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Compile Data Set for Download or QSAR

Found 310 hits with Last Name = 'streiner' and Initial = 'n'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50384714
PNG
(CHEMBL2037200)
Show SMILES CN1CCCN(CC1)C(=O)c1cccc(c1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1
Show InChI InChI=1S/C26H24ClN3O3/c1-29-10-3-11-30(13-12-29)26(32)18-5-2-4-17(14-18)24-9-7-20(33-24)16-22-21-15-19(27)6-8-23(21)28-25(22)31/h2,4-9,14-16H,3,10-13H2,1H3,(H,28,31)/b22-16+
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5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Reversible inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate


ACS Med Chem Lett 3: 135-139 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50357594
PNG
(CHEMBL1915445)
Show SMILES Oc1ccc(Nc2nc3c(cccc3c3cnccc23)-c2nnc[nH]2)c(Cl)c1
Show InChI InChI=1S/C20H13ClN6O/c21-16-8-11(28)4-5-17(16)25-20-13-6-7-22-9-15(13)12-2-1-3-14(18(12)26-20)19-23-10-24-27-19/h1-10,28H,(H,25,26)(H,23,24,27)
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n/an/a 1n/an/an/an/an/an/a



Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of PIM2 by millipore assay in the presence of 15 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50357599
PNG
(CHEMBL1915633)
Show SMILES COc1cccc(Nc2nc3c(cccc3c3cnccc23)-c2nnc[nH]2)c1Cl
Show InChI InChI=1S/C21H15ClN6O/c1-29-17-7-3-6-16(18(17)22)26-21-13-8-9-23-10-15(13)12-4-2-5-14(19(12)27-21)20-24-11-25-28-20/h2-11H,1H3,(H,26,27)(H,24,25,28)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 5 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50357587
PNG
(CHEMBL1915438)
Show SMILES Clc1ccccc1Nc1nc2c(cccc2c2cnccc12)-c1nnc[nH]1
Show InChI InChI=1S/C20H13ClN6/c21-16-6-1-2-7-17(16)25-20-13-8-9-22-10-15(13)12-4-3-5-14(18(12)26-20)19-23-11-24-27-19/h1-11H,(H,25,26)(H,23,24,27)
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n/an/a 1n/an/an/an/an/an/a



Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of PIM1 using KKRNRTLTV as substrate by millipore assay in the presence of 90 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50357610
PNG
(CHEMBL1915644)
Show SMILES CNC(=O)c1cccc2c1nc(Nc1ccccc1Cl)c1ccncc21
Show InChI InChI=1S/C20H15ClN4O/c1-22-20(26)14-6-4-5-12-15-11-23-10-9-13(15)19(25-18(12)14)24-17-8-3-2-7-16(17)21/h2-11H,1H3,(H,22,26)(H,24,25)
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n/an/a 1n/an/an/an/an/an/a



Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 5 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Casein Kinase II


(Homo sapiens (human))
BDBM50335638
PNG
(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Show SMILES OC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc21
Show InChI InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H,(H,22,23)(H,24,25)
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n/an/a 1n/an/an/an/an/an/a



Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CK2alpha by radiometric assay


J Med Chem 54: 635-54 (2011)

More data for this
Ligand-Target Pair
Casein Kinase II


(Homo sapiens (human))
BDBM50335638
PNG
(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Show SMILES OC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc21
Show InChI InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H,(H,22,23)(H,24,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CK2alpha at enzyme-substrate complex by radiometric assay


J Med Chem 54: 635-54 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50357602
PNG
(CHEMBL1915636)
Show SMILES Fc1cccc(F)c1Nc1nc2c(cccc2c2cnccc12)-c1nnc[nH]1
Show InChI InChI=1S/C20H12F2N6/c21-15-5-2-6-16(22)18(15)27-20-12-7-8-23-9-14(12)11-3-1-4-13(17(11)26-20)19-24-10-25-28-19/h1-10H,(H,26,27)(H,24,25,28)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 5 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50357602
PNG
(CHEMBL1915636)
Show SMILES Fc1cccc(F)c1Nc1nc2c(cccc2c2cnccc12)-c1nnc[nH]1
Show InChI InChI=1S/C20H12F2N6/c21-15-5-2-6-16(22)18(15)27-20-12-7-8-23-9-14(12)11-3-1-4-13(17(11)26-20)19-24-10-25-28-19/h1-10H,(H,26,27)(H,24,25,28)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 30 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50357598
PNG
(CHEMBL1915449)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nc3c(cccc3c3cnccc23)-c2nnc[nH]2)c(Cl)c1
Show InChI InChI=1S/C25H23ClN8/c1-33-9-11-34(12-10-33)16-5-6-22(21(26)13-16)30-25-18-7-8-27-14-20(18)17-3-2-4-19(23(17)31-25)24-28-15-29-32-24/h2-8,13-15H,9-12H2,1H3,(H,30,31)(H,28,29,32)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 30 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50357597
PNG
(CHEMBL1915448)
Show SMILES Clc1cc(OCCN2CCOCC2)ccc1Nc1nc2c(cccc2c2cnccc12)-c1nnc[nH]1
Show InChI InChI=1S/C26H24ClN7O2/c27-22-14-17(36-13-10-34-8-11-35-12-9-34)4-5-23(22)31-26-19-6-7-28-15-21(19)18-2-1-3-20(24(18)32-26)25-29-16-30-33-25/h1-7,14-16H,8-13H2,(H,31,32)(H,29,30,33)
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n/an/a 2n/an/an/an/an/an/a



Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 30 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50357594
PNG
(CHEMBL1915445)
Show SMILES Oc1ccc(Nc2nc3c(cccc3c3cnccc23)-c2nnc[nH]2)c(Cl)c1
Show InChI InChI=1S/C20H13ClN6O/c21-16-8-11(28)4-5-17(16)25-20-13-6-7-22-9-15(13)12-2-1-3-14(18(12)26-20)19-23-10-24-27-19/h1-10,28H,(H,25,26)(H,23,24,27)
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n/an/a 2n/an/an/an/an/an/a



Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of PIM1 using KKRNRTLTV as substrate by millipore assay in the presence of 90 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50381040
PNG
(CHEMBL2017348)
Show SMILES Fc1ccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)c(F)c1
Show InChI InChI=1S/C19H11F2N5S/c20-10-4-5-15(14(21)8-10)24-19-13-6-7-27-17(13)11-2-1-3-12(16(11)25-19)18-22-9-23-26-18/h1-9H,(H,24,25)(H,22,23,26)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate and 5 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381040
PNG
(CHEMBL2017348)
Show SMILES Fc1ccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)c(F)c1
Show InChI InChI=1S/C19H11F2N5S/c20-10-4-5-15(14(21)8-10)24-19-13-6-7-27-17(13)11-2-1-3-12(16(11)25-19)18-22-9-23-26-18/h1-9H,(H,24,25)(H,22,23,26)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381055
PNG
(CHEMBL2017324)
Show SMILES Fc1ccccc1Nc1nc2c(cccc2c2sccc12)-c1nnc[nH]1
Show InChI InChI=1S/C19H12FN5S/c20-14-6-1-2-7-15(14)23-19-13-8-9-26-17(13)11-4-3-5-12(16(11)24-19)18-21-10-22-25-18/h1-10H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50381055
PNG
(CHEMBL2017324)
Show SMILES Fc1ccccc1Nc1nc2c(cccc2c2sccc12)-c1nnc[nH]1
Show InChI InChI=1S/C19H12FN5S/c20-14-6-1-2-7-15(14)23-19-13-8-9-26-17(13)11-4-3-5-12(16(11)24-19)18-21-10-22-25-18/h1-10H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate and 5 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50381054
PNG
(CHEMBL2017323)
Show SMILES Clc1ccccc1Nc1nc2c(cccc2c2sccc12)-c1nnc[nH]1
Show InChI InChI=1S/C19H12ClN5S/c20-14-6-1-2-7-15(14)23-19-13-8-9-26-17(13)11-4-3-5-12(16(11)24-19)18-21-10-22-25-18/h1-10H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate and 5 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50357597
PNG
(CHEMBL1915448)
Show SMILES Clc1cc(OCCN2CCOCC2)ccc1Nc1nc2c(cccc2c2cnccc12)-c1nnc[nH]1
Show InChI InChI=1S/C26H24ClN7O2/c27-22-14-17(36-13-10-34-8-11-35-12-9-34)4-5-23(22)31-26-19-6-7-28-15-21(19)18-2-1-3-20(24(18)32-26)25-29-16-30-33-25/h1-7,14-16H,8-13H2,(H,31,32)(H,29,30,33)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of PIM1 using KKRNRTLTV as substrate by millipore assay in the presence of 90 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50357618
PNG
(CHEMBL1914471)
Show SMILES CNC(=O)c1cccc2c1nc(Nc1c(F)cccc1F)c1ccncc21
Show InChI InChI=1S/C20H14F2N4O/c1-23-20(27)13-5-2-4-11-14-10-24-9-8-12(14)19(25-17(11)13)26-18-15(21)6-3-7-16(18)22/h2-10H,1H3,(H,23,27)(H,25,26)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 5 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50357613
PNG
(CHEMBL1915647)
Show SMILES CC(C)NC(=O)c1cccc2c1nc(Nc1ccccc1Cl)c1ccncc21
Show InChI InChI=1S/C22H19ClN4O/c1-13(2)25-22(28)16-7-5-6-14-17-12-24-11-10-15(17)21(27-20(14)16)26-19-9-4-3-8-18(19)23/h3-13H,1-2H3,(H,25,28)(H,26,27)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 5 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50357612
PNG
(CHEMBL1915646)
Show SMILES CCNC(=O)c1cccc2c1nc(Nc1ccccc1Cl)c1ccncc21
Show InChI InChI=1S/C21H17ClN4O/c1-2-24-21(27)15-7-5-6-13-16-12-23-11-10-14(16)20(26-19(13)15)25-18-9-4-3-8-17(18)22/h3-12H,2H2,1H3,(H,24,27)(H,25,26)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 5 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50357594
PNG
(CHEMBL1915445)
Show SMILES Oc1ccc(Nc2nc3c(cccc3c3cnccc23)-c2nnc[nH]2)c(Cl)c1
Show InChI InChI=1S/C20H13ClN6O/c21-16-8-11(28)4-5-17(16)25-20-13-6-7-22-9-15(13)12-2-1-3-14(18(12)26-20)19-23-10-24-27-19/h1-10,28H,(H,25,26)(H,23,24,27)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 5 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381038
PNG
(CHEMBL2017346)
Show SMILES Fc1cccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)c1
Show InChI InChI=1S/C19H12FN5S/c20-11-3-1-4-12(9-11)23-19-15-7-8-26-17(15)13-5-2-6-14(16(13)24-19)18-21-10-22-25-18/h1-10H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50384706
PNG
(CHEMBL2037204)
Show SMILES CN1CCCN(CC1)C(=O)c1ccc(F)c(c1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1
Show InChI InChI=1S/C26H23ClFN3O3/c1-30-9-2-10-31(12-11-30)26(33)16-3-6-22(28)21(13-16)24-8-5-18(34-24)15-20-19-14-17(27)4-7-23(19)29-25(20)32/h3-8,13-15H,2,9-12H2,1H3,(H,29,32)/b20-15+
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay


ACS Med Chem Lett 3: 135-139 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381054
PNG
(CHEMBL2017323)
Show SMILES Clc1ccccc1Nc1nc2c(cccc2c2sccc12)-c1nnc[nH]1
Show InChI InChI=1S/C19H12ClN5S/c20-14-6-1-2-7-15(14)23-19-13-8-9-26-17(13)11-4-3-5-12(16(11)24-19)18-21-10-22-25-18/h1-10H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50357591
PNG
(CHEMBL1915442)
Show SMILES Fc1ccccc1Nc1nc2c(cccc2c2cnccc12)-c1nnc[nH]1
Show InChI InChI=1S/C20H13FN6/c21-16-6-1-2-7-17(16)25-20-13-8-9-22-10-15(13)12-4-3-5-14(18(12)26-20)19-23-11-24-27-19/h1-11H,(H,25,26)(H,23,24,27)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 5 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381059
PNG
(CHEMBL2017328)
Show SMILES Clc1ccccc1Nc1nc2c(cccc2c2ccsc12)-c1nnc[nH]1
Show InChI InChI=1S/C19H12ClN5S/c20-14-6-1-2-7-15(14)23-19-17-12(8-9-26-17)11-4-3-5-13(16(11)24-19)18-21-10-22-25-18/h1-10H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50357616
PNG
(CHEMBL1915650)
Show SMILES CNC(=O)c1cccc2c1nc(Nc1ccccc1F)c1ccncc21
Show InChI InChI=1S/C20H15FN4O/c1-22-20(26)14-6-4-5-12-15-11-23-10-9-13(15)19(25-18(12)14)24-17-8-3-2-7-16(17)21/h2-11H,1H3,(H,22,26)(H,24,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 5 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381045
PNG
(CHEMBL2017352)
Show SMILES COc1ccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)cc1
Show InChI InChI=1S/C20H15N5OS/c1-26-13-7-5-12(6-8-13)23-20-16-9-10-27-18(16)14-3-2-4-15(17(14)24-20)19-21-11-22-25-19/h2-11H,1H3,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381053
PNG
(CHEMBL2017322)
Show SMILES N(c1ccccc1)c1nc2c(cccc2c2sccc12)-c1nnc[nH]1
Show InChI InChI=1S/C19H13N5S/c1-2-5-12(6-3-1)22-19-15-9-10-25-17(15)13-7-4-8-14(16(13)23-19)18-20-11-21-24-18/h1-11H,(H,22,23)(H,20,21,24)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381039
PNG
(CHEMBL2017347)
Show SMILES Fc1ccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)cc1
Show InChI InChI=1S/C19H12FN5S/c20-11-4-6-12(7-5-11)23-19-15-8-9-26-17(15)13-2-1-3-14(16(13)24-19)18-21-10-22-25-18/h1-10H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50381071
PNG
(CHEMBL2017341)
Show SMILES Oc1ccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)c(Cl)c1
Show InChI InChI=1S/C19H12ClN5OS/c20-14-8-10(26)4-5-15(14)23-19-13-6-7-27-17(13)11-2-1-3-12(16(11)24-19)18-21-9-22-25-18/h1-9,26H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate and 5 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50357607
PNG
(CHEMBL1915641)
Show SMILES Fc1cc(OCCN2CCCC2)ccc1Nc1nc2c(cccc2c2cnccc12)-c1nnc[nH]1
Show InChI InChI=1S/C26H24FN7O/c27-22-14-17(35-13-12-34-10-1-2-11-34)6-7-23(22)31-26-19-8-9-28-15-21(19)18-4-3-5-20(24(18)32-26)25-29-16-30-33-25/h3-9,14-16H,1-2,10-13H2,(H,31,32)(H,29,30,33)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 30 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381066
PNG
(CHEMBL2017336)
Show SMILES C(Nc1nc2c(cccc2c2sccc12)-c1nnc[nH]1)c1ccccc1
Show InChI InChI=1S/C20H15N5S/c1-2-5-13(6-3-1)11-21-19-16-9-10-26-18(16)14-7-4-8-15(17(14)24-19)20-22-12-23-25-20/h1-10,12H,11H2,(H,21,24)(H,22,23,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50357617
PNG
(CHEMBL1915651)
Show SMILES NC(=O)c1cccc2c1nc(Nc1c(F)cccc1F)c1ccncc21
Show InChI InChI=1S/C19H12F2N4O/c20-14-5-2-6-15(21)17(14)25-19-11-7-8-23-9-13(11)10-3-1-4-12(18(22)26)16(10)24-19/h1-9H,(H2,22,26)(H,24,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 5 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50381038
PNG
(CHEMBL2017346)
Show SMILES Fc1cccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)c1
Show InChI InChI=1S/C19H12FN5S/c20-11-3-1-4-12(9-11)23-19-15-7-8-26-17(15)13-5-2-6-14(16(13)24-19)18-21-10-22-25-18/h1-10H,(H,23,24)(H,21,22,25)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate and 5 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50357614
PNG
(CHEMBL1915648)
Show SMILES CC(C)CNC(=O)c1cccc2c3cnccc3c(Nc3ccccc3Cl)nc12
Show InChI InChI=1S/C23H21ClN4O/c1-14(2)12-26-23(29)17-7-5-6-15-18-13-25-11-10-16(18)22(28-21(15)17)27-20-9-4-3-8-19(20)24/h3-11,13-14H,12H2,1-2H3,(H,26,29)(H,27,28)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 5 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381073
PNG
(CHEMBL2017343)
Show SMILES COc1cccc(Nc2nc3c(cccc3c3sccc23)-c2nnc[nH]2)c1Cl
Show InChI InChI=1S/C20H14ClN5OS/c1-27-15-7-3-6-14(16(15)21)24-20-13-8-9-28-18(13)11-4-2-5-12(17(11)25-20)19-22-10-23-26-19/h2-10H,1H3,(H,24,25)(H,22,23,26)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50357591
PNG
(CHEMBL1915442)
Show SMILES Fc1ccccc1Nc1nc2c(cccc2c2cnccc12)-c1nnc[nH]1
Show InChI InChI=1S/C20H13FN6/c21-16-6-1-2-7-17(16)25-20-13-8-9-22-10-15(13)12-4-3-5-14(18(12)26-20)19-23-11-24-27-19/h1-11H,(H,25,26)(H,23,24,27)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of PIM2 by millipore assay in the presence of 15 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50384706
PNG
(CHEMBL2037204)
Show SMILES CN1CCCN(CC1)C(=O)c1ccc(F)c(c1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1
Show InChI InChI=1S/C26H23ClFN3O3/c1-30-9-2-10-31(12-11-30)26(33)16-3-6-22(28)21(13-16)24-8-5-18(34-24)15-20-19-14-17(27)4-7-23(19)29-25(20)32/h3-8,13-15H,2,9-12H2,1H3,(H,29,32)/b20-15+
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay


ACS Med Chem Lett 3: 135-139 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50357587
PNG
(CHEMBL1915438)
Show SMILES Clc1ccccc1Nc1nc2c(cccc2c2cnccc12)-c1nnc[nH]1
Show InChI InChI=1S/C20H13ClN6/c21-16-6-1-2-7-17(16)25-20-13-8-9-22-10-15(13)12-4-3-5-14(18(12)26-20)19-23-11-24-27-19/h1-11H,(H,25,26)(H,23,24,27)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 30 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381052
PNG
(CHEMBL2017360)
Show SMILES CNC(=O)c1cccc2c3sccc3c(Nc3ccccc3Cl)nc12
Show InChI InChI=1S/C19H14ClN3OS/c1-21-19(24)12-6-4-5-11-16(12)23-18(13-9-10-25-17(11)13)22-15-8-3-2-7-14(15)20/h2-10H,1H3,(H,21,24)(H,22,23)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50381051
PNG
(CHEMBL2017359)
Show SMILES NC(=O)c1cccc2c3sccc3c(Nc3ccccc3Cl)nc12
Show InChI InChI=1S/C18H12ClN3OS/c19-13-6-1-2-7-14(13)21-18-12-8-9-24-16(12)10-4-3-5-11(17(20)23)15(10)22-18/h1-9H,(H2,20,23)(H,21,22)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay


Bioorg Med Chem Lett 22: 3327-31 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50357611
PNG
(CHEMBL1915645)
Show SMILES CNC(=O)c1cccc2c1nc(Nc1cccc(OC)c1Cl)c1ccncc21
Show InChI InChI=1S/C21H17ClN4O2/c1-23-21(27)14-6-3-5-12-15-11-24-10-9-13(15)20(26-19(12)14)25-16-7-4-8-17(28-2)18(16)22/h3-11H,1-2H3,(H,23,27)(H,25,26)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 5 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50357607
PNG
(CHEMBL1915641)
Show SMILES Fc1cc(OCCN2CCCC2)ccc1Nc1nc2c(cccc2c2cnccc12)-c1nnc[nH]1
Show InChI InChI=1S/C26H24FN7O/c27-22-14-17(35-13-12-34-10-1-2-11-34)6-7-23(22)31-26-19-8-9-28-15-21(19)18-4-3-5-20(24(18)32-26)25-29-16-30-33-25/h3-9,14-16H,1-2,10-13H2,(H,31,32)(H,29,30,33)
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n/an/a 5n/an/an/an/an/an/a



Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of PIM1 using KKRNRTLTV as substrate by millipore assay in the presence of 90 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50384715
PNG
(CHEMBL2037201)
Show SMILES Clc1ccc2NC(=O)\C(=C\c3ccc(o3)-c3cccc(c3)C(=O)N3CCCNCC3)c2c1
Show InChI InChI=1S/C25H22ClN3O3/c26-18-5-7-22-20(14-18)21(24(30)28-22)15-19-6-8-23(32-19)16-3-1-4-17(13-16)25(31)29-11-2-9-27-10-12-29/h1,3-8,13-15,27H,2,9-12H2,(H,28,30)/b21-15+
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay


ACS Med Chem Lett 3: 135-139 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50357594
PNG
(CHEMBL1915445)
Show SMILES Oc1ccc(Nc2nc3c(cccc3c3cnccc23)-c2nnc[nH]2)c(Cl)c1
Show InChI InChI=1S/C20H13ClN6O/c21-16-8-11(28)4-5-17(16)25-20-13-6-7-22-9-15(13)12-2-1-3-14(18(12)26-20)19-23-10-24-27-19/h1-10,28H,(H,25,26)(H,23,24,27)
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 30 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50384714
PNG
(CHEMBL2037200)
Show SMILES CN1CCCN(CC1)C(=O)c1cccc(c1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1
Show InChI InChI=1S/C26H24ClN3O3/c1-29-10-3-11-30(13-12-29)26(32)18-5-2-4-17(14-18)24-9-7-20(33-24)16-22-21-15-19(27)6-8-23(21)28-25(22)31/h2,4-9,14-16H,3,10-13H2,1H3,(H,28,31)/b22-16+
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay


ACS Med Chem Lett 3: 135-139 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50357591
PNG
(CHEMBL1915442)
Show SMILES Fc1ccccc1Nc1nc2c(cccc2c2cnccc12)-c1nnc[nH]1
Show InChI InChI=1S/C20H13FN6/c21-16-6-1-2-7-17(16)25-20-13-8-9-22-10-15(13)12-4-3-5-14(18(12)26-20)19-23-11-24-27-19/h1-11H,(H,25,26)(H,23,24,27)
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n/an/a 5n/an/an/an/an/an/a



Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 30 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50357591
PNG
(CHEMBL1915442)
Show SMILES Fc1ccccc1Nc1nc2c(cccc2c2cnccc12)-c1nnc[nH]1
Show InChI InChI=1S/C20H13FN6/c21-16-6-1-2-7-17(16)25-20-13-8-9-22-10-15(13)12-4-3-5-14(18(12)26-20)19-23-11-24-27-19/h1-11H,(H,25,26)(H,23,24,27)
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n/an/a 5n/an/an/an/an/an/a



Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of PIM1 using KKRNRTLTV as substrate by millipore assay in the presence of 90 uM [ATP]


Bioorg Med Chem Lett 21: 6687-92 (2011)

More data for this
Ligand-Target Pair
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