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Compile Data Set for Download or QSAR

Found 165 hits with Last Name = 'sonnenberg' and Initial = 'jd'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50101563
PNG
(1-(2-Hydroxy-1-methyl-2-phenyl-ethyl)-1-methyl-3-(...)
Show SMILES C[C@H]([C@@H](O)c1ccccc1)N(C)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H24N2O3/c1-17(22(26)18-9-5-3-6-10-18)25(2)23(27)24-19-13-15-21(16-14-19)28-20-11-7-4-8-12-20/h3-17,22,26H,1-2H3,(H,24,27)/t17-,22-/m1/s1
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24n/an/an/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Tested in a cellular assay measuring forskolin-induced cyclic AMP accumulation in 293 cells transfected with the human NPY5 receptor


J Med Chem 44: 2344-56 (2001)


Article DOI: 10.1021/jm0004547
BindingDB Entry DOI: 10.7270/Q2DV1J56
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50101548
PNG
(3-(4-Benzyloxy-phenyl)-1-(2-hydroxy-1-methyl-2-phe...)
Show SMILES C[C@H]([C@@H](O)c1ccccc1)N(C)C(=O)Nc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C24H26N2O3/c1-18(23(27)20-11-7-4-8-12-20)26(2)24(28)25-21-13-15-22(16-14-21)29-17-19-9-5-3-6-10-19/h3-16,18,23,27H,17H2,1-2H3,(H,25,28)/t18-,23-/m1/s1
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101n/an/an/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Tested in a cellular assay measuring forskolin-induced cyclic AMP accumulation in 293 cells transfected with the human NPY5 receptor


J Med Chem 44: 2344-56 (2001)


Article DOI: 10.1021/jm0004547
BindingDB Entry DOI: 10.7270/Q2DV1J56
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50101536
PNG
(1-(2-Hydroxy-1-methyl-2-phenyl-ethyl)-1-methyl-3-(...)
Show SMILES C[C@H]([C@H](O)c1ccccc1)N(C)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H24N2O3/c1-17(22(26)18-9-5-3-6-10-18)25(2)23(27)24-19-13-15-21(16-14-19)28-20-11-7-4-8-12-20/h3-17,22,26H,1-2H3,(H,24,27)/t17-,22+/m1/s1
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477n/an/an/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Tested in a cellular assay measuring forskolin-induced cyclic AMP accumulation in 293 cells transfected with the human NPY5 receptor


J Med Chem 44: 2344-56 (2001)


Article DOI: 10.1021/jm0004547
BindingDB Entry DOI: 10.7270/Q2DV1J56
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50101543
PNG
(1-(2-Hydroxy-1-methyl-2-phenyl-ethyl)-1-methyl-3-(...)
Show SMILES C[C@@H]([C@H](O)c1ccccc1)N(C)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H24N2O3/c1-17(22(26)18-9-5-3-6-10-18)25(2)23(27)24-19-13-15-21(16-14-19)28-20-11-7-4-8-12-20/h3-17,22,26H,1-2H3,(H,24,27)/t17-,22-/m0/s1
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515n/an/an/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Tested in a cellular assay measuring forskolin-induced cyclic AMP accumulation in 293 cells transfected with the human NPY5 receptor


J Med Chem 44: 2344-56 (2001)


Article DOI: 10.1021/jm0004547
BindingDB Entry DOI: 10.7270/Q2DV1J56
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093652
PNG
(2-Methyl-6-pentyl-4-piperidin-1-yl-5H-pyrrolo[3,2-...)
Show SMILES CCCCCc1cc2nc(C)nc(N3CCCCC3)c2[nH]1
Show InChI InChI=1S/C17H26N4/c1-3-4-6-9-14-12-15-16(20-14)17(19-13(2)18-15)21-10-7-5-8-11-21/h12,20H,3-11H2,1-2H3
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n/an/a 0.200n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093696
PNG
(6-(3-Fluoro-phenyl)-2-methyl-4-piperidin-1-yl-5H-p...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C18H19FN4/c1-12-20-16-11-15(13-6-5-7-14(19)10-13)22-17(16)18(21-12)23-8-3-2-4-9-23/h5-7,10-11,22H,2-4,8-9H2,1H3
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n/an/a 0.300n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093664
PNG
(6-(4-Fluoro-phenyl)-2-methyl-4-piperidin-1-yl-5H-p...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C18H19FN4/c1-12-20-16-11-15(13-5-7-14(19)8-6-13)22-17(16)18(21-12)23-9-3-2-4-10-23/h5-8,11,22H,2-4,9-10H2,1H3
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n/an/a 0.300n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093646
PNG
(6-Benzofuran-2-yl-2-methyl-4-piperidin-1-yl-5H-pyr...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1cc2ccccc2o1
Show InChI InChI=1S/C20H20N4O/c1-13-21-16-12-15(18-11-14-7-3-4-8-17(14)25-18)23-19(16)20(22-13)24-9-5-2-6-10-24/h3-4,7-8,11-12,23H,2,5-6,9-10H2,1H3
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n/an/a 0.300n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093691
PNG
(4-(3,6-Dihydro-2H-pyridin-1-yl)-2-methyl-6-phenyl-...)
Show SMILES Cc1nc(N2CCC=CC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C18H18N4/c1-13-19-16-12-15(14-8-4-2-5-9-14)21-17(16)18(20-13)22-10-6-3-7-11-22/h2-6,8-9,12,21H,7,10-11H2,1H3
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n/an/a 0.400n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093675
PNG
(6-(3,5-Difluoro-phenyl)-2-methyl-4-piperidin-1-yl-...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C18H18F2N4/c1-11-21-16-10-15(12-7-13(19)9-14(20)8-12)23-17(16)18(22-11)24-5-3-2-4-6-24/h7-10,23H,2-6H2,1H3
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n/an/a 0.400n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50101571
PNG
(1-Methyl-1-(1-methyl-2-pyridin-4-yl-ethyl)-3-(4-ph...)
Show SMILES CC(Cc1ccncc1)N(C)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C22H23N3O2/c1-17(16-18-12-14-23-15-13-18)25(2)22(26)24-19-8-10-21(11-9-19)27-20-6-4-3-5-7-20/h3-15,17H,16H2,1-2H3,(H,24,26)
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n/an/a 0.5n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibitory activity tested against Human Neuropeptide Y5 Receptor.


J Med Chem 44: 2344-56 (2001)


Article DOI: 10.1021/jm0004547
BindingDB Entry DOI: 10.7270/Q2DV1J56
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093697
PNG
(2-Methyl-4-piperidin-1-yl-6-p-tolyl-5H-pyrrolo[3,2...)
Show SMILES Cc1ccc(cc1)-c1cc2nc(C)nc(N3CCCCC3)c2[nH]1
Show InChI InChI=1S/C19H22N4/c1-13-6-8-15(9-7-13)16-12-17-18(22-16)19(21-14(2)20-17)23-10-4-3-5-11-23/h6-9,12,22H,3-5,10-11H2,1-2H3
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n/an/a 0.5n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093647
PNG
(2-Methyl-6-(5-methyl-furan-2-yl)-4-piperidin-1-yl-...)
Show SMILES Cc1ccc(o1)-c1cc2nc(C)nc(N3CCCCC3)c2[nH]1
Show InChI InChI=1S/C17H20N4O/c1-11-6-7-15(22-11)13-10-14-16(20-13)17(19-12(2)18-14)21-8-4-3-5-9-21/h6-7,10,20H,3-5,8-9H2,1-2H3
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n/an/a 0.5n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093678
PNG
(2-Methyl-6-phenyl-4-pyrrolidin-1-yl-5H-pyrrolo[3,2...)
Show SMILES Cc1nc(N2CCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C17H18N4/c1-12-18-15-11-14(13-7-3-2-4-8-13)20-16(15)17(19-12)21-9-5-6-10-21/h2-4,7-8,11,20H,5-6,9-10H2,1H3
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n/an/a 0.700n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093673
PNG
(2-Methyl-4-piperidin-1-yl-6-(4-trifluoromethyl-phe...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H19F3N4/c1-12-23-16-11-15(13-5-7-14(8-6-13)19(20,21)22)25-17(16)18(24-12)26-9-3-2-4-10-26/h5-8,11,25H,2-4,9-10H2,1H3
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n/an/a 0.700n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50101533
PNG
(1-[2-(4-Chloro-phenyl)-1-methyl-ethyl]-1-methyl-3-...)
Show SMILES CC(Cc1ccc(Cl)cc1)N(C)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H23ClN2O2/c1-17(16-18-8-10-19(24)11-9-18)26(2)23(27)25-20-12-14-22(15-13-20)28-21-6-4-3-5-7-21/h3-15,17H,16H2,1-2H3,(H,25,27)
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n/an/a 0.900n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibitory activity tested against Human Neuropeptide Y5 Receptor.


J Med Chem 44: 2344-56 (2001)


Article DOI: 10.1021/jm0004547
BindingDB Entry DOI: 10.7270/Q2DV1J56
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093683
PNG
(2-Methyl-6-phenyl-4-piperidin-1-yl-5H-pyrrolo[3,2-...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C18H20N4/c1-13-19-16-12-15(14-8-4-2-5-9-14)21-17(16)18(20-13)22-10-6-3-7-11-22/h2,4-5,8-9,12,21H,3,6-7,10-11H2,1H3
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n/an/a 1.10n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093651
PNG
(6-Phenyl-4-piperidin-1-yl-5H-pyrrolo[3,2-d]pyrimid...)
Show SMILES Nc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C17H19N5/c18-17-20-14-11-13(12-7-3-1-4-8-12)19-15(14)16(21-17)22-9-5-2-6-10-22/h1,3-4,7-8,11,19H,2,5-6,9-10H2,(H2,18,20,21)
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n/an/a 1.20n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093692
PNG
(5-Methyl-2-phenyl-7-piperidin-1-yl-1H-pyrrolo[3,2-...)
Show SMILES Cc1cc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C19H21N3/c1-14-12-18(22-10-6-3-7-11-22)19-17(20-14)13-16(21-19)15-8-4-2-5-9-15/h2,4-5,8-9,12-13,21H,3,6-7,10-11H2,1H3
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n/an/a 1.70n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093616
PNG
(4-Azepan-1-yl-2-methyl-6-phenyl-5H-pyrrolo[3,2-d]p...)
Show SMILES Cc1nc(N2CCCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C19H22N4/c1-14-20-17-13-16(15-9-5-4-6-10-15)22-18(17)19(21-14)23-11-7-2-3-8-12-23/h4-6,9-10,13,22H,2-3,7-8,11-12H2,1H3
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n/an/a 1.80n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093640
PNG
(4-(2,5-Dihydro-pyrrol-1-yl)-2-methyl-6-phenyl-5H-p...)
Show SMILES Cc1nc(N2CC=CC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C17H16N4/c1-12-18-15-11-14(13-7-3-2-4-8-13)20-16(15)17(19-12)21-9-5-6-10-21/h2-8,11,20H,9-10H2,1H3
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n/an/a 2.20n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093672
PNG
(2-Methyl-4-(2-methyl-piperidin-1-yl)-6-phenyl-5H-p...)
Show SMILES CC1CCCCN1c1nc(C)nc2cc([nH]c12)-c1ccccc1
Show InChI InChI=1S/C19H22N4/c1-13-8-6-7-11-23(13)19-18-17(20-14(2)21-19)12-16(22-18)15-9-4-3-5-10-15/h3-5,9-10,12-13,22H,6-8,11H2,1-2H3
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n/an/a 3n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50101540
PNG
(1-Methyl-1-(1-methyl-2-phenyl-ethyl)-3-(4-phenoxy-...)
Show SMILES C[C@H](Cc1ccccc1)N(C)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H24N2O2/c1-18(17-19-9-5-3-6-10-19)25(2)23(26)24-20-13-15-22(16-14-20)27-21-11-7-4-8-12-21/h3-16,18H,17H2,1-2H3,(H,24,26)/t18-/m1/s1
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n/an/a 3.10n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibitory activity tested against Human Neuropeptide Y5 Receptor.


J Med Chem 44: 2344-56 (2001)


Article DOI: 10.1021/jm0004547
BindingDB Entry DOI: 10.7270/Q2DV1J56
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50101559
PNG
(1-(2-Hydroxy-1-methyl-2-phenyl-ethyl)-1-methyl-3-[...)
Show SMILES C[C@H]([C@@H](O)c1ccccc1)N(C)C(=O)Nc1ccc(Oc2cccc(c2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C23H23N3O5/c1-16(22(27)17-7-4-3-5-8-17)25(2)23(28)24-18-11-13-20(14-12-18)31-21-10-6-9-19(15-21)26(29)30/h3-16,22,27H,1-2H3,(H,24,28)/t16-,22-/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibitory activity tested against Human Neuropeptide Y5 Receptor.


J Med Chem 44: 2344-56 (2001)


Article DOI: 10.1021/jm0004547
BindingDB Entry DOI: 10.7270/Q2DV1J56
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50101531
PNG
(3-Dibenzofuran-2-yl-1-(2-hydroxy-1-methyl-2-phenyl...)
Show SMILES C[C@H]([C@@H](O)c1ccccc1)N(C)C(=O)Nc1ccc2oc3ccccc3c2c1
Show InChI InChI=1S/C23H22N2O3/c1-15(22(26)16-8-4-3-5-9-16)25(2)23(27)24-17-12-13-21-19(14-17)18-10-6-7-11-20(18)28-21/h3-15,22,26H,1-2H3,(H,24,27)/t15-,22-/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibitory activity tested against Human Neuropeptide Y5 Receptor.


J Med Chem 44: 2344-56 (2001)


Article DOI: 10.1021/jm0004547
BindingDB Entry DOI: 10.7270/Q2DV1J56
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50101537
PNG
(3-[4-(4-Chloro-phenoxy)-phenyl]-1-(2-hydroxy-1-met...)
Show SMILES C[C@H]([C@@H](O)c1ccccc1)N(C)C(=O)Nc1ccc(Oc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C23H23ClN2O3/c1-16(22(27)17-6-4-3-5-7-17)26(2)23(28)25-19-10-14-21(15-11-19)29-20-12-8-18(24)9-13-20/h3-16,22,27H,1-2H3,(H,25,28)/t16-,22-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibitory activity tested against Human Neuropeptide Y5 Receptor.


J Med Chem 44: 2344-56 (2001)


Article DOI: 10.1021/jm0004547
BindingDB Entry DOI: 10.7270/Q2DV1J56
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093624
PNG
(2-Methyl-6-phenethyl-4-piperidin-1-yl-5H-pyrrolo[3...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(CCc3ccccc3)cc2n1
Show InChI InChI=1S/C20H24N4/c1-15-21-18-14-17(11-10-16-8-4-2-5-9-16)23-19(18)20(22-15)24-12-6-3-7-13-24/h2,4-5,8-9,14,23H,3,6-7,10-13H2,1H3
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n/an/a 5.30n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50101563
PNG
(1-(2-Hydroxy-1-methyl-2-phenyl-ethyl)-1-methyl-3-(...)
Show SMILES C[C@H]([C@@H](O)c1ccccc1)N(C)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H24N2O3/c1-17(22(26)18-9-5-3-6-10-18)25(2)23(27)24-19-13-15-21(16-14-19)28-20-11-7-4-8-12-20/h3-17,22,26H,1-2H3,(H,24,27)/t17-,22-/m1/s1
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n/an/a 6.5n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibitory activity tested against Human Neuropeptide Y5 Receptor.


J Med Chem 44: 2344-56 (2001)


Article DOI: 10.1021/jm0004547
BindingDB Entry DOI: 10.7270/Q2DV1J56
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50101562
PNG
(1-(1,2-Diphenyl-ethyl)-1-methyl-3-(4-phenoxy-pheny...)
Show SMILES CN(C(Cc1ccccc1)c1ccccc1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C28H26N2O2/c1-30(27(23-13-7-3-8-14-23)21-22-11-5-2-6-12-22)28(31)29-24-17-19-26(20-18-24)32-25-15-9-4-10-16-25/h2-20,27H,21H2,1H3,(H,29,31)
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n/an/a 8n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibitory activity tested against Human Neuropeptide Y5 Receptor.


J Med Chem 44: 2344-56 (2001)


Article DOI: 10.1021/jm0004547
BindingDB Entry DOI: 10.7270/Q2DV1J56
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093632
PNG
(6-Cyclohexylmethyl-2-methyl-4-piperidin-1-yl-5H-py...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(CC3CCCCC3)cc2n1
Show InChI InChI=1S/C19H28N4/c1-14-20-17-13-16(12-15-8-4-2-5-9-15)22-18(17)19(21-14)23-10-6-3-7-11-23/h13,15,22H,2-12H2,1H3
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n/an/a 8.5n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50101549
PNG
(1-(2-Hydroxy-1-methyl-2-phenyl-ethyl)-1-methyl-3-(...)
Show SMILES C[C@H]([C@@H](O)c1ccccc1)N(C)C(=O)Nc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C23H24N2O3/c1-17(22(26)18-10-5-3-6-11-18)25(2)23(27)24-19-12-9-15-21(16-19)28-20-13-7-4-8-14-20/h3-17,22,26H,1-2H3,(H,24,27)/t17-,22-/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibitory activity tested against Human Neuropeptide Y5 Receptor.


J Med Chem 44: 2344-56 (2001)


Article DOI: 10.1021/jm0004547
BindingDB Entry DOI: 10.7270/Q2DV1J56
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093666
PNG
(6-Butyl-2-methyl-4-piperidin-1-yl-5H-pyrrolo[3,2-d...)
Show SMILES CCCCc1cc2nc(C)nc(N3CCCCC3)c2[nH]1
Show InChI InChI=1S/C16H24N4/c1-3-4-8-13-11-14-15(19-13)16(18-12(2)17-14)20-9-6-5-7-10-20/h11,19H,3-10H2,1-2H3
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n/an/a 10n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093693
PNG
(6-Cyclohexyl-2-methyl-4-piperidin-1-yl-5H-pyrrolo[...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)C1CCCCC1
Show InChI InChI=1S/C18H26N4/c1-13-19-16-12-15(14-8-4-2-5-9-14)21-17(16)18(20-13)22-10-6-3-7-11-22/h12,14,21H,2-11H2,1H3
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n/an/a 11n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093704
PNG
(4-(2,6-Dimethyl-piperidin-1-yl)-2-methyl-6-phenyl-...)
Show SMILES CC1CCCC(C)N1c1nc(C)nc2cc([nH]c12)-c1ccccc1
Show InChI InChI=1S/C20H24N4/c1-13-8-7-9-14(2)24(13)20-19-18(21-15(3)22-20)12-17(23-19)16-10-5-4-6-11-16/h4-6,10-14,23H,7-9H2,1-3H3
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n/an/a 17n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093633
PNG
(2-Methyl-6-phenoxymethyl-4-piperidin-1-yl-5H-pyrro...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(COc3ccccc3)cc2n1
Show InChI InChI=1S/C19H22N4O/c1-14-20-17-12-15(13-24-16-8-4-2-5-9-16)22-18(17)19(21-14)23-10-6-3-7-11-23/h2,4-5,8-9,12,22H,3,6-7,10-11,13H2,1H3
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n/an/a 18n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093679
PNG
(2-Ethyl-6-phenyl-4-piperidin-1-yl-5H-pyrrolo[3,2-d...)
Show SMILES CCc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C19H22N4/c1-2-17-20-16-13-15(14-9-5-3-6-10-14)21-18(16)19(22-17)23-11-7-4-8-12-23/h3,5-6,9-10,13,21H,2,4,7-8,11-12H2,1H3
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n/an/a 20n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50101548
PNG
(3-(4-Benzyloxy-phenyl)-1-(2-hydroxy-1-methyl-2-phe...)
Show SMILES C[C@H]([C@@H](O)c1ccccc1)N(C)C(=O)Nc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C24H26N2O3/c1-18(23(27)20-11-7-4-8-12-20)26(2)24(28)25-21-13-15-22(16-14-21)29-17-19-9-5-3-6-10-19/h3-16,18,23,27H,17H2,1-2H3,(H,25,28)/t18-,23-/m1/s1
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Amgen Inc

Curated by ChEMBL


Assay Description
Inhibitory activity tested against Human Neuropeptide Y5 Receptor.


J Med Chem 44: 2344-56 (2001)


Article DOI: 10.1021/jm0004547
BindingDB Entry DOI: 10.7270/Q2DV1J56
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50101547
PNG
(1-sec-Butyl-1-methyl-3-(4-phenoxy-phenyl)-urea | C...)
Show SMILES CC[C@@H](C)N(C)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C18H22N2O2/c1-4-14(2)20(3)18(21)19-15-10-12-17(13-11-15)22-16-8-6-5-7-9-16/h5-14H,4H2,1-3H3,(H,19,21)/t14-/m1/s1
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n/an/a 24n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibitory activity tested against Human Neuropeptide Y5 Receptor.


J Med Chem 44: 2344-56 (2001)


Article DOI: 10.1021/jm0004547
BindingDB Entry DOI: 10.7270/Q2DV1J56
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093700
PNG
(6-Phenyl-4-piperidin-1-yl-2-propyl-5H-pyrrolo[3,2-...)
Show SMILES CCCc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C20H24N4/c1-2-9-18-21-17-14-16(15-10-5-3-6-11-15)22-19(17)20(23-18)24-12-7-4-8-13-24/h3,5-6,10-11,14,22H,2,4,7-9,12-13H2,1H3
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n/an/a 28n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093662
PNG
(CHEMBL136650 | Methyl-(6-phenyl-4-piperidin-1-yl-5...)
Show SMILES CNc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C18H21N5/c1-19-18-21-15-12-14(13-8-4-2-5-9-13)20-16(15)17(22-18)23-10-6-3-7-11-23/h2,4-5,8-9,12,20H,3,6-7,10-11H2,1H3,(H,19,21,22)
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n/an/a 29n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093658
PNG
(2-Methyl-6-phenyl-4-piperidin-1-yl-furo[3,2-d]pyri...)
Show SMILES Cc1nc(N2CCCCC2)c2oc(cc2n1)-c1ccccc1
Show InChI InChI=1S/C18H19N3O/c1-13-19-15-12-16(14-8-4-2-5-9-14)22-17(15)18(20-13)21-10-6-3-7-11-21/h2,4-5,8-9,12H,3,6-7,10-11H2,1H3
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n/an/a 30n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093684
PNG
(2-Cyclopropyl-6-phenyl-4-piperidin-1-yl-5H-pyrrolo...)
Show SMILES C1CC1c1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C20H22N4/c1-3-7-14(8-4-1)16-13-17-18(21-16)20(24-11-5-2-6-12-24)23-19(22-17)15-9-10-15/h1,3-4,7-8,13,15,21H,2,5-6,9-12H2
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n/an/a 32n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50101553
PNG
(1-Methyl-3-(4-phenoxy-phenyl)-1-(1,2,3,4-tetrahydr...)
Show SMILES CN(C1CCc2ccccc2C1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C24H24N2O2/c1-26(21-14-11-18-7-5-6-8-19(18)17-21)24(27)25-20-12-15-23(16-13-20)28-22-9-3-2-4-10-22/h2-10,12-13,15-16,21H,11,14,17H2,1H3,(H,25,27)
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n/an/a 34n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibitory activity tested against Human Neuropeptide Y5 Receptor.


J Med Chem 44: 2344-56 (2001)


Article DOI: 10.1021/jm0004547
BindingDB Entry DOI: 10.7270/Q2DV1J56
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50101554
PNG
(1-Methyl-1-phenethyl-3-(4-phenoxy-phenyl)-urea | C...)
Show SMILES CN(CCc1ccccc1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C22H22N2O2/c1-24(17-16-18-8-4-2-5-9-18)22(25)23-19-12-14-21(15-13-19)26-20-10-6-3-7-11-20/h2-15H,16-17H2,1H3,(H,23,25)
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n/an/a 35n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibitory activity tested against Human Neuropeptide Y5 Receptor.


J Med Chem 44: 2344-56 (2001)


Article DOI: 10.1021/jm0004547
BindingDB Entry DOI: 10.7270/Q2DV1J56
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093614
PNG
(CHEMBL337152 | Diethyl-(2-methyl-6-phenyl-5H-pyrro...)
Show SMILES CCN(CC)c1nc(C)nc2cc([nH]c12)-c1ccccc1
Show InChI InChI=1S/C17H20N4/c1-4-21(5-2)17-16-15(18-12(3)19-17)11-14(20-16)13-9-7-6-8-10-13/h6-11,20H,4-5H2,1-3H3
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n/an/a 36n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093613
PNG
(6-(4-Methoxy-phenyl)-2-methyl-4-piperidin-1-yl-5H-...)
Show SMILES COc1ccc(cc1)-c1cc2nc(C)nc(N3CCCCC3)c2[nH]1
Show InChI InChI=1S/C19H22N4O/c1-13-20-17-12-16(14-6-8-15(24-2)9-7-14)22-18(17)19(21-13)23-10-4-3-5-11-23/h6-9,12,22H,3-5,10-11H2,1-2H3
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n/an/a 41n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093618
PNG
(6-(2-Fluoro-phenyl)-2-methyl-4-piperidin-1-yl-5H-p...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1F
Show InChI InChI=1S/C18H19FN4/c1-12-20-16-11-15(13-7-3-4-8-14(13)19)22-17(16)18(21-12)23-9-5-2-6-10-23/h3-4,7-8,11,22H,2,5-6,9-10H2,1H3
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n/an/a 44n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50101536
PNG
(1-(2-Hydroxy-1-methyl-2-phenyl-ethyl)-1-methyl-3-(...)
Show SMILES C[C@H]([C@H](O)c1ccccc1)N(C)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H24N2O3/c1-17(22(26)18-9-5-3-6-10-18)25(2)23(27)24-19-13-15-21(16-14-19)28-20-11-7-4-8-12-20/h3-17,22,26H,1-2H3,(H,24,27)/t17-,22+/m1/s1
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n/an/a 45n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibitory activity tested against Human Neuropeptide Y5 Receptor.


J Med Chem 44: 2344-56 (2001)


Article DOI: 10.1021/jm0004547
BindingDB Entry DOI: 10.7270/Q2DV1J56
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093674
PNG
(6-Adamantan-1-yl-2-methyl-4-piperidin-1-yl-5H-pyrr...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2
Show InChI InChI=1S/C22H30N4/c1-14-23-18-10-19(22-11-15-7-16(12-22)9-17(8-15)13-22)25-20(18)21(24-14)26-5-3-2-4-6-26/h10,15-17,25H,2-9,11-13H2,1H3/t15-,16+,17-,22?
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n/an/a 45n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50093657
PNG
(CHEMBL137613 | Furan-2-ylmethyl-methyl-(2-methyl-6...)
Show SMILES CN(Cc1ccco1)c1nc(C)nc2cc([nH]c12)-c1ccccc1
Show InChI InChI=1S/C19H18N4O/c1-13-20-17-11-16(14-7-4-3-5-8-14)22-18(17)19(21-13)23(2)12-15-9-6-10-24-15/h3-11,22H,12H2,1-2H3
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n/an/a 52n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


Article DOI: 10.1021/jm000269t
BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
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