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Compile Data Set for Download or QSAR

Found 5 hits with Last Name = 'wang' and Initial = 'sl'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50325419
PNG
(4-(2-(1-(1-(3,4-dimethylphenyl)-2-oxoindolin-3-yli...)
Show SMILES CC(=NNC(=S)c1ccc(cc1)C(O)=O)C1C(=O)N(c2ccccc12)c1ccc(C)c(C)c1
Show InChI InChI=1S/C26H23N3O3S/c1-15-8-13-20(14-16(15)2)29-22-7-5-4-6-21(22)23(25(29)30)17(3)27-28-24(33)18-9-11-19(12-10-18)26(31)32/h4-14,23H,1-3H3,(H,28,33)(H,31,32)
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n/an/an/an/a 82n/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant TPO receptor expressed in mouse BaF3 cells after 24 hrs


Bioorg Med Chem Lett 20: 5062-4 (2010)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50325420
PNG
(4-(2-(1-(1-(2,3-dihydro-1H-inden-5-yl)-2-oxoindoli...)
Show SMILES CC(=NNC(=S)c1ccc(cc1)C(O)=O)C1C(=O)N(c2ccccc12)c1ccc2CCCc2c1
Show InChI InChI=1S/C27H23N3O3S/c1-16(28-29-25(34)18-9-11-19(12-10-18)27(32)33)24-22-7-2-3-8-23(22)30(26(24)31)21-14-13-17-5-4-6-20(17)15-21/h2-3,7-15,24H,4-6H2,1H3,(H,29,34)(H,32,33)
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n/an/an/an/a>200n/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant TPO receptor expressed in mouse BaF3 cells after 24 hrs


Bioorg Med Chem Lett 20: 5062-4 (2010)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50325423
PNG
(4-(2-(1-(1-(2,3-dihydro-1H-inden-5-yl)-5-fluoro-2-...)
Show SMILES CC(=NNC(=S)c1ccc(cc1)C(O)=O)C1C(=O)N(c2ccc(F)cc12)c1ccc2CCCc2c1
Show InChI InChI=1S/C27H22FN3O3S/c1-15(29-30-25(35)17-5-7-18(8-6-17)27(33)34)24-22-14-20(28)10-12-23(22)31(26(24)32)21-11-9-16-3-2-4-19(16)13-21/h5-14,24H,2-4H2,1H3,(H,30,35)(H,33,34)
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n/an/an/an/a>200n/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant TPO receptor expressed in mouse BaF3 cells after 24 hrs


Bioorg Med Chem Lett 20: 5062-4 (2010)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50325422
PNG
(4-(2-(1-(1-(3,4-dimethylphenyl)-5-fluoro-2-oxoindo...)
Show SMILES CC(=NNC(=S)c1ccc(cc1)C(O)=O)C1C(=O)N(c2ccc(F)cc12)c1ccc(C)c(C)c1
Show InChI InChI=1S/C26H22FN3O3S/c1-14-4-10-20(12-15(14)2)30-22-11-9-19(27)13-21(22)23(25(30)31)16(3)28-29-24(34)17-5-7-18(8-6-17)26(32)33/h4-13,23H,1-3H3,(H,29,34)(H,32,33)
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n/an/an/an/a 103n/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant TPO receptor expressed in mouse BaF3 cells after 24 hrs


Bioorg Med Chem Lett 20: 5062-4 (2010)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50325421
PNG
(4-(2-(1-(5-fluoro-2-oxo-1-p-tolylindolin-3-ylidene...)
Show SMILES CC(=NNC(=S)c1ccc(cc1)C(O)=O)C1C(=O)N(c2ccc(F)cc12)c1ccc(C)cc1
Show InChI InChI=1S/C25H20FN3O3S/c1-14-3-10-19(11-4-14)29-21-12-9-18(26)13-20(21)22(24(29)30)15(2)27-28-23(33)16-5-7-17(8-6-16)25(31)32/h3-13,22H,1-2H3,(H,28,33)(H,31,32)
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Article
PubMed
n/an/an/an/a 44n/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant TPO receptor expressed in mouse BaF3 cells after 24 hrs


Bioorg Med Chem Lett 20: 5062-4 (2010)

More data for this
Ligand-Target Pair