BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 766 hits with Last Name = 'soni' and Initial = 'nb'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26707
PNG
(7-chloro-9-ethyl-6-hydroxy-1H,3H,4H,9H-quinolino[2...)
Show SMILES CCn1c2noc(=O)c2c(O)c2cc(O)c(Cl)cc12
Show InChI InChI=1S/C12H9ClN2O4/c1-2-15-7-4-6(13)8(16)3-5(7)10(17)9-11(15)14-19-12(9)18/h3-4,16-17H,2H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.5 -48.6n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...


Bioorg Med Chem Lett 18: 5206-8 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26698
PNG
(7-chloro-6-fluoro-9-(propan-2-yl)-1H,3H,4H,9H-quin...)
Show SMILES CC(C)n1c2noc(=O)c2c(O)c2cc(F)c(Cl)cc12
Show InChI InChI=1S/C13H10ClFN2O3/c1-5(2)17-9-4-7(14)8(15)3-6(9)11(18)10-12(17)16-20-13(10)19/h3-5,18H,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
12.3 -44.7n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...


Bioorg Med Chem Lett 18: 5206-8 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26699
PNG
(9-butyl-7-chloro-6-fluoro-1H,3H,4H,9H-quinolino[2,...)
Show SMILES CCCCn1c2noc(=O)c2c(O)c2cc(F)c(Cl)cc12
Show InChI InChI=1S/C14H12ClFN2O3/c1-2-3-4-18-10-6-8(15)9(16)5-7(10)12(19)11-13(18)17-21-14(11)20/h5-6,19H,2-4H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
15 -44.2n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...


Bioorg Med Chem Lett 18: 5206-8 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26697
PNG
(7-chloro-9-ethyl-6-fluoro-1H,3H,4H,9H-quinolino[2,...)
Show SMILES CCn1c2noc(=O)c2c(O)c2cc(F)c(Cl)cc12
Show InChI InChI=1S/C12H8ClFN2O3/c1-2-16-8-4-6(13)7(14)3-5(8)10(17)9-11(16)15-19-12(9)18/h3-4,17H,2H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
21.8 -43.3n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...


Bioorg Med Chem Lett 18: 5206-8 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26700
PNG
(9-benzyl-7-chloro-6-fluoro-1H,3H,4H,9H-quinolino[2...)
Show SMILES Oc1c2c(noc2=O)n(Cc2ccccc2)c2cc(Cl)c(F)cc12
Show InChI InChI=1S/C17H10ClFN2O3/c18-11-7-13-10(6-12(11)19)15(22)14-16(20-24-17(14)23)21(13)8-9-4-2-1-3-5-9/h1-7,22H,8H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
36.5 -42.0n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...


Bioorg Med Chem Lett 18: 5206-8 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM26707
PNG
(7-chloro-9-ethyl-6-hydroxy-1H,3H,4H,9H-quinolino[2...)
Show SMILES CCn1c2noc(=O)c2c(O)c2cc(O)c(Cl)cc12
Show InChI InChI=1S/C12H9ClN2O4/c1-2-15-7-4-6(13)8(16)3-5(7)10(17)9-11(15)14-19-12(9)18/h3-4,16-17H,2H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
43.5 -41.6n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...


Bioorg Med Chem Lett 18: 5206-8 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26701
PNG
(7-chloro-9-ethyl-6-fluoro-1-methyl-1H,3H,4H,9H-qui...)
Show SMILES CCn1c2n(C)oc(=O)c2c(=O)c2cc(F)c(Cl)cc12
Show InChI InChI=1S/C13H10ClFN2O3/c1-3-17-9-5-7(14)8(15)4-6(9)11(18)10-12(17)16(2)20-13(10)19/h4-5H,3H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
50.1 -41.2n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...


Bioorg Med Chem Lett 18: 5206-8 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM26698
PNG
(7-chloro-6-fluoro-9-(propan-2-yl)-1H,3H,4H,9H-quin...)
Show SMILES CC(C)n1c2noc(=O)c2c(O)c2cc(F)c(Cl)cc12
Show InChI InChI=1S/C13H10ClFN2O3/c1-5(2)17-9-4-7(14)8(15)3-6(9)11(18)10-12(17)16-20-13(10)19/h3-5,18H,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
62.8 -40.7n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...


Bioorg Med Chem Lett 18: 5206-8 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM26699
PNG
(9-butyl-7-chloro-6-fluoro-1H,3H,4H,9H-quinolino[2,...)
Show SMILES CCCCn1c2noc(=O)c2c(O)c2cc(F)c(Cl)cc12
Show InChI InChI=1S/C14H12ClFN2O3/c1-2-3-4-18-10-6-8(15)9(16)5-7(10)12(19)11-13(18)17-21-14(11)20/h5-6,19H,2-4H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
165 -38.3n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...


Bioorg Med Chem Lett 18: 5206-8 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM26697
PNG
(7-chloro-9-ethyl-6-fluoro-1H,3H,4H,9H-quinolino[2,...)
Show SMILES CCn1c2noc(=O)c2c(O)c2cc(F)c(Cl)cc12
Show InChI InChI=1S/C12H8ClFN2O3/c1-2-16-8-4-6(13)7(14)3-5(8)10(17)9-11(16)15-19-12(9)18/h3-4,17H,2H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
174 -38.2n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...


Bioorg Med Chem Lett 18: 5206-8 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26703
PNG
(7-chloro-9-ethyl-6-fluoro-1-[(3-hydroxyphenyl)meth...)
Show SMILES CCn1c2n(Cc3cccc(O)c3)oc(=O)c2c(=O)c2cc(F)c(Cl)cc12
Show InChI InChI=1S/C19H14ClFN2O4/c1-2-22-15-8-13(20)14(21)7-12(15)17(25)16-18(22)23(27-19(16)26)9-10-4-3-5-11(24)6-10/h3-8,24H,2,9H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
271 -37.1n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...


Bioorg Med Chem Lett 18: 5206-8 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM26700
PNG
(9-benzyl-7-chloro-6-fluoro-1H,3H,4H,9H-quinolino[2...)
Show SMILES Oc1c2c(noc2=O)n(Cc2ccccc2)c2cc(Cl)c(F)cc12
Show InChI InChI=1S/C17H10ClFN2O3/c18-11-7-13-10(6-12(11)19)15(22)14-16(20-24-17(14)23)21(13)8-9-4-2-1-3-5-9/h1-7,22H,8H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
558 -35.3n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...


Bioorg Med Chem Lett 18: 5206-8 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26705
PNG
(7-chloro-9-ethyl-6-fluoro-1-(2-hydroxyethyl)-1H,3H...)
Show SMILES CCn1c2n(CCO)oc(=O)c2c(=O)c2cc(F)c(Cl)cc12
Show InChI InChI=1S/C14H12ClFN2O4/c1-2-17-10-6-8(15)9(16)5-7(10)12(20)11-13(17)18(3-4-19)22-14(11)21/h5-6,19H,2-4H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.16E+3 -33.5n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...


Bioorg Med Chem Lett 18: 5206-8 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26702
PNG
(1-benzyl-7-chloro-9-ethyl-6-fluoro-1H,3H,4H,9H-qui...)
Show SMILES CCn1c2n(Cc3ccccc3)oc(=O)c2c(=O)c2cc(F)c(Cl)cc12
Show InChI InChI=1S/C19H14ClFN2O3/c1-2-22-15-9-13(20)14(21)8-12(15)17(24)16-18(22)23(26-19(16)25)10-11-6-4-3-5-7-11/h3-9H,2,10H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.27E+3 -33.3n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...


Bioorg Med Chem Lett 18: 5206-8 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM26701
PNG
(7-chloro-9-ethyl-6-fluoro-1-methyl-1H,3H,4H,9H-qui...)
Show SMILES CCn1c2n(C)oc(=O)c2c(=O)c2cc(F)c(Cl)cc12
Show InChI InChI=1S/C13H10ClFN2O3/c1-3-17-9-5-7(14)8(15)4-6(9)11(18)10-12(17)16(2)20-13(10)19/h4-5H,3H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.42E+3>-33.0n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...


Bioorg Med Chem Lett 18: 5206-8 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM26706
PNG
(7-chloro-9-ethyl-6-methoxy-1H,3H,4H,9H-quinolino[2...)
Show SMILES CCn1c2noc(=O)c2c(O)c2cc(OC)c(Cl)cc12
Show InChI InChI=1S/C13H11ClN2O4/c1-3-16-8-5-7(14)9(19-2)4-6(8)11(17)10-12(16)15-20-13(10)18/h4-5,17H,3H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.42E+3>-33.0n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...


Bioorg Med Chem Lett 18: 5206-8 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM26702
PNG
(1-benzyl-7-chloro-9-ethyl-6-fluoro-1H,3H,4H,9H-qui...)
Show SMILES CCn1c2n(Cc3ccccc3)oc(=O)c2c(=O)c2cc(F)c(Cl)cc12
Show InChI InChI=1S/C19H14ClFN2O3/c1-2-22-15-9-13(20)14(21)8-12(15)17(24)16-18(22)23(26-19(16)25)10-11-6-4-3-5-7-11/h3-9H,2,10H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.42E+3>-33.0n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...


Bioorg Med Chem Lett 18: 5206-8 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM26703
PNG
(7-chloro-9-ethyl-6-fluoro-1-[(3-hydroxyphenyl)meth...)
Show SMILES CCn1c2n(Cc3cccc(O)c3)oc(=O)c2c(=O)c2cc(F)c(Cl)cc12
Show InChI InChI=1S/C19H14ClFN2O4/c1-2-22-15-8-13(20)14(21)7-12(15)17(25)16-18(22)23(27-19(16)26)9-10-4-3-5-11(24)6-10/h3-8,24H,2,9H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.42E+3>-33.0n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...


Bioorg Med Chem Lett 18: 5206-8 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM26704
PNG
(1-[2-(benzyloxy)ethyl]-7-chloro-9-ethyl-6-fluoro-1...)
Show SMILES CCn1c2n(CCOCc3ccccc3)oc(=O)c2c(=O)c2cc(F)c(Cl)cc12
Show InChI InChI=1S/C21H18ClFN2O4/c1-2-24-17-11-15(22)16(23)10-14(17)19(26)18-20(24)25(29-21(18)27)8-9-28-12-13-6-4-3-5-7-13/h3-7,10-11H,2,8-9,12H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.42E+3>-33.0n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...


Bioorg Med Chem Lett 18: 5206-8 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM26705
PNG
(7-chloro-9-ethyl-6-fluoro-1-(2-hydroxyethyl)-1H,3H...)
Show SMILES CCn1c2n(CCO)oc(=O)c2c(=O)c2cc(F)c(Cl)cc12
Show InChI InChI=1S/C14H12ClFN2O4/c1-2-17-10-6-8(15)9(16)5-7(10)12(20)11-13(17)18(3-4-19)22-14(11)21/h5-6,19H,2-4H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.42E+3>-33.0n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...


Bioorg Med Chem Lett 18: 5206-8 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26706
PNG
(7-chloro-9-ethyl-6-methoxy-1H,3H,4H,9H-quinolino[2...)
Show SMILES CCn1c2noc(=O)c2c(O)c2cc(OC)c(Cl)cc12
Show InChI InChI=1S/C13H11ClN2O4/c1-3-16-8-5-7(14)9(19-2)4-6(8)11(17)10-12(16)15-20-13(10)18/h4-5,17H,3H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.70E+3 -31.5n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...


Bioorg Med Chem Lett 18: 5206-8 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26704
PNG
(1-[2-(benzyloxy)ethyl]-7-chloro-9-ethyl-6-fluoro-1...)
Show SMILES CCn1c2n(CCOCc3ccccc3)oc(=O)c2c(=O)c2cc(F)c(Cl)cc12
Show InChI InChI=1S/C21H18ClFN2O4/c1-2-24-17-11-15(22)16(23)10-14(17)19(26)18-20(24)25(29-21(18)27)8-9-28-12-13-6-4-3-5-7-13/h3-7,10-11H,2,8-9,12H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.89E+3 -30.0n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...


Bioorg Med Chem Lett 18: 5206-8 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50372144
PNG
(CHEMBL272938)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cncc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C20H18N6O/c1-12-3-2-4-15(9-12)24-20(27)23-14-7-5-13(6-8-14)16-10-22-11-17-18(16)19(21)26-25-17/h2-11H,1H3,(H3,21,25,26)(H2,23,24,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.600n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells


Bioorg Med Chem Lett 18: 386-90 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50372144
PNG
(CHEMBL272938)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cncc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C20H18N6O/c1-12-3-2-4-15(9-12)24-20(27)23-14-7-5-13(6-8-14)16-10-22-11-17-18(16)19(21)26-25-17/h2-11H,1H3,(H3,21,25,26)(H2,23,24,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.700n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 18: 386-90 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50372140
PNG
(CHEMBL404669)
Show SMILES Cc1cc(NC(=O)Nc2ccc(cc2)-c2cncc3[nH]nc(N)c23)ccc1F
Show InChI InChI=1S/C20H17FN6O/c1-11-8-14(6-7-16(11)21)25-20(28)24-13-4-2-12(3-5-13)15-9-23-10-17-18(15)19(22)27-26-17/h2-10H,1H3,(H3,22,26,27)(H2,24,25,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.700n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells


Bioorg Med Chem Lett 18: 386-90 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50372140
PNG
(CHEMBL404669)
Show SMILES Cc1cc(NC(=O)Nc2ccc(cc2)-c2cncc3[nH]nc(N)c23)ccc1F
Show InChI InChI=1S/C20H17FN6O/c1-11-8-14(6-7-16(11)21)25-20(28)24-13-4-2-12(3-5-13)15-9-23-10-17-18(15)19(22)27-26-17/h2-10H,1H3,(H3,22,26,27)(H2,24,25,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.700n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 18: 386-90 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243417
PNG
(1-{4-[7-Amino-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(ccn3c2N)-c2cnn(C)c2)c1
Show InChI InChI=1S/C25H23N7O/c1-16-4-3-5-20(12-16)30-25(33)29-19-8-6-17(7-9-19)22-14-27-24-21(10-11-32(24)23(22)26)18-13-28-31(2)15-18/h3-15H,26H2,1-2H3,(H2,29,30,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.700n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells by ELISA


J Med Chem 51: 3777-87 (2008)

More data for this
Ligand-Target Pair
Aurora kinase B/Inner centromere protein


(Homo sapiens (Human))
BDBM50389262
PNG
(CHEMBL2063459)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3cccc(CNC(=O)Nc4ccc(Cl)cc4)c3)c12
Show InChI InChI=1S/C21H18ClN7O2/c22-14-4-6-15(7-5-14)28-21(31)24-11-13-2-1-3-16(10-13)27-20(30)17-8-9-29-18(17)19(23)25-12-26-29/h1-10,12H,11H2,(H,27,30)(H2,23,25,26)(H2,24,28,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.900n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Aurora B kinase by HTRF analysis in presence of 1 mM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50243360
PNG
(1-{4-[7-Amino-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(cnn3c2N)-c2cnn(C)c2)c1
Show InChI InChI=1S/C24H22N8O/c1-15-4-3-5-19(10-15)30-24(33)29-18-8-6-16(7-9-18)20-12-26-23-21(13-28-32(23)22(20)25)17-11-27-31(2)14-17/h3-14H,25H2,1-2H3,(H2,29,30,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells by ELISA


J Med Chem 51: 3777-87 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50372154
PNG
(CHEMBL255746)
Show SMILES Nc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12
Show InChI InChI=1S/C19H15ClN6O/c20-12-2-1-3-14(10-12)24-19(27)23-13-6-4-11(5-7-13)15-8-9-22-18-16(15)17(21)25-26-18/h1-10H,(H2,23,24,27)(H3,21,22,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 18: 386-90 (2008)

More data for this
Ligand-Target Pair
Aurora kinase B/Inner centromere protein


(Homo sapiens (Human))
BDBM50389261
PNG
(CHEMBL2063461)
Show SMILES Cc1ccc(NC(=O)NCc2cccc(NC(=O)c3ccn4ncnc(N)c34)c2)cc1
Show InChI InChI=1S/C22H21N7O2/c1-14-5-7-16(8-6-14)28-22(31)24-12-15-3-2-4-17(11-15)27-21(30)18-9-10-29-19(18)20(23)25-13-26-29/h2-11,13H,12H2,1H3,(H,27,30)(H2,23,25,26)(H2,24,28,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Aurora B kinase by HTRF analysis in presence of 1 mM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50381693
PNG
(CHEMBL2023221)
Show SMILES CNC(=O)c1cnc(N)c2c(csc12)-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C23H21N5O2S/c1-13-4-3-5-16(10-13)28-23(30)27-15-8-6-14(7-9-15)18-12-31-20-17(22(29)25-2)11-26-21(24)19(18)20/h3-12H,1-2H3,(H2,24,26)(H,25,29)(H2,27,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells


Bioorg Med Chem Lett 22: 3208-12 (2012)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50372156
PNG
(CHEMBL257479)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccnc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C20H18N6O/c1-12-3-2-4-15(11-12)24-20(27)23-14-7-5-13(6-8-14)16-9-10-22-19-17(16)18(21)25-26-19/h2-11H,1H3,(H2,23,24,27)(H3,21,22,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells


Bioorg Med Chem Lett 18: 386-90 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50372142
PNG
(CHEMBL271441)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cncc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C20H17FN6O/c1-11-2-7-15(21)16(8-11)25-20(28)24-13-5-3-12(4-6-13)14-9-23-10-17-18(14)19(22)27-26-17/h2-10H,1H3,(H3,22,26,27)(H2,24,25,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells


Bioorg Med Chem Lett 18: 386-90 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50381696
PNG
(CHEMBL2021941)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2cc[nH]c2)c1
Show InChI InChI=1S/C25H21N5OS/c1-15-3-2-4-19(11-15)30-25(31)29-18-7-5-16(6-8-18)21-14-32-23-20(17-9-10-27-12-17)13-28-24(26)22(21)23/h2-14,27H,1H3,(H2,26,28)(H2,29,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells


Bioorg Med Chem Lett 22: 3208-12 (2012)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50372149
PNG
(CHEMBL255743)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2ccnc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C20H17FN6O/c1-11-2-7-15(21)16(10-11)25-20(28)24-13-5-3-12(4-6-13)14-8-9-23-19-17(14)18(22)26-27-19/h2-10H,1H3,(H2,24,25,28)(H3,22,23,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells


Bioorg Med Chem Lett 18: 386-90 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201303
PNG
(1-(4-(4-amino-7-(pyrimidin-5-yl)thieno[3,2-c]pyrid...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2cncnc2)c1
Show InChI InChI=1S/C25H20N6OS/c1-15-3-2-4-19(9-15)31-25(32)30-18-7-5-16(6-8-18)21-13-33-23-20(12-29-24(26)22(21)23)17-10-27-14-28-11-17/h2-14H,1H3,(H2,26,29)(H2,30,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation in NIH3T3 cells


Bioorg Med Chem Lett 17: 1246-9 (2007)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50372150
PNG
(CHEMBL255744)
Show SMILES Cc1cc(C)cc(NC(=O)Nc2ccc(cc2)-c2ccnc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H20N6O/c1-12-9-13(2)11-16(10-12)25-21(28)24-15-5-3-14(4-6-15)17-7-8-23-20-18(17)19(22)26-27-20/h3-11H,1-2H3,(H2,24,25,28)(H3,22,23,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 18: 386-90 (2008)

More data for this
Ligand-Target Pair
Aurora kinase B/Inner centromere protein


(Homo sapiens (Human))
BDBM50381719
PNG
(CHEMBL2022856)
Show SMILES C[C@@H](O)Cn1cc(cn1)-c1cnc(N)c2c(csc12)-c1ccc(NC(=O)Nc2cccc(F)c2)cc1
Show InChI InChI=1S/C26H23FN6O2S/c1-15(34)12-33-13-17(10-30-33)21-11-29-25(28)23-22(14-36-24(21)23)16-5-7-19(8-6-16)31-26(35)32-20-4-2-3-18(27)9-20/h2-11,13-15,34H,12H2,1H3,(H2,28,29)(H2,31,32,35)/t15-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Aurora B using 1 mM ATP by HTRF assay


Bioorg Med Chem Lett 22: 3208-12 (2012)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50372141
PNG
(CHEMBL256246)
Show SMILES Nc1n[nH]c2cncc(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C20H14F4N6O/c21-14-6-3-11(20(22,23)24)7-15(14)28-19(31)27-12-4-1-10(2-5-12)13-8-26-9-16-17(13)18(25)30-29-16/h1-9H,(H3,25,29,30)(H2,27,28,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 18: 386-90 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50381713
PNG
(CHEMBL2022853)
Show SMILES CS(=O)(=O)CCn1cc(cn1)-c1cnc(N)c2c(csc12)-c1ccc(NC(=O)Nc2cccc(F)c2)cc1
Show InChI InChI=1S/C26H23FN6O3S2/c1-38(35,36)10-9-33-14-17(12-30-33)21-13-29-25(28)23-22(15-37-24(21)23)16-5-7-19(8-6-16)31-26(34)32-20-4-2-3-18(27)11-20/h2-8,11-15H,9-10H2,1H3,(H2,28,29)(H2,31,32,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells


Bioorg Med Chem Lett 22: 3208-12 (2012)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50372147
PNG
(CHEMBL273187)
Show SMILES Cc1cc(NC(=O)Nc2ccc(cc2)-c2ccnc3[nH]nc(N)c23)ccc1F
Show InChI InChI=1S/C20H17FN6O/c1-11-10-14(6-7-16(11)21)25-20(28)24-13-4-2-12(3-5-13)15-8-9-23-19-17(15)18(22)26-27-19/h2-10H,1H3,(H2,24,25,28)(H3,22,23,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.10n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 18: 386-90 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50372150
PNG
(CHEMBL255744)
Show SMILES Cc1cc(C)cc(NC(=O)Nc2ccc(cc2)-c2ccnc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H20N6O/c1-12-9-13(2)11-16(10-12)25-21(28)24-15-5-3-14(4-6-15)17-7-8-23-20-18(17)19(22)26-27-20/h3-11H,1-2H3,(H2,24,25,28)(H3,22,23,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.10n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells


Bioorg Med Chem Lett 18: 386-90 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50372147
PNG
(CHEMBL273187)
Show SMILES Cc1cc(NC(=O)Nc2ccc(cc2)-c2ccnc3[nH]nc(N)c23)ccc1F
Show InChI InChI=1S/C20H17FN6O/c1-11-10-14(6-7-16(11)21)25-20(28)24-13-4-2-12(3-5-13)15-8-9-23-19-17(15)18(22)26-27-19/h2-10H,1H3,(H2,24,25,28)(H3,22,23,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.20n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells


Bioorg Med Chem Lett 18: 386-90 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50372143
PNG
(CHEMBL404342)
Show SMILES Nc1n[nH]c2cncc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12
Show InChI InChI=1S/C19H15ClN6O/c20-12-2-1-3-14(8-12)24-19(27)23-13-6-4-11(5-7-13)15-9-22-10-16-17(15)18(21)26-25-16/h1-10H,(H3,21,25,26)(H2,23,24,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.20n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 18: 386-90 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50372141
PNG
(CHEMBL256246)
Show SMILES Nc1n[nH]c2cncc(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C20H14F4N6O/c21-14-6-3-11(20(22,23)24)7-15(14)28-19(31)27-12-4-1-10(2-5-12)13-8-26-9-16-17(13)18(25)30-29-16/h1-9H,(H3,25,29,30)(H2,27,28,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.30n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells


Bioorg Med Chem Lett 18: 386-90 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50372154
PNG
(CHEMBL255746)
Show SMILES Nc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12
Show InChI InChI=1S/C19H15ClN6O/c20-12-2-1-3-14(10-12)24-19(27)23-13-6-4-11(5-7-13)15-8-9-22-18-16(15)17(21)25-26-18/h1-10H,(H2,23,24,27)(H3,21,22,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.5n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells


Bioorg Med Chem Lett 18: 386-90 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50372162
PNG
(CHEMBL404366)
Show SMILES Cn1nc(N)c2c(cncc12)-c1ccc(NC(=O)Nc2cccc(Cl)c2)cc1
Show InChI InChI=1S/C20H17ClN6O/c1-27-17-11-23-10-16(18(17)19(22)26-27)12-5-7-14(8-6-12)24-20(28)25-15-4-2-3-13(21)9-15/h2-11H,1H3,(H2,22,26)(H2,24,25,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.5n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 18: 386-90 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50372153
PNG
(CHEMBL255955)
Show SMILES Nc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cccc(c4)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C20H15F3N6O/c21-20(22,23)12-2-1-3-14(10-12)27-19(30)26-13-6-4-11(5-7-13)15-8-9-25-18-16(15)17(24)28-29-18/h1-10H,(H2,26,27,30)(H3,24,25,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.70n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 18: 386-90 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50372145
PNG
(CHEMBL256205)
Show SMILES Nc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4ccc(F)c(Cl)c4)cc3)c12
Show InChI InChI=1S/C19H14ClFN6O/c20-14-9-12(5-6-15(14)21)25-19(28)24-11-3-1-10(2-4-11)13-7-8-23-18-16(13)17(22)26-27-18/h1-9H,(H2,24,25,28)(H3,22,23,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.80n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


Bioorg Med Chem Lett 18: 386-90 (2008)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 766 total )  |  Next  |  Last  >>
Jump to: