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Compile Data Set for Download or QSAR

Found 450 hits with Last Name = 'takahashi' and Initial = 'n'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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Article
0.440n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1


Bioorg Med Chem Lett 7: 2303-2306 (1997)


Article DOI: 10.1016/S0960-894X(97)00417-4
BindingDB Entry DOI: 10.7270/Q2319VVV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50290098
PNG
((R)-3-Cyclohexylmethyl-1,8,8-trimethyl-3-aza-bicyc...)
Show SMILES CC1(C)C2CC[C@@]1(C)CN(CC1CCCCC1)C2
Show InChI InChI=1S/C17H31N/c1-16(2)15-9-10-17(16,3)13-18(12-15)11-14-7-5-4-6-8-14/h14-15H,4-13H2,1-3H3/t15?,17-/m0/s1
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1.10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1


Bioorg Med Chem Lett 7: 2303-2306 (1997)


Article DOI: 10.1016/S0960-894X(97)00417-4
BindingDB Entry DOI: 10.7270/Q2319VVV
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50290099
PNG
((S)-3-(4-Cyclohexyl-butyl)-1,8,8-trimethyl-3-aza-b...)
Show SMILES CC1(C)C2CC[C@]1(C)CN(CCCCC1CCCCC1)C2
Show InChI InChI=1S/C20H37N/c1-19(2)18-12-13-20(19,3)16-21(15-18)14-8-7-11-17-9-5-4-6-10-17/h17-18H,4-16H2,1-3H3/t18?,20-/m1/s1
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1.20n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1


Bioorg Med Chem Lett 7: 2303-2306 (1997)


Article DOI: 10.1016/S0960-894X(97)00417-4
BindingDB Entry DOI: 10.7270/Q2319VVV
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50290100
PNG
((S)-3-Cyclohexylmethyl-1,8,8-trimethyl-3-aza-bicyc...)
Show SMILES CC1(C)C2CC[C@]1(C)CN(CC1CCCCC1)C2
Show InChI InChI=1S/C17H31N/c1-16(2)15-9-10-17(16,3)13-18(12-15)11-14-7-5-4-6-8-14/h14-15H,4-13H2,1-3H3/t15?,17-/m1/s1
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1.30n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1


Bioorg Med Chem Lett 7: 2303-2306 (1997)


Article DOI: 10.1016/S0960-894X(97)00417-4
BindingDB Entry DOI: 10.7270/Q2319VVV
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50290095
PNG
((R)-3-(2-Cyclohexyl-ethyl)-1,8,8-trimethyl-3-aza-b...)
Show SMILES CC1(C)C2CC[C@@]1(C)CN(CCC1CCCCC1)C2
Show InChI InChI=1S/C18H33N/c1-17(2)16-9-11-18(17,3)14-19(13-16)12-10-15-7-5-4-6-8-15/h15-16H,4-14H2,1-3H3/t16?,18-/m0/s1
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1.40n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1


Bioorg Med Chem Lett 7: 2303-2306 (1997)


Article DOI: 10.1016/S0960-894X(97)00417-4
BindingDB Entry DOI: 10.7270/Q2319VVV
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50290096
PNG
((S)-3-(2-Cyclopentyl-ethyl)-1,8,8-trimethyl-3-aza-...)
Show SMILES CC1(C)C2CC[C@]1(C)CN(CCC1CCCC1)C2
Show InChI InChI=1S/C17H31N/c1-16(2)15-8-10-17(16,3)13-18(12-15)11-9-14-6-4-5-7-14/h14-15H,4-13H2,1-3H3/t15?,17-/m1/s1
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1.70n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1


Bioorg Med Chem Lett 7: 2303-2306 (1997)


Article DOI: 10.1016/S0960-894X(97)00417-4
BindingDB Entry DOI: 10.7270/Q2319VVV
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50290094
PNG
((S)-3-(2-Cyclohexyl-ethyl)-1,8,8-trimethyl-3-aza-b...)
Show SMILES CC1(C)C2CC[C@]1(C)CN(CCC1CCCCC1)C2
Show InChI InChI=1S/C18H33N/c1-17(2)16-9-11-18(17,3)14-19(13-16)12-10-15-7-5-4-6-8-15/h15-16H,4-14H2,1-3H3/t16?,18-/m1/s1
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2.20n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1


Bioorg Med Chem Lett 7: 2303-2306 (1997)


Article DOI: 10.1016/S0960-894X(97)00417-4
BindingDB Entry DOI: 10.7270/Q2319VVV
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50290101
PNG
((S)-3-(3-Cyclohexyl-propyl)-1,8,8-trimethyl-3-aza-...)
Show SMILES CC1(C)C2CC[C@]1(C)CN(CCCC1CCCCC1)C2
Show InChI InChI=1S/C19H35N/c1-18(2)17-11-12-19(18,3)15-20(14-17)13-7-10-16-8-5-4-6-9-16/h16-17H,4-15H2,1-3H3/t17?,19-/m1/s1
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2.5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1


Bioorg Med Chem Lett 7: 2303-2306 (1997)


Article DOI: 10.1016/S0960-894X(97)00417-4
BindingDB Entry DOI: 10.7270/Q2319VVV
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50290093
PNG
((S)-3-(2-Cyclooctyl-ethyl)-1,8,8-trimethyl-3-aza-b...)
Show SMILES CC1(C)C2CC[C@]1(C)CN(CCC1CCCCCCC1)C2
Show InChI InChI=1S/C20H37N/c1-19(2)18-11-13-20(19,3)16-21(15-18)14-12-17-9-7-5-4-6-8-10-17/h17-18H,4-16H2,1-3H3/t18?,20-/m1/s1
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2.90n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1


Bioorg Med Chem Lett 7: 2303-2306 (1997)


Article DOI: 10.1016/S0960-894X(97)00417-4
BindingDB Entry DOI: 10.7270/Q2319VVV
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50290092
PNG
((S)-3-(2-Cycloheptyl-ethyl)-1,8,8-trimethyl-3-aza-...)
Show SMILES CC1(C)C2CC[C@]1(C)CN(CCC1CCCCCC1)C2
Show InChI InChI=1S/C19H35N/c1-18(2)17-10-12-19(18,3)15-20(14-17)13-11-16-8-6-4-5-7-9-16/h16-17H,4-15H2,1-3H3/t17?,19-/m1/s1
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2.90n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1


Bioorg Med Chem Lett 7: 2303-2306 (1997)


Article DOI: 10.1016/S0960-894X(97)00417-4
BindingDB Entry DOI: 10.7270/Q2319VVV
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50290097
PNG
((S)-3-Cyclohexyl-1,8,8-trimethyl-3-aza-bicyclo[3.2...)
Show SMILES CC1(C)C2CC[C@]1(C)CN(C2)C1CCCCC1
Show InChI InChI=1S/C16H29N/c1-15(2)13-9-10-16(15,3)12-17(11-13)14-7-5-4-6-8-14/h13-14H,4-12H2,1-3H3/t13?,16-/m1/s1
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3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1


Bioorg Med Chem Lett 7: 2303-2306 (1997)


Article DOI: 10.1016/S0960-894X(97)00417-4
BindingDB Entry DOI: 10.7270/Q2319VVV
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50290091
PNG
((S)-3-(2-Adamantan-2-yl-ethyl)-1,8,8-trimethyl-3-a...)
Show SMILES CC1(C)C2CC[C@]1(C)CN(CCC1C3CC4CC(C3)CC1C4)C2
Show InChI InChI=1S/C22H37N/c1-21(2)19-4-6-22(21,3)14-23(13-19)7-5-20-17-9-15-8-16(11-17)12-18(20)10-15/h15-20H,4-14H2,1-3H3/t15?,16?,17?,18?,19?,20?,22-/m1/s1
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4.30n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1


Bioorg Med Chem Lett 7: 2303-2306 (1997)


Article DOI: 10.1016/S0960-894X(97)00417-4
BindingDB Entry DOI: 10.7270/Q2319VVV
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM81982
PNG
(CAS_97-39-2 | DITOLYLGUANIDINE | DTG | Di-o-tolylg...)
Show SMILES Cc1ccccc1NC(N)=Nc1ccccc1C
Show InChI InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)
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27n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1


Bioorg Med Chem Lett 7: 2303-2306 (1997)


Article DOI: 10.1016/S0960-894X(97)00417-4
BindingDB Entry DOI: 10.7270/Q2319VVV
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50001044
PNG
((1S,9S,13S)-10-allyl-1,13-dimethyl-10-azatricyclo[...)
Show SMILES C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CC=C
Show InChI InChI=1S/C17H23NO/c1-4-8-18-9-7-17(3)12(2)16(18)10-13-5-6-14(19)11-15(13)17/h4-6,11-12,16,19H,1,7-10H2,2-3H3/t12-,16+,17-/m1/s1
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157n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1


Bioorg Med Chem Lett 7: 2303-2306 (1997)


Article DOI: 10.1016/S0960-894X(97)00417-4
BindingDB Entry DOI: 10.7270/Q2319VVV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162144
PNG
(1-(4-Chloro-phenyl)-3-[4-(6,7-dimethoxy-quinolin-4...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(Cl)cc4)cc3)c2cc1OC
Show InChI InChI=1S/C24H20ClN3O4/c1-30-22-13-19-20(14-23(22)31-2)26-12-11-21(19)32-18-9-7-17(8-10-18)28-24(29)27-16-5-3-15(25)4-6-16/h3-14H,1-2H3,(H2,27,28,29)
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PubMed
n/an/a 0.200n/an/an/an/an/an/a



Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162154
PNG
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(2...)
Show SMILES COc1ccccc1NC(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C25H23N3O5/c1-30-22-7-5-4-6-19(22)28-25(29)27-16-8-10-17(11-9-16)33-21-12-13-26-20-15-24(32-3)23(31-2)14-18(20)21/h4-15H,1-3H3,(H2,27,28,29)
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n/an/a 0.200n/an/an/an/an/an/a



Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162167
PNG
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-ph...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C24H21N3O4/c1-29-22-14-19-20(15-23(22)30-2)25-13-12-21(19)31-18-10-8-17(9-11-18)27-24(28)26-16-6-4-3-5-7-16/h3-15H,1-2H3,(H2,26,27,28)
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n/an/a 0.200n/an/an/an/an/an/a



Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162143
PNG
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-m-...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(C)c4)cc3)c2cc1OC
Show InChI InChI=1S/C25H23N3O4/c1-16-5-4-6-18(13-16)28-25(29)27-17-7-9-19(10-8-17)32-22-11-12-26-21-15-24(31-3)23(30-2)14-20(21)22/h4-15H,1-3H3,(H2,27,28,29)
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n/an/a 0.200n/an/an/an/an/an/a



Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50042053
PNG
(CHEMBL3360172)
Show SMILES CCn1c(Nc2ccncc2F)nc2c(csc2c1=O)C1CCCN(C1)C(=O)C1(CC1)C#N
Show InChI InChI=1S/C23H23FN6O2S/c1-2-30-20(31)19-18(28-22(30)27-17-5-8-26-10-16(17)24)15(12-33-19)14-4-3-9-29(11-14)21(32)23(13-25)6-7-23/h5,8,10,12,14H,2-4,6-7,9,11H2,1H3,(H,26,27,28)
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n/an/a 0.320n/an/an/an/an/an/a



Kyoto 607-8042

Curated by ChEMBL


Assay Description
Inhibition of PDE7A (unknown origin)


Bioorg Med Chem Lett 25: 649-53 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.090
BindingDB Entry DOI: 10.7270/Q2542Q6P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162168
PNG
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(4...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c2cc1OC
Show InChI InChI=1S/C24H20FN3O4/c1-30-22-13-19-20(14-23(22)31-2)26-12-11-21(19)32-18-9-7-17(8-10-18)28-24(29)27-16-5-3-15(25)4-6-16/h3-14H,1-2H3,(H2,27,28,29)
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n/an/a 0.400n/an/an/an/an/an/a



Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162169
PNG
(1-(2,5-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(F)ccc4F)cc3)c2cc1OC
Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-17-19(13-23(22)32-2)27-10-9-21(17)33-16-6-4-15(5-7-16)28-24(30)29-20-11-14(25)3-8-18(20)26/h3-13H,1-2H3,(H2,28,29,30)
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Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162166
PNG
(1-[2-Chloro-4-(6,7-dimethoxy-quinolin-4-yloxy)-phe...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C24H18ClF2N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-18(16(25)10-14)29-24(31)30-19-5-3-13(26)9-17(19)27/h3-12H,1-2H3,(H2,29,30,31)
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Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162155
PNG
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-p-...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(C)cc4)cc3)c2cc1OC
Show InChI InChI=1S/C25H23N3O4/c1-16-4-6-17(7-5-16)27-25(29)28-18-8-10-19(11-9-18)32-22-12-13-26-21-15-24(31-3)23(30-2)14-20(21)22/h4-15H,1-3H3,(H2,27,28,29)
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Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162142
PNG
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(2...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4F)cc3)c2cc1OC
Show InChI InChI=1S/C24H20FN3O4/c1-30-22-13-17-20(14-23(22)31-2)26-12-11-21(17)32-16-9-7-15(8-10-16)27-24(29)28-19-6-4-3-5-18(19)25/h3-14H,1-2H3,(H2,27,28,29)
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Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50042036
PNG
(CHEMBL3360170)
Show SMILES CCn1c(Nc2ccncc2F)nc2c(csc2c1=O)C1CCCN(C1)C(=O)OC
Show InChI InChI=1S/C20H22FN5O3S/c1-3-26-18(27)17-16(24-19(26)23-15-6-7-22-9-14(15)21)13(11-30-17)12-5-4-8-25(10-12)20(28)29-2/h6-7,9,11-12H,3-5,8,10H2,1-2H3,(H,22,23,24)
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n/an/a 0.680n/an/an/an/an/an/a



Kyoto 607-8042

Curated by ChEMBL


Assay Description
Inhibition of PDE7A (unknown origin)


Bioorg Med Chem Lett 25: 649-53 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.090
BindingDB Entry DOI: 10.7270/Q2542Q6P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162156
PNG
(1-(2,3-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(F)c4F)cc3)c2cc1OC
Show InChI InChI=1S/C24H19F2N3O4/c1-31-21-12-16-19(13-22(21)32-2)27-11-10-20(16)33-15-8-6-14(7-9-15)28-24(30)29-18-5-3-4-17(25)23(18)26/h3-13H,1-2H3,(H2,28,29,30)
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Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162148
PNG
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)c2cc1OC
Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-17-20(13-23(22)32-2)27-10-9-21(17)33-16-6-4-15(5-7-16)28-24(30)29-19-8-3-14(25)11-18(19)26/h3-13H,1-2H3,(H2,28,29,30)
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Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162147
PNG
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC
Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
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Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2 in cell-intact assay


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162160
PNG
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3F)c2cc1OC
Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-19(12-23(22)33-2)28-8-7-20(15)34-21-6-4-14(10-17(21)27)29-24(31)30-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
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Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162145
PNG
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(3...)
Show SMILES COc1cccc(NC(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)c1
Show InChI InChI=1S/C25H23N3O5/c1-30-19-6-4-5-17(13-19)28-25(29)27-16-7-9-18(10-8-16)33-22-11-12-26-21-15-24(32-3)23(31-2)14-20(21)22/h4-15H,1-3H3,(H2,27,28,29)
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Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50032547
PNG
(CHEMBL3354181)
Show SMILES CCn1c(NC2CCCC2)nc2c(csc2c1=O)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C22H27N5O2S/c1-2-27-21(28)20-19(25-22(27)24-16-5-3-4-6-16)17(14-30-20)15-7-8-18(23-13-15)26-9-11-29-12-10-26/h7-8,13-14,16H,2-6,9-12H2,1H3,(H,24,25)
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Kyoto 607-8042

Curated by ChEMBL


Assay Description
Inhibition of human PDE7A1 expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting


J Med Chem 57: 9844-54 (2014)


Article DOI: 10.1021/jm5008215
BindingDB Entry DOI: 10.7270/Q228096D
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162152
PNG
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(4...)
Show SMILES COc1ccc(NC(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)cc1
Show InChI InChI=1S/C25H23N3O5/c1-30-18-8-4-16(5-9-18)27-25(29)28-17-6-10-19(11-7-17)33-22-12-13-26-21-15-24(32-3)23(31-2)14-20(21)22/h4-15H,1-3H3,(H2,27,28,29)
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Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162140
PNG
(1-(3,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)c(F)c4)cc3)c2cc1OC
Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-17-20(13-23(22)32-2)27-10-9-21(17)33-16-6-3-14(4-7-16)28-24(30)29-15-5-8-18(25)19(26)11-15/h3-13H,1-2H3,(H2,28,29,30)
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Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162158
PNG
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(3...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(c4)[N+]([O-])=O)cc3)c2cc1OC
Show InChI InChI=1S/C24H20N4O6/c1-32-22-13-19-20(14-23(22)33-2)25-11-10-21(19)34-18-8-6-15(7-9-18)26-24(29)27-16-4-3-5-17(12-16)28(30)31/h3-14H,1-2H3,(H2,26,27,29)
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Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50042037
PNG
(CHEMBL3360169)
Show SMILES CCn1c(Nc2ccncc2F)nc2c(csc2c1=O)C1CCN(CC1)C(=O)OC
Show InChI InChI=1S/C20H22FN5O3S/c1-3-26-18(27)17-16(24-19(26)23-15-4-7-22-10-14(15)21)13(11-30-17)12-5-8-25(9-6-12)20(28)29-2/h4,7,10-12H,3,5-6,8-9H2,1-2H3,(H,22,23,24)
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Kyoto 607-8042

Curated by ChEMBL


Assay Description
Inhibition of PDE7A (unknown origin)


Bioorg Med Chem Lett 25: 649-53 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.090
BindingDB Entry DOI: 10.7270/Q2542Q6P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50042035
PNG
(CHEMBL3360171)
Show SMILES CCn1c(Nc2ccncc2F)nc2c(csc2c1=O)C1CCCN(C1)C(=O)C(C)(C)CO
Show InChI InChI=1S/C23H28FN5O3S/c1-4-29-20(31)19-18(27-22(29)26-17-7-8-25-10-16(17)24)15(12-33-19)14-6-5-9-28(11-14)21(32)23(2,3)13-30/h7-8,10,12,14,30H,4-6,9,11,13H2,1-3H3,(H,25,26,27)
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Kyoto 607-8042

Curated by ChEMBL


Assay Description
Inhibition of PDE7A (unknown origin)


Bioorg Med Chem Lett 25: 649-53 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.090
BindingDB Entry DOI: 10.7270/Q2542Q6P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162162
PNG
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(3...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c2cc1OC
Show InChI InChI=1S/C24H20FN3O4/c1-30-22-13-19-20(14-23(22)31-2)26-11-10-21(19)32-18-8-6-16(7-9-18)27-24(29)28-17-5-3-4-15(25)12-17/h3-14H,1-2H3,(H2,27,28,29)
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Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50068286
PNG
(CHEMBL3403373)
Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)c1ncccc1C
Show InChI InChI=1S/C22H27N5O2S/c1-5-27-21(29)19-18(25-22(27)24-13(2)3)16(12-30-19)15-8-10-26(11-15)20(28)17-14(4)7-6-9-23-17/h6-7,9,12-13,15H,5,8,10-11H2,1-4H3,(H,24,25)
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Kaken Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting


Bioorg Med Chem Lett 25: 1910-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50068283
PNG
(CHEMBL3403371)
Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)c1ccccc1
Show InChI InChI=1S/C22H26N4O2S/c1-4-26-21(28)19-18(24-22(26)23-14(2)3)17(13-29-19)16-10-11-25(12-16)20(27)15-8-6-5-7-9-15/h5-9,13-14,16H,4,10-12H2,1-3H3,(H,23,24)
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Kaken Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting


Bioorg Med Chem Lett 25: 1910-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162171
PNG
(1-(3-Chloro-phenyl)-3-[4-(6,7-dimethoxy-quinolin-4...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c2cc1OC
Show InChI InChI=1S/C24H20ClN3O4/c1-30-22-13-19-20(14-23(22)31-2)26-11-10-21(19)32-18-8-6-16(7-9-18)27-24(29)28-17-5-3-4-15(25)12-17/h3-14H,1-2H3,(H2,27,28,29)
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n/an/a 1.60n/an/an/an/an/an/a



Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50162156
PNG
(1-(2,3-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(F)c4F)cc3)c2cc1OC
Show InChI InChI=1S/C24H19F2N3O4/c1-31-21-12-16-19(13-22(21)32-2)27-11-10-20(16)33-15-8-6-14(7-9-15)28-24(30)29-18-5-3-4-17(25)23(18)26/h3-13H,1-2H3,(H2,28,29,30)
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n/an/a 1.60n/an/an/an/an/an/a



Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor alpha


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162163
PNG
(1-(3,5-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(F)cc(F)c4)cc3)c2cc1OC
Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-19-20(13-23(22)32-2)27-8-7-21(19)33-18-5-3-16(4-6-18)28-24(30)29-17-10-14(25)9-15(26)11-17/h3-13H,1-2H3,(H2,28,29,30)
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n/an/a 1.80n/an/an/an/an/an/a



Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162170
PNG
(1-(2,6-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4c(F)cccc4F)cc3)c2cc1OC
Show InChI InChI=1S/C24H19F2N3O4/c1-31-21-12-16-19(13-22(21)32-2)27-11-10-20(16)33-15-8-6-14(7-9-15)28-24(30)29-23-17(25)4-3-5-18(23)26/h3-13H,1-2H3,(H2,28,29,30)
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n/an/a 1.80n/an/an/an/an/an/a



Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50162145
PNG
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(3...)
Show SMILES COc1cccc(NC(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)c1
Show InChI InChI=1S/C25H23N3O5/c1-30-19-6-4-5-17(13-19)28-25(29)27-16-7-9-18(10-8-16)33-22-11-12-26-21-15-24(32-3)23(31-2)14-20(21)22/h4-15H,1-3H3,(H2,27,28,29)
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n/an/a 2n/an/an/an/an/an/a



Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor alpha


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50032540
PNG
(CHEMBL3354179)
Show SMILES CCn1c(NC2CCCC2)nc2c(csc2c1=O)-c1cccnc1
Show InChI InChI=1S/C18H20N4OS/c1-2-22-17(23)16-15(21-18(22)20-13-7-3-4-8-13)14(11-24-16)12-6-5-9-19-10-12/h5-6,9-11,13H,2-4,7-8H2,1H3,(H,20,21)
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n/an/a 2n/an/an/an/an/an/a



Kyoto 607-8042

Curated by ChEMBL


Assay Description
Inhibition of PDE7A (unknown origin)


Bioorg Med Chem Lett 25: 649-53 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.090
BindingDB Entry DOI: 10.7270/Q2542Q6P
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50162152
PNG
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(4...)
Show SMILES COc1ccc(NC(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)cc1
Show InChI InChI=1S/C25H23N3O5/c1-30-18-8-4-16(5-9-18)27-25(29)28-17-6-10-19(11-7-17)33-22-12-13-26-21-15-24(32-3)23(31-2)14-20(21)22/h4-15H,1-3H3,(H2,27,28,29)
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Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor alpha


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50032540
PNG
(CHEMBL3354179)
Show SMILES CCn1c(NC2CCCC2)nc2c(csc2c1=O)-c1cccnc1
Show InChI InChI=1S/C18H20N4OS/c1-2-22-17(23)16-15(21-18(22)20-13-7-3-4-8-13)14(11-24-16)12-6-5-9-19-10-12/h5-6,9-11,13H,2-4,7-8H2,1H3,(H,20,21)
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n/an/a 2n/an/an/an/an/an/a



Kyoto 607-8042

Curated by ChEMBL


Assay Description
Inhibition of human PDE7A1 expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting


J Med Chem 57: 9844-54 (2014)


Article DOI: 10.1021/jm5008215
BindingDB Entry DOI: 10.7270/Q228096D
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50042039
PNG
(CHEMBL3360167)
Show SMILES CCn1c(Nc2ccncc2F)nc2c(csc2c1=O)C(C)(C)O
Show InChI InChI=1S/C16H17FN4O2S/c1-4-21-14(22)13-12(9(8-24-13)16(2,3)23)20-15(21)19-11-5-6-18-7-10(11)17/h5-8,23H,4H2,1-3H3,(H,18,19,20)
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n/an/a 2.10n/an/an/an/an/an/a



Kyoto 607-8042

Curated by ChEMBL


Assay Description
Inhibition of PDE7A (unknown origin)


Bioorg Med Chem Lett 25: 649-53 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.090
BindingDB Entry DOI: 10.7270/Q2542Q6P
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162157
PNG
(1-[4-(6,7-Dimethoxy-quinazolin-4-yloxy)-phenyl]-3-...)
Show SMILES COc1ccc(NC(=O)Nc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)cc1
Show InChI InChI=1S/C24H22N4O5/c1-30-17-8-4-15(5-9-17)27-24(29)28-16-6-10-18(11-7-16)33-23-19-12-21(31-2)22(32-3)13-20(19)25-14-26-23/h4-14H,1-3H3,(H2,27,28,29)
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n/an/a 2.20n/an/an/an/an/an/a



Kirin Brewery Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50032543
PNG
(CHEMBL3354180)
Show SMILES CCn1c(NC2CCCC2)nc2c(csc2c1=O)-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C24H30N4O2S/c1-2-28-23(29)22-21(26-24(28)25-19-5-3-4-6-19)20(16-31-22)18-9-7-17(8-10-18)15-27-11-13-30-14-12-27/h7-10,16,19H,2-6,11-15H2,1H3,(H,25,26)
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n/an/a 2.30n/an/an/an/an/an/a



Kyoto 607-8042

Curated by ChEMBL


Assay Description
Inhibition of human PDE7A1 expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting


J Med Chem 57: 9844-54 (2014)


Article DOI: 10.1021/jm5008215
BindingDB Entry DOI: 10.7270/Q228096D
More data for this
Ligand-Target Pair
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