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Compile Data Set for Download or QSAR

Found 90 hits with Last Name = 'sonnino' and Initial = 'pa'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50006819
PNG
(2-(4-Benzyloxy-phenyl)-N-hydroxy-N-phenethyl-aceta...)
Show SMILES ON(CCc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C23H23NO3/c25-23(24(26)16-15-19-7-3-1-4-8-19)17-20-11-13-22(14-12-20)27-18-21-9-5-2-6-10-21/h1-14,26H,15-18H2
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100n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Invitro inhibitory activity against polymorphonuclear leukocyte 5-lipoxygenase in human cell


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50016673
PNG
(CHEMBL52896 | N-Hydroxy-N-methyl-2-[4-(quinolin-2-...)
Show SMILES CN(O)C(=O)Cc1ccc(OCc2ccc3ccccc3n2)cc1
Show InChI InChI=1S/C19H18N2O3/c1-21(23)19(22)12-14-6-10-17(11-7-14)24-13-16-9-8-15-4-2-3-5-18(15)20-16/h2-11,23H,12-13H2,1H3
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800n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Invitro inhibitory activity against polymorphonuclear leukocyte 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50016673
PNG
(CHEMBL52896 | N-Hydroxy-N-methyl-2-[4-(quinolin-2-...)
Show SMILES CN(O)C(=O)Cc1ccc(OCc2ccc3ccccc3n2)cc1
Show InChI InChI=1S/C19H18N2O3/c1-21(23)19(22)12-14-6-10-17(11-7-14)24-13-16-9-8-15-4-2-3-5-18(15)20-16/h2-11,23H,12-13H2,1H3
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1.00E+3n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Activity of the compound to bind against [3H]-LTD4 radioligand in guinea pig


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Rattus norvegicus)
BDBM50006819
PNG
(2-(4-Benzyloxy-phenyl)-N-hydroxy-N-phenethyl-aceta...)
Show SMILES ON(CCc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C23H23NO3/c25-23(24(26)16-15-19-7-3-1-4-8-19)17-20-11-13-22(14-12-20)27-18-21-9-5-2-6-10-21/h1-14,26H,15-18H2
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1.60E+3n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against rat platelet 12-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50016687
PNG
(2-(4-Benzyloxy-phenyl)-N-hydroxy-N-methyl-acetamid...)
Show SMILES CN(O)C(=O)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C16H17NO3/c1-17(19)16(18)11-13-7-9-15(10-8-13)20-12-14-5-3-2-4-6-14/h2-10,19H,11-12H2,1H3
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1.00E+5n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Activity of the compound to bind against [3H]-LTD4 radioligand in guinea pig


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50016671
PNG
(2-(4-Benzyloxy-phenyl)-N-hydroxy-N-(1-phenyl-ethyl...)
Show SMILES CC(N(O)C(=O)Cc1ccc(OCc2ccccc2)cc1)c1ccccc1
Show InChI InChI=1S/C23H23NO3/c1-18(21-10-6-3-7-11-21)24(26)23(25)16-19-12-14-22(15-13-19)27-17-20-8-4-2-5-9-20/h2-15,18,26H,16-17H2,1H3
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n/an/a 30n/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory activity against polymorphonuclear leukocyte 5-lipoxygenase using guinea pig supernatant


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50016680
PNG
(5-Phenyl-pentanoic acid benzyl-hydroxy-amide | CHE...)
Show SMILES ON(Cc1ccccc1)C(=O)CCCCc1ccccc1
Show InChI InChI=1S/C18H21NO2/c20-18(19(21)15-17-12-5-2-6-13-17)14-8-7-11-16-9-3-1-4-10-16/h1-6,9-10,12-13,21H,7-8,11,14-15H2
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Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of rat polymorphonuclear leukocyte 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50016694
PNG
(4-Benzyloxy-N-hydroxy-N-phenethyl-benzamide | CHEM...)
Show SMILES ON(CCc1ccccc1)C(=O)c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C22H21NO3/c24-22(23(25)16-15-18-7-3-1-4-8-18)20-11-13-21(14-12-20)26-17-19-9-5-2-6-10-19/h1-14,25H,15-17H2
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Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory activity against polymorphonuclear leukocyte 5-lipoxygenase using guinea pig supernatant


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50016679
PNG
(CHEMBL52085 | N-Hydroxy-N-methyl-2-[3-(quinolin-2-...)
Show SMILES CN(O)C(=O)Cc1cccc(OCc2ccc3ccccc3n2)c1
Show InChI InChI=1S/C19H18N2O3/c1-21(23)19(22)12-14-5-4-7-17(11-14)24-13-16-10-9-15-6-2-3-8-18(15)20-16/h2-11,23H,12-13H2,1H3
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n/an/a 80n/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of rat polymorphonuclear leukocyte 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50016686
PNG
(CHEMBL54013 | N-Hydroxy-3-phenyl-N-(3-phenyl-propy...)
Show SMILES ON(CCCc1ccccc1)C(=O)CCc1ccccc1
Show InChI InChI=1S/C18H21NO2/c20-18(14-13-17-10-5-2-6-11-17)19(21)15-7-12-16-8-3-1-4-9-16/h1-6,8-11,21H,7,12-15H2
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Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of rat polymorphonuclear leukocyte 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50006819
PNG
(2-(4-Benzyloxy-phenyl)-N-hydroxy-N-phenethyl-aceta...)
Show SMILES ON(CCc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C23H23NO3/c25-23(24(26)16-15-19-7-3-1-4-8-19)17-20-11-13-22(14-12-20)27-18-21-9-5-2-6-10-21/h1-14,26H,15-18H2
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n/an/a 100n/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory activity against polymorphonuclear leukocyte 5-lipoxygenase using guinea pig supernatant


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Cyclooxygenase


(RAT)
BDBM17638
PNG
(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1
Show InChI InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
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n/an/a 100n/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Invitro inhibition of polymorphonuclear leukocyte derived human 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50016681
PNG
(2-(3-Benzyloxy-phenyl)-N-hydroxy-N-phenethyl-propi...)
Show SMILES CC(C(=O)N(O)CCc1ccccc1)c1cccc(OCc2ccccc2)c1
Show InChI InChI=1S/C24H25NO3/c1-19(24(26)25(27)16-15-20-9-4-2-5-10-20)22-13-8-14-23(17-22)28-18-21-11-6-3-7-12-21/h2-14,17,19,27H,15-16,18H2,1H3
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Rorer Central Research

Curated by ChEMBL


Assay Description
Invitro inhibition of polymorphonuclear leukocyte derived human 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50016686
PNG
(CHEMBL54013 | N-Hydroxy-3-phenyl-N-(3-phenyl-propy...)
Show SMILES ON(CCCc1ccccc1)C(=O)CCc1ccccc1
Show InChI InChI=1S/C18H21NO2/c20-18(14-13-17-10-5-2-6-11-17)19(21)15-7-12-16-8-3-1-4-9-16/h1-6,8-11,21H,7,12-15H2
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Rorer Central Research

Curated by ChEMBL


Assay Description
Invitro inhibition of polymorphonuclear leukocyte derived human 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50016683
PNG
(2-[4-(3-Chloro-benzyloxy)-phenyl]-N-hydroxy-N-meth...)
Show SMILES CN(O)C(=O)Cc1ccc(OCc2cccc(Cl)c2)cc1
Show InChI InChI=1S/C16H16ClNO3/c1-18(20)16(19)10-12-5-7-15(8-6-12)21-11-13-3-2-4-14(17)9-13/h2-9,20H,10-11H2,1H3
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Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of rat polymorphonuclear leukocyte 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50016688
PNG
(CHEMBL52749 | N-Benzyl-2-(4-benzyloxy-phenyl)-N-hy...)
Show SMILES ON(Cc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C22H21NO3/c24-22(23(25)16-19-7-3-1-4-8-19)15-18-11-13-21(14-12-18)26-17-20-9-5-2-6-10-20/h1-14,25H,15-17H2
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Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of rat polymorphonuclear leukocyte 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50016672
PNG
(2-(4-Benzyloxy-phenyl)-N-hydroxy-N-propyl-acetamid...)
Show SMILES CCCN(O)C(=O)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C18H21NO3/c1-2-12-19(21)18(20)13-15-8-10-17(11-9-15)22-14-16-6-4-3-5-7-16/h3-11,21H,2,12-14H2,1H3
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Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of rat polymorphonuclear leukocyte 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50016687
PNG
(2-(4-Benzyloxy-phenyl)-N-hydroxy-N-methyl-acetamid...)
Show SMILES CN(O)C(=O)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C16H17NO3/c1-17(19)16(18)11-13-7-9-15(10-8-13)20-12-14-5-3-2-4-6-14/h2-10,19H,11-12H2,1H3
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Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of rat polymorphonuclear leukocyte 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50016690
PNG
(5-Phenyl-pentanoic acid hydroxy-methyl-amide | CHE...)
Show SMILES CN(O)C(=O)CCCCc1ccccc1
Show InChI InChI=1S/C12H17NO2/c1-13(15)12(14)10-6-5-9-11-7-3-2-4-8-11/h2-4,7-8,15H,5-6,9-10H2,1H3
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Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of rat polymorphonuclear leukocyte 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50016688
PNG
(CHEMBL52749 | N-Benzyl-2-(4-benzyloxy-phenyl)-N-hy...)
Show SMILES ON(Cc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C22H21NO3/c24-22(23(25)16-19-7-3-1-4-8-19)15-18-11-13-21(14-12-18)26-17-20-9-5-2-6-10-20/h1-14,25H,15-17H2
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Rorer Central Research

Curated by ChEMBL


Assay Description
Invitro inhibition of polymorphonuclear leukocyte derived human 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50016676
PNG
(CHEMBL293264 | N-Hydroxy-4-(4-methoxy-phenyl)-N-ph...)
Show SMILES COc1ccc(CCCC(=O)N(O)CCc2ccccc2)cc1
Show InChI InChI=1S/C19H23NO3/c1-23-18-12-10-17(11-13-18)8-5-9-19(21)20(22)15-14-16-6-3-2-4-7-16/h2-4,6-7,10-13,22H,5,8-9,14-15H2,1H3
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Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of rat polymorphonuclear leukocyte 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50016682
PNG
(CHEMBL53028 | N-Benzyl-N-hydroxy-4-phenyl-butyrami...)
Show SMILES ON(Cc1ccccc1)C(=O)CCCc1ccccc1
Show InChI InChI=1S/C17H19NO2/c19-17(13-7-12-15-8-3-1-4-9-15)18(20)14-16-10-5-2-6-11-16/h1-6,8-11,20H,7,12-14H2
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n/an/a 130n/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Invitro inhibition of polymorphonuclear leukocyte derived human 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50016675
PNG
(CHEMBL55053 | N-Hydroxy-N-phenethyl-4-phenyl-butyr...)
Show SMILES ON(CCc1ccccc1)C(=O)CCCc1ccccc1
Show InChI InChI=1S/C18H21NO2/c20-18(13-7-12-16-8-3-1-4-9-16)19(21)15-14-17-10-5-2-6-11-17/h1-6,8-11,21H,7,12-15H2
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n/an/a 130n/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory activity against polymorphonuclear leukocyte 5-lipoxygenase using guinea pig supernatant


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50016680
PNG
(5-Phenyl-pentanoic acid benzyl-hydroxy-amide | CHE...)
Show SMILES ON(Cc1ccccc1)C(=O)CCCCc1ccccc1
Show InChI InChI=1S/C18H21NO2/c20-18(19(21)15-17-12-5-2-6-13-17)14-8-7-11-16-9-3-1-4-10-16/h1-6,9-10,12-13,21H,7-8,11,14-15H2
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n/an/a 150n/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Invitro inhibition of polymorphonuclear leukocyte derived human 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50016682
PNG
(CHEMBL53028 | N-Benzyl-N-hydroxy-4-phenyl-butyrami...)
Show SMILES ON(Cc1ccccc1)C(=O)CCCc1ccccc1
Show InChI InChI=1S/C17H19NO2/c19-17(13-7-12-15-8-3-1-4-9-15)18(20)14-16-10-5-2-6-11-16/h1-6,8-11,20H,7,12-14H2
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n/an/a 150n/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of rat polymorphonuclear leukocyte 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50016672
PNG
(2-(4-Benzyloxy-phenyl)-N-hydroxy-N-propyl-acetamid...)
Show SMILES CCCN(O)C(=O)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C18H21NO3/c1-2-12-19(21)18(20)13-15-8-10-17(11-9-15)22-14-16-6-4-3-5-7-16/h3-11,21H,2,12-14H2,1H3
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n/an/a 160n/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Invitro inhibition of polymorphonuclear leukocyte derived human 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50016675
PNG
(CHEMBL55053 | N-Hydroxy-N-phenethyl-4-phenyl-butyr...)
Show SMILES ON(CCc1ccccc1)C(=O)CCCc1ccccc1
Show InChI InChI=1S/C18H21NO2/c20-18(13-7-12-16-8-3-1-4-9-16)19(21)15-14-17-10-5-2-6-11-17/h1-6,8-11,21H,7,12-15H2
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n/an/a 180n/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Invitro inhibition of polymorphonuclear leukocyte derived human 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50016687
PNG
(2-(4-Benzyloxy-phenyl)-N-hydroxy-N-methyl-acetamid...)
Show SMILES CN(O)C(=O)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C16H17NO3/c1-17(19)16(18)11-13-7-9-15(10-8-13)20-12-14-5-3-2-4-6-14/h2-10,19H,11-12H2,1H3
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n/an/a 200n/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against rat platelet 12-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50016683
PNG
(2-[4-(3-Chloro-benzyloxy)-phenyl]-N-hydroxy-N-meth...)
Show SMILES CN(O)C(=O)Cc1ccc(OCc2cccc(Cl)c2)cc1
Show InChI InChI=1S/C16H16ClNO3/c1-18(20)16(19)10-12-5-7-15(8-6-12)21-11-13-3-2-4-14(17)9-13/h2-9,20H,10-11H2,1H3
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n/an/a 200n/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Invitro inhibition of polymorphonuclear leukocyte derived human 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50016685
PNG
(CHEMBL54838 | N-Hydroxy-N-phenethyl-3-phenoxy-prop...)
Show SMILES ON(CCc1ccccc1)C(=O)CCOc1ccccc1
Show InChI InChI=1S/C17H19NO3/c19-17(12-14-21-16-9-5-2-6-10-16)18(20)13-11-15-7-3-1-4-8-15/h1-10,20H,11-14H2
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n/an/a 250n/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of rat polymorphonuclear leukocyte 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50016690
PNG
(5-Phenyl-pentanoic acid hydroxy-methyl-amide | CHE...)
Show SMILES CN(O)C(=O)CCCCc1ccccc1
Show InChI InChI=1S/C12H17NO2/c1-13(15)12(14)10-6-5-9-11-7-3-2-4-8-11/h2-4,7-8,15H,5-6,9-10H2,1H3
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n/an/a 250n/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Invitro inhibition of polymorphonuclear leukocyte derived human 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50016676
PNG
(CHEMBL293264 | N-Hydroxy-4-(4-methoxy-phenyl)-N-ph...)
Show SMILES COc1ccc(CCCC(=O)N(O)CCc2ccccc2)cc1
Show InChI InChI=1S/C19H23NO3/c1-23-18-12-10-17(11-13-18)8-5-9-19(21)20(22)15-14-16-6-3-2-4-7-16/h2-4,6-7,10-13,22H,5,8-9,14-15H2,1H3
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Rorer Central Research

Curated by ChEMBL


Assay Description
Invitro inhibition of polymorphonuclear leukocyte derived human 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50016687
PNG
(2-(4-Benzyloxy-phenyl)-N-hydroxy-N-methyl-acetamid...)
Show SMILES CN(O)C(=O)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C16H17NO3/c1-17(19)16(18)11-13-7-9-15(10-8-13)20-12-14-5-3-2-4-6-14/h2-10,19H,11-12H2,1H3
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n/an/a 300n/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Invitro inhibition of polymorphonuclear leukocyte derived human 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50016689
PNG
(CHEMBL55762 | N-Hydroxy-4-(4-methoxy-phenyl)-N-met...)
Show SMILES COc1ccc(CCCC(=O)N(C)O)cc1
Show InChI InChI=1S/C12H17NO3/c1-13(15)12(14)5-3-4-10-6-8-11(16-2)9-7-10/h6-9,15H,3-5H2,1-2H3
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n/an/a 300n/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of rat polymorphonuclear leukocyte 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50016671
PNG
(2-(4-Benzyloxy-phenyl)-N-hydroxy-N-(1-phenyl-ethyl...)
Show SMILES CC(N(O)C(=O)Cc1ccc(OCc2ccccc2)cc1)c1ccccc1
Show InChI InChI=1S/C23H23NO3/c1-18(21-10-6-3-7-11-21)24(26)23(25)16-19-12-14-22(15-13-19)27-17-20-8-4-2-5-9-20/h2-15,18,26H,16-17H2,1H3
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Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of rat polymorphonuclear leukocyte 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Rattus norvegicus)
BDBM50016680
PNG
(5-Phenyl-pentanoic acid benzyl-hydroxy-amide | CHE...)
Show SMILES ON(Cc1ccccc1)C(=O)CCCCc1ccccc1
Show InChI InChI=1S/C18H21NO2/c20-18(19(21)15-17-12-5-2-6-13-17)14-8-7-11-16-9-3-1-4-10-16/h1-6,9-10,12-13,21H,7-8,11,14-15H2
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Rorer Central Research

Curated by ChEMBL


Assay Description
Invitro inhibition of rat platelet 12-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50016685
PNG
(CHEMBL54838 | N-Hydroxy-N-phenethyl-3-phenoxy-prop...)
Show SMILES ON(CCc1ccccc1)C(=O)CCOc1ccccc1
Show InChI InChI=1S/C17H19NO3/c19-17(12-14-21-16-9-5-2-6-10-16)18(20)13-11-15-7-3-1-4-8-15/h1-10,20H,11-14H2
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Rorer Central Research

Curated by ChEMBL


Assay Description
Invitro inhibition of polymorphonuclear leukocyte derived human 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50016675
PNG
(CHEMBL55053 | N-Hydroxy-N-phenethyl-4-phenyl-butyr...)
Show SMILES ON(CCc1ccccc1)C(=O)CCCc1ccccc1
Show InChI InChI=1S/C18H21NO2/c20-18(13-7-12-16-8-3-1-4-9-16)19(21)15-14-17-10-5-2-6-11-17/h1-6,8-11,21H,7,12-15H2
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Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of rat polymorphonuclear leukocyte 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50016674
PNG
(4-[Hydroxy-(4-phenyl-butyryl)-amino]-butyric acid ...)
Show SMILES CCOC(=O)CCCN(O)C(=O)CCCc1ccccc1
Show InChI InChI=1S/C16H23NO4/c1-2-21-16(19)12-7-13-17(20)15(18)11-6-10-14-8-4-3-5-9-14/h3-5,8-9,20H,2,6-7,10-13H2,1H3
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Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of rat polymorphonuclear leukocyte 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50016681
PNG
(2-(3-Benzyloxy-phenyl)-N-hydroxy-N-phenethyl-propi...)
Show SMILES CC(C(=O)N(O)CCc1ccccc1)c1cccc(OCc2ccccc2)c1
Show InChI InChI=1S/C24H25NO3/c1-19(24(26)25(27)16-15-20-9-4-2-5-10-20)22-13-8-14-23(17-22)28-18-21-11-6-3-7-12-21/h2-14,17,19,27H,15-16,18H2,1H3
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Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of rat polymorphonuclear leukocyte 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50006819
PNG
(2-(4-Benzyloxy-phenyl)-N-hydroxy-N-phenethyl-aceta...)
Show SMILES ON(CCc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C23H23NO3/c25-23(24(26)16-15-19-7-3-1-4-8-19)17-20-11-13-22(14-12-20)27-18-21-9-5-2-6-10-21/h1-14,26H,15-18H2
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Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of rat polymorphonuclear leukocyte 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50006819
PNG
(2-(4-Benzyloxy-phenyl)-N-hydroxy-N-phenethyl-aceta...)
Show SMILES ON(CCc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C23H23NO3/c25-23(24(26)16-15-19-7-3-1-4-8-19)17-20-11-13-22(14-12-20)27-18-21-9-5-2-6-10-21/h1-14,26H,15-18H2
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Rorer Central Research

Curated by ChEMBL


Assay Description
Invitro inhibition of polymorphonuclear leukocyte derived human 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50016673
PNG
(CHEMBL52896 | N-Hydroxy-N-methyl-2-[4-(quinolin-2-...)
Show SMILES CN(O)C(=O)Cc1ccc(OCc2ccc3ccccc3n2)cc1
Show InChI InChI=1S/C19H18N2O3/c1-21(23)19(22)12-14-6-10-17(11-7-14)24-13-16-9-8-15-4-2-3-5-18(15)20-16/h2-11,23H,12-13H2,1H3
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Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of rat polymorphonuclear leukocyte 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Rattus norvegicus)
BDBM50016675
PNG
(CHEMBL55053 | N-Hydroxy-N-phenethyl-4-phenyl-butyr...)
Show SMILES ON(CCc1ccccc1)C(=O)CCCc1ccccc1
Show InChI InChI=1S/C18H21NO2/c20-18(13-7-12-16-8-3-1-4-9-16)19(21)15-14-17-10-5-2-6-11-17/h1-6,8-11,21H,7,12-15H2
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Rorer Central Research

Curated by ChEMBL


Assay Description
Invitro inhibition of rat platelet 12-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50016671
PNG
(2-(4-Benzyloxy-phenyl)-N-hydroxy-N-(1-phenyl-ethyl...)
Show SMILES CC(N(O)C(=O)Cc1ccc(OCc2ccccc2)cc1)c1ccccc1
Show InChI InChI=1S/C23H23NO3/c1-18(21-10-6-3-7-11-21)24(26)23(25)16-19-12-14-22(15-13-19)27-17-20-8-4-2-5-9-20/h2-15,18,26H,16-17H2,1H3
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n/an/a 400n/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Invitro inhibition of polymorphonuclear leukocyte derived human 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Rattus norvegicus)
BDBM50016687
PNG
(2-(4-Benzyloxy-phenyl)-N-hydroxy-N-methyl-acetamid...)
Show SMILES CN(O)C(=O)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C16H17NO3/c1-17(19)16(18)11-13-7-9-15(10-8-13)20-12-14-5-3-2-4-6-14/h2-10,19H,11-12H2,1H3
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n/an/a 500n/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Invitro inhibition of rat platelet 12-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50016674
PNG
(4-[Hydroxy-(4-phenyl-butyryl)-amino]-butyric acid ...)
Show SMILES CCOC(=O)CCCN(O)C(=O)CCCc1ccccc1
Show InChI InChI=1S/C16H23NO4/c1-2-21-16(19)12-7-13-17(20)15(18)11-6-10-14-8-4-3-5-9-14/h3-5,8-9,20H,2,6-7,10-13H2,1H3
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n/an/a 500n/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Invitro inhibition of polymorphonuclear leukocyte derived human 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50016670
PNG
(2-(4-Benzyloxy-phenyl)-N-hydroxy-N-(3-phenyl-propy...)
Show SMILES ON(CCCc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C24H25NO3/c26-24(25(27)17-7-12-20-8-3-1-4-9-20)18-21-13-15-23(16-14-21)28-19-22-10-5-2-6-11-22/h1-6,8-11,13-16,27H,7,12,17-19H2
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n/an/a 500n/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of rat polymorphonuclear leukocyte 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Rattus norvegicus)
BDBM50016682
PNG
(CHEMBL53028 | N-Benzyl-N-hydroxy-4-phenyl-butyrami...)
Show SMILES ON(Cc1ccccc1)C(=O)CCCc1ccccc1
Show InChI InChI=1S/C17H19NO2/c19-17(13-7-12-15-8-3-1-4-9-15)18(20)14-16-10-5-2-6-11-16/h1-6,8-11,20H,7,12-14H2
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n/an/a 500n/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Invitro inhibition of rat platelet 12-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Rattus norvegicus)
BDBM50016686
PNG
(CHEMBL54013 | N-Hydroxy-3-phenyl-N-(3-phenyl-propy...)
Show SMILES ON(CCCc1ccccc1)C(=O)CCc1ccccc1
Show InChI InChI=1S/C18H21NO2/c20-18(14-13-17-10-5-2-6-11-17)19(21)15-7-12-16-8-3-1-4-9-16/h1-6,8-11,21H,7,12-15H2
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n/an/a 600n/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Invitro inhibition of rat platelet 12-lipoxygenase


J Med Chem 32: 1836-42 (1989)


Article DOI: 10.1021/jm00128a027
BindingDB Entry DOI: 10.7270/Q2VT1R21
More data for this
Ligand-Target Pair
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