ligand-Target Pair
Fatty Acid Amide Hydrolase (Homo sapiens (Human))	BDBM23063 (7-(2,3-dichlorophenyl)-1-[5-(pyridin-2-yl)-1,3-oxa...) Show SMILES Clc1cccc(CCCCCCC(=O)c2ncc(o2)-c2ccccn2)c1Cl Show InChI InChI=1S/C21H20Cl2N2O2/c22-16-10-7-9-15(20(16)23)8-3-1-2-4-12-18(26)21-25-14-19(27-21)17-11-5-6-13-24-17/h5-7,9-11,13-14H,1-4,8,12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem Patents Similars	Article PubMed	0.900	-51.6	7	n/a	n/a	n/a	n/a	n/a	25
The Scripps Research Institute					Assay Description The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...				J Med Chem 50: 3359-68 (2007) Article DOI: 10.1021/jm061414r BindingDB Entry DOI: 10.7270/Q2DR2SSH
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50204490 (CHEMBL220784 | methyl 2-(7-phenylheptanoyl)oxazole...) Show SMILES COC(=O)c1cnc(o1)C(=O)CCCCCCc1ccccc1 Show InChI InChI=1S/C18H21NO4/c1-22-18(21)16-13-19-17(23-16)15(20)12-8-3-2-5-9-14-10-6-4-7-11-14/h4,6-7,10-11,13H,2-3,5,8-9,12H2,1H3	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown				J Med Chem 50: 1058-68 (2007) Article DOI: 10.1021/jm0611509 BindingDB Entry DOI: 10.7270/Q26H4J6G
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM394367 (N-[3-[2-(difluoromethoxy)-5-(2- fluoroethyl)phenyl...) Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(CCF)ccc1OC(F)F Show InChI InChI=1S/C23H22F3N7O3/c1-31(2)19(34)13-32-12-17(29-22(35)16-11-28-33-9-3-8-27-21(16)33)20(30-32)15-10-14(6-7-24)4-5-18(15)36-23(25)26/h3-5,8-12,23H,6-7,13H2,1-2H3,(H,29,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.970	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US10307426 (2019) BindingDB Entry DOI: 10.7270/Q2PZ5C55
					More data for this Ligand-Target Pair

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