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Compile Data Set for Download or QSAR

Found 170 hits with Last Name = 'sundquist' and Initial = 's'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50010096
PNG
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Show SMILES OC(C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2
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0.0450n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50010096
PNG
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Show SMILES OC(C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2
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0.0510n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50010096
PNG
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Show SMILES OC(C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2
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0.240n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50036185
PNG
(3-(2'-Benzofuranyl)-quinuclidine-2-ene | 3-Benzofu...)
Show SMILES C1CN2CCC1C(=C2)c1cc2ccccc2o1
Show InChI InChI=1S/C15H15NO/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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9.60n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM39341
PNG
(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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14n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50036185
PNG
(3-(2'-Benzofuranyl)-quinuclidine-2-ene | 3-Benzofu...)
Show SMILES C1CN2CCC1C(=C2)c1cc2ccccc2o1
Show InChI InChI=1S/C15H15NO/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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31n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50036195
PNG
(3-Benzofuran-3-yl-1-aza-bicyclo[2.2.2]oct-2-ene | ...)
Show SMILES C1CN2CCC1C(=C2)c1coc2ccccc12
Show InChI InChI=1S/C15H15NO/c1-2-4-15-12(3-1)14(10-17-15)13-9-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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34n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50036173
PNG
(3-Benzo[b]thiophen-3-yl-1-aza-bicyclo[2.2.2]oct-2-...)
Show SMILES C1CN2CCC1C(=C2)c1csc2ccccc12
Show InChI InChI=1S/C15H15NS/c1-2-4-15-12(3-1)14(10-17-15)13-9-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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37n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50283791
PNG
(3-Fluoren-9-ylidene-1-aza-bicyclo[2.2.2]octane | C...)
Show SMILES C1CN2CCC1C(C2)=C1c2ccccc2-c2ccccc12
Show InChI InChI=1S/C20H19N/c1-3-7-17-15(5-1)16-6-2-4-8-18(16)20(17)19-13-21-11-9-14(19)10-12-21/h1-8,14H,9-13H2
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50n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity of the compound towards muscarinic receptor in cerebral cortex (M1) was determined


Bioorg Med Chem Lett 4: 2837-2840 (1994)


Article DOI: 10.1016/S0960-894X(01)80824-6
BindingDB Entry DOI: 10.7270/Q2CV4HPB
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50036171
PNG
(3-Benzofuran-2-yl-1-aza-bicyclo[2.2.2]octane | CHE...)
Show SMILES C1CN2CCC1C(C2)c1cc2ccccc2o1
Show InChI InChI=1/C15H17NO/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,9,11,13H,5-8,10H2
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57n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50036175
PNG
(3-(2,3-Dihydro-benzofuran-2-yl)-1-aza-bicyclo[2.2....)
Show SMILES C1C(Oc2ccccc12)C1CN2CCC1CC2
Show InChI InChI=1/C15H19NO/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,11,13,15H,5-10H2
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59n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50036185
PNG
(3-(2'-Benzofuranyl)-quinuclidine-2-ene | 3-Benzofu...)
Show SMILES C1CN2CCC1C(=C2)c1cc2ccccc2o1
Show InChI InChI=1S/C15H15NO/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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59n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50036183
PNG
(3-(2'-Benzothiophenyl)-quinuclidine-2-ene | 3-Benz...)
Show SMILES C1CN2CCC1C(=C2)c1cc2ccccc2s1
Show InChI InChI=1S/C15H15NS/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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81n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50036173
PNG
(3-Benzo[b]thiophen-3-yl-1-aza-bicyclo[2.2.2]oct-2-...)
Show SMILES C1CN2CCC1C(=C2)c1csc2ccccc12
Show InChI InChI=1S/C15H15NS/c1-2-4-15-12(3-1)14(10-17-15)13-9-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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96n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50283791
PNG
(3-Fluoren-9-ylidene-1-aza-bicyclo[2.2.2]octane | C...)
Show SMILES C1CN2CCC1C(C2)=C1c2ccccc2-c2ccccc12
Show InChI InChI=1S/C20H19N/c1-3-7-17-15(5-1)16-6-2-4-8-18(16)20(17)19-13-21-11-9-14(19)10-12-21/h1-8,14H,9-13H2
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98n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity of the compound towards muscarinic receptor in heart (M2) was determined


Bioorg Med Chem Lett 4: 2837-2840 (1994)


Article DOI: 10.1016/S0960-894X(01)80824-6
BindingDB Entry DOI: 10.7270/Q2CV4HPB
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50036195
PNG
(3-Benzofuran-3-yl-1-aza-bicyclo[2.2.2]oct-2-ene | ...)
Show SMILES C1CN2CCC1C(=C2)c1coc2ccccc12
Show InChI InChI=1S/C15H15NO/c1-2-4-15-12(3-1)14(10-17-15)13-9-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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99n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50283791
PNG
(3-Fluoren-9-ylidene-1-aza-bicyclo[2.2.2]octane | C...)
Show SMILES C1CN2CCC1C(C2)=C1c2ccccc2-c2ccccc12
Show InChI InChI=1S/C20H19N/c1-3-7-17-15(5-1)16-6-2-4-8-18(16)20(17)19-13-21-11-9-14(19)10-12-21/h1-8,14H,9-13H2
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100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity towards muscarinic receptor in parotid gland (M3)


Bioorg Med Chem Lett 4: 2837-2840 (1994)


Article DOI: 10.1016/S0960-894X(01)80824-6
BindingDB Entry DOI: 10.7270/Q2CV4HPB
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50036190
PNG
(3-Benzooxazol-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene |...)
Show SMILES C1CN2CCC1C(=C2)c1nc2ccccc2o1
Show InChI InChI=1S/C14H14N2O/c1-2-4-13-12(3-1)15-14(17-13)11-9-16-7-5-10(11)6-8-16/h1-4,9-10H,5-8H2
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100n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50036173
PNG
(3-Benzo[b]thiophen-3-yl-1-aza-bicyclo[2.2.2]oct-2-...)
Show SMILES C1CN2CCC1C(=C2)c1csc2ccccc12
Show InChI InChI=1S/C15H15NS/c1-2-4-15-12(3-1)14(10-17-15)13-9-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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110n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM39341
PNG
(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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110n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50036195
PNG
(3-Benzofuran-3-yl-1-aza-bicyclo[2.2.2]oct-2-ene | ...)
Show SMILES C1CN2CCC1C(=C2)c1coc2ccccc12
Show InChI InChI=1S/C15H15NO/c1-2-4-15-12(3-1)14(10-17-15)13-9-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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160n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50036175
PNG
(3-(2,3-Dihydro-benzofuran-2-yl)-1-aza-bicyclo[2.2....)
Show SMILES C1C(Oc2ccccc12)C1CN2CCC1CC2
Show InChI InChI=1/C15H19NO/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,11,13,15H,5-10H2
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160n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50036170
PNG
(3-Benzothiazol-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene ...)
Show SMILES C1CN2CCC1C(=C2)c1nc2ccccc2s1
Show InChI InChI=1S/C14H14N2S/c1-2-4-13-12(3-1)15-14(17-13)11-9-16-7-5-10(11)6-8-16/h1-4,9-10H,5-8H2
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170n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50036171
PNG
(3-Benzofuran-2-yl-1-aza-bicyclo[2.2.2]octane | CHE...)
Show SMILES C1CN2CCC1C(C2)c1cc2ccccc2o1
Show InChI InChI=1/C15H17NO/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,9,11,13H,5-8,10H2
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200n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50036193
PNG
(3-(2-Methoxy-phenyl)-1-aza-bicyclo[2.2.2]oct-2-ene...)
Show SMILES COc1ccccc1C1=CN2CCC1CC2
Show InChI InChI=1S/C14H17NO/c1-16-14-5-3-2-4-12(14)13-10-15-8-6-11(13)7-9-15/h2-5,10-11H,6-9H2,1H3
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220n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50036171
PNG
(3-Benzofuran-2-yl-1-aza-bicyclo[2.2.2]octane | CHE...)
Show SMILES C1CN2CCC1C(C2)c1cc2ccccc2o1
Show InChI InChI=1/C15H17NO/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,9,11,13H,5-8,10H2
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240n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50283791
PNG
(3-Fluoren-9-ylidene-1-aza-bicyclo[2.2.2]octane | C...)
Show SMILES C1CN2CCC1C(C2)=C1c2ccccc2-c2ccccc12
Show InChI InChI=1S/C20H19N/c1-3-7-17-15(5-1)16-6-2-4-8-18(16)20(17)19-13-21-11-9-14(19)10-12-21/h1-8,14H,9-13H2
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249n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity towards muscarinic receptor in urinary bladder was determined


Bioorg Med Chem Lett 4: 2837-2840 (1994)


Article DOI: 10.1016/S0960-894X(01)80824-6
BindingDB Entry DOI: 10.7270/Q2CV4HPB
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM39341
PNG
(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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270n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50036183
PNG
(3-(2'-Benzothiophenyl)-quinuclidine-2-ene | 3-Benz...)
Show SMILES C1CN2CCC1C(=C2)c1cc2ccccc2s1
Show InChI InChI=1S/C15H15NS/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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270n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50036182
PNG
(3-Thiophen-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene | CH...)
Show SMILES C1CN2CCC1C(=C2)c1cccs1
Show InChI InChI=1S/C11H13NS/c1-2-11(13-7-1)10-8-12-5-3-9(10)4-6-12/h1-2,7-9H,3-6H2
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290n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50036196
PNG
(3-Furan-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene | CHEMB...)
Show SMILES C1CN2CCC1C(=C2)c1ccco1
Show InChI InChI=1S/C11H13NO/c1-2-11(13-7-1)10-8-12-5-3-9(10)4-6-12/h1-2,7-9H,3-6H2
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300n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50283794
PNG
((1-Aza-bicyclo[2.2.2]oct-2-en-3-yl)-(2-methoxy-phe...)
Show SMILES COc1ccccc1C(O)C1=CN2CCC1CC2
Show InChI InChI=1/C15H19NO2/c1-18-14-5-3-2-4-12(14)15(17)13-10-16-8-6-11(13)7-9-16/h2-5,10-11,15,17H,6-9H2,1H3
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330n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity of the compound towards muscarinic receptor in cerebral cortex (M1) was determined


Bioorg Med Chem Lett 4: 2837-2840 (1994)


Article DOI: 10.1016/S0960-894X(01)80824-6
BindingDB Entry DOI: 10.7270/Q2CV4HPB
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50036194
PNG
(2-(1-Aza-bicyclo[2.2.2]oct-2-en-3-yl)-phenol | CHE...)
Show SMILES Oc1ccccc1C1=CN2CCC1CC2
Show InChI InChI=1S/C13H15NO/c15-13-4-2-1-3-11(13)12-9-14-7-5-10(12)6-8-14/h1-4,9-10,15H,5-8H2
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330n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50036175
PNG
(3-(2,3-Dihydro-benzofuran-2-yl)-1-aza-bicyclo[2.2....)
Show SMILES C1C(Oc2ccccc12)C1CN2CCC1CC2
Show InChI InChI=1/C15H19NO/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,11,13,15H,5-10H2
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340n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50036163
PNG
(3-Benzofuran-2-yl-1-methyl-1-azonia-bicyclo[2.2.2]...)
Show SMILES C[N+]12CCC(CC1)C(=C2)c1cc2ccccc2o1
Show InChI InChI=1S/C16H18NO/c1-17-8-6-12(7-9-17)14(11-17)16-10-13-4-2-3-5-15(13)18-16/h2-5,10-12H,6-9H2,1H3/q+1
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360n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50036194
PNG
(2-(1-Aza-bicyclo[2.2.2]oct-2-en-3-yl)-phenol | CHE...)
Show SMILES Oc1ccccc1C1=CN2CCC1CC2
Show InChI InChI=1S/C13H15NO/c15-13-4-2-1-3-11(13)12-9-14-7-5-10(12)6-8-14/h1-4,9-10,15H,5-8H2
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360n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50036196
PNG
(3-Furan-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene | CHEMB...)
Show SMILES C1CN2CCC1C(=C2)c1ccco1
Show InChI InChI=1S/C11H13NO/c1-2-11(13-7-1)10-8-12-5-3-9(10)4-6-12/h1-2,7-9H,3-6H2
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390n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50036190
PNG
(3-Benzooxazol-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene |...)
Show SMILES C1CN2CCC1C(=C2)c1nc2ccccc2o1
Show InChI InChI=1S/C14H14N2O/c1-2-4-13-12(3-1)15-14(17-13)11-9-16-7-5-10(11)6-8-16/h1-4,9-10H,5-8H2
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400n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50036193
PNG
(3-(2-Methoxy-phenyl)-1-aza-bicyclo[2.2.2]oct-2-ene...)
Show SMILES COc1ccccc1C1=CN2CCC1CC2
Show InChI InChI=1S/C14H17NO/c1-16-14-5-3-2-4-12(14)13-10-15-8-6-11(13)7-9-15/h2-5,10-11H,6-9H2,1H3
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410n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50036169
PNG
(3-Selenophen-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene | ...)
Show SMILES C1CN2CCC1C(=C2)c1ccc[se]1
Show InChI InChI=1S/C11H13NSe/c1-2-11(13-7-1)10-8-12-5-3-9(10)4-6-12/h1-2,7-9H,3-6H2
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410n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50036183
PNG
(3-(2'-Benzothiophenyl)-quinuclidine-2-ene | 3-Benz...)
Show SMILES C1CN2CCC1C(=C2)c1cc2ccccc2s1
Show InChI InChI=1S/C15H15NS/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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420n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50283793
PNG
((1-Aza-bicyclo[2.2.2]oct-2-en-3-yl)-(2-methoxy-phe...)
Show SMILES COc1ccccc1C(=O)C1=CN2CCC1CC2
Show InChI InChI=1S/C15H17NO2/c1-18-14-5-3-2-4-12(14)15(17)13-10-16-8-6-11(13)7-9-16/h2-5,10-11H,6-9H2,1H3
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422n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity of the compound towards muscarinic receptor in cerebral cortex (M1) was determined


Bioorg Med Chem Lett 4: 2837-2840 (1994)


Article DOI: 10.1016/S0960-894X(01)80824-6
BindingDB Entry DOI: 10.7270/Q2CV4HPB
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50036175
PNG
(3-(2,3-Dihydro-benzofuran-2-yl)-1-aza-bicyclo[2.2....)
Show SMILES C1C(Oc2ccccc12)C1CN2CCC1CC2
Show InChI InChI=1/C15H19NO/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,11,13,15H,5-10H2
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440n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50036163
PNG
(3-Benzofuran-2-yl-1-methyl-1-azonia-bicyclo[2.2.2]...)
Show SMILES C[N+]12CCC(CC1)C(=C2)c1cc2ccccc2o1
Show InChI InChI=1S/C16H18NO/c1-17-8-6-12(7-9-17)14(11-17)16-10-13-4-2-3-5-15(13)18-16/h2-5,10-12H,6-9H2,1H3/q+1
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460n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50283792
PNG
(1-[5-(1-Aza-bicyclo[2.2.2]oct-2-en-3-yl)-thiophen-...)
Show SMILES CC(=O)c1ccc(s1)C1=CN2CCC1CC2
Show InChI InChI=1S/C13H15NOS/c1-9(15)12-2-3-13(16-12)11-8-14-6-4-10(11)5-7-14/h2-3,8,10H,4-7H2,1H3
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480n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity of the compound towards muscarinic receptor in cerebral cortex (M1) was determined


Bioorg Med Chem Lett 4: 2837-2840 (1994)


Article DOI: 10.1016/S0960-894X(01)80824-6
BindingDB Entry DOI: 10.7270/Q2CV4HPB
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50036192
PNG
(3-Benzofuran-2-yl-1-methyl-1-azonia-bicyclo[2.2.2]...)
Show SMILES C[N+]12CCC(CC1)C(C2)c1cc2ccccc2o1
Show InChI InChI=1/C16H20NO/c1-17-8-6-12(7-9-17)14(11-17)16-10-13-4-2-3-5-15(13)18-16/h2-5,10,12,14H,6-9,11H2,1H3/q+1
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520n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50036191
PNG
(3-Furan-2-yl-1-aza-bicyclo[2.2.2]octane | CHEMBL14...)
Show SMILES C1CN2CCC1C(C2)c1ccco1
Show InChI InChI=1/C11H15NO/c1-2-11(13-7-1)10-8-12-5-3-9(10)4-6-12/h1-2,7,9-10H,3-6,8H2
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540n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50036170
PNG
(3-Benzothiazol-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene ...)
Show SMILES C1CN2CCC1C(=C2)c1nc2ccccc2s1
Show InChI InChI=1S/C14H14N2S/c1-2-4-13-12(3-1)15-14(17-13)11-9-16-7-5-10(11)6-8-16/h1-4,9-10H,5-8H2
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600n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50036182
PNG
(3-Thiophen-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene | CH...)
Show SMILES C1CN2CCC1C(=C2)c1cccs1
Show InChI InChI=1S/C11H13NS/c1-2-11(13-7-1)10-8-12-5-3-9(10)4-6-12/h1-2,7-9H,3-6H2
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PubMed
620n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50036165
PNG
(3-Thiophen-3-yl-1-aza-bicyclo[2.2.2]oct-2-ene | CH...)
Show SMILES C1CN2CCC1C(=C2)c1ccsc1
Show InChI InChI=1S/C11H13NS/c1-4-12-5-2-9(1)11(7-12)10-3-6-13-8-10/h3,6-9H,1-2,4-5H2
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710n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
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