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Compile Data Set for Download or QSAR

Found 49 hits with Last Name = 'shimoji' and Initial = 'y'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049128
PNG
(5-(1-Hydroxy-ethyl)-2-propyl-3-[2'-(2H-tetrazol-5-...)
Show SMILES CCCc1nc(C(C)O)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C23H24N6O3/c1-3-6-19-24-20(14(2)30)21(23(31)32)29(19)13-15-9-11-16(12-10-15)17-7-4-5-8-18(17)22-25-27-28-26-22/h4-5,7-12,14,30H,3,6,13H2,1-2H3,(H,31,32)(H,25,26,27,28)
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n/an/a 4.90n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049118
PNG
(2-Ethyl-5-(1-hydroxy-1-methyl-ethyl)-3-[2'-(2H-tet...)
Show SMILES CCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(C)(C)O
Show InChI InChI=1S/C23H24N6O3/c1-4-18-24-20(23(2,3)32)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-7-5-6-8-17(16)21-25-27-28-26-21/h5-12,32H,4,13H2,1-3H3,(H,30,31)(H,25,26,27,28)
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n/an/a 5.30n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049123
PNG
(5-Hydroxymethyl-2-propyl-3-[2'-(2H-tetrazol-5-yl)-...)
Show SMILES CCCc1nc(CO)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H22N6O3/c1-2-5-19-23-18(13-29)20(22(30)31)28(19)12-14-8-10-15(11-9-14)16-6-3-4-7-17(16)21-24-26-27-25-21/h3-4,6-11,29H,2,5,12-13H2,1H3,(H,30,31)(H,24,25,26,27)
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n/an/a 6.90n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50241364
PNG
(4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-te...)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(C)(C)O
Show InChI InChI=1S/C24H26N6O3/c1-4-7-19-25-21(24(2,3)33)20(23(31)32)30(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-26-28-29-27-22/h5-6,8-13,33H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29)
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n/an/a 8.10n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049107
PNG
(2-Propyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmet...)
Show SMILES CCCc1ncc(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C21H20N6O2/c1-2-5-19-22-12-18(21(28)29)27(19)13-14-8-10-15(11-9-14)16-6-3-4-7-17(16)20-23-25-26-24-20/h3-4,6-12H,2,5,13H2,1H3,(H,28,29)(H,23,24,25,26)
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n/an/a 9.10n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049109
PNG
(2-Butyl-5-(1-hydroxy-1-methyl-ethyl)-3-[2'-(2H-tet...)
Show SMILES CCCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(C)(C)O
Show InChI InChI=1S/C25H28N6O3/c1-4-5-10-20-26-22(25(2,3)34)21(24(32)33)31(20)15-16-11-13-17(14-12-16)18-8-6-7-9-19(18)23-27-29-30-28-23/h6-9,11-14,34H,4-5,10,15H2,1-3H3,(H,32,33)(H,27,28,29,30)
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n/an/a 9.5n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049124
PNG
(5-Methyl-2-propyl-3-[2'-(1H-tetrazol-5-yl)-bipheny...)
Show SMILES CCCc1nc(C)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H22N6O2/c1-3-6-19-23-14(2)20(22(29)30)28(19)13-15-9-11-16(12-10-15)17-7-4-5-8-18(17)21-24-26-27-25-21/h4-5,7-12H,3,6,13H2,1-2H3,(H,29,30)(H,24,25,26,27)
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n/an/a 11n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049116
PNG
(5-Ethyl-2-propyl-3-(2'-tetrazol-1-yl-biphenyl-4-yl...)
Show SMILES CCCc1nc(CC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C23H24N6O2/c1-3-7-20-24-19(4-2)21(23(30)31)29(20)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-25-27-28-26-22/h5-6,8-13H,3-4,7,14H2,1-2H3,(H,30,31)(H,25,26,27,28)
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n/an/a 12n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50006909
PNG
(2-Butyl-5-chloro-3-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Show SMILES CCCCc1nc(Cl)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28)
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n/an/a 22n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50006909
PNG
(2-Butyl-5-chloro-3-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Show SMILES CCCCc1nc(Cl)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28)
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n/an/a 22n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125l]-All binding to bovine adrenal cortex


Bioorg Med Chem Lett 4: 177-182 (1994)


Article DOI: 10.1016/S0960-894X(01)81143-4
BindingDB Entry DOI: 10.7270/Q2BG2NZQ
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049112
PNG
(3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-(1-hydroxy-et...)
Show SMILES CCCc1nc(C(C)O)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C23H24N2O5/c1-3-6-19-24-20(14(2)26)21(23(29)30)25(19)13-15-9-11-16(12-10-15)17-7-4-5-8-18(17)22(27)28/h4-5,7-12,14,26H,3,6,13H2,1-2H3,(H,27,28)(H,29,30)
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n/an/a 28n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049132
PNG
(3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-(1-hydroxy-1-...)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O)C(C)(C)O
Show InChI InChI=1S/C24H26N2O5/c1-4-7-19-25-21(24(2,3)31)20(23(29)30)26(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22(27)28/h5-6,8-13,31H,4,7,14H2,1-3H3,(H,27,28)(H,29,30)
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n/an/a 28n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049122
PNG
(2-Butyl-3-(2'-carboxy-biphenyl-4-ylmethyl)-5-(1-hy...)
Show SMILES CCCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O)C(C)(C)O
Show InChI InChI=1S/C25H28N2O5/c1-4-5-10-20-26-22(25(2,3)32)21(24(30)31)27(20)15-16-11-13-17(14-12-16)18-8-6-7-9-19(18)23(28)29/h6-9,11-14,32H,4-5,10,15H2,1-3H3,(H,28,29)(H,30,31)
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n/an/a 30n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049117
PNG
(3-(2'-Carboxy-biphenyl-4-ylmethyl)-2-ethyl-5-(1-hy...)
Show SMILES CCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O)C(C)(C)O
Show InChI InChI=1S/C23H24N2O5/c1-4-18-24-20(23(2,3)30)19(22(28)29)25(18)13-14-9-11-15(12-10-14)16-7-5-6-8-17(16)21(26)27/h5-12,30H,4,13H2,1-3H3,(H,26,27)(H,28,29)
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n/an/a 37n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049130
PNG
(5-Isopropyl-2-propyl-3-[2'-(1H-tetrazol-5-yl)-biph...)
Show SMILES CCCc1nc(C(C)C)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C24H26N6O2/c1-4-7-20-25-21(15(2)3)22(24(31)32)30(20)14-16-10-12-17(13-11-16)18-8-5-6-9-19(18)23-26-28-29-27-23/h5-6,8-13,15H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29)
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n/an/a 46n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049113
PNG
(5-Isopropenyl-2-propyl-3-[2'-(2H-tetrazol-5-yl)-bi...)
Show SMILES CCCc1nc(C(C)=C)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C24H24N6O2/c1-4-7-20-25-21(15(2)3)22(24(31)32)30(20)14-16-10-12-17(13-11-16)18-8-5-6-9-19(18)23-26-28-29-27-23/h5-6,8-13H,2,4,7,14H2,1,3H3,(H,31,32)(H,26,27,28,29)
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n/an/a 50n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049106
PNG
(3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-(1-hydroxy-1-...)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O)C(C)(O)CC
Show InChI InChI=1S/C25H28N2O5/c1-4-8-20-26-22(25(3,32)5-2)21(24(30)31)27(20)15-16-11-13-17(14-12-16)18-9-6-7-10-19(18)23(28)29/h6-7,9-14,32H,4-5,8,15H2,1-3H3,(H,28,29)(H,30,31)
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n/an/a 51n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049108
PNG
(3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-hydroxymethyl...)
Show SMILES CCCc1nc(CO)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H22N2O5/c1-2-5-19-23-18(13-25)20(22(28)29)24(19)12-14-8-10-15(11-9-14)16-6-3-4-7-17(16)21(26)27/h3-4,6-11,25H,2,5,12-13H2,1H3,(H,26,27)(H,28,29)
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n/an/a 58n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125l]-All binding to bovine adrenal cortex


Bioorg Med Chem Lett 4: 177-182 (1994)


Article DOI: 10.1016/S0960-894X(01)81143-4
BindingDB Entry DOI: 10.7270/Q2BG2NZQ
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049108
PNG
(3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-hydroxymethyl...)
Show SMILES CCCc1nc(CO)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H22N2O5/c1-2-5-19-23-18(13-25)20(22(28)29)24(19)12-14-8-10-15(11-9-14)16-6-3-4-7-17(16)21(26)27/h3-4,6-11,25H,2,5,12-13H2,1H3,(H,26,27)(H,28,29)
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n/an/a 58n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049126
PNG
(3-(2'-Carboxy-biphenyl-4-ylmethyl)-2-propyl-3H-imi...)
Show SMILES CCCc1ncc(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C21H20N2O4/c1-2-5-19-22-12-18(21(26)27)23(19)13-14-8-10-15(11-9-14)16-6-3-4-7-17(16)20(24)25/h3-4,6-12H,2,5,13H2,1H3,(H,24,25)(H,26,27)
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n/an/a 60n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50282291
PNG
(2-Butyl-3-(2'-carboxy-biphenyl-4-ylmethyl)-5-hydro...)
Show SMILES CCCCc1nc(CO)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C23H24N2O5/c1-2-3-8-20-24-19(14-26)21(23(29)30)25(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22(27)28/h4-7,9-12,26H,2-3,8,13-14H2,1H3,(H,27,28)(H,29,30)
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n/an/a 65n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125l]-All binding to bovine adrenal cortex


Bioorg Med Chem Lett 4: 177-182 (1994)


Article DOI: 10.1016/S0960-894X(01)81143-4
BindingDB Entry DOI: 10.7270/Q2BG2NZQ
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049110
PNG
(2-Propyl-1-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmet...)
Show SMILES CCCc1nc(C(O)=O)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H20N6O4/c1-2-5-17-23-18(21(29)30)19(22(31)32)28(17)12-13-8-10-14(11-9-13)15-6-3-4-7-16(15)20-24-26-27-25-20/h3-4,6-11H,2,5,12H2,1H3,(H,29,30)(H,31,32)(H,24,25,26,27)
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n/an/a 100n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049103
PNG
(3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-ethyl-2-propy...)
Show SMILES CCCc1nc(CC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C23H24N2O4/c1-3-7-20-24-19(4-2)21(23(28)29)25(20)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22(26)27/h5-6,8-13H,3-4,7,14H2,1-2H3,(H,26,27)(H,28,29)
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n/an/a 100n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049129
PNG
(3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-(1-ethyl-1-hy...)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O)C(O)(CC)CC
Show InChI InChI=1S/C26H30N2O5/c1-4-9-21-27-23(26(33,5-2)6-3)22(25(31)32)28(21)16-17-12-14-18(15-13-17)19-10-7-8-11-20(19)24(29)30/h7-8,10-15,33H,4-6,9,16H2,1-3H3,(H,29,30)(H,31,32)
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n/an/a 110n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049104
PNG
(3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-methyl-2-prop...)
Show SMILES CCCc1nc(C)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H22N2O4/c1-3-6-19-23-14(2)20(22(27)28)24(19)13-15-9-11-16(12-10-15)17-7-4-5-8-18(17)21(25)26/h4-5,7-12H,3,6,13H2,1-2H3,(H,25,26)(H,27,28)
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n/an/a 110n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50009714
PNG
(CHEMBL191 | {2-Butyl-5-chloro-3-[2'-(2H-tetrazol-5...)
Show SMILES CCCCC1=NC(Cl)C(CO)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H25ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,19,21,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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n/an/a 120n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125l]-All binding to bovine adrenal cortex


Bioorg Med Chem Lett 4: 177-182 (1994)


Article DOI: 10.1016/S0960-894X(01)81143-4
BindingDB Entry DOI: 10.7270/Q2BG2NZQ
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50009714
PNG
(CHEMBL191 | {2-Butyl-5-chloro-3-[2'-(2H-tetrazol-5...)
Show SMILES CCCCC1=NC(Cl)C(CO)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H25ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,19,21,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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n/an/a 120n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50009505
PNG
(2-Butyl-3-(2'-carboxy-biphenyl-4-ylmethyl)-5-chlor...)
Show SMILES CCCCc1nc(Cl)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H21ClN2O4/c1-2-3-8-18-24-20(23)19(22(28)29)25(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21(26)27/h4-7,9-12H,2-3,8,13H2,1H3,(H,26,27)(H,28,29)
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n/an/a 130n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125l]-All binding to bovine adrenal cortex


Bioorg Med Chem Lett 4: 177-182 (1994)


Article DOI: 10.1016/S0960-894X(01)81143-4
BindingDB Entry DOI: 10.7270/Q2BG2NZQ
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50009505
PNG
(2-Butyl-3-(2'-carboxy-biphenyl-4-ylmethyl)-5-chlor...)
Show SMILES CCCCc1nc(Cl)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H21ClN2O4/c1-2-3-8-18-24-20(23)19(22(28)29)25(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21(26)27/h4-7,9-12H,2-3,8,13H2,1H3,(H,26,27)(H,28,29)
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n/an/a 130n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50282290
PNG
(3-(2'-Carboxy-biphenyl-4-ylmethyl)-2-ethyl-5-hydro...)
Show SMILES CCc1nc(CO)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C21H20N2O5/c1-2-18-22-17(12-24)19(21(27)28)23(18)11-13-7-9-14(10-8-13)15-5-3-4-6-16(15)20(25)26/h3-10,24H,2,11-12H2,1H3,(H,25,26)(H,27,28)
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n/an/a 150n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125l]-All binding to bovine adrenal cortex


Bioorg Med Chem Lett 4: 177-182 (1994)


Article DOI: 10.1016/S0960-894X(01)81143-4
BindingDB Entry DOI: 10.7270/Q2BG2NZQ
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049115
PNG
(5-(1-Hydroxy-1-methyl-ethyl)-2-propyl-3-[2'-(2H-te...)
Show SMILES CCCc1nc(c(C(=O)OCC)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(C)(C)O
Show InChI InChI=1S/C26H30N6O3/c1-5-9-21-27-23(26(3,4)34)22(25(33)35-6-2)32(21)16-17-12-14-18(15-13-17)19-10-7-8-11-20(19)24-28-30-31-29-24/h7-8,10-15,34H,5-6,9,16H2,1-4H3,(H,28,29,30,31)
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n/an/a 200n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049125
PNG
(3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-isopropenyl-2...)
Show SMILES CCCc1nc(C(C)=C)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C24H24N2O4/c1-4-7-20-25-21(15(2)3)22(24(29)30)26(20)14-16-10-12-17(13-11-16)18-8-5-6-9-19(18)23(27)28/h5-6,8-13H,2,4,7,14H2,1,3H3,(H,27,28)(H,29,30)
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n/an/a 270n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049119
PNG
(1-(2'-Carboxy-biphenyl-4-ylmethyl)-2-propyl-1H-imi...)
Show SMILES CCCc1nc(C(O)=O)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H20N2O6/c1-2-5-17-23-18(21(27)28)19(22(29)30)24(17)12-13-8-10-14(11-9-13)15-6-3-4-7-16(15)20(25)26/h3-4,6-11H,2,5,12H2,1H3,(H,25,26)(H,27,28)(H,29,30)
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n/an/a 320n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125l]-All binding to bovine adrenal cortex


Bioorg Med Chem Lett 4: 177-182 (1994)


Article DOI: 10.1016/S0960-894X(01)81143-4
BindingDB Entry DOI: 10.7270/Q2BG2NZQ
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049119
PNG
(1-(2'-Carboxy-biphenyl-4-ylmethyl)-2-propyl-1H-imi...)
Show SMILES CCCc1nc(C(O)=O)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H20N2O6/c1-2-5-17-23-18(21(27)28)19(22(29)30)24(17)12-13-8-10-14(11-9-13)15-6-3-4-7-16(15)20(25)26/h3-4,6-11H,2,5,12H2,1H3,(H,25,26)(H,27,28)(H,29,30)
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n/an/a 320n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049111
PNG
(3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-isopropyl-2-p...)
Show SMILES CCCc1nc(C(C)C)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C24H26N2O4/c1-4-7-20-25-21(15(2)3)22(24(29)30)26(20)14-16-10-12-17(13-11-16)18-8-5-6-9-19(18)23(27)28/h5-6,8-13,15H,4,7,14H2,1-3H3,(H,27,28)(H,29,30)
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n/an/a 360n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50003399
PNG
(4'-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl...)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H23ClN2O3/c1-2-3-8-20-24-21(23)19(14-26)25(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22(27)28/h4-7,9-12,26H,2-3,8,13-14H2,1H3,(H,27,28)
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n/an/a 490n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125l]-All binding to bovine adrenal cortex


Bioorg Med Chem Lett 4: 177-182 (1994)


Article DOI: 10.1016/S0960-894X(01)81143-4
BindingDB Entry DOI: 10.7270/Q2BG2NZQ
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50003399
PNG
(4'-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl...)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H23ClN2O3/c1-2-3-8-20-24-21(23)19(14-26)25(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22(27)28/h4-7,9-12,26H,2-3,8,13-14H2,1H3,(H,27,28)
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n/an/a 490n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049120
PNG
(3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-(1-hydroxy-1-...)
Show SMILES CCCc1nc(c(C(=O)OCC)n1Cc1ccc(cc1)-c1ccccc1C(O)=O)C(C)(C)O
Show InChI InChI=1S/C26H30N2O5/c1-5-9-21-27-23(26(3,4)32)22(25(31)33-6-2)28(21)16-17-12-14-18(15-13-17)19-10-7-8-11-20(19)24(29)30/h7-8,10-15,32H,5-6,9,16H2,1-4H3,(H,29,30)
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n/an/a 600n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049105
PNG
(3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-hydroxymethyl...)
Show SMILES CCCc1nc(CO)c(C(=O)OCC)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C24H26N2O5/c1-3-7-21-25-20(15-27)22(24(30)31-4-2)26(21)14-16-10-12-17(13-11-16)18-8-5-6-9-19(18)23(28)29/h5-6,8-13,27H,3-4,7,14-15H2,1-2H3,(H,28,29)
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n/an/a 840n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125l]-All binding to bovine adrenal cortex


Bioorg Med Chem Lett 4: 177-182 (1994)


Article DOI: 10.1016/S0960-894X(01)81143-4
BindingDB Entry DOI: 10.7270/Q2BG2NZQ
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049105
PNG
(3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-hydroxymethyl...)
Show SMILES CCCc1nc(CO)c(C(=O)OCC)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C24H26N2O5/c1-3-7-21-25-20(15-27)22(24(30)31-4-2)26(21)14-16-10-12-17(13-11-16)18-8-5-6-9-19(18)23(28)29/h5-6,8-13,27H,3-4,7,14-15H2,1-2H3,(H,28,29)
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n/an/a 840n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50282289
PNG
(1-(2'-Carboxy-biphenyl-4-ylmethyl)-2-hydroxymethyl...)
Show SMILES CCCc1cc(C(O)=O)c(CO)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C23H23NO5/c1-2-5-17-12-20(23(28)29)21(14-25)24(17)13-15-8-10-16(11-9-15)18-6-3-4-7-19(18)22(26)27/h3-4,6-12,25H,2,5,13-14H2,1H3,(H,26,27)(H,28,29)
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n/an/a 2.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125l]-All binding to bovine adrenal cortex


Bioorg Med Chem Lett 4: 177-182 (1994)


Article DOI: 10.1016/S0960-894X(01)81143-4
BindingDB Entry DOI: 10.7270/Q2BG2NZQ
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049114
PNG
(4'-(4,5-Bis-hydroxymethyl-2-propyl-imidazol-1-ylme...)
Show SMILES CCCc1nc(CO)c(CO)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H24N2O4/c1-2-5-21-23-19(13-25)20(14-26)24(21)12-15-8-10-16(11-9-15)17-6-3-4-7-18(17)22(27)28/h3-4,6-11,25-26H,2,5,12-14H2,1H3,(H,27,28)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049114
PNG
(4'-(4,5-Bis-hydroxymethyl-2-propyl-imidazol-1-ylme...)
Show SMILES CCCc1nc(CO)c(CO)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H24N2O4/c1-2-5-21-23-19(13-25)20(14-26)24(21)12-15-8-10-16(11-9-15)17-6-3-4-7-18(17)22(27)28/h3-4,6-11,25-26H,2,5,12-14H2,1H3,(H,27,28)
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n/an/a 2.70E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125l]-All binding to bovine adrenal cortex


Bioorg Med Chem Lett 4: 177-182 (1994)


Article DOI: 10.1016/S0960-894X(01)81143-4
BindingDB Entry DOI: 10.7270/Q2BG2NZQ
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50282288
PNG
(1-(2'-Carboxy-biphenyl-4-ylmethyl)-3-methoxymethyl...)
Show SMILES CCCc1cc(COC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C24H25NO5/c1-3-6-19-13-18(15-30-2)22(24(28)29)25(19)14-16-9-11-17(12-10-16)20-7-4-5-8-21(20)23(26)27/h4-5,7-13H,3,6,14-15H2,1-2H3,(H,26,27)(H,28,29)
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n/an/a 4.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125l]-All binding to bovine adrenal cortex


Bioorg Med Chem Lett 4: 177-182 (1994)


Article DOI: 10.1016/S0960-894X(01)81143-4
BindingDB Entry DOI: 10.7270/Q2BG2NZQ
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049127
PNG
(5-Hydroxymethyl-2-propyl-1-[2'-(2H-tetrazol-5-yl)-...)
Show SMILES CCCc1nc(C(O)=O)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H22N6O3/c1-2-5-19-23-20(22(30)31)18(13-29)28(19)12-14-8-10-15(11-9-14)16-6-3-4-7-17(16)21-24-26-27-25-21/h3-4,6-11,29H,2,5,12-13H2,1H3,(H,30,31)(H,24,25,26,27)
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n/an/a 4.60E+3n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049131
PNG
(2-Propyl-1-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmet...)
Show SMILES CCCc1nc(cn1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(O)=O
Show InChI InChI=1S/C21H20N6O2/c1-2-5-19-22-18(21(28)29)13-27(19)12-14-8-10-15(11-9-14)16-6-3-4-7-17(16)20-23-25-26-24-20/h3-4,6-11,13H,2,5,12H2,1H3,(H,28,29)(H,23,24,25,26)
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n/an/a 1.40E+4n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049121
PNG
(1-(2'-Carboxy-biphenyl-4-ylmethyl)-5-hydroxymethyl...)
Show SMILES CCCc1nc(C(O)=O)c(CO)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H22N2O5/c1-2-5-19-23-20(22(28)29)18(13-25)24(19)12-14-8-10-15(11-9-14)16-6-3-4-7-17(16)21(26)27/h3-4,6-11,25H,2,5,12-13H2,1H3,(H,26,27)(H,28,29)
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n/an/a 2.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125l]-All binding to bovine adrenal cortex


Bioorg Med Chem Lett 4: 177-182 (1994)


Article DOI: 10.1016/S0960-894X(01)81143-4
BindingDB Entry DOI: 10.7270/Q2BG2NZQ
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049121
PNG
(1-(2'-Carboxy-biphenyl-4-ylmethyl)-5-hydroxymethyl...)
Show SMILES CCCc1nc(C(O)=O)c(CO)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H22N2O5/c1-2-5-19-23-20(22(28)29)18(13-25)24(19)12-14-8-10-15(11-9-14)16-6-3-4-7-17(16)21(26)27/h3-4,6-11,25H,2,5,12-13H2,1H3,(H,26,27)(H,28,29)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50049101
PNG
(1-(2'-Carboxy-biphenyl-4-ylmethyl)-2-propyl-1H-imi...)
Show SMILES CCCc1nc(cn1Cc1ccc(cc1)-c1ccccc1C(O)=O)C(O)=O
Show InChI InChI=1S/C21H20N2O4/c1-2-5-19-22-18(21(26)27)13-23(19)12-14-8-10-15(11-9-14)16-6-3-4-7-17(16)20(24)25/h3-4,6-11,13H,2,5,12H2,1H3,(H,24,25)(H,26,27)
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n/an/a 4.50E+4n/an/an/an/an/an/a



Sankyo Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex


J Med Chem 39: 323-38 (1996)


Article DOI: 10.1021/jm950450f
BindingDB Entry DOI: 10.7270/Q28S4P18
More data for this
Ligand-Target Pair