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Found 24 hits affinity hit(s) for enzyme = Enoyl-ACP Reductase (FabI) with UniProtKB: P44432
Target (Institution)	Ligand	Target Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	pH	Temp °C
Enoyl-ACP Reductase (FabI) Haemophilus influenzae	indole naphthyridinone 31 ((2E)-N-[(1,2-dimethyl-1H-indol-3-yl)methyl]-N-meth...)	GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	25.0	n/a	n/a	6.5	30
GlaxoSmithKline		GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	J Med Chem. 46: 1627-35 (2003)
Enoyl-ACP Reductase (FabI) Haemophilus influenzae	indole naphthyridinone 32 ((2E)-N-methyl-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naph...)	GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	70.0	n/a	n/a	6.5	30
GlaxoSmithKline		GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	J Med Chem. 46: 1627-35 (2003)
Enoyl-ACP Reductase (FabI) Haemophilus influenzae	indole naphthyridinone 30 ((2E)-N-methyl-N-[(2-methyl-1H-indol-3-yl)methyl]-3...)	GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	130.0	n/a	n/a	6.5	30
GlaxoSmithKline		GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	J Med Chem. 46: 1627-35 (2003)
Enoyl-ACP Reductase (FabI) Haemophilus influenzae	indole naphthyridinone 29 ((2E)-N-methyl-N-[(1-methyl-1H-indol-3-yl)methyl]-3...)	GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CSLS DrugBank PDB PubChem	PubMed	n/a	n/a	390.0	n/a	n/a	6.5	30
GlaxoSmithKline		GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CSLS DrugBank PDB PubChem	PubMed	J Med Chem. 46: 1627-35 (2003)
Enoyl-ACP Reductase (FabI) Haemophilus influenzae	indole naphthyridinone 21 ((2E)-N-methyl-N-[(1-methyl-1H-indol-2-yl)methyl]-3...)	GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	560.0	n/a	n/a	6.5	30
GlaxoSmithKline		GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	J Med Chem. 46: 1627-35 (2003)
Enoyl-ACP Reductase (FabI) Haemophilus influenzae	Acetamido deriv. 12 ((2E)-3-(6-acetamidopyridin-3-yl)-N-methyl-N-[(1-me...)	GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	1300.0	n/a	n/a	6.5	30
GlaxoSmithKline		GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	J Med Chem. 46: 1627-35 (2003)
Enoyl-ACP Reductase (FabI) Haemophilus influenzae	1,4-Benzodiazepine deriv. 4 (N,4-Dimethyl-N-(1-methyl-1H-indol-2-ylmethyl)-3-ox...)	GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	2500.0	n/a	n/a	6.5	30
GlaxoSmithKline		GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	J Med Chem. 45: 3246-56 (2002)
Enoyl-ACP Reductase (FabI) Haemophilus influenzae	benzamide deriv. 7 (4-Amino-N-methyl-N-(1-methyl-1H-indol-2-ylmethyl)-...)	GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	2600.0	n/a	n/a	6.5	30
GlaxoSmithKline		GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	J Med Chem. 45: 3246-56 (2002)
Enoyl-ACP Reductase (FabI) Haemophilus influenzae	Piperidine 11 ((2E)-N-methyl-N-[(1-methyl-1H-indol-2-yl)methyl]-3...)	GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	2700.0	n/a	n/a	6.5	30
GlaxoSmithKline		GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	J Med Chem. 46: 1627-35 (2003)
Enoyl-ACP Reductase (FabI) Haemophilus influenzae	aminopyridine deriv. 9 ((2E)-3-(6-aminopyridin-3-yl)-N-methyl-N-[(1-methyl...)	GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CSLS DrugBank PDB PubChem	PubMed	n/a	n/a	4200.0	n/a	n/a	6.5	30
GlaxoSmithKline		GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CSLS DrugBank PDB PubChem	PubMed	J Med Chem. 45: 3246-56 (2002)
Enoyl-ACP Reductase (FabI) Haemophilus influenzae	aminopyridine deriv. 9 ((2E)-3-(6-aminopyridin-3-yl)-N-methyl-N-[(1-methyl...)	GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CSLS DrugBank PDB PubChem	PubMed	n/a	n/a	4200.0	n/a	n/a	6.5	30
GlaxoSmithKline		GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CSLS DrugBank PDB PubChem	PubMed	J Med Chem. 46: 1627-35 (2003)
Enoyl-ACP Reductase (FabI) Haemophilus influenzae	aminopyrimidine deriv. 10 ((2E)-3-(2-aminopyrimidin-5-yl)-N-methyl-N-[(1-meth...)	GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	4300.0	n/a	n/a	6.5	30
GlaxoSmithKline		GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	J Med Chem. 45: 3246-56 (2002)
Enoyl-ACP Reductase (FabI) Haemophilus influenzae	benzamide deriv. 5 (3-[(N-Acetyl-N-methylamino)methyl]-4-amino-N-methy...)	GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CSLS DrugBank PDB PubChem	PubMed	n/a	n/a	4700.0	n/a	n/a	6.5	30
GlaxoSmithKline		GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CSLS DrugBank PDB PubChem	PubMed	J Med Chem. 45: 3246-56 (2002)
Enoyl-ACP Reductase (FabI) Haemophilus influenzae	1,4-Benzodiazepine deriv. 2 ((2R)-2-[(Carbomethoxy)methyl]-N,4-dimethyl-N-(1-me...)	GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	5100.0	n/a	n/a	6.5	30
GlaxoSmithKline		GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	J Med Chem. 45: 3246-56 (2002)
Enoyl-ACP Reductase (FabI) Haemophilus influenzae	aminopyridine 5 ((2E)-3-(6-amino-5-methylpyridin-3-yl)-N-methyl-N-[...)	GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	6100.0	n/a	n/a	6.5	30
GlaxoSmithKline		GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	J Med Chem. 46: 1627-35 (2003)
Enoyl-ACP Reductase (FabI) Haemophilus influenzae	1,4-Benzodiazepine deriv. 1 (methyl 2-(4-methyl-7-{methyl[(1-methyl-1H-indol-2-...)	GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	6900.0	n/a	n/a	6.5	30
GlaxoSmithKline		GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	J Med Chem. 45: 3246-56 (2002)
Enoyl-ACP Reductase (FabI) Haemophilus influenzae	Acetamido deriv. 13 ((2E)-3-(6-acetamido-5-methylpyridin-3-yl)-N-methyl...)	GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	7600.0	n/a	n/a	6.5	30
GlaxoSmithKline		GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	J Med Chem. 46: 1627-35 (2003)
Enoyl-ACP Reductase (FabI) Haemophilus influenzae	acrylamide deriv. 13 ((2E)-3-(4-aminophenyl)-N-methyl-N-[(1-methyl-1H-in...)	GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	9000.0	n/a	n/a	6.5	30
GlaxoSmithKline		GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	J Med Chem. 45: 3246-56 (2002)
Enoyl-ACP Reductase (FabI) Haemophilus influenzae	aminopyridine deriv. 14 ((2E)-N-methyl-N-[(1-methyl-1H-indol-2-yl)methyl]-3...)	GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	15200.0	n/a	n/a	6.5	30
GlaxoSmithKline		GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	J Med Chem. 45: 3246-56 (2002)
Enoyl-ACP Reductase (FabI) Haemophilus influenzae	aminopyridine deriv. 12 (6-Amino-N-methyl-N-(1-methyl-1H-indol-2-yl)nicotin...)	GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	19200.0	n/a	n/a	6.5	30
GlaxoSmithKline		GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	J Med Chem. 45: 3246-56 (2002)
Enoyl-ACP Reductase (FabI) Haemophilus influenzae	aminopyridine deriv. 11 (3-(6-Aminopyridin-3-yl)-N-methyl-N-[(1-methyl-1H-i...)	GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	97400.0	n/a	n/a	6.5	30
GlaxoSmithKline		GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	J Med Chem. 45: 3246-56 (2002)
Enoyl-ACP Reductase (FabI) Haemophilus influenzae	benzamide deriv. 8 (N-Methyl-N-(1-methyl-1H-indol-2-ylmethyl)benzamide...)	GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	>100000.0	n/a	n/a	6.5	30
GlaxoSmithKline		GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	J Med Chem. 45: 3246-56 (2002)
Enoyl-ACP Reductase (FabI) Haemophilus influenzae	1,4-Benzodiazepine deriv. 3 ((2S)-2-[(Carbomethoxy)methyl]-N,4-dimethyl-N-(1-me...)	GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	>100000.0	n/a	n/a	6.5	30
GlaxoSmithKline		GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	J Med Chem. 45: 3246-56 (2002)
Enoyl-ACP Reductase (FabI) Haemophilus influenzae	benzamide deriv. 6 (3-[(N-Acetyl-N-methylamino)methyl]-N-methyl-N-(1-m...)	GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	121000.0	n/a	n/a	6.5	30
GlaxoSmithKline		GoogleScholar UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	J Med Chem. 45: 3246-56 (2002)

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