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Compile Data Set for Download or QSAR

Found 504 hits with Last Name = 'whitten' and Initial = 'jp'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054245
PNG
(5-Chloro-N-cyclopropylmethyl-2-methyl-N-propyl-N''...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1Cl
Show InChI InChI=1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)
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1.70n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054252
PNG
(5-Bromo-N-cyclopropylmethyl-2-methyl-N-propyl-N'-(...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1Br
Show InChI InChI=1S/C18H20BrCl3N4/c1-3-6-26(9-11-4-5-11)18-15(19)17(23-10(2)24-18)25-16-13(21)7-12(20)8-14(16)22/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)
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2n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054250
PNG
(CHEMBL306482 | N-Cyclopropylmethyl-2,5-dimethyl-N-...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1C
Show InChI InChI=1S/C19H23Cl3N4/c1-4-7-26(10-13-5-6-13)19-11(2)18(23-12(3)24-19)25-17-15(21)8-14(20)9-16(17)22/h8-9,13H,4-7,10H2,1-3H3,(H,23,24,25)
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2.30n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054248
PNG
(2,5-Dimethyl-N,N-dipropyl-N'-(2,4,6-trichloro-phen...)
Show SMILES CCCN(CCC)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1C
Show InChI InChI=1S/C18H23Cl3N4/c1-5-7-25(8-6-2)18-11(3)17(22-12(4)23-18)24-16-14(20)9-13(19)10-15(16)21/h9-10H,5-8H2,1-4H3,(H,22,23,24)
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2.5n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054253
PNG
(CHEMBL77716 | N-Cyclopropylmethyl-5-ethyl-2-methyl...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1CC
Show InChI InChI=1S/C20H25Cl3N4/c1-4-8-27(11-13-6-7-13)20-15(5-2)19(24-12(3)25-20)26-18-16(22)9-14(21)10-17(18)23/h9-10,13H,4-8,11H2,1-3H3,(H,24,25,26)
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3.80n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50144204
PNG
(CHEMBL63989 | [4-(2-Chloro-4,6-dimethoxy-phenyl)-p...)
Show SMILES CCCN(C(C1CC1)C1CC1)c1nccc(n1)-c1c(Cl)cc(OC)cc1OC
Show InChI InChI=1S/C22H28ClN3O2/c1-4-11-26(21(14-5-6-14)15-7-8-15)22-24-10-9-18(25-22)20-17(23)12-16(27-2)13-19(20)28-3/h9-10,12-15,21H,4-8,11H2,1-3H3
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11n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc

Curated by ChEMBL


Assay Description
Binding affinity towards human Corticotropin releasing factor receptor 1 by the displacement of [125I]-CRF from CHO cells


Bioorg Med Chem Lett 14: 2083-6 (2004)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50144193
PNG
(CHEMBL65484 | Dicyclopropylmethyl-propyl-[4-(2,4,6...)
Show SMILES CCCN(C(C1CC1)C1CC1)c1nccc(n1)-c1c(OC)cc(OC)cc1OC
Show InChI InChI=1S/C23H31N3O3/c1-5-12-26(22(15-6-7-15)16-8-9-16)23-24-11-10-18(25-23)21-19(28-3)13-17(27-2)14-20(21)29-4/h10-11,13-16,22H,5-9,12H2,1-4H3
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15n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc

Curated by ChEMBL


Assay Description
Binding affinity towards human Corticotropin releasing factor receptor 1 by the displacement of [125I]-CRF from CHO cells


Bioorg Med Chem Lett 14: 2083-6 (2004)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50144191
PNG
(CHEMBL61954 | Dicyclopropylmethyl-[4-(2,4-dimethox...)
Show SMILES CCCN(C(C1CC1)C1CC1)c1ncc(C)c(n1)-c1c(C)cc(OC)cc1OC
Show InChI InChI=1S/C24H33N3O2/c1-6-11-27(23(17-7-8-17)18-9-10-18)24-25-14-16(3)22(26-24)21-15(2)12-19(28-4)13-20(21)29-5/h12-14,17-18,23H,6-11H2,1-5H3
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15n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc

Curated by ChEMBL


Assay Description
Binding affinity towards human Corticotropin releasing factor receptor 1 by the displacement of [125I]-CRF from CHO cells


Bioorg Med Chem Lett 14: 2083-6 (2004)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50144194
PNG
(CHEMBL293627 | Dicyclopropylmethyl-[4-(2,4-dimetho...)
Show SMILES CCCN(C(C1CC1)C1CC1)c1ncc(C)c(n1)-c1ccc(OC)cc1OC
Show InChI InChI=1S/C23H31N3O2/c1-5-12-26(22(16-6-7-16)17-8-9-17)23-24-14-15(2)21(25-23)19-11-10-18(27-3)13-20(19)28-4/h10-11,13-14,16-17,22H,5-9,12H2,1-4H3
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19n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc

Curated by ChEMBL


Assay Description
Binding affinity towards human Corticotropin releasing factor receptor 1 by the displacement of [125I]-CRF from CHO cells


Bioorg Med Chem Lett 14: 2083-6 (2004)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054246
PNG
(CHEMBL77006 | N-Cyclopropylmethyl-2-methyl-N-propy...)
Show SMILES CCCN(CC1CC1)c1cc(Nc2c(Cl)cc(Cl)cc2Cl)nc(C)n1
Show InChI InChI=1S/C18H21Cl3N4/c1-3-6-25(10-12-4-5-12)17-9-16(22-11(2)23-17)24-18-14(20)7-13(19)8-15(18)21/h7-9,12H,3-6,10H2,1-2H3,(H,22,23,24)
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30n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50144196
PNG
(CHEMBL63029 | [4-(4-Bromo-phenyl)-5-methyl-pyrimid...)
Show SMILES CCCN(C(C1CC1)C1CC1)c1ncc(C)c(n1)-c1ccc(Br)cc1
Show InChI InChI=1S/C21H26BrN3/c1-3-12-25(20(16-4-5-16)17-6-7-17)21-23-13-14(2)19(24-21)15-8-10-18(22)11-9-15/h8-11,13,16-17,20H,3-7,12H2,1-2H3
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49n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc

Curated by ChEMBL


Assay Description
Binding affinity towards human Corticotropin releasing factor receptor 1 by the displacement of [125I]-CRF from CHO cells


Bioorg Med Chem Lett 14: 2083-6 (2004)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054225
PNG
(CHEMBL306618 | N-Cyclopropylmethyl-6-methyl-N-prop...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1
Show InChI InChI=1S/C20H29N5/c1-6-9-25(12-17-7-8-17)20-22-16(5)21-19(24-20)23-18-14(3)10-13(2)11-15(18)4/h10-11,17H,6-9,12H2,1-5H3,(H,21,22,23,24)
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57n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054225
PNG
(CHEMBL306618 | N-Cyclopropylmethyl-6-methyl-N-prop...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1
Show InChI InChI=1S/C20H29N5/c1-6-9-25(12-17-7-8-17)20-22-16(5)21-19(24-20)23-18-14(3)10-13(2)11-15(18)4/h10-11,17H,6-9,12H2,1-5H3,(H,21,22,23,24)
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57n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human corticotropin releasing factor receptor 1


J Med Chem 39: 4354-7 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50144197
PNG
(CHEMBL66249 | [4-(4-Bromo-2-methyl-phenyl)-5-methy...)
Show SMILES CCCN(C(C1CC1)C1CC1)c1ncc(C)c(n1)-c1ccc(Br)cc1C
Show InChI InChI=1S/C22H28BrN3/c1-4-11-26(21(16-5-6-16)17-7-8-17)22-24-13-15(3)20(25-22)19-10-9-18(23)12-14(19)2/h9-10,12-13,16-17,21H,4-8,11H2,1-3H3
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63n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc

Curated by ChEMBL


Assay Description
Binding affinity towards human Corticotropin releasing factor receptor 1 by the displacement of [125I]-CRF from CHO cells


Bioorg Med Chem Lett 14: 2083-6 (2004)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50144200
PNG
(CHEMBL63457 | Dicyclopropylmethyl-[4-(2-fluoro-4,6...)
Show SMILES CCCN(C(C1CC1)C1CC1)c1nccc(n1)-c1c(F)cc(OC)cc1OC
Show InChI InChI=1S/C22H28FN3O2/c1-4-11-26(21(14-5-6-14)15-7-8-15)22-24-10-9-18(25-22)20-17(23)12-16(27-2)13-19(20)28-3/h9-10,12-15,21H,4-8,11H2,1-3H3
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63n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc

Curated by ChEMBL


Assay Description
Binding affinity towards human Corticotropin releasing factor receptor 1 by the displacement of [125I]-CRF from CHO cells


Bioorg Med Chem Lett 14: 2083-6 (2004)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054249
PNG
(CHEMBL140175 | N*4*-Cyclopropylmethyl-6-methyl-N*4...)
Show SMILES CCCN(CC1CC1)c1cc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)n1
Show InChI InChI=1S/C18H21Cl3N4/c1-3-6-25(10-12-4-5-12)16-7-11(2)22-18(23-16)24-17-14(20)8-13(19)9-15(17)21/h7-9,12H,3-6,10H2,1-2H3,(H,22,23,24)
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70n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50144203
PNG
(Allyl-dicyclopropylmethyl-[4-(2,4,6-trimethoxy-phe...)
Show SMILES COc1cc(OC)c(c(OC)c1)-c1ccnc(n1)N(CC=C)C(C1CC1)C1CC1
Show InChI InChI=1S/C23H29N3O3/c1-5-12-26(22(15-6-7-15)16-8-9-16)23-24-11-10-18(25-23)21-19(28-3)13-17(27-2)14-20(21)29-4/h5,10-11,13-16,22H,1,6-9,12H2,2-4H3
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100n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc

Curated by ChEMBL


Assay Description
Binding affinity towards human Corticotropin releasing factor receptor 1 by the displacement of [125I]-CRF from CHO cells


Bioorg Med Chem Lett 14: 2083-6 (2004)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054226
PNG
(CHEMBL77391 | N,N-Diallyl-6-methyl-N'-(2,4,6-trime...)
Show SMILES Cc1cc(C)c(Nc2nc(C)nc(n2)N(CC=C)CC=C)c(C)c1
Show InChI InChI=1S/C19H25N5/c1-7-9-24(10-8-2)19-21-16(6)20-18(23-19)22-17-14(4)11-13(3)12-15(17)5/h7-8,11-12H,1-2,9-10H2,3-6H3,(H,20,21,22,23)
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115n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human corticotropin releasing factor receptor 1


J Med Chem 39: 4354-7 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054230
PNG
(6-Methyl-N,N-dipropyl-N'-(2,4,6-trimethyl-phenyl)-...)
Show SMILES CCCN(CCC)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1
Show InChI InChI=1S/C19H29N5/c1-7-9-24(10-8-2)19-21-16(6)20-18(23-19)22-17-14(4)11-13(3)12-15(17)5/h11-12H,7-10H2,1-6H3,(H,20,21,22,23)
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130n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human corticotropin releasing factor receptor 1


J Med Chem 39: 4354-7 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054247
PNG
(CHEMBL344805 | N-Cyclopropylmethyl-2,5,N'-trimethy...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(N(C)c2c(Cl)cc(Cl)cc2Cl)c1C
Show InChI InChI=1S/C20H25Cl3N4/c1-5-8-27(11-14-6-7-14)20-12(2)19(24-13(3)25-20)26(4)18-16(22)9-15(21)10-17(18)23/h9-10,14H,5-8,11H2,1-4H3
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150n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50144192
PNG
(CHEMBL291657 | [4-(4-Bromo-phenyl)-5,6-dimethyl-py...)
Show SMILES COc1cc(Cl)c(cc1C)-c1nc(sc1C)N(CC#C)[C@@H](CC1CC1)c1ccc(C)c(F)c1
Show InChI InChI=1S/C27H28ClFN2OS/c1-6-11-31(24(13-19-8-9-19)20-10-7-16(2)23(29)14-20)27-30-26(18(4)33-27)21-12-17(3)25(32-5)15-22(21)28/h1,7,10,12,14-15,19,24H,8-9,11,13H2,2-5H3/t24-/m0/s1
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240n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc

Curated by ChEMBL


Assay Description
Binding affinity towards human Corticotropin releasing factor receptor 1 by the displacement of [125I]-CRF from CHO cells


Bioorg Med Chem Lett 14: 2083-6 (2004)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50144202
PNG
(((R)-Cyclopropyl-phenyl-methyl)-propyl-[4-(2,4,6-t...)
Show SMILES CCCN([C@H](C1CC1)c1ccccc1)c1nccc(n1)-c1c(OC)cc(OC)cc1OC
Show InChI InChI=1S/C26H31N3O3/c1-5-15-29(25(19-11-12-19)18-9-7-6-8-10-18)26-27-14-13-21(28-26)24-22(31-3)16-20(30-2)17-23(24)32-4/h6-10,13-14,16-17,19,25H,5,11-12,15H2,1-4H3/t25-/m0/s1
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240n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc

Curated by ChEMBL


Assay Description
Binding affinity towards human Corticotropin releasing factor receptor 1 by the displacement of [125I]-CRF from CHO cells


Bioorg Med Chem Lett 14: 2083-6 (2004)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50144190
PNG
(CHEMBL302396 | Propyl-(1-thiophen-2-yl-cyclopropyl...)
Show SMILES CCCN(c1nccc(n1)-c1c(OC)cc(OC)cc1OC)C1(CC1)c1cccs1
Show InChI InChI=1S/C23H27N3O3S/c1-5-12-26(23(9-10-23)20-7-6-13-30-20)22-24-11-8-17(25-22)21-18(28-3)14-16(27-2)15-19(21)29-4/h6-8,11,13-15H,5,9-10,12H2,1-4H3
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250n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc

Curated by ChEMBL


Assay Description
Binding affinity towards human Corticotropin releasing factor receptor 1 by the displacement of [125I]-CRF from CHO cells


Bioorg Med Chem Lett 14: 2083-6 (2004)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054244
PNG
(CHEMBL134475 | N-Cyclopropylmethyl-2-methyl-N-prop...)
Show SMILES CCCN(CC1CC1)c1cc(Nc2cc(Cl)c(Cl)cc2Cl)nc(C)n1
Show InChI InChI=1S/C18H21Cl3N4/c1-3-6-25(10-12-4-5-12)18-9-17(22-11(2)23-18)24-16-8-14(20)13(19)7-15(16)21/h7-9,12H,3-6,10H2,1-2H3,(H,22,23,24)
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253n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50144201
PNG
(CHEMBL305354 | Dicyclopropylmethyl-[4-(2,4-dimetho...)
Show SMILES CCCN(C(C1CC1)C1CC1)c1nccc(n1)-c1ccc(OC)cc1OC
Show InChI InChI=1S/C22H29N3O2/c1-4-13-25(21(15-5-6-15)16-7-8-16)22-23-12-11-19(24-22)18-10-9-17(26-2)14-20(18)27-3/h9-12,14-16,21H,4-8,13H2,1-3H3
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460n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc

Curated by ChEMBL


Assay Description
Binding affinity towards human Corticotropin releasing factor receptor 1 by the displacement of [125I]-CRF from CHO cells


Bioorg Med Chem Lett 14: 2083-6 (2004)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054221
PNG
(CHEMBL419636 | N,N-Dibutyl-6-methyl-N'-(2,4,6-trim...)
Show SMILES CCCCN(CCCC)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1
Show InChI InChI=1S/C21H33N5/c1-7-9-11-26(12-10-8-2)21-23-18(6)22-20(25-21)24-19-16(4)13-15(3)14-17(19)5/h13-14H,7-12H2,1-6H3,(H,22,23,24,25)
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490n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human corticotropin releasing factor receptor 1


J Med Chem 39: 4354-7 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054216
PNG
(CHEMBL307419 | N-Benzyl-6-methyl-N-propyl-N'-(2,4,...)
Show SMILES CCCN(Cc1ccccc1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1
Show InChI InChI=1S/C23H29N5/c1-6-12-28(15-20-10-8-7-9-11-20)23-25-19(5)24-22(27-23)26-21-17(3)13-16(2)14-18(21)4/h7-11,13-14H,6,12,15H2,1-5H3,(H,24,25,26,27)
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490n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human corticotropin releasing factor receptor 1


J Med Chem 39: 4354-7 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50144199
PNG
((1-Furan-3-yl-cyclopropyl)-propyl-[4-(2,4,6-trimet...)
Show SMILES CCCN(c1nccc(n1)-c1c(OC)cc(OC)cc1OC)C1(CC1)c1ccoc1
Show InChI InChI=1S/C23H27N3O4/c1-5-11-26(23(8-9-23)16-7-12-30-15-16)22-24-10-6-18(25-22)21-19(28-3)13-17(27-2)14-20(21)29-4/h6-7,10,12-15H,5,8-9,11H2,1-4H3
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700n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc

Curated by ChEMBL


Assay Description
Binding affinity towards human Corticotropin releasing factor receptor 1 by the displacement of [125I]-CRF from CHO cells


Bioorg Med Chem Lett 14: 2083-6 (2004)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50144195
PNG
(CHEMBL63585 | Dicyclopropylmethyl-[4-(2,4-dimethox...)
Show SMILES CCCN(C(C1CC1)C1CC1)c1ncc(CC)c(n1)-c1ccc(OC)cc1OC
Show InChI InChI=1S/C24H33N3O2/c1-5-13-27(23(17-7-8-17)18-9-10-18)24-25-15-16(6-2)22(26-24)20-12-11-19(28-3)14-21(20)29-4/h11-12,14-15,17-18,23H,5-10,13H2,1-4H3
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860n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc

Curated by ChEMBL


Assay Description
Binding affinity towards human Corticotropin releasing factor receptor 1 by the displacement of [125I]-CRF from CHO cells


Bioorg Med Chem Lett 14: 2083-6 (2004)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054219
PNG
(CHEMBL305671 | N-Benzyl-N-butyl-6-methyl-N'-(2,4,6...)
Show SMILES CCCCN(Cc1ccccc1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1
Show InChI InChI=1S/C24H31N5/c1-6-7-13-29(16-21-11-9-8-10-12-21)24-26-20(5)25-23(28-24)27-22-18(3)14-17(2)15-19(22)4/h8-12,14-15H,6-7,13,16H2,1-5H3,(H,25,26,27,28)
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1.05E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human corticotropin releasing factor receptor 1


J Med Chem 39: 4354-7 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054239
PNG
(CHEMBL78035 | [4-(3,6-Dihydro-2H-pyridin-1-yl)-6-m...)
Show SMILES Cc1cc(C)c(Nc2nc(C)nc(n2)N2CCC=CC2)c(C)c1
Show InChI InChI=1S/C18H23N5/c1-12-10-13(2)16(14(3)11-12)21-17-19-15(4)20-18(22-17)23-8-6-5-7-9-23/h5-6,10-11H,7-9H2,1-4H3,(H,19,20,21,22)
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1.05E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human corticotropin releasing factor receptor 1


J Med Chem 39: 4354-7 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054255
PNG
(CHEMBL80806 | N-Cyclopropylmethyl-2-methyl-N-propy...)
Show SMILES CCCN(CC1CC1)c1cc(Nc2c(C)cc(C)cc2C)nc(C)n1
Show InChI InChI=1S/C21H30N4/c1-6-9-25(13-18-7-8-18)20-12-19(22-17(5)23-20)24-21-15(3)10-14(2)11-16(21)4/h10-12,18H,6-9,13H2,1-5H3,(H,22,23,24)
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1.39E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054223
PNG
(CHEMBL307871 | N-Benzyl-N-ethyl-6-methyl-N'-(2,4,6...)
Show SMILES CCN(Cc1ccccc1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1
Show InChI InChI=1S/C22H27N5/c1-6-27(14-19-10-8-7-9-11-19)22-24-18(5)23-21(26-22)25-20-16(3)12-15(2)13-17(20)4/h7-13H,6,14H2,1-5H3,(H,23,24,25,26)
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1.47E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human corticotropin releasing factor receptor 1


J Med Chem 39: 4354-7 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054241
PNG
(6-Methyl-N-(4-trifluoromethyl-benzyl)-N'-(2,4,6-tr...)
Show SMILES Cc1cc(C)c(Nc2nc(C)nc(NCc3ccc(cc3)C(F)(F)F)n2)c(C)c1
Show InChI InChI=1S/C21H22F3N5/c1-12-9-13(2)18(14(3)10-12)28-20-27-15(4)26-19(29-20)25-11-16-5-7-17(8-6-16)21(22,23)24/h5-10H,11H2,1-4H3,(H2,25,26,27,28,29)
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1.69E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human corticotropin releasing factor receptor 1


J Med Chem 39: 4354-7 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054238
PNG
(CHEMBL137434 | N-Benzyl-N'-(2,6-diethyl-phenyl)-N-...)
Show SMILES CCN(Cc1ccccc1)c1nc(C)nc(Nc2c(CC)cccc2CC)n1
Show InChI InChI=1S/C23H29N5/c1-5-19-14-11-15-20(6-2)21(19)26-22-24-17(4)25-23(27-22)28(7-3)16-18-12-9-8-10-13-18/h8-15H,5-7,16H2,1-4H3,(H,24,25,26,27)
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1.70E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human corticotropin releasing factor receptor 1


J Med Chem 39: 4354-7 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50144198
PNG
(CHEMBL305583 | Propyl-(1-thiophen-3-yl-cyclopropyl...)
Show SMILES CCCN(c1nccc(n1)-c1c(OC)cc(OC)cc1OC)C1(CC1)c1ccsc1
Show InChI InChI=1S/C23H27N3O3S/c1-5-11-26(23(8-9-23)16-7-12-30-15-16)22-24-10-6-18(25-22)21-19(28-3)13-17(27-2)14-20(21)29-4/h6-7,10,12-15H,5,8-9,11H2,1-4H3
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2.00E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc

Curated by ChEMBL


Assay Description
Binding affinity towards human Corticotropin releasing factor receptor 1 by the displacement of [125I]-CRF from CHO cells


Bioorg Med Chem Lett 14: 2083-6 (2004)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054234
PNG
(6,N-Dimethyl-N-phenethyl-N'-(2,4,6-trimethyl-pheny...)
Show SMILES CN(CCc1ccccc1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1
Show InChI InChI=1S/C22H27N5/c1-15-13-16(2)20(17(3)14-15)25-21-23-18(4)24-22(26-21)27(5)12-11-19-9-7-6-8-10-19/h6-10,13-14H,11-12H2,1-5H3,(H,23,24,25,26)
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2.10E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human corticotropin releasing factor receptor 1


J Med Chem 39: 4354-7 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50144189
PNG
(CHEMBL65979 | Cyclopentyl-propyl-[4-(2,4,6-trimeth...)
Show SMILES CCCN(C1CCCC1)c1nccc(n1)-c1c(OC)cc(OC)cc1OC
Show InChI InChI=1S/C21H29N3O3/c1-5-12-24(15-8-6-7-9-15)21-22-11-10-17(23-21)20-18(26-3)13-16(25-2)14-19(20)27-4/h10-11,13-15H,5-9,12H2,1-4H3
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2.20E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc

Curated by ChEMBL


Assay Description
Binding affinity towards human Corticotropin releasing factor receptor 1 by the displacement of [125I]-CRF from CHO cells


Bioorg Med Chem Lett 14: 2083-6 (2004)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054222
PNG
(CHEMBL136519 | N,N-Diallyl-N'-(2,6-diethyl-phenyl)...)
Show SMILES CCc1cccc(CC)c1Nc1nc(C)nc(n1)N(CC=C)CC=C
Show InChI InChI=1S/C20H27N5/c1-6-13-25(14-7-2)20-22-15(5)21-19(24-20)23-18-16(8-3)11-10-12-17(18)9-4/h6-7,10-12H,1-2,8-9,13-14H2,3-5H3,(H,21,22,23,24)
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5.70E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human corticotropin releasing factor receptor 1


J Med Chem 39: 4354-7 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054229
PNG
(CHEMBL136828 | N-Cyclopropylmethyl-N'-(2,4-dimetho...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2ccc(OC)cc2OC)n1
Show InChI InChI=1S/C19H27N5O2/c1-5-10-24(12-14-6-7-14)19-21-13(2)20-18(23-19)22-16-9-8-15(25-3)11-17(16)26-4/h8-9,11,14H,5-7,10,12H2,1-4H3,(H,20,21,22,23)
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8.00E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human corticotropin releasing factor receptor 1


J Med Chem 39: 4354-7 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054220
PNG
(CHEMBL135615 | N-Cyclopropylmethyl-6-methyl-N-prop...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2ccc(C)cc2)n1
Show InChI InChI=1S/C18H25N5/c1-4-11-23(12-15-7-8-15)18-20-14(3)19-17(22-18)21-16-9-5-13(2)6-10-16/h5-6,9-10,15H,4,7-8,11-12H2,1-3H3,(H,19,20,21,22)
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>1.00E+4n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human corticotropin releasing factor receptor 1


J Med Chem 39: 4354-7 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054224
PNG
(CHEMBL138124 | N,N-Diallyl-6-methyl-N'-p-tolyl-[1,...)
Show SMILES Cc1ccc(Nc2nc(C)nc(n2)N(CC=C)CC=C)cc1
Show InChI InChI=1S/C17H21N5/c1-5-11-22(12-6-2)17-19-14(4)18-16(21-17)20-15-9-7-13(3)8-10-15/h5-10H,1-2,11-12H2,3-4H3,(H,18,19,20,21)
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>1.00E+4n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human corticotropin releasing factor receptor 1


J Med Chem 39: 4354-7 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054227
PNG
(CHEMBL136596 | N-Benzyl-N'-(2,6-dimethyl-phenyl)-6...)
Show SMILES CCCN(Cc1ccccc1)c1nc(C)nc(Nc2c(C)cccc2C)n1
Show InChI InChI=1S/C22H27N5/c1-5-14-27(15-19-12-7-6-8-13-19)22-24-18(4)23-21(26-22)25-20-16(2)10-9-11-17(20)3/h6-13H,5,14-15H2,1-4H3,(H,23,24,25,26)
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>1.00E+4n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human corticotropin releasing factor receptor 1


J Med Chem 39: 4354-7 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054228
PNG
(CHEMBL138597 | N-(2,6-Dimethyl-phenyl)-6-methyl-N'...)
Show SMILES Cc1nc(NCc2ccc(cc2)C(F)(F)F)nc(Nc2c(C)cccc2C)n1
Show InChI InChI=1S/C20H20F3N5/c1-12-5-4-6-13(2)17(12)27-19-26-14(3)25-18(28-19)24-11-15-7-9-16(10-8-15)20(21,22)23/h4-10H,11H2,1-3H3,(H2,24,25,26,27,28)
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>1.00E+4n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human corticotropin releasing factor receptor 1


J Med Chem 39: 4354-7 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054254
PNG
(CHEMBL136593 | N-Cyclopropylmethyl-N-propyl-N'-(2,...)
Show SMILES CCCN(CC1CC1)c1cc(Nc2c(Cl)cc(Cl)cc2Cl)ncn1
Show InChI InChI=1S/C17H19Cl3N4/c1-2-5-24(9-11-3-4-11)16-8-15(21-10-22-16)23-17-13(19)6-12(18)7-14(17)20/h6-8,10-11H,2-5,9H2,1H3,(H,21,22,23)
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>1.00E+4n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054232
PNG
(CHEMBL137122 | N-Benzyl-N'-(2,6-dimethyl-phenyl)-N...)
Show SMILES CCN(Cc1ccccc1)c1nc(C)nc(Nc2c(C)cccc2C)n1
Show InChI InChI=1S/C21H25N5/c1-5-26(14-18-12-7-6-8-13-18)21-23-17(4)22-20(25-21)24-19-15(2)10-9-11-16(19)3/h6-13H,5,14H2,1-4H3,(H,22,23,24,25)
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>1.00E+4n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human corticotropin releasing factor receptor 1


J Med Chem 39: 4354-7 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054233
PNG
(CHEMBL343704 | N-Cyclopropylmethyl-N'-(2,6-diethyl...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(CC)cccc2CC)n1
Show InChI InChI=1S/C21H31N5/c1-5-13-26(14-16-11-12-16)21-23-15(4)22-20(25-21)24-19-17(6-2)9-8-10-18(19)7-3/h8-10,16H,5-7,11-14H2,1-4H3,(H,22,23,24,25)
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>1.00E+4n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human corticotropin releasing factor receptor 1


J Med Chem 39: 4354-7 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054251
PNG
(CHEMBL138687 | N*2*-Cyclopropylmethyl-6-methyl-N*2...)
Show SMILES CCCN(CC1CC1)c1nc(C)cc(Nc2c(Cl)cc(Cl)cc2Cl)n1
Show InChI InChI=1S/C18H21Cl3N4/c1-3-6-25(10-12-4-5-12)18-22-11(2)7-16(24-18)23-17-14(20)8-13(19)9-15(17)21/h7-9,12H,3-6,10H2,1-2H3,(H,22,23,24)
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>1.00E+4n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054231
PNG
(CHEMBL137291 | N-Benzyl-N'-(2,6-diethyl-phenyl)-6-...)
Show SMILES CCCN(Cc1ccccc1)c1nc(C)nc(Nc2c(CC)cccc2CC)n1
Show InChI InChI=1S/C24H31N5/c1-5-16-29(17-19-12-9-8-10-13-19)24-26-18(4)25-23(28-24)27-22-20(6-2)14-11-15-21(22)7-3/h8-15H,5-7,16-17H2,1-4H3,(H,25,26,27,28)
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>1.00E+4n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human corticotropin releasing factor receptor 1


J Med Chem 39: 4354-7 (1996)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054236
PNG
(6-Methyl-N-p-tolyl-N'-(4-trifluoromethyl-benzyl)-[...)
Show SMILES Cc1ccc(Nc2nc(C)nc(NCc3ccc(cc3)C(F)(F)F)n2)cc1
Show InChI InChI=1S/C19H18F3N5/c1-12-3-9-16(10-4-12)26-18-25-13(2)24-17(27-18)23-11-14-5-7-15(8-6-14)19(20,21)22/h3-10H,11H2,1-2H3,(H2,23,24,25,26,27)
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>1.00E+4n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human corticotropin releasing factor receptor 1


J Med Chem 39: 4354-7 (1996)

More data for this
Ligand-Target Pair
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