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Compile Data Set for Download or QSAR

Found 119 hits of ec50 data for polymerid = 1024,50000929   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014777
PNG
(1-Di-p-tolylmethyl-1H-imidazole | CHEMBL135381)
Show SMILES Cc1ccc(cc1)C(c1ccc(C)cc1)n1ccnc1
Show InChI InChI=1S/C18H18N2/c1-14-3-7-16(8-4-14)18(20-12-11-19-13-20)17-9-5-15(2)6-10-17/h3-13,18H,1-2H3
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n/an/an/an/a 6.40n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014754
PNG
(1-[(4-Chloro-phenyl)-(4-methoxy-phenyl)-methyl]-1H...)
Show SMILES COc1ccc(cc1)C(c1ccc(Cl)cc1)n1ccnc1
Show InChI InChI=1S/C17H15ClN2O/c1-21-16-8-4-14(5-9-16)17(20-11-10-19-12-20)13-2-6-15(18)7-3-13/h2-12,17H,1H3
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n/an/an/an/a 8.40n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014780
PNG
(1-[Bis-(4-chloro-phenyl)-methyl]-1H-[1,2,4]triazol...)
Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)n1cncn1
Show InChI InChI=1S/C15H11Cl2N3/c16-13-5-1-11(2-6-13)15(20-10-18-9-19-20)12-3-7-14(17)8-4-12/h1-10,15H
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n/an/an/an/a 8.80n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014773
PNG
(1-[Bis-(4-bromo-phenyl)-methyl]-1H-imidazole | CHE...)
Show SMILES Brc1ccc(cc1)C(c1ccc(Br)cc1)n1ccnc1
Show InChI InChI=1S/C16H12Br2N2/c17-14-5-1-12(2-6-14)16(20-10-9-19-11-20)13-3-7-15(18)8-4-13/h1-11,16H
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n/an/an/an/a 8.90n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014803
PNG
(4-[Bis-(4-chloro-phenyl)-methyl]-4H-[1,2,4]triazol...)
Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)n1cnnc1
Show InChI InChI=1S/C15H11Cl2N3/c16-13-5-1-11(2-6-13)15(20-9-18-19-10-20)12-3-7-14(17)8-4-12/h1-10,15H
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n/an/an/an/a 9.30n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014776
PNG
(1-[bis(4-chlorophenyl)(1H-imidazol-2-yl)methyl]-1H...)
Show SMILES Clc1ccc(cc1)C(c1ncc[nH]1)(c1ccc(Cl)cc1)n1ccnc1
Show InChI InChI=1S/C19H14Cl2N4/c20-16-5-1-14(2-6-16)19(18-23-9-10-24-18,25-12-11-22-13-25)15-3-7-17(21)8-4-15/h1-13H,(H,23,24)
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n/an/an/an/a 9.40n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014771
PNG
(Bis-(4-chloro-phenyl)-thiazol-5-yl-methanol | CHEM...)
Show SMILES OC(c1cncs1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H11Cl2NOS/c17-13-5-1-11(2-6-13)16(20,15-9-19-10-21-15)12-3-7-14(18)8-4-12/h1-10,20H
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n/an/an/an/a 9.60n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014764
PNG
(5-[Bis-(4-chloro-phenyl)-imidazol-1-yl-methyl]-1H-...)
Show SMILES Clc1ccc(cc1)C(c1nnc[nH]1)(c1ccc(Cl)cc1)n1ccnc1
Show InChI InChI=1S/C18H13Cl2N5/c19-15-5-1-13(2-6-15)18(17-22-11-23-24-17,25-10-9-21-12-25)14-3-7-16(20)8-4-14/h1-12H,(H,22,23,24)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014809
PNG
(1-[(4-Chloro-phenyl)-(4-trifluoromethyl-phenyl)-me...)
Show SMILES FC(F)(F)c1ccc(cc1)C(c1ccc(Cl)cc1)n1ccnc1
Show InChI InChI=1S/C17H12ClF3N2/c18-15-7-3-13(4-8-15)16(23-10-9-22-11-23)12-1-5-14(6-2-12)17(19,20)21/h1-11,16H
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014796
PNG
(1-[(4-Methoxy-phenyl)-p-tolyl-methyl]-1H-imidazole...)
Show SMILES COc1ccc(cc1)C(c1ccc(C)cc1)n1ccnc1
Show InChI InChI=1S/C18H18N2O/c1-14-3-5-15(6-4-14)18(20-12-11-19-13-20)16-7-9-17(21-2)10-8-16/h3-13,18H,1-2H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014763
PNG
(4-[Bis-(4-chloro-phenyl)-imidazol-1-yl-methyl]-1H-...)
Show SMILES Clc1ccc(cc1)C(c1cn[nH]c1)(c1ccc(Cl)cc1)n1ccnc1
Show InChI InChI=1S/C19H14Cl2N4/c20-17-5-1-14(2-6-17)19(16-11-23-24-12-16,25-10-9-22-13-25)15-3-7-18(21)8-4-15/h1-13H,(H,23,24)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014755
PNG
(1-[Bis-(4-methoxy-phenyl)-methyl]-1H-imidazole | C...)
Show SMILES COc1ccc(cc1)C(c1ccc(OC)cc1)n1ccnc1
Show InChI InChI=1S/C18H18N2O2/c1-21-16-7-3-14(4-8-16)18(20-12-11-19-13-20)15-5-9-17(22-2)10-6-15/h3-13,18H,1-2H3
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n/an/an/an/a 13n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014800
PNG
(1-[bis(4-chlorophenyl)(1H-imidazol-4-yl)methyl]-1H...)
Show SMILES Clc1ccc(cc1)C(c1cnc[nH]1)(c1ccc(Cl)cc1)n1ccnc1
Show InChI InChI=1S/C19H14Cl2N4/c20-16-5-1-14(2-6-16)19(18-11-23-12-24-18,25-10-9-22-13-25)15-3-7-17(21)8-4-15/h1-13H,(H,23,24)
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n/an/an/an/a 16n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014759
PNG
(5-[Bis-(4-chloro-phenyl)-imidazol-1-yl-methyl]-thi...)
Show SMILES Clc1ccc(cc1)C(c1cncs1)(c1ccc(Cl)cc1)n1ccnc1
Show InChI InChI=1S/C19H13Cl2N3S/c20-16-5-1-14(2-6-16)19(18-11-23-13-25-18,24-10-9-22-12-24)15-3-7-17(21)8-4-15/h1-13H
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n/an/an/an/a 17n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014814
PNG
(4-[Bis-(4-chloro-phenyl)-imidazol-1-yl-methyl]-1H-...)
Show SMILES Clc1ccc(cc1)C(c1cnn[nH]1)(c1ccc(Cl)cc1)n1ccnc1
Show InChI InChI=1S/C18H13Cl2N5/c19-15-5-1-13(2-6-15)18(17-11-22-24-23-17,25-10-9-21-12-25)14-3-7-16(20)8-4-14/h1-12H,(H,22,23,24)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014804
PNG
(Bis-(4-chloro-phenyl)-isothiazol-5-yl-methanol | C...)
Show SMILES OC(c1ccns1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H11Cl2NOS/c17-13-5-1-11(2-6-13)16(20,15-9-10-19-21-15)12-3-7-14(18)8-4-12/h1-10,20H
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n/an/an/an/a 19n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014782
PNG
(1-[Bis-(4-chloro-phenyl)-methyl]-1H-[1,2,3]triazol...)
Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)n1ccnn1
Show InChI InChI=1S/C15H11Cl2N3/c16-13-5-1-11(2-6-13)15(20-10-9-18-19-20)12-3-7-14(17)8-4-12/h1-10,15H
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014808
PNG
(1-[(4-Chloro-phenyl)-phenyl-methyl]-1H-imidazole |...)
Show SMILES Clc1ccc(cc1)C(c1ccccc1)n1ccnc1
Show InChI InChI=1S/C16H13ClN2/c17-15-8-6-14(7-9-15)16(19-11-10-18-12-19)13-4-2-1-3-5-13/h1-12,16H
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014775
PNG
(5-[Bis-(4-chloro-phenyl)-imidazol-1-yl-methyl]-pyr...)
Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)(c1cncnc1)n1ccnc1
Show InChI InChI=1S/C20H14Cl2N4/c21-18-5-1-15(2-6-18)20(26-10-9-23-14-26,17-11-24-13-25-12-17)16-3-7-19(22)8-4-16/h1-14H
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Lilly Research Laboratories

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Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014785
PNG
(Bis-(4-chloro-phenyl)-(1H-imidazol-4-yl)-methanol ...)
Show SMILES OC(c1cnc[nH]1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H12Cl2N2O/c17-13-5-1-11(2-6-13)16(21,15-9-19-10-20-15)12-3-7-14(18)8-4-12/h1-10,21H,(H,19,20)
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Lilly Research Laboratories

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Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014783
PNG
(2-[Bis-(4-chloro-phenyl)-imidazol-1-yl-methyl]-pyr...)
Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)(c1ccccn1)n1ccnc1
Show InChI InChI=1S/C21H15Cl2N3/c22-18-8-4-16(5-9-18)21(26-14-13-24-15-26,20-3-1-2-12-25-20)17-6-10-19(23)11-7-17/h1-15H
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Lilly Research Laboratories

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Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014778
PNG
(Bis-(4-chloro-phenyl)-(1H-pyrazol-4-yl)-methanol |...)
Show SMILES OC(c1cn[nH]c1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H12Cl2N2O/c17-14-5-1-11(2-6-14)16(21,13-9-19-20-10-13)12-3-7-15(18)8-4-12/h1-10,21H,(H,19,20)
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Lilly Research Laboratories

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Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014810
PNG
(1-[Bis-(4-nitro-phenyl)-methyl]-1H-imidazole | CHE...)
Show SMILES [O-][N+](=O)c1ccc(cc1)C(c1ccc(cc1)[N+]([O-])=O)n1ccnc1
Show InChI InChI=1S/C16H12N4O4/c21-19(22)14-5-1-12(2-6-14)16(18-10-9-17-11-18)13-3-7-15(8-4-13)20(23)24/h1-11,16H
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014797
PNG
(1-[Bis-(4-fluoro-phenyl)-methyl]-1H-imidazole | CH...)
Show SMILES Fc1ccc(cc1)C(c1ccc(F)cc1)n1ccnc1
Show InChI InChI=1S/C16H12F2N2/c17-14-5-1-12(2-6-14)16(20-10-9-19-11-20)13-3-7-15(18)8-4-13/h1-11,16H
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Lilly Research Laboratories

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Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014756
PNG
(1-[Bis-(4-chloro-phenyl)-methyl]-1H-imidazole | CH...)
Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)n1ccnc1
Show InChI InChI=1S/C16H12Cl2N2/c17-14-5-1-12(2-6-14)16(20-10-9-19-11-20)13-3-7-15(18)8-4-13/h1-11,16H
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Lilly Research Laboratories

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Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50367548
PNG
(CHEMBL1794921)
Show SMILES Clc1ccc(cc1)C(C1=CN=CNC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C17H14Cl2N2/c18-15-5-1-12(2-6-15)17(14-9-20-11-21-10-14)13-3-7-16(19)8-4-13/h1-9,11,17H,10H2,(H,20,21)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]androstenedione and NADPH-generating system.


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014750
PNG
(3-[Bis-(4-chloro-phenyl)-imidazol-1-yl-methyl]-pyr...)
Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)(c1cccnc1)n1ccnc1
Show InChI InChI=1S/C21H15Cl2N3/c22-19-7-3-16(4-8-19)21(26-13-12-25-15-26,18-2-1-11-24-14-18)17-5-9-20(23)10-6-17/h1-15H
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Lilly Research Laboratories

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Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014802
PNG
(4-[Bis-(4-chloro-phenyl)-imidazol-1-yl-methyl]-pyr...)
Show SMILES Clc1ccc(cc1)C(c1ccncc1)(c1ccc(Cl)cc1)n1ccnc1
Show InChI InChI=1S/C21H15Cl2N3/c22-19-5-1-16(2-6-19)21(26-14-13-25-15-26,18-9-11-24-12-10-18)17-3-7-20(23)8-4-17/h1-15H
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Lilly Research Laboratories

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Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014324
PNG
(5-[Bis-(4-chloro-phenyl)-methyl]-pyrimidine | 5-[B...)
Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1cncnc1
Show InChI InChI=1S/C17H12Cl2N2/c18-15-5-1-12(2-6-15)17(14-9-20-11-21-10-14)13-3-7-16(19)8-4-13/h1-11,17H
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014324
PNG
(5-[Bis-(4-chloro-phenyl)-methyl]-pyrimidine | 5-[B...)
Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1cncnc1
Show InChI InChI=1S/C17H12Cl2N2/c18-15-5-1-12(2-6-15)17(14-9-20-11-21-10-14)13-3-7-16(19)8-4-13/h1-11,17H
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TBA

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Assay Description
In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]androstenedione and NADPH-generating system.


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014793
PNG
(5-[Bis-(4-chloro-phenyl)-imidazol-1-yl-methyl]-iso...)
Show SMILES Clc1ccc(cc1)C(c1ccns1)(c1ccc(Cl)cc1)n1ccnc1
Show InChI InChI=1S/C19H13Cl2N3S/c20-16-5-1-14(2-6-16)19(18-9-10-23-25-18,24-12-11-22-13-24)15-3-7-17(21)8-4-15/h1-13H
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Lilly Research Laboratories

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Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014749
PNG
(3-[Bis-(4-chloro-phenyl)-imidazol-1-yl-methyl]-1H-...)
Show SMILES Clc1ccc(cc1)C(c1ccn[nH]1)(c1ccc(Cl)cc1)n1ccnc1
Show InChI InChI=1S/C19H14Cl2N4/c20-16-5-1-14(2-6-16)19(18-9-10-23-24-18,25-12-11-22-13-25)15-3-7-17(21)8-4-15/h1-13H,(H,23,24)
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Lilly Research Laboratories

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Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014781
PNG
(1-[(2-Methoxy-phenyl)-phenyl-methyl]-1H-imidazole ...)
Show SMILES COc1ccccc1C(c1ccccc1)n1ccnc1
Show InChI InChI=1S/C17H16N2O/c1-20-16-10-6-5-9-15(16)17(19-12-11-18-13-19)14-7-3-2-4-8-14/h2-13,17H,1H3
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Lilly Research Laboratories

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Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50024481
PNG
((4-Chloro-phenyl)-pyrimidin-5-yl-(4-trifluoromethy...)
Show SMILES OC(c1ccc(Cl)cc1)(c1ccc(cc1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C18H12ClF3N2O/c19-16-7-5-13(6-8-16)17(25,15-9-23-11-24-10-15)12-1-3-14(4-2-12)18(20,21)22/h1-11,25H
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]androstenedione and NADPH-generating system.


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014815
PNG
(Bis-(4-chloro-phenyl)-pyrimidin-5-yl-methanol | CH...)
Show SMILES OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1cncnc1
Show InChI InChI=1S/C17H12Cl2N2O/c18-15-5-1-12(2-6-15)17(22,14-9-20-11-21-10-14)13-3-7-16(19)8-4-13/h1-11,22H
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Lilly Research Laboratories

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Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014815
PNG
(Bis-(4-chloro-phenyl)-pyrimidin-5-yl-methanol | CH...)
Show SMILES OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1cncnc1
Show InChI InChI=1S/C17H12Cl2N2O/c18-15-5-1-12(2-6-15)17(22,14-9-20-11-21-10-14)13-3-7-16(19)8-4-13/h1-11,22H
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TBA

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Assay Description
In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]androstenedione and NADPH-generating system.


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014752
PNG
(1-[Bis-(2-chloro-phenyl)-methyl]-1H-imidazole | CH...)
Show SMILES Clc1ccccc1C(c1ccccc1Cl)n1ccnc1
Show InChI InChI=1S/C16H12Cl2N2/c17-14-7-3-1-5-12(14)16(20-10-9-19-11-20)13-6-2-4-8-15(13)18/h1-11,16H
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Lilly Research Laboratories

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Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50024516
PNG
(5-[Bis-(4-chloro-phenyl)-fluoro-methyl]-pyrimidine...)
Show SMILES FC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1cncnc1
Show InChI InChI=1S/C17H11Cl2FN2/c18-15-5-1-12(2-6-15)17(20,14-9-21-11-22-10-14)13-3-7-16(19)8-4-13/h1-11H
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]androstenedione and NADPH-generating system.


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50024524
PNG
(5-[1,1-Bis-(4-chloro-phenyl)-ethyl]-pyrimidine | C...)
Show SMILES CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1cncnc1
Show InChI InChI=1S/C18H14Cl2N2/c1-18(15-10-21-12-22-11-15,13-2-6-16(19)7-3-13)14-4-8-17(20)9-5-14/h2-12H,1H3
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]androstenedione and NADPH-generating system.


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014794
PNG
(3-[Bis-(4-chloro-phenyl)-methyl]-pyridine | CHEMBL...)
Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1cccnc1
Show InChI InChI=1S/C18H13Cl2N/c19-16-7-3-13(4-8-16)18(15-2-1-11-21-12-15)14-5-9-17(20)10-6-14/h1-12,18H
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Lilly Research Laboratories

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Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014798
PNG
(Bis-(4-chloro-phenyl)-pyridin-4-yl-methanol | CHEM...)
Show SMILES OC(c1ccncc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H13Cl2NO/c19-16-5-1-13(2-6-16)18(22,15-9-11-21-12-10-15)14-3-7-17(20)8-4-14/h1-12,22H
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Lilly Research Laboratories

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Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014791
PNG
(Bis-(4-chloro-phenyl)-(1H-pyrazol-3-yl)-methanol |...)
Show SMILES OC(c1ccn[nH]1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H12Cl2N2O/c17-13-5-1-11(2-6-13)16(21,15-9-10-19-20-15)12-3-7-14(18)8-4-12/h1-10,21H,(H,19,20)
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Lilly Research Laboratories

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Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014774
PNG
(Bis-(4-chloro-phenyl)-pyrazin-2-yl-methanol | CHEM...)
Show SMILES OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1cnccn1
Show InChI InChI=1S/C17H12Cl2N2O/c18-14-5-1-12(2-6-14)17(22,16-11-20-9-10-21-16)13-3-7-15(19)8-4-13/h1-11,22H
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Lilly Research Laboratories

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Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014788
PNG
(1-Benzhydryl-1H-imidazole | CHEMBL336638)
Show SMILES c1cn(cn1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C16H14N2/c1-3-7-14(8-4-1)16(18-12-11-17-13-18)15-9-5-2-6-10-15/h1-13,16H
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Lilly Research Laboratories

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Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50024513
PNG
(6-Acetylsulfanyl-8-[2-[(4-amino-2-methyl-pyrimidin...)
Show SMILES COC(=O)CCCCC(CCSS\C(CCO)=C(/C)N(Cc1cnc(C)nc1N)C=O)SC(C)=O
Show InChI InChI=1S/C23H36N4O5S3/c1-16(27(15-29)14-19-13-25-17(2)26-23(19)24)21(9-11-28)35-33-12-10-20(34-18(3)30)7-5-6-8-22(31)32-4/h13,15,20,28H,5-12,14H2,1-4H3,(H2,24,25,26)/b21-16+
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]androstenedione and NADPH-generating system.


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014751
PNG
(3-[1,1-Bis-(4-chloro-phenyl)-ethyl]-pyridine | CHE...)
Show SMILES CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1cccnc1
Show InChI InChI=1S/C19H15Cl2N/c1-19(16-3-2-12-22-13-16,14-4-8-17(20)9-5-14)15-6-10-18(21)11-7-15/h2-13H,1H3
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Lilly Research Laboratories

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Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014786
PNG
(2-[Bis-(4-chloro-phenyl)-methyl]-2H-tetrazole | CH...)
Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)n1ncnn1
Show InChI InChI=1S/C14H10Cl2N4/c15-12-5-1-10(2-6-12)14(20-18-9-17-19-20)11-3-7-13(16)8-4-11/h1-9,14H
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Lilly Research Laboratories

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Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014758
PNG
(Bis-(4-chloro-phenyl)-pyridin-3-yl-methanol | CHEM...)
Show SMILES OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1cccnc1
Show InChI InChI=1S/C18H13Cl2NO/c19-16-7-3-13(4-8-16)18(22,15-2-1-11-21-12-15)14-5-9-17(20)10-6-14/h1-12,22H
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Lilly Research Laboratories

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Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014801
PNG
(4-[Bis-(4-chloro-phenyl)-methyl]-pyridine; hydroch...)
Show SMILES Clc1ccc(cc1)C(c1ccncc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H13Cl2N/c19-16-5-1-13(2-6-16)18(15-9-11-21-12-10-15)14-3-7-17(20)8-4-14/h1-12,18H
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Lilly Research Laboratories

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Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50024522
PNG
((4-Chloro-phenyl)-(4-fluoro-phenyl)-pyrimidin-5-yl...)
Show SMILES OC(c1ccc(F)cc1)(c1ccc(Cl)cc1)c1cncnc1
Show InChI InChI=1S/C17H12ClFN2O/c18-15-5-1-12(2-6-15)17(22,14-9-20-11-21-10-14)13-3-7-16(19)8-4-13/h1-11,22H
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]androstenedione and NADPH-generating system.


Citation and Details
More data for this
Ligand-Target Pair
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