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Found 12 of ic50 for drug = Aerolone
TargetBeta-2 adrenergic receptor(Canis familiaris)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM25392(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Affinity DataIC50:  0.100nMAssay Description:Agonistic activity for Beta-2 adrenergic receptor was assessed by it's inhibitory effect on spontaneous contractions in isolated rat uterusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Canis familiaris)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM25392(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Affinity DataIC50:  0.100nMAssay Description:Agonistic activity towards beta-2 adrenoceptor. IC50, the mean concentration required to produce 50% inhibition of uterine contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Rattus norvegicus)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM25392(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of spontaneous contractions in isolated rat uterusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Rattus norvegicus (Rat))
American Cyanamid

Curated by ChEMBL
LigandPNGBDBM25392(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Affinity DataIC50:  5.30nMAssay Description:Compound was evaluated in vitro for beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1/Beta-2/Beta-3 adrenergic receptor(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM25392(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Affinity DataIC50:  100nMAssay Description:Inhibition of H-Ras-mediated farnesylation expressed in mouse NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1/Beta-2/Beta-3 adrenergic receptor(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM25392(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Affinity DataIC50:  325nMAssay Description:The compound was evaluated for the inhibition of [125I]cyanopindolol binding to beta adrenergic receptor in rat reticulocyte membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Rattus norvegicus (Rat))
American Cyanamid

Curated by ChEMBL
LigandPNGBDBM25392(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Affinity DataIC50:  600nMAssay Description:Compound was evaluated for its binding affinity towards beta-1 adrenergic receptor in rat heart membrane by displacing [125I]- iodocyanopindololMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Canis familiaris)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM25392(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Affinity DataIC50:  1.00E+3nMAssay Description:Compound was evaluated for its binding affinity towards beta-2 adrenergic receptor in rat soleus membrane by displacing(-)-isoproterenol (50 microM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25392(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Rap1A-mediated geranylgeranylation expressed in mouse NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM25392(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Affinity DataIC50: >9.86E+5nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM25392(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Rattus norvegicus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM25392(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed