Found 1511 hits with Last Name = 'welch' and Initial = 'm' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)) | BDBM50005118
((S)-3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)...)Show InChI InChI=1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1 | PDB
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| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University
Curated by ChEMBL
| Assay Description
In vitro binding affinity against dopamine receptor D2 in rat striata; value ranges from 1.8-3.0 nM |
J Med Chem 33: 2430-7 (1990)
Article DOI: 10.1021/jm00171a017
BindingDB Entry DOI: 10.7270/Q23J3BXF |
More data for this
Ligand-Target Pair | |
GRIA3
(RAT) | BDBM50096326
(6-{(E)-2-[3-(2-Chloro-phenyl)-6-fluoro-4-oxo-3,4-d...)Show SMILES Fc1ccc2nc(\C=C\c3cccc(n3)C#N)n(-c3ccccc3Cl)c(=O)c2c1 Show InChI InChI=1S/C22H12ClFN4O/c23-18-6-1-2-7-20(18)28-21(11-9-15-4-3-5-16(13-25)26-15)27-19-10-8-14(24)12-17(19)22(28)29/h1-12H/b11-9+ | PDB
Reactome pathway
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| CHEMBL
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PC sid
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| Article
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| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by PDSP Ki Database
| |
Mol Pharmacol 58: 1310-7 (2000)
Article DOI: 10.1124/mol.58.6.1310
BindingDB Entry DOI: 10.7270/Q24X56B1 |
More data for this
Ligand-Target Pair | |
Caspase-3
(Homo sapiens (Human)) | BDBM10351
(1-(4-Methoxybenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-...)Show SMILES COc1ccc(CN2C(=O)C(=O)c3cc(ccc23)S(=O)(=O)N2CCC[C@H]2COc2cccnc2)cc1 Show InChI InChI=1S/C26H25N3O6S/c1-34-20-8-6-18(7-9-20)16-28-24-11-10-22(14-23(24)25(30)26(28)31)36(32,33)29-13-3-4-19(29)17-35-21-5-2-12-27-15-21/h2,5-12,14-15,19H,3-4,13,16-17H2,1H3/t19-/m0/s1 | PDB
MMDB
NCI pathway
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| 4.40 | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University
| Assay Description
The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ... |
J Med Chem 48: 7637-47 (2005)
Article DOI: 10.1021/jm0506625
BindingDB Entry DOI: 10.7270/Q2V40SDN |
More data for this
Ligand-Target Pair | |
Adrenergic receptor alpha-2
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222081
(CHEMBL327654)Show InChI InChI=1S/C15H16N4/c1-11-13(12-4-3-7-16-10-12)5-2-6-14(11)19-15-17-8-9-18-15/h2-7,10H,8-9H2,1H3,(H2,17,18,19) | PDB
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| 5.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Dopamine receptor
(Homo sapiens (Human)) | BDBM50005118
((S)-3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)...)Show InChI InChI=1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1 | PDB
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| 5.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-Spiperone binding to Dopamine receptor D2 in Macaca nemestrina striatal membranes (using L-tartrate salt of authentic rac... |
J Med Chem 33: 2430-7 (1990)
Article DOI: 10.1021/jm00171a017
BindingDB Entry DOI: 10.7270/Q23J3BXF |
More data for this
Ligand-Target Pair | |
Nitric Oxide Synthase, inducible
(Mus musculus (mouse)) | BDBM50055281
(2-Ethyl-isothiourea | CHEMBL321691 | ETHYLISOTHIOU...)Show InChI InChI=1S/C3H8N2S/c1-2-6-3(4)5/h2H2,1H3,(H3,4,5) | PDB
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| PDB
Article
PubMed
| 5.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University
Curated by ChEMBL
| Assay Description
Binding affinity against mouse Inducible nitric oxide synthase (iNOS) |
J Med Chem 39: 5110-8 (1997)
Article DOI: 10.1021/jm960481q
BindingDB Entry DOI: 10.7270/Q29W0DKZ |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Norepinephrine transporter
(RAT) | BDBM35229
(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)Show InChI InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3 | GoogleScholar
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| PubMed
| 5.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 226: 686-700 (1983)
BindingDB Entry DOI: 10.7270/Q2XP73D5 |
More data for this
Ligand-Target Pair | |
Adrenergic receptor alpha-2
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222052
(CHEMBL329548)Show InChI InChI=1S/C14H15N3S/c1-10-11(13-6-3-9-18-13)4-2-5-12(10)17-14-15-7-8-16-14/h2-6,9H,7-8H2,1H3,(H2,15,16,17) | PDB
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| 6.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M2
(RAT) | BDBM50015720
((hyoscine)3-Hydroxy-2-phenyl-propionic acid 9-meth...)Show InChI InChI=1S/C17H21NO4/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10/h2-6,11-16,19H,7-9H2,1H3 | PDB
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| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 226: 686-700 (1983)
BindingDB Entry DOI: 10.7270/Q2XP73D5 |
More data for this
Ligand-Target Pair | |
Dopamine receptor
(Homo sapiens (Human)) | BDBM50005118
((S)-3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)...)Show InChI InChI=1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1 | PDB
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| Article
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| 8.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 in Macaca nemestrina striatal membranes |
J Med Chem 33: 2430-7 (1990)
Article DOI: 10.1021/jm00171a017
BindingDB Entry DOI: 10.7270/Q23J3BXF |
More data for this
Ligand-Target Pair | |
Adrenergic receptor alpha-2
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222056
(CHEMBL94017)Show InChI InChI=1S/C17H19N3O/c1-12-15(13-5-3-6-14(11-13)21-2)7-4-8-16(12)20-17-18-9-10-19-17/h3-8,11H,9-10H2,1-2H3,(H2,18,19,20) | PDB
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Norepinephrine transporter
(RAT) | BDBM82217
(CHEMBL284994 | CP-52003 | SERTRALINE | [4-(3,4-Dic...)Show SMILES CN[C@@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc12 Show InChI InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17+/m0/s1 | GoogleScholar
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| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 226: 686-700 (1983)
BindingDB Entry DOI: 10.7270/Q2XP73D5 |
More data for this
Ligand-Target Pair | |
Adrenergic receptor alpha-2
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222051
(CHEMBL90118)Show InChI InChI=1S/C14H15N3S/c1-10-12(11-5-8-18-9-11)3-2-4-13(10)17-14-15-6-7-16-14/h2-5,8-9H,6-7H2,1H3,(H2,15,16,17) | PDB
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| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Serotonin (5-HT) receptor
(Rattus norvegicus (rat)) | BDBM50130287
((4,5-Dihydro-1H-imidazol-2-yl)-(2-methyl-biphenyl-...)Show InChI InChI=1S/C16H17N3/c1-12-14(13-6-3-2-4-7-13)8-5-9-15(12)19-16-17-10-11-18-16/h2-9H,10-11H2,1H3,(H2,17,18,19) | Reactome pathway
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| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Serotonin (5-HT) receptor
(Rattus norvegicus (rat)) | BDBM50222052
(CHEMBL329548)Show InChI InChI=1S/C14H15N3S/c1-10-11(13-6-3-9-18-13)4-2-5-12(10)17-14-15-7-8-16-14/h2-6,9H,7-8H2,1H3,(H2,15,16,17) | Reactome pathway
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PC sid
UniChem
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| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Dopamine receptor
(Homo sapiens (Human)) | BDBM50228777
(CHEMBL80127)Show InChI InChI=1S/C16H22Cl2N2O3/c1-3-6-20-7-4-5-10(20)9-19-16(22)13-14(21)11(17)8-12(18)15(13)23-2/h8,10,21H,3-7,9H2,1-2H3,(H,19,22)/t10-/m0/s1 | PDB
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PC sid
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| Article
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 in Macaca nemestrina striatal membranes |
J Med Chem 33: 2430-7 (1990)
Article DOI: 10.1021/jm00171a017
BindingDB Entry DOI: 10.7270/Q23J3BXF |
More data for this
Ligand-Target Pair | |
Adrenergic receptor alpha-2
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222053
(CHEMBL90752)Show InChI InChI=1S/C17H19N3/c1-12-5-3-6-14(11-12)15-7-4-8-16(13(15)2)20-17-18-9-10-19-17/h3-8,11H,9-10H2,1-2H3,(H2,18,19,20) | PDB
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| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Norepinephrine transporter
(RAT) | BDBM82219
(CAS_52760-47-1 | CHEMBL38120 | CP-24441 | Tametral...)Show InChI InChI=1S/C17H19N/c1-18-17-12-11-14(13-7-3-2-4-8-13)15-9-5-6-10-16(15)17/h2-10,14,17-18H,11-12H2,1H3/t14-,17+/m0/s1 | GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 226: 686-700 (1983)
BindingDB Entry DOI: 10.7270/Q2XP73D5 |
More data for this
Ligand-Target Pair | |
Adrenergic receptor alpha-2
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50130287
((4,5-Dihydro-1H-imidazol-2-yl)-(2-methyl-biphenyl-...)Show InChI InChI=1S/C16H17N3/c1-12-14(13-6-3-2-4-7-13)8-5-9-15(12)19-16-17-10-11-18-16/h2-9H,10-11H2,1H3,(H2,17,18,19) | PDB
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| Article
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| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M2
(RAT) | BDBM86231
(ATR | ATROPINE | Atropine,(-) | CAS_51-55-8 | CHEM...)Show InChI InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3 | PDB
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| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 226: 686-700 (1983)
BindingDB Entry DOI: 10.7270/Q2XP73D5 |
More data for this
Ligand-Target Pair | |
Serotonin (5-HT) receptor
(Rattus norvegicus (rat)) | BDBM50222053
(CHEMBL90752)Show InChI InChI=1S/C17H19N3/c1-12-5-3-6-14(11-12)15-7-4-8-16(13(15)2)20-17-18-9-10-19-17/h3-8,11H,9-10H2,1-2H3,(H2,18,19,20) | Reactome pathway
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| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Adrenergic receptor alpha-2
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222082
(CHEMBL544315)Show InChI InChI=1S/C17H16N4/c1-12-15(14-5-2-4-13(10-14)11-18)6-3-7-16(12)21-17-19-8-9-20-17/h2-7,10H,8-9H2,1H3,(H2,19,20,21) | PDB
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| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Adrenergic receptor alpha-2
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222055
(CHEMBL327906)Show InChI InChI=1S/C16H16ClN3/c1-11-14(12-4-2-5-13(17)10-12)6-3-7-15(11)20-16-18-8-9-19-16/h2-7,10H,8-9H2,1H3,(H2,18,19,20) | PDB
Reactome pathway
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| Article
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| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M2
(RAT) | BDBM86698
(BENZTROPINE | CAS_132-17-2 | CHEMBL116590 | NSC_23...)Show InChI InChI=1S/C21H25NO/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-21H,12-15H2,1H3 | PDB
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Pfizer Inc
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 226: 686-700 (1983)
BindingDB Entry DOI: 10.7270/Q2XP73D5 |
More data for this
Ligand-Target Pair | |
GRIA3
(RAT) | BDBM50096327
((R)-3-(2-Chloro-phenyl)-2-[(E)-2-(6-diethylaminome...)Show SMILES CCN(CC)Cc1cccc(\C=C\c2nc3ccc(F)cc3c(=O)n2-c2ccccc2Cl)n1 Show InChI InChI=1S/C26H24ClFN4O/c1-3-31(4-2)17-20-9-7-8-19(29-20)13-15-25-30-23-14-12-18(28)16-21(23)26(33)32(25)24-11-6-5-10-22(24)27/h5-16H,3-4,17H2,1-2H3/b15-13+ | PDB
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| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by PDSP Ki Database
| |
Mol Pharmacol 58: 1310-7 (2000)
Article DOI: 10.1124/mol.58.6.1310
BindingDB Entry DOI: 10.7270/Q24X56B1 |
More data for this
Ligand-Target Pair | |
Norepinephrine transporter
(RAT) | BDBM112777
(NORTRIPTYLINE | US8629135, SW-02)Show InChI InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3 | GoogleScholar
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| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 226: 686-700 (1983)
BindingDB Entry DOI: 10.7270/Q2XP73D5 |
More data for this
Ligand-Target Pair | |
Adrenergic receptor alpha-2
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222083
(CHEMBL90538)Show InChI InChI=1S/C16H16FN3/c1-11-14(12-4-2-5-13(17)10-12)6-3-7-15(11)20-16-18-8-9-19-16/h2-7,10H,8-9H2,1H3,(H2,18,19,20) | PDB
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| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Serotonin (5-HT) receptor
(Rattus norvegicus (rat)) | BDBM50222055
(CHEMBL327906)Show InChI InChI=1S/C16H16ClN3/c1-11-14(12-4-2-5-13(17)10-12)6-3-7-15(11)20-16-18-8-9-19-16/h2-7,10H,8-9H2,1H3,(H2,18,19,20) | Reactome pathway
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| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Adrenergic receptor alpha-2
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222047
(CHEMBL316283)Show InChI InChI=1S/C17H19N3O/c1-12-15(13-6-8-14(21-2)9-7-13)4-3-5-16(12)20-17-18-10-11-19-17/h3-9H,10-11H2,1-2H3,(H2,18,19,20) | PDB
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| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Serotonin (5-HT) receptor
(Rattus norvegicus (rat)) | BDBM50222083
(CHEMBL90538)Show InChI InChI=1S/C16H16FN3/c1-11-14(12-4-2-5-13(17)10-12)6-3-7-15(11)20-16-18-8-9-19-16/h2-7,10H,8-9H2,1H3,(H2,18,19,20) | Reactome pathway
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| 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Serotonin (5-HT) receptor
(Rattus norvegicus (rat)) | BDBM50222047
(CHEMBL316283)Show InChI InChI=1S/C17H19N3O/c1-12-15(13-6-8-14(21-2)9-7-13)4-3-5-16(12)20-17-18-10-11-19-17/h3-9H,10-11H2,1-2H3,(H2,18,19,20) | Reactome pathway
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| 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Adrenergic receptor alpha-2
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222048
(CHEMBL540821)Show InChI InChI=1S/C18H19N3O/c1-12-16(15-6-3-5-14(11-15)13(2)22)7-4-8-17(12)21-18-19-9-10-20-18/h3-8,11H,9-10H2,1-2H3,(H2,19,20,21) | PDB
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| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Serotonin (5-HT) receptor
(Rattus norvegicus (rat)) | BDBM50222051
(CHEMBL90118)Show InChI InChI=1S/C14H15N3S/c1-10-12(11-5-8-18-9-11)3-2-4-13(10)17-14-15-6-7-16-14/h2-5,8-9H,6-7H2,1H3,(H2,15,16,17) | Reactome pathway
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| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM82217
(CHEMBL284994 | CP-52003 | SERTRALINE | [4-(3,4-Dic...)Show SMILES CN[C@@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc12 Show InChI InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17+/m0/s1 | PDB
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| 33 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 226: 686-700 (1983)
BindingDB Entry DOI: 10.7270/Q2XP73D5 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM82217
(CHEMBL284994 | CP-52003 | SERTRALINE | [4-(3,4-Dic...)Show SMILES CN[C@@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc12 Show InChI InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17+/m0/s1 | Reactome pathway
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| 33 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 226: 686-700 (1983)
BindingDB Entry DOI: 10.7270/Q2XP73D5 |
More data for this
Ligand-Target Pair | |
Serotonin (5-HT) receptor
(Rattus norvegicus (rat)) | BDBM50222056
(CHEMBL94017)Show InChI InChI=1S/C17H19N3O/c1-12-15(13-5-3-6-14(11-13)21-2)7-4-8-16(12)20-17-18-9-10-19-17/h3-8,11H,9-10H2,1-2H3,(H2,18,19,20) | Reactome pathway
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| 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Dopamine receptor
(Homo sapiens (Human)) | BDBM50228772
(CHEMBL418922)Show SMILES CCCCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(Cl)c1OC Show InChI InChI=1S/C17H24Cl2N2O3/c1-3-4-7-21-8-5-6-11(21)10-20-17(23)14-15(22)12(18)9-13(19)16(14)24-2/h9,11,22H,3-8,10H2,1-2H3,(H,20,23)/t11-/m0/s1 | PDB
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| 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 in Macaca nemestrina striatal membranes |
J Med Chem 33: 2430-7 (1990)
Article DOI: 10.1021/jm00171a017
BindingDB Entry DOI: 10.7270/Q23J3BXF |
More data for this
Ligand-Target Pair | |
Serotonin (5-HT) receptor
(Rattus norvegicus (rat)) | BDBM50222050
(CHEMBL92856)Show InChI InChI=1S/C18H21N3O2/c1-12-14(15-8-7-13(22-2)11-17(15)23-3)5-4-6-16(12)21-18-19-9-10-20-18/h4-8,11H,9-10H2,1-3H3,(H2,19,20,21) | Reactome pathway
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| 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50222056
(CHEMBL94017)Show InChI InChI=1S/C17H19N3O/c1-12-15(13-5-3-6-14(11-13)21-2)7-4-8-16(12)20-17-18-9-10-19-17/h3-8,11H,9-10H2,1-2H3,(H2,18,19,20) | Reactome pathway
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| 44 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Affinity for Alpha-1 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Serotonin (5-HT) receptor
(Rattus norvegicus (rat)) | BDBM50222049
(CHEMBL90150)Show InChI InChI=1S/C17H16F3N3/c1-11-14(12-4-2-5-13(10-12)17(18,19)20)6-3-7-15(11)23-16-21-8-9-22-16/h2-7,10H,8-9H2,1H3,(H2,21,22,23) | Reactome pathway
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| 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Norepinephrine transporter
(RAT) | BDBM82216
(CP-52002)Show InChI InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17+/m1/s1 | GoogleScholar
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| 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 226: 686-700 (1983)
BindingDB Entry DOI: 10.7270/Q2XP73D5 |
More data for this
Ligand-Target Pair | |
GRIA3
(RAT) | BDBM85710
(CP-471236)Show SMILES CC1NC(CS1)\C=C\c1nc2ccccc2c(=O)n1-c1cccnc1C Show InChI InChI=1S/C20H20N4OS/c1-13-18(8-5-11-21-13)24-19(10-9-15-12-26-14(2)22-15)23-17-7-4-3-6-16(17)20(24)25/h3-11,14-15,22H,12H2,1-2H3/b10-9+ | PDB
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| 57 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by PDSP Ki Database
| |
Mol Pharmacol 58: 1310-7 (2000)
Article DOI: 10.1124/mol.58.6.1310
BindingDB Entry DOI: 10.7270/Q24X56B1 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM82217
(CHEMBL284994 | CP-52003 | SERTRALINE | [4-(3,4-Dic...)Show SMILES CN[C@@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc12 Show InChI InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17+/m0/s1 | PDB
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| 58 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 226: 686-700 (1983)
BindingDB Entry DOI: 10.7270/Q2XP73D5 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM82217
(CHEMBL284994 | CP-52003 | SERTRALINE | [4-(3,4-Dic...)Show SMILES CN[C@@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc12 Show InChI InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17+/m0/s1 | PDB
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| 58 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 226: 686-700 (1983)
BindingDB Entry DOI: 10.7270/Q2XP73D5 |
More data for this
Ligand-Target Pair | |
Norepinephrine transporter
(RAT) | BDBM50010859
(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)Show InChI InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 | GoogleScholar
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| 66 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 226: 686-700 (1983)
BindingDB Entry DOI: 10.7270/Q2XP73D5 |
More data for this
Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50222051
(CHEMBL90118)Show InChI InChI=1S/C14H15N3S/c1-10-12(11-5-8-18-9-11)3-2-4-13(10)17-14-15-6-7-16-14/h2-5,8-9H,6-7H2,1H3,(H2,15,16,17) | Reactome pathway
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| 69 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Affinity for Alpha-1 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Adrenergic receptor alpha-2
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222050
(CHEMBL92856)Show InChI InChI=1S/C18H21N3O2/c1-12-14(15-8-7-13(22-2)11-17(15)23-3)5-4-6-16(12)21-18-19-9-10-20-18/h4-8,11H,9-10H2,1-3H3,(H2,19,20,21) | PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 74 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Adrenergic receptor alpha-2
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222049
(CHEMBL90150)Show InChI InChI=1S/C17H16F3N3/c1-11-14(12-4-2-5-13(10-12)17(18,19)20)6-3-7-15(11)23-16-21-8-9-22-16/h2-7,10H,8-9H2,1H3,(H2,21,22,23) | PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 79 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50222048
(CHEMBL540821)Show InChI InChI=1S/C18H19N3O/c1-12-16(15-6-3-5-14(11-15)13(2)22)7-4-8-17(12)21-18-19-9-10-20-18/h3-8,11H,9-10H2,1-2H3,(H2,19,20,21) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 89 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description
Affinity for Alpha-1 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
Article DOI: 10.1016/s0960-894x(02)00925-3
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Dopamine receptor
(Homo sapiens (Human)) | BDBM50228774
(CHEMBL80126)Show SMILES COc1c(Cl)cc(Cl)c(O)c1C(=O)NC[C@@H]1CCCN1CCCCF Show InChI InChI=1S/C17H23Cl2FN2O3/c1-25-16-13(19)9-12(18)15(23)14(16)17(24)21-10-11-5-4-8-22(11)7-3-2-6-20/h9,11,23H,2-8,10H2,1H3,(H,21,24)/t11-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 89 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 in Macaca nemestrina striatal membranes |
J Med Chem 33: 2430-7 (1990)
Article DOI: 10.1021/jm00171a017
BindingDB Entry DOI: 10.7270/Q23J3BXF |
More data for this
Ligand-Target Pair | |
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