Compile Data Set for Download or QSAR
maximum 50k data
Found 283 of ic50 data for polymerid = 1098,129,50000450
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590927(APILIMOD | Apilimod | STA 5326 | STA-5326 | Sta-53...)
Affinity DataIC50:  0.309nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590927(APILIMOD | Apilimod | STA 5326 | STA-5326 | Sta-53...)
Affinity DataIC50:  0.312nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590928(CHEMBL2178735)
Affinity DataIC50:  0.820nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590929(CHEMBL4303292 | US20240016810, Compound TABLE 16.2)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590929(CHEMBL4303292 | US20240016810, Compound TABLE 16.2)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590943(CHEMBL5189479)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590942(CHEMBL5193848)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50429615(CHEMBL2334586)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50429615(CHEMBL2334586)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human wild type partial length PIKfyve (F1512 to C2098 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590927(APILIMOD | Apilimod | STA 5326 | STA-5326 | Sta-53...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590929(CHEMBL4303292 | US20240016810, Compound TABLE 16.2)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590939(CHEMBL5174830)
Affinity DataIC50:  4nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590939(CHEMBL5174830)
Affinity DataIC50:  4nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590956(CHEMBL5171359)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590931(CHEMBL5181163)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590941(CHEMBL5198944)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590939(CHEMBL5174830)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590934(CHEMBL5207387)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50595937(CHEMBL5194705)
Affinity DataIC50:  9nMAssay Description:Inhibition of PIKFYVE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590935(CHEMBL5171753)
Affinity DataIC50:  9.30nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590942(CHEMBL5193848)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCaspase-2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50160957(CHEMBL179503 | [3-(2-{5-tert-Butyl-3-[(4-methyl-fu...)
Affinity DataIC50: >10nMAssay Description:Inhibitory concentration against casp-2 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50160974(CHEMBL366927 | [3-(2-{5-tert-Butyl-3-[(4-methyl-fu...)
Affinity DataIC50: >10nMAssay Description:Inhibitory concentration against casp-2 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590935(CHEMBL5171753)
Affinity DataIC50:  11nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590935(CHEMBL5171753)
Affinity DataIC50:  11nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590943(CHEMBL5189479)
Affinity DataIC50:  13nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590943(CHEMBL5189479)
Affinity DataIC50:  13nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590927(APILIMOD | Apilimod | STA 5326 | STA-5326 | Sta-53...)
Affinity DataIC50:  14nMAssay Description:Inhibition of PIKFYVE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590927(APILIMOD | Apilimod | STA 5326 | STA-5326 | Sta-53...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human PIKfyve (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50429615(CHEMBL2334586)
Affinity DataIC50:  14nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590927(APILIMOD | Apilimod | STA 5326 | STA-5326 | Sta-53...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human PIKfyve in HEK293 lysate using di-C8 PI(3)P as substrate preincubated for 5 mins followed by substrate addition measured after 2 ...More data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590931(CHEMBL5181163)
Affinity DataIC50:  21nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590932(CHEMBL5190524)
Affinity DataIC50:  22nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCaspase-2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355101(CHEMBL1835324)
Affinity DataIC50:  22nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590937(CHEMBL5188159)
Affinity DataIC50:  26nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590928(CHEMBL2178735)
Affinity DataIC50:  33nMAssay Description:Inhibition of PIKFYVE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590928(CHEMBL2178735)
Affinity DataIC50:  33nMAssay Description:Inhibition of PIKFYVE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590936(CHEMBL5200109)
Affinity DataIC50:  34nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50511422(CHEMBL4446338)
Affinity DataIC50:  40nMAssay Description:Inhibition of N-terminal GST-tagged full length human PIKFYVE (1 to 2098 residues) using PI(3)P and Phosphatidylserine as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590957(CHEMBL5185288)
Affinity DataIC50:  40nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCaspase-2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355111(CHEMBL1835210)
Affinity DataIC50:  41nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355110(CHEMBL1835208)
Affinity DataIC50:  41nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355109(CHEMBL1835209)
Affinity DataIC50:  46nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590952(CHEMBL5190153)
Affinity DataIC50:  46nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCaspase-2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50355103(CHEMBL1835399)
Affinity DataIC50:  50nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM645744(US20240018151, Example 1 | US20240018151, Example ...)
Affinity DataIC50: <50nMAssay Description:Briefly, 4?? compound solution and 4??ATP solution are prepared with assay buffer (50 mM MOPS, 1 mM DTT, pH7.2). 4?? Substrate solution and 4?? kinas...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM645746(US20240018151, Example 3)
Affinity DataIC50: <50nMAssay Description:Briefly, 4?? compound solution and 4??ATP solution are prepared with assay buffer (50 mM MOPS, 1 mM DTT, pH7.2). 4?? Substrate solution and 4?? kinas...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM645747(US20240018151, Example 4)
Affinity DataIC50: <50nMAssay Description:Briefly, 4?? compound solution and 4??ATP solution are prepared with assay buffer (50 mM MOPS, 1 mM DTT, pH7.2). 4?? Substrate solution and 4?? kinas...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM645749(US20240018151, Example 15 | US20240018151, Example...)
Affinity DataIC50: <50nMAssay Description:Briefly, 4?? compound solution and 4??ATP solution are prepared with assay buffer (50 mM MOPS, 1 mM DTT, pH7.2). 4?? Substrate solution and 4?? kinas...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM645751(US20240018151, Example 8)
Affinity DataIC50: <50nMAssay Description:Briefly, 4?? compound solution and 4??ATP solution are prepared with assay buffer (50 mM MOPS, 1 mM DTT, pH7.2). 4?? Substrate solution and 4?? kinas...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
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