Compile Data Set for Download or QSAR

Found 296 hits of ec50 data for polymerid = 1023,179   

Target (Institution)	Ligand	Target Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249226 (US9458135, 14) Show SMILES CN1C(=O)CCc2cc(ccc12)-c1cncc(CSc2cccc(C)n2)c1 Show InChI InChI=1S/C22H21N3OS/c1-15-4-3-5-21(24-15)27-14-16-10-19(13-23-12-16)17-6-8-20-18(11-17)7-9-22(26)25(20)2/h3-6,8,10-13H,7,9,14H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	0.0120	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249223 (US9458135, 11) Show SMILES CN1C(=O)CCc2cc(ccc12)-c1cncc(COc2cnc(Cl)nc2)c1 Show InChI InChI=1S/C20H17ClN4O2/c1-25-18-4-2-14(7-15(18)3-5-19(25)26)16-6-13(8-22-9-16)12-27-17-10-23-20(21)24-11-17/h2,4,6-11H,3,5,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	0.100	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249221 (US9458135, 9) Show SMILES CN1C(=O)CCc2cc(ccc12)-c1cncc(COc2ccnc(C)n2)c1 Show InChI InChI=1S/C21H20N4O2/c1-14-23-8-7-20(24-14)27-13-15-9-18(12-22-11-15)16-3-5-19-17(10-16)4-6-21(26)25(19)2/h3,5,7-12H,4,6,13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	0.100	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249215 (US9458135, 3) Show SMILES CN1C(=O)CCc2cc(ccc12)-c1cncc(COc2cccc(C)n2)c1 Show InChI InChI=1S/C22H21N3O2/c1-15-4-3-5-21(24-15)27-14-16-10-19(13-23-12-16)17-6-8-20-18(11-17)7-9-22(26)25(20)2/h3-6,8,10-13H,7,9,14H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	0.100	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249232 (US9458135, 20) Show SMILES CN1C(=O)CCc2cc(c(F)cc12)-c1cncc(COc2ccc(Cl)cn2)c1 Show InChI InChI=1S/C21H17ClFN3O2/c1-26-19-8-18(23)17(7-14(19)2-5-21(26)27)15-6-13(9-24-10-15)12-28-20-4-3-16(22)11-25-20/h3-4,6-11H,2,5,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	0.100	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249217 (US9458135, 5) Show SMILES CN1C(=O)CCc2cc(ccc12)-c1cncc(COc2cc(C)ccn2)c1 Show InChI InChI=1S/C22H21N3O2/c1-15-7-8-24-21(9-15)27-14-16-10-19(13-23-12-16)17-3-5-20-18(11-17)4-6-22(26)25(20)2/h3,5,7-13H,4,6,14H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	0.100	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249218 (US9458135, 6) Show SMILES CN1C(=O)CCc2cc(ccc12)-c1cncc(COc2ccc(Cl)cn2)c1 Show InChI InChI=1S/C21H18ClN3O2/c1-25-19-5-2-15(9-16(19)3-7-21(25)26)17-8-14(10-23-11-17)13-27-20-6-4-18(22)12-24-20/h2,4-6,8-12H,3,7,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	0.100	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249235 (US9458135, 23) Show SMILES CN1C(=O)CCc2cc(c(F)cc12)-c1cncc(COc2cc(C)ccn2)c1 Show InChI InChI=1S/C22H20FN3O2/c1-14-5-6-25-21(7-14)28-13-15-8-17(12-24-11-15)18-9-16-3-4-22(27)26(2)20(16)10-19(18)23/h5-12H,3-4,13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	0.100	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249219 (US9458135, 7) Show SMILES CN1C(=O)CCc2cc(ccc12)-c1cncc(COc2ccccn2)c1 Show InChI InChI=1S/C21H19N3O2/c1-24-19-7-5-16(11-17(19)6-8-21(24)25)18-10-15(12-22-13-18)14-26-20-4-2-3-9-23-20/h2-5,7,9-13H,6,8,14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	0.200	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249214 (US9458135, 2) Show SMILES CN1C(=O)CCc2cc(ccc12)-c1cncc(COc2ccc(F)cn2)c1 Show InChI InChI=1S/C21H18FN3O2/c1-25-19-5-2-15(9-16(19)3-7-21(25)26)17-8-14(10-23-11-17)13-27-20-6-4-18(22)12-24-20/h2,4-6,8-12H,3,7,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	0.200	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM191958 (US9187429, 103) Show SMILES CC1(COC2CCc3c2cncc3-c2ccc(cc2)C(F)(F)F)COC1 Show InChI InChI=1/C20H20F3NO2/c1-19(10-25-11-19)12-26-18-7-6-15-16(8-24-9-17(15)18)13-2-4-14(5-3-13)20(21,22)23/h2-5,8-9,18H,6-7,10-12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	US Patent	n/a	n/a	n/a	n/a	0.200	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description G-402 cells can be obtained from ATCC(CRL-1440) and were originally derived from a renal leiomyoblastoma. The expression plasmids contains the ORF ...				US Patent US9187429 (2015)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249213 (US9458135, 1) Show SMILES CN1C(=O)CCc2cc(ccc12)-c1cncc(COc2cccc(Cl)n2)c1 Show InChI InChI=1S/C21H18ClN3O2/c1-25-18-7-5-15(10-16(18)6-8-21(25)26)17-9-14(11-23-12-17)13-27-20-4-2-3-19(22)24-20/h2-5,7,9-12H,6,8,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	0.200	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249239 (US9458135, 27) Show SMILES CN1C(=O)CCc2cc(c(F)cc12)-c1cncc(COc2cccc(F)n2)c1C Show InChI InChI=1S/C22H19F2N3O2/c1-13-15(12-29-21-5-3-4-20(24)26-21)10-25-11-17(13)16-8-14-6-7-22(28)27(2)19(14)9-18(16)23/h3-5,8-11H,6-7,12H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	0.200	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249229 (US9458135, 17) Show SMILES CN1C(=O)CCc2cc(ccc12)-c1cncc(COc2cc(ccn2)C#N)c1 Show InChI InChI=1S/C22H18N4O2/c1-26-20-4-2-17(10-18(20)3-5-22(26)27)19-8-16(12-24-13-19)14-28-21-9-15(11-23)6-7-25-21/h2,4,6-10,12-13H,3,5,14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	0.200	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249230 (US9458135, 18) Show SMILES CN1C(=O)CCc2cc(ccc12)-c1cncc(COc2cccc(F)n2)c1 Show InChI InChI=1S/C21H18FN3O2/c1-25-18-7-5-15(10-16(18)6-8-21(25)26)17-9-14(11-23-12-17)13-27-20-4-2-3-19(22)24-20/h2-5,7,9-12H,6,8,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249222 (US9458135, 10) Show SMILES CN1C(=O)CCc2cc(ccc12)-c1cncc(COc2ccnc(n2)C(F)(F)F)c1 Show InChI InChI=1S/C21H17F3N4O2/c1-28-17-4-2-14(9-15(17)3-5-19(28)29)16-8-13(10-25-11-16)12-30-18-6-7-26-20(27-18)21(22,23)24/h2,4,6-11H,3,5,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249233 (US9458135, 21) Show SMILES CN1C(=O)CCc2cc(c(F)cc12)-c1cncc(COc2cccc(Cl)n2)c1 Show InChI InChI=1S/C21H17ClFN3O2/c1-26-18-9-17(23)16(8-14(18)5-6-21(26)27)15-7-13(10-24-11-15)12-28-20-4-2-3-19(22)25-20/h2-4,7-11H,5-6,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249225 (US9458135, 13) Show SMILES CN1C(=O)CCc2cc(ccc12)-c1cncc(CSc2nc3ccccc3o2)c1 Show InChI InChI=1S/C23H19N3O2S/c1-26-20-8-6-16(11-17(20)7-9-22(26)27)18-10-15(12-24-13-18)14-29-23-25-19-4-2-3-5-21(19)28-23/h2-6,8,10-13H,7,9,14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM101382 (US9695152, 3) Show SMILES CN(C1CN(C1)S(=O)(=O)C1CC1)c1cncc(c1)N1C(=O)c2ccc(Cl)cc2C1(C)C Show InChI InChI=1S/C22H25ClN4O3S/c1-22(2)20-8-14(23)4-7-19(20)21(28)27(22)16-9-15(10-24-11-16)25(3)17-12-26(13-17)31(29,30)18-5-6-18/h4,7-11,17-18H,5-6,12-13H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem Similars AffyNet	US Patent	n/a	n/a	n/a	n/a	0.400	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells expressing CYP11 constructs were established as described above and maintained in McCoy's 5a Medium Modified, ATCC Catalog No. 30-2007 co...				US Patent US9695152 (2017)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249216 (US9458135, 4) Show SMILES CN1C(=O)CCc2cc(ccc12)-c1cncc(COc2cc(C)cc(n2)C(F)(F)F)c1 Show InChI InChI=1S/C23H20F3N3O2/c1-14-7-20(23(24,25)26)28-21(8-14)31-13-15-9-18(12-27-11-15)16-3-5-19-17(10-16)4-6-22(30)29(19)2/h3,5,7-12H,4,6,13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	0.400	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM101347 (US9695151, 13) Show SMILES CC(C)S(=O)(=O)N1CC(C1)N(C)c1cncc(c1)N1C(=O)c2ccc(Cl)cc2C1(C)C Show InChI InChI=1S/C22H27ClN4O3S/c1-14(2)31(29,30)26-12-18(13-26)25(5)16-9-17(11-24-10-16)27-21(28)19-7-6-15(23)8-20(19)22(27,3)4/h6-11,14,18H,12-13H2,1-5H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem Similars AffyNet	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells expressing CYP11 constructs were established as described above and maintained in McCoy's 5a Medium Modified, ATCC Catalog No. 30-2007 co...				US Patent US9695151 (2017)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM101350 (US9695151, 16) Show SMILES CC(C)S(=O)(=O)N1CCC(C1)N(C)c1cncc(c1)N1C(=O)c2ccc(Cl)cc2C1(C)C Show InChI InChI=1/C23H29ClN4O3S/c1-15(2)32(30,31)27-9-8-17(14-27)26(5)18-11-19(13-25-12-18)28-22(29)20-7-6-16(24)10-21(20)23(28,3)4/h6-7,10-13,15,17H,8-9,14H2,1-5H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem Similars AffyNet	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells expressing CYP11 constructs were established as described above and maintained in McCoy's 5a Medium Modified, ATCC Catalog No. 30-2007 co...				US Patent US9695151 (2017)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249227 (US9458135, 15) Show SMILES CN1C(=O)CCc2cc(ccc12)-c1cncc(CSc2ncccc2C(F)(F)F)c1 Show InChI InChI=1S/C22H18F3N3OS/c1-28-19-6-4-15(10-16(19)5-7-20(28)29)17-9-14(11-26-12-17)13-30-21-18(22(23,24)25)3-2-8-27-21/h2-4,6,8-12H,5,7,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM101343 (US9695151, 10) Show SMILES CCS(=O)(=O)N1CC(C1)N(C)c1cncc(c1)N1C(=O)c2ccc(Cl)cc2C1(C)C Show InChI InChI=1S/C21H25ClN4O3S/c1-5-30(28,29)25-12-17(13-25)24(4)15-9-16(11-23-10-15)26-20(27)18-7-6-14(22)8-19(18)21(26,2)3/h6-11,17H,5,12-13H2,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem Similars AffyNet	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells expressing CYP11 constructs were established as described above and maintained in McCoy's 5a Medium Modified, ATCC Catalog No. 30-2007 co...				US Patent US9695151 (2017)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM101348 (US9695151, 14) Show SMILES CCCS(=O)(=O)N1CC(C1)N(C)c1cncc(c1)N1C(=O)c2ccc(Cl)cc2C1(C)C Show InChI InChI=1S/C22H27ClN4O3S/c1-5-8-31(29,30)26-13-18(14-26)25(4)16-10-17(12-24-11-16)27-21(28)19-7-6-15(23)9-20(19)22(27,2)3/h6-7,9-12,18H,5,8,13-14H2,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem Similars AffyNet	US Patent	n/a	n/a	n/a	n/a	0.600	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells expressing CYP11 constructs were established as described above and maintained in McCoy's 5a Medium Modified, ATCC Catalog No. 30-2007 co...				US Patent US9695151 (2017)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM101309 (US9695151, 3 | US9695151, 4) Show SMILES O=C1CCCN1c1ccc(N2CCOCC2)c(COc2ccc(cc2)-c2c(C3CCCCC3)c3ccc4cc3n2CC(=O)NCC\C=C/CCNC4=O)c1 Show InChI InChI=1/2C22H27ClN4O3S/c2*1-5-31(29,30)26-9-8-16(14-26)25(4)17-11-18(13-24-12-17)27-21(28)19-7-6-15(23)10-20(19)22(27,2)3/h2*6-7,10-13,16H,5,8-9,14H2,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	US Patent	n/a	n/a	n/a	n/a	0.600	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells expressing CYP11 constructs were established as described above and maintained in McCoy's 5a Medium Modified, ATCC Catalog No. 30-2007 co...				US Patent US9695151 (2017)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM101353 (US9695151, 19) Show SMILES CCC(=O)N1CCC(CC1)N(C)c1cncc(c1)N1C(=O)c2ccc(Cl)cc2C1(C)C Show InChI InChI=1S/C24H29ClN4O2/c1-5-22(30)28-10-8-17(9-11-28)27(4)18-13-19(15-26-14-18)29-23(31)20-7-6-16(25)12-21(20)24(29,2)3/h6-7,12-15,17H,5,8-11H2,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem Similars AffyNet	US Patent	n/a	n/a	n/a	n/a	0.700	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells expressing CYP11 constructs were established as described above and maintained in McCoy's 5a Medium Modified, ATCC Catalog No. 30-2007 co...				US Patent US9695151 (2017)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249236 (US9458135, 24) Show SMILES CN1C(=O)CCc2cc(c(F)cc12)-c1cncc(COc2cccc(C)n2)c1C Show InChI InChI=1S/C23H22FN3O2/c1-14-5-4-6-22(26-14)29-13-17-11-25-12-19(15(17)2)18-9-16-7-8-23(28)27(3)21(16)10-20(18)24/h4-6,9-12H,7-8,13H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	0.700	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM101354 (US9695151, 20) Show SMILES CCS(=O)(=O)N1CCC(CC1)N(C)c1cncc(c1)N1C(=O)c2ccc(Cl)cc2C1(C)C Show InChI InChI=1S/C23H29ClN4O3S/c1-5-32(30,31)27-10-8-17(9-11-27)26(4)18-13-19(15-25-14-18)28-22(29)20-7-6-16(24)12-21(20)23(28,2)3/h6-7,12-15,17H,5,8-11H2,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem Similars AffyNet	US Patent	n/a	n/a	n/a	n/a	0.800	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells expressing CYP11 constructs were established as described above and maintained in McCoy's 5a Medium Modified, ATCC Catalog No. 30-2007 co...				US Patent US9695151 (2017)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM101383 (US9695152, 4 | US9695152, 5) Show SMILES CN(C1CCN(C1)S(=O)(=O)C1CC1)c1cncc(c1)N1C(=O)c2ccc(Cl)cc2C1(C)C Show InChI InChI=1/C23H27ClN4O3S/c1-23(2)21-10-15(24)4-7-20(21)22(29)28(23)18-11-17(12-25-13-18)26(3)16-8-9-27(14-16)32(30,31)19-5-6-19/h4,7,10-13,16,19H,5-6,8-9,14H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem Similars AffyNet	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells expressing CYP11 constructs were established as described above and maintained in McCoy's 5a Medium Modified, ATCC Catalog No. 30-2007 co...				US Patent US9695152 (2017)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM101385 (US9695152, 6) Show SMILES CN(C1CCN(CC1)S(=O)(=O)C1CC1)c1cncc(c1)N1C(=O)c2ccc(Cl)cc2C1(C)C Show InChI InChI=1S/C24H29ClN4O3S/c1-24(2)22-12-16(25)4-7-21(22)23(30)29(24)19-13-18(14-26-15-19)27(3)17-8-10-28(11-9-17)33(31,32)20-5-6-20/h4,7,12-15,17,20H,5-6,8-11H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem Similars AffyNet	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells expressing CYP11 constructs were established as described above and maintained in McCoy's 5a Medium Modified, ATCC Catalog No. 30-2007 co...				US Patent US9695152 (2017)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM101403 (US9695152, 24) Show SMILES Cn1cc(cn1)C(=O)N1CC(C1)Nc1cncc(c1)N1C(=O)c2ccc(Cl)cc2C1(C)C Show InChI InChI=1S/C23H23ClN6O2/c1-23(2)20-6-15(24)4-5-19(20)22(32)30(23)18-7-16(9-25-10-18)27-17-12-29(13-17)21(31)14-8-26-28(3)11-14/h4-11,17,27H,12-13H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells expressing CYP11 constructs were established as described above and maintained in McCoy's 5a Medium Modified, ATCC Catalog No. 30-2007 co...				US Patent US9695152 (2017)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM101309 (US9695151, 3 | US9695151, 4) Show SMILES O=C1CCCN1c1ccc(N2CCOCC2)c(COc2ccc(cc2)-c2c(C3CCCCC3)c3ccc4cc3n2CC(=O)NCC\C=C/CCNC4=O)c1 Show InChI InChI=1/2C22H27ClN4O3S/c2*1-5-31(29,30)26-9-8-16(14-26)25(4)17-11-18(13-24-12-17)27-21(28)19-7-6-15(23)10-20(19)22(27,2)3/h2*6-7,10-13,16H,5,8-9,14H2,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells expressing CYP11 constructs were established as described above and maintained in McCoy's 5a Medium Modified, ATCC Catalog No. 30-2007 co...				US Patent US9695151 (2017)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM101352 (US9695151, 18) Show SMILES CCCS(=O)(=O)N1CCC(C1)N(C)c1cncc(c1)N1C(=O)c2ccc(Cl)cc2C1(C)C Show InChI InChI=1/C23H29ClN4O3S/c1-5-10-32(30,31)27-9-8-17(15-27)26(4)18-12-19(14-25-13-18)28-22(29)20-7-6-16(24)11-21(20)23(28,2)3/h6-7,11-14,17H,5,8-10,15H2,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem Similars AffyNet	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells expressing CYP11 constructs were established as described above and maintained in McCoy's 5a Medium Modified, ATCC Catalog No. 30-2007 co...				US Patent US9695151 (2017)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM101351 (US9695151, 17) Show SMILES CCCS(=O)(=O)N1CCC(C1)N(C)c1cncc(c1)N1C(=O)c2ccc(Cl)cc2C1(C)C Show InChI InChI=1/C23H29ClN4O3S/c1-5-10-32(30,31)27-9-8-17(15-27)26(4)18-12-19(14-25-13-18)28-22(29)20-7-6-16(24)11-21(20)23(28,2)3/h6-7,11-14,17H,5,8-10,15H2,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem Similars AffyNet	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells expressing CYP11 constructs were established as described above and maintained in McCoy's 5a Medium Modified, ATCC Catalog No. 30-2007 co...				US Patent US9695151 (2017)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM101349 (US9695151, 15) Show SMILES CC(C)S(=O)(=O)N1CCC(C1)N(C)c1cncc(c1)N1C(=O)c2ccc(Cl)cc2C1(C)C Show InChI InChI=1/C23H29ClN4O3S/c1-15(2)32(30,31)27-9-8-17(14-27)26(5)18-11-19(13-25-12-18)28-22(29)20-7-6-16(24)10-21(20)23(28,3)4/h6-7,10-13,15,17H,8-9,14H2,1-5H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem Similars AffyNet	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells expressing CYP11 constructs were established as described above and maintained in McCoy's 5a Medium Modified, ATCC Catalog No. 30-2007 co...				US Patent US9695151 (2017)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM191957 (US9187429, 102) Show SMILES NC(=O)COC1CCc2c1cncc2-c1ccc(cc1)C(F)(F)F Show InChI InChI=1/C17H15F3N2O2/c18-17(19,20)11-3-1-10(2-4-11)13-7-22-8-14-12(13)5-6-15(14)24-9-16(21)23/h1-4,7-8,15H,5-6,9H2,(H2,21,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	US Patent	n/a	n/a	n/a	n/a	1.10	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description G-402 cells can be obtained from ATCC(CRL-1440) and were originally derived from a renal leiomyoblastoma. The expression plasmids contains the ORF ...				US Patent US9187429 (2015)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM191938 (US9187429, 81) Show SMILES OC1CCc2c1cncc2-c1ccc(cc1)C#N Show InChI InChI=1/C15H12N2O/c16-7-10-1-3-11(4-2-10)13-8-17-9-14-12(13)5-6-15(14)18/h1-4,8-9,15,18H,5-6H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	US Patent	n/a	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description G-402 cells can be obtained from ATCC(CRL-1440) and were originally derived from a renal leiomyoblastoma. The expression plasmids contains the ORF ...				US Patent US9187429 (2015)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249237 (US9458135, 25) Show SMILES CN1C(=O)CCc2cc(c(F)cc12)-c1cncc(COc2cccc(Cl)n2)c1C Show InChI InChI=1S/C22H19ClFN3O2/c1-13-15(12-29-21-5-3-4-20(23)26-21)10-25-11-17(13)16-8-14-6-7-22(28)27(2)19(14)9-18(16)24/h3-5,8-11H,6-7,12H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM191952 (US9187429, 97) Show SMILES CC(C)(C)OC(=O)COC1CCc2c1cncc2-c1ccc(cc1)C(F)(F)F Show InChI InChI=1/C21H22F3NO3/c1-20(2,3)28-19(26)12-27-18-9-8-15-16(10-25-11-17(15)18)13-4-6-14(7-5-13)21(22,23)24/h4-7,10-11,18H,8-9,12H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	US Patent	n/a	n/a	n/a	n/a	1.40	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description G-402 cells can be obtained from ATCC(CRL-1440) and were originally derived from a renal leiomyoblastoma. The expression plasmids contains the ORF ...				US Patent US9187429 (2015)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249228 (US9458135, 16) Show SMILES CN1C(=O)CCc2cc(ccc12)-c1cncc(CSc2ncccc2Cl)c1 Show InChI InChI=1S/C21H18ClN3OS/c1-25-19-6-4-15(10-16(19)5-7-20(25)26)17-9-14(11-23-12-17)13-27-21-18(22)3-2-8-24-21/h2-4,6,8-12H,5,7,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	1.40	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM101383 (US9695152, 4 | US9695152, 5) Show SMILES CN(C1CCN(C1)S(=O)(=O)C1CC1)c1cncc(c1)N1C(=O)c2ccc(Cl)cc2C1(C)C Show InChI InChI=1/C23H27ClN4O3S/c1-23(2)21-10-15(24)4-7-20(21)22(29)28(23)18-11-17(12-25-13-18)26(3)16-8-9-27(14-16)32(30,31)19-5-6-19/h4,7,10-13,16,19H,5-6,8-9,14H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem Similars AffyNet	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells expressing CYP11 constructs were established as described above and maintained in McCoy's 5a Medium Modified, ATCC Catalog No. 30-2007 co...				US Patent US9695152 (2017)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM233856 (US9353081, 67 | US9353081, 68 | US9353081, 69) Show SMILES CN1C(=O)CCc2cc(ccc12)-c1cncc2C(O)CCCc12 Show InChI InChI=1/C19H20N2O2/c1-21-17-7-5-12(9-13(17)6-8-19(21)23)15-10-20-11-16-14(15)3-2-4-18(16)22/h5,7,9-11,18,22H,2-4,6,8H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita...				US Patent US9353081 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249234 (US9458135, 22) Show SMILES CN1C(=O)CCc2cc(c(F)cc12)-c1cncc(COc2cccc(C)n2)c1 Show InChI InChI=1S/C22H20FN3O2/c1-14-4-3-5-21(25-14)28-13-15-8-17(12-24-11-15)18-9-16-6-7-22(27)26(2)20(16)10-19(18)23/h3-5,8-12H,6-7,13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM60879 (US9187429, 60) Show SMILES CCC(=O)N[C@H]1CCc2c1cncc2-c1ccc(F)c(C)c1 Show InChI InChI=1/C18H19FN2O/c1-3-18(22)21-17-7-5-13-14(9-20-10-15(13)17)12-4-6-16(19)11(2)8-12/h4,6,8-10,17H,3,5,7H2,1-2H3,(H,21,22)/t17-/s2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description G-402 cells can be obtained from ATCC(CRL-1440) and were originally derived from a renal leiomyoblastoma. The expression plasmids contains the ORF ...				US Patent US9187429 (2015)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM101346 (US9695151, 12) Show SMILES CCC(=O)N1CC(C1)N(C)c1cncc(c1)N1C(=O)c2ccc(Cl)cc2C1(C)C Show InChI InChI=1S/C22H25ClN4O2/c1-5-20(28)26-12-17(13-26)25(4)15-9-16(11-24-10-15)27-21(29)18-7-6-14(23)8-19(18)22(27,2)3/h6-11,17H,5,12-13H2,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem Similars AffyNet	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells expressing CYP11 constructs were established as described above and maintained in McCoy's 5a Medium Modified, ATCC Catalog No. 30-2007 co...				US Patent US9695151 (2017)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249240 (US9458135, 28) Show SMILES CN1C(=O)CCc2cc(ccc12)-c1cncc(CC(=O)Nc2cccc(C)n2)c1 Show InChI InChI=1S/C23H22N4O2/c1-15-4-3-5-21(25-15)26-22(28)11-16-10-19(14-24-13-16)17-6-8-20-18(12-17)7-9-23(29)27(20)2/h3-6,8,10,12-14H,7,9,11H2,1-2H3,(H,25,26,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	2.20	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM191943 (US9187429, 87 | US9187429, 88) Show SMILES CC1(C)Cc2c(cncc2-c2ccc(cc2)C#N)C1O Show InChI InChI=1/C17H16N2O/c1-17(2)7-13-14(9-19-10-15(13)16(17)20)12-5-3-11(8-18)4-6-12/h3-6,9-10,16,20H,7H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	US Patent	n/a	n/a	n/a	n/a	2.20	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description G-402 cells can be obtained from ATCC(CRL-1440) and were originally derived from a renal leiomyoblastoma. The expression plasmids contains the ORF ...				US Patent US9187429 (2015)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM249220 (US9458135, 8) Show SMILES CN1C(=O)CCc2cc(ccc12)-c1cncc(COc2ncccc2C(F)(F)F)c1 Show InChI InChI=1S/C22H18F3N3O2/c1-28-19-6-4-15(10-16(19)5-7-20(28)29)17-9-14(11-26-12-17)13-30-21-18(22(23,24)25)3-2-8-27-21/h2-4,6,8-12H,5,7,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	US Patent	n/a	n/a	n/a	n/a	2.30	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016)
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (Homo sapiens (human))	BDBM101390 (US9695152, 11) Show SMILES Cc1cncc(c1)C(=O)N1CC(C1)Nc1cncc(c1)N1C(=O)c2ccc(Cl)cc2C1(C)C Show InChI InChI=1S/C25H24ClN5O2/c1-15-6-16(10-27-9-15)23(32)30-13-19(14-30)29-18-8-20(12-28-11-18)31-24(33)21-5-4-17(26)7-22(21)25(31,2)3/h4-12,19,29H,13-14H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	US Patent	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells expressing CYP11 constructs were established as described above and maintained in McCoy's 5a Medium Modified, ATCC Catalog No. 30-2007 co...				US Patent US9695152 (2017)
					More data for this Ligand-Target Pair

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