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Compile Data Set for Download or QSAR

Found 138 hits for UniProtKB: Q9UDY8   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50169049
PNG
(CHEMBL3806155)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(c(c2)C(F)(F)F)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H15ClF3N9O2/c1-9(33-2)15-12(8-23-14-6-13(19)29-30(14)15)28-17(32)27-10-5-11(18(20,21)22)16(24-7-10)31-25-3-4-26-31/h3-9H,1-2H3,(H2,27,28,32)/t9-/m0/s1
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PubMed
n/an/a 0.00200n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 C domain (329 to 824 residues) (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg-Cys(PT14)-NH2 as substrate preincubated for 60 mins ...


ACS Med Chem Lett 7: 205-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00015
BindingDB Entry DOI: 10.7270/Q2K07658
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50169052
PNG
(CHEMBL3806235)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2cnc3cc(Cl)nn3c2C2CCCO2)cnc1-n1nccn1
Show InChI InChI=1S/C19H15ClF3N9O2/c20-14-7-15-24-9-12(16(31(15)30-14)13-2-1-5-34-13)29-18(33)28-10-6-11(19(21,22)23)17(25-8-10)32-26-3-4-27-32/h3-4,6-9,13H,1-2,5H2,(H2,28,29,33)
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UniProtKB/SwissProt

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UniChem
Article
PubMed
n/an/a 0.00400n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 C domain (329 to 824 residues) (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg-Cys(PT14)-NH2 as substrate preincubated for 60 mins ...


ACS Med Chem Lett 7: 205-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00015
BindingDB Entry DOI: 10.7270/Q2K07658
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50169051
PNG
(CHEMBL3805576)
Show SMILES CC(C)c1c(NC(=O)Nc2cnc(N3CCCS3(=O)=O)c(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H19ClF3N7O3S/c1-10(2)16-13(9-24-15-7-14(20)28-30(15)16)27-18(31)26-11-6-12(19(21,22)23)17(25-8-11)29-4-3-5-34(29,32)33/h6-10H,3-5H2,1-2H3,(H2,26,27,31)
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PubMed
n/an/a 0.00600n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 C domain (329 to 824 residues) (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg-Cys(PT14)-NH2 as substrate preincubated for 60 mins ...


ACS Med Chem Lett 7: 205-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00015
BindingDB Entry DOI: 10.7270/Q2K07658
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50169054
PNG
(CHEMBL3805390)
Show SMILES COCC(C1CC1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C20H19Cl2N9O2/c1-33-10-13(11-2-3-11)18-15(9-23-17-7-16(22)29-30(17)18)28-20(32)27-12-6-14(21)19(24-8-12)31-25-4-5-26-31/h4-9,11,13H,2-3,10H2,1H3,(H2,27,28,32)
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PubMed
n/an/a 0.00600n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 C domain (329 to 824 residues) (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg-Cys(PT14)-NH2 as substrate preincubated for 60 mins ...


ACS Med Chem Lett 7: 205-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00015
BindingDB Entry DOI: 10.7270/Q2K07658
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50169055
PNG
(CHEMBL3806299)
Show SMILES CC(C)c1c(NC(=O)Nc2ccc(c(Cl)c2)-n2cc(CN)cn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C20H20Cl2N8O/c1-11(2)19-15(9-24-18-6-17(22)28-30(18)19)27-20(31)26-13-3-4-16(14(21)5-13)29-10-12(7-23)8-25-29/h3-6,8-11H,7,23H2,1-2H3,(H2,26,27,31)
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PubMed
n/an/a 0.00800n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 C domain (329 to 824 residues) (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg-Cys(PT14)-NH2 as substrate preincubated for 60 mins ...


ACS Med Chem Lett 7: 205-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00015
BindingDB Entry DOI: 10.7270/Q2K07658
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50169050
PNG
(CHEMBL3806279)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cncc(c2)C(F)(F)F)cnc2cc(C)nn12
Show InChI InChI=1S/C17H17F3N6O2/c1-9-4-14-22-8-13(15(10(2)28-3)26(14)25-9)24-16(27)23-12-5-11(6-21-7-12)17(18,19)20/h4-8,10H,1-3H3,(H2,23,24,27)/t10-/m0/s1
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Article
PubMed
n/an/a 0.0100n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 C domain (329 to 824 residues) (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg-Cys(PT14)-NH2 as substrate preincubated for 60 mins ...


ACS Med Chem Lett 7: 205-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00015
BindingDB Entry DOI: 10.7270/Q2K07658
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50169049
PNG
(CHEMBL3806155)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(c(c2)C(F)(F)F)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C18H15ClF3N9O2/c1-9(33-2)15-12(8-23-14-6-13(19)29-30(14)15)28-17(32)27-10-5-11(18(20,21)22)16(24-7-10)31-25-3-4-26-31/h3-9H,1-2H3,(H2,27,28,32)/t9-/m0/s1
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PubMed
n/an/a 0.0230n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 (unknown origin) expressed in human Jurkat Clone K22 29Q_H23 cells assessed as IL2 production preincubated for 30 mins followed b...


ACS Med Chem Lett 7: 205-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00015
BindingDB Entry DOI: 10.7270/Q2K07658
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50169054
PNG
(CHEMBL3805390)
Show SMILES COCC(C1CC1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C20H19Cl2N9O2/c1-33-10-13(11-2-3-11)18-15(9-23-17-7-16(22)29-30(17)18)28-20(32)27-12-6-14(21)19(24-8-12)31-25-4-5-26-31/h4-9,11,13H,2-3,10H2,1H3,(H2,27,28,32)
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PC sid
UniChem
Article
PubMed
n/an/a 0.0280n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 (unknown origin) expressed in human Jurkat Clone K22 29Q_H23 cells assessed as IL2 production preincubated for 30 mins followed b...


ACS Med Chem Lett 7: 205-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00015
BindingDB Entry DOI: 10.7270/Q2K07658
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50169050
PNG
(CHEMBL3806279)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cncc(c2)C(F)(F)F)cnc2cc(C)nn12
Show InChI InChI=1S/C17H17F3N6O2/c1-9-4-14-22-8-13(15(10(2)28-3)26(14)25-9)24-16(27)23-12-5-11(6-21-7-12)17(18,19)20/h4-8,10H,1-3H3,(H2,23,24,27)/t10-/m0/s1
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PubMed
n/an/a 0.0520n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 (unknown origin) expressed in human Jurkat Clone K22 29Q_H23 cells assessed as IL2 production preincubated for 30 mins followed b...


ACS Med Chem Lett 7: 205-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00015
BindingDB Entry DOI: 10.7270/Q2K07658
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50169052
PNG
(CHEMBL3806235)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2cnc3cc(Cl)nn3c2C2CCCO2)cnc1-n1nccn1
Show InChI InChI=1S/C19H15ClF3N9O2/c20-14-7-15-24-9-12(16(31(15)30-14)13-2-1-5-34-13)29-18(33)28-10-6-11(19(21,22)23)17(25-8-10)32-26-3-4-27-32/h3-4,6-9,13H,1-2,5H2,(H2,28,29,33)
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Article
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n/an/a 0.0940n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 (unknown origin) expressed in human Jurkat Clone K22 29Q_H23 cells assessed as IL2 production preincubated for 30 mins followed b...


ACS Med Chem Lett 7: 205-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00015
BindingDB Entry DOI: 10.7270/Q2K07658
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50169055
PNG
(CHEMBL3806299)
Show SMILES CC(C)c1c(NC(=O)Nc2ccc(c(Cl)c2)-n2cc(CN)cn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C20H20Cl2N8O/c1-11(2)19-15(9-24-18-6-17(22)28-30(18)19)27-20(31)26-13-3-4-16(14(21)5-13)29-10-12(7-23)8-25-29/h3-6,8-11H,7,23H2,1-2H3,(H2,26,27,31)
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n/an/a 0.134n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 (unknown origin) expressed in human Jurkat Clone K22 29Q_H23 cells assessed as IL2 production preincubated for 30 mins followed b...


ACS Med Chem Lett 7: 205-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00015
BindingDB Entry DOI: 10.7270/Q2K07658
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50169051
PNG
(CHEMBL3805576)
Show SMILES CC(C)c1c(NC(=O)Nc2cnc(N3CCCS3(=O)=O)c(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H19ClF3N7O3S/c1-10(2)16-13(9-24-15-7-14(20)28-30(15)16)27-18(31)26-11-6-12(19(21,22)23)17(25-8-11)29-4-3-5-34(29,32)33/h6-10H,3-5H2,1-2H3,(H2,26,27,31)
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PubMed
n/an/a 0.248n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 (unknown origin) expressed in human Jurkat Clone K22 29Q_H23 cells assessed as IL2 production preincubated for 30 mins followed b...


ACS Med Chem Lett 7: 205-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00015
BindingDB Entry DOI: 10.7270/Q2K07658
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50133328
PNG
(CHEMBL3632807)
Show SMILES CC1(C)CCC2=C(O1)c1ccc(cc1C(=O)C2=O)[N+]([O-])=O
Show InChI InChI=1S/C15H13NO5/c1-15(2)6-5-10-12(17)13(18)11-7-8(16(19)20)3-4-9(11)14(10)21-15/h3-4,7H,5-6H2,1-2H3
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n/an/a 400n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate


J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM260159
PNG
(BDBM50177661 | US9504692, Mepezine)
Show SMILES CN1CCCC(CN2c3ccccc3Sc3ccccc23)C1
Show InChI InChI=1S/C19H22N2S/c1-20-12-6-7-15(13-20)14-21-16-8-2-4-10-18(16)22-19-11-5-3-9-17(19)21/h2-5,8-11,15H,6-7,12-14H2,1H3
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n/an/a 420n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of GST-MALT1 (325 to 760 residues) (unknown origin) using Ac-LRSR-AMC as substrate by fluorescence analysis


Bioorg Med Chem 24: 3312-29 (2016)


Article DOI: 10.1016/j.bmc.2016.03.035
BindingDB Entry DOI: 10.7270/Q21G0P58
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50133350
PNG
(8-methoxy-beta-lapachone | CHEMBL2036880)
Show SMILES COc1ccc2C3=C(CCC(C)(C)O3)C(=O)C(=O)c2c1
Show InChI InChI=1S/C16H16O4/c1-16(2)7-6-11-13(17)14(18)12-8-9(19-3)4-5-10(12)15(11)20-16/h4-5,8H,6-7H2,1-3H3
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n/an/a 600n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate


J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
GST-MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM260181
PNG
(US9504692, 4116)
Show SMILES CN1CCC(O)C(CN2c3ccccc3Sc3ccccc23)C1
Show InChI InChI=1S/C19H22N2OS/c1-20-11-10-17(22)14(12-20)13-21-15-6-2-4-8-18(15)23-19-9-5-3-7-16(19)21/h2-9,14,17,22H,10-13H2,1H3
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n/an/a 690n/an/an/an/an/a30



HELMHOLTZ ZENTRUM MUNCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH)

US Patent


Assay Description
To screen for small molecular weight compounds that can inhibit MALT1 protease activity, recombinant GSTMALT1 was purified from E. coli to establish ...


US Patent US9504692 (2016)


BindingDB Entry DOI: 10.7270/Q21C1VSR
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM260159
PNG
(BDBM50177661 | US9504692, Mepezine)
Show SMILES CN1CCCC(CN2c3ccccc3Sc3ccccc23)C1
Show InChI InChI=1S/C19H22N2S/c1-20-12-6-7-15(13-20)14-21-16-8-2-4-10-18(16)22-19-11-5-3-9-17(19)21/h2-5,8-11,15H,6-7,12-14H2,1H3
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n/an/a 830n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length GST-MALT1 (unknown origin) expressed in Escherichia coli using Ac-LRSR-AMC as substrate by fluorescence analysi...


Bioorg Med Chem 24: 3312-29 (2016)


Article DOI: 10.1016/j.bmc.2016.03.035
BindingDB Entry DOI: 10.7270/Q21G0P58
More data for this
Ligand-Target Pair
GST-MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM260159
PNG
(BDBM50177661 | US9504692, Mepezine)
Show SMILES CN1CCCC(CN2c3ccccc3Sc3ccccc23)C1
Show InChI InChI=1S/C19H22N2S/c1-20-12-6-7-15(13-20)14-21-16-8-2-4-10-18(16)22-19-11-5-3-9-17(19)21/h2-5,8-11,15H,6-7,12-14H2,1H3
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n/an/a 850n/an/an/an/an/a30



HELMHOLTZ ZENTRUM MUNCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH)

US Patent


Assay Description
To screen for small molecular weight compounds that can inhibit MALT1 protease activity, recombinant GSTMALT1 was purified from E. coli to establish ...


US Patent US9504692 (2016)


BindingDB Entry DOI: 10.7270/Q21C1VSR
More data for this
Ligand-Target Pair
GST-MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM260190
PNG
(US9504692, 3998)
Show SMILES CN1CCCC(CN2c3ccccc3Sc3ccc(Cl)cc23)C1
Show InChI InChI=1S/C19H21ClN2S/c1-21-10-4-5-14(12-21)13-22-16-6-2-3-7-18(16)23-19-9-8-15(20)11-17(19)22/h2-3,6-9,11,14H,4-5,10,12-13H2,1H3
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n/an/a 970n/an/an/an/an/a30



HELMHOLTZ ZENTRUM MUNCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH)

US Patent


Assay Description
To screen for small molecular weight compounds that can inhibit MALT1 protease activity, recombinant GSTMALT1 was purified from E. coli to establish ...


US Patent US9504692 (2016)


BindingDB Entry DOI: 10.7270/Q21C1VSR
More data for this
Ligand-Target Pair
GST-MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM260193
PNG
(US9504692, 4057)
Show SMILES CN1CCCC(CN2c3ccccc3Sc3cc(Cl)ccc23)C1
Show InChI InChI=1S/C19H21ClN2S/c1-21-10-4-5-14(12-21)13-22-16-6-2-3-7-18(16)23-19-11-15(20)8-9-17(19)22/h2-3,6-9,11,14H,4-5,10,12-13H2,1H3
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n/an/a 973n/an/an/an/an/a30



HELMHOLTZ ZENTRUM MUNCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH)

US Patent


Assay Description
To screen for small molecular weight compounds that can inhibit MALT1 protease activity, recombinant GSTMALT1 was purified from E. coli to establish ...


US Patent US9504692 (2016)


BindingDB Entry DOI: 10.7270/Q21C1VSR
More data for this
Ligand-Target Pair
GST-MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM260178
PNG
(US9504692, 3916)
Show SMILES CN1CCOC(CN2c3ccccc3Sc3ccccc23)C1
Show InChI InChI=1S/C18H20N2OS/c1-19-10-11-21-14(12-19)13-20-15-6-2-4-8-17(15)22-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3
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n/an/a 1.18E+3n/an/an/an/an/a30



HELMHOLTZ ZENTRUM MUNCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH)

US Patent


Assay Description
To screen for small molecular weight compounds that can inhibit MALT1 protease activity, recombinant GSTMALT1 was purified from E. coli to establish ...


US Patent US9504692 (2016)


BindingDB Entry DOI: 10.7270/Q21C1VSR
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM81348
PNG
(β-Lapachone (A3) | R115 (Reactive Blue 2))
Show SMILES CC1(C)CCC2=C(O1)c1ccccc1C(=O)C2=O
Show InChI InChI=1S/C15H14O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6H,7-8H2,1-2H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate


J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
GST-MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM260172
PNG
(US9504692, 3951)
Show SMILES CCN1CCCC(CN2c3ccccc3Sc3ccccc23)C1
Show InChI InChI=1S/C20H24N2S/c1-2-21-13-7-8-16(14-21)15-22-17-9-3-5-11-19(17)23-20-12-6-4-10-18(20)22/h3-6,9-12,16H,2,7-8,13-15H2,1H3
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n/an/a 1.42E+3n/an/an/an/an/a30



HELMHOLTZ ZENTRUM MUNCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH)

US Patent


Assay Description
To screen for small molecular weight compounds that can inhibit MALT1 protease activity, recombinant GSTMALT1 was purified from E. coli to establish ...


US Patent US9504692 (2016)


BindingDB Entry DOI: 10.7270/Q21C1VSR
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50133331
PNG
(CHEMBL3632804)
Show SMILES CC1(C)CCC2=C(O1)c1ccc(F)cc1C(=O)C2=O
Show InChI InChI=1S/C15H13FO3/c1-15(2)6-5-10-12(17)13(18)11-7-8(16)3-4-9(11)14(10)19-15/h3-4,7H,5-6H2,1-2H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate


J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50133340
PNG
(CHEMBL3635001)
Show SMILES O=C1C=C(NC2CCN(Cc3ccccc3)C2)c2ccccc2C1=O
Show InChI InChI=1S/C21H20N2O2/c24-20-12-19(17-8-4-5-9-18(17)21(20)25)22-16-10-11-23(14-16)13-15-6-2-1-3-7-15/h1-9,12,16,22H,10-11,13-14H2
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n/an/a 1.50E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...


J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50177471
PNG
(CHEMBL3813831)
Show SMILES COCCOc1nc(-c2ccc(Br)cc2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C19H18BrClN4O3/c1-27-10-11-28-19-23-18(13-2-4-14(20)5-3-13)25(24-19)16-8-6-15(7-9-16)22-17(26)12-21/h2-9H,10-12H2,1H3,(H,22,26)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Malt1 (unknown origin) at 10 to 1000 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyph...


Bioorg Med Chem 24: 3312-29 (2016)


Article DOI: 10.1016/j.bmc.2016.03.035
BindingDB Entry DOI: 10.7270/Q21G0P58
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50177471
PNG
(CHEMBL3813831)
Show SMILES COCCOc1nc(-c2ccc(Br)cc2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C19H18BrClN4O3/c1-27-10-11-28-19-23-18(13-2-4-14(20)5-3-13)25(24-19)16-8-6-15(7-9-16)22-17(26)12-21/h2-9H,10-12H2,1H3,(H,22,26)
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n/an/a 1.51E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Malt1 (unknown origin) at 10 to 1000 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyph...


Bioorg Med Chem 24: 3312-29 (2016)


Article DOI: 10.1016/j.bmc.2016.03.035
BindingDB Entry DOI: 10.7270/Q21G0P58
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50177153
PNG
(CHEMBL3814576)
Show SMILES COCCOc1nc(-c2ccc(Cl)cc2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C19H18Cl2N4O3/c1-27-10-11-28-19-23-18(13-2-4-14(21)5-3-13)25(24-19)16-8-6-15(7-9-16)22-17(26)12-20/h2-9H,10-12H2,1H3,(H,22,26)
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n/an/a 1.55E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Malt1 (unknown origin) at 10 to 1000 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyph...


Bioorg Med Chem 24: 3312-29 (2016)


Article DOI: 10.1016/j.bmc.2016.03.035
BindingDB Entry DOI: 10.7270/Q21G0P58
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50177153
PNG
(CHEMBL3814576)
Show SMILES COCCOc1nc(-c2ccc(Cl)cc2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C19H18Cl2N4O3/c1-27-10-11-28-19-23-18(13-2-4-14(21)5-3-13)25(24-19)16-8-6-15(7-9-16)22-17(26)12-20/h2-9H,10-12H2,1H3,(H,22,26)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Malt1 (unknown origin) at 10 to 1000 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyph...


Bioorg Med Chem 24: 3312-29 (2016)


Article DOI: 10.1016/j.bmc.2016.03.035
BindingDB Entry DOI: 10.7270/Q21G0P58
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50133347
PNG
(CHEMBL3634995)
Show SMILES CN(C)CCNC1=CC(=O)C(=O)c2ccccc12
Show InChI InChI=1S/C14H16N2O2/c1-16(2)8-7-15-12-9-13(17)14(18)11-6-4-3-5-10(11)12/h3-6,9,15H,7-8H2,1-2H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...


J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50133329
PNG
(CHEMBL3632806)
Show SMILES CC1(C)CCC2=C(O1)c1ccc(cc1C(=O)C2=O)C#N
Show InChI InChI=1S/C16H13NO3/c1-16(2)6-5-11-13(18)14(19)12-7-9(8-17)3-4-10(12)15(11)20-16/h3-4,7H,5-6H2,1-2H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate


J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
GST-MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM260194
PNG
(US9504692, 4090)
Show SMILES COc1ccc2N(CC3CCCN(C)C3)c3ccccc3Sc2c1
Show InChI InChI=1S/C20H24N2OS/c1-21-11-5-6-15(13-21)14-22-17-7-3-4-8-19(17)24-20-12-16(23-2)9-10-18(20)22/h3-4,7-10,12,15H,5-6,11,13-14H2,1-2H3
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n/an/a 1.75E+3n/an/an/an/an/a30



HELMHOLTZ ZENTRUM MUNCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH)

US Patent


Assay Description
To screen for small molecular weight compounds that can inhibit MALT1 protease activity, recombinant GSTMALT1 was purified from E. coli to establish ...


US Patent US9504692 (2016)


BindingDB Entry DOI: 10.7270/Q21C1VSR
More data for this
Ligand-Target Pair
GST-MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM260191
PNG
(US9504692, 4124)
Show SMILES CN1CCCC(CN2c3ccccc3Sc3cc(C)ccc23)C1
Show InChI InChI=1S/C20H24N2S/c1-15-9-10-18-20(12-15)23-19-8-4-3-7-17(19)22(18)14-16-6-5-11-21(2)13-16/h3-4,7-10,12,16H,5-6,11,13-14H2,1-2H3
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n/an/a 1.85E+3n/an/an/an/an/a30



HELMHOLTZ ZENTRUM MUNCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH)

US Patent


Assay Description
To screen for small molecular weight compounds that can inhibit MALT1 protease activity, recombinant GSTMALT1 was purified from E. coli to establish ...


US Patent US9504692 (2016)


BindingDB Entry DOI: 10.7270/Q21C1VSR
More data for this
Ligand-Target Pair
GST-MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM260191
PNG
(US9504692, 4124)
Show SMILES CN1CCCC(CN2c3ccccc3Sc3cc(C)ccc23)C1
Show InChI InChI=1S/C20H24N2S/c1-15-9-10-18-20(12-15)23-19-8-4-3-7-17(19)22(18)14-16-6-5-11-21(2)13-16/h3-4,7-10,12,16H,5-6,11,13-14H2,1-2H3
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n/an/a 1.85E+3n/an/an/an/an/a30



HELMHOLTZ ZENTRUM MUNCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH)

US Patent


Assay Description
To screen for small molecular weight compounds that can inhibit MALT1 protease activity, recombinant GSTMALT1 was purified from E. coli to establish ...


US Patent US9504692 (2016)


BindingDB Entry DOI: 10.7270/Q21C1VSR
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM81348
PNG
(β-Lapachone (A3) | R115 (Reactive Blue 2))
Show SMILES CC1(C)CCC2=C(O1)c1ccccc1C(=O)C2=O
Show InChI InChI=1S/C15H14O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6H,7-8H2,1-2H3
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n/an/a 1.90E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...


J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
GST-MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM260190
PNG
(US9504692, 3998)
Show SMILES CN1CCCC(CN2c3ccccc3Sc3ccc(Cl)cc23)C1
Show InChI InChI=1S/C19H21ClN2S/c1-21-10-4-5-14(12-21)13-22-16-6-2-3-7-18(16)23-19-9-8-15(20)11-17(19)22/h2-3,6-9,11,14H,4-5,10,12-13H2,1H3
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n/an/a 2.00E+3n/an/an/an/an/a30



HELMHOLTZ ZENTRUM MUNCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH)

US Patent


Assay Description
To screen for small molecular weight compounds that can inhibit MALT1 protease activity, recombinant GSTMALT1 was purified from E. coli to establish ...


US Patent US9504692 (2016)


BindingDB Entry DOI: 10.7270/Q21C1VSR
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50177471
PNG
(CHEMBL3813831)
Show SMILES COCCOc1nc(-c2ccc(Br)cc2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C19H18BrClN4O3/c1-27-10-11-28-19-23-18(13-2-4-14(20)5-3-13)25(24-19)16-8-6-15(7-9-16)22-17(26)12-21/h2-9H,10-12H2,1H3,(H,22,26)
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n/an/a 2.09E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Malt1 (unknown origin) at 1 to 100 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyphen...


Bioorg Med Chem 24: 3312-29 (2016)


Article DOI: 10.1016/j.bmc.2016.03.035
BindingDB Entry DOI: 10.7270/Q21G0P58
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50177471
PNG
(CHEMBL3813831)
Show SMILES COCCOc1nc(-c2ccc(Br)cc2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C19H18BrClN4O3/c1-27-10-11-28-19-23-18(13-2-4-14(20)5-3-13)25(24-19)16-8-6-15(7-9-16)22-17(26)12-21/h2-9H,10-12H2,1H3,(H,22,26)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Malt1 (unknown origin) at 1 to 100 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyphen...


Bioorg Med Chem 24: 3312-29 (2016)


Article DOI: 10.1016/j.bmc.2016.03.035
BindingDB Entry DOI: 10.7270/Q21G0P58
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50133351
PNG
(CHEMBL177685)
Show SMILES COc1cc2C(=O)C(=O)C3=C(OC(C)(C)CC3)c2cc1OC
Show InChI InChI=1S/C17H18O5/c1-17(2)6-5-9-14(18)15(19)10-7-12(20-3)13(21-4)8-11(10)16(9)22-17/h7-8H,5-6H2,1-4H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate


J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
GST-MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM260189
PNG
(US9504692, 3997)
Show SMILES CN1CCCC(CN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)C1
Show InChI InChI=1S/C20H21F3N2S/c1-24-10-4-5-14(12-24)13-25-16-6-2-3-7-18(16)26-19-9-8-15(11-17(19)25)20(21,22)23/h2-3,6-9,11,14H,4-5,10,12-13H2,1H3
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n/an/a 2.40E+3n/an/an/an/an/a30



HELMHOLTZ ZENTRUM MUNCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH)

US Patent


Assay Description
To screen for small molecular weight compounds that can inhibit MALT1 protease activity, recombinant GSTMALT1 was purified from E. coli to establish ...


US Patent US9504692 (2016)


BindingDB Entry DOI: 10.7270/Q21C1VSR
More data for this
Ligand-Target Pair
GST-MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM260192
PNG
(US9504692, 4058)
Show SMILES CN1CCCC(CN2c3ccccc3Sc3cc(ccc23)C(F)(F)F)C1
Show InChI InChI=1S/C20H21F3N2S/c1-24-10-4-5-14(12-24)13-25-16-6-2-3-7-18(16)26-19-11-15(20(21,22)23)8-9-17(19)25/h2-3,6-9,11,14H,4-5,10,12-13H2,1H3
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US Patent
n/an/a 2.41E+3n/an/an/an/an/a30



HELMHOLTZ ZENTRUM MUNCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH)

US Patent


Assay Description
To screen for small molecular weight compounds that can inhibit MALT1 protease activity, recombinant GSTMALT1 was purified from E. coli to establish ...


US Patent US9504692 (2016)


BindingDB Entry DOI: 10.7270/Q21C1VSR
More data for this
Ligand-Target Pair
GST-MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM260180
PNG
(US9504692, 4020)
Show SMILES CN1CCCCC1CN1c2ccccc2Sc2ccccc12
Show InChI InChI=1S/C19H22N2S/c1-20-13-7-6-8-15(20)14-21-16-9-2-4-11-18(16)22-19-12-5-3-10-17(19)21/h2-5,9-12,15H,6-8,13-14H2,1H3
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n/an/a 2.50E+3n/an/an/an/an/a30



HELMHOLTZ ZENTRUM MUNCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH)

US Patent


Assay Description
To screen for small molecular weight compounds that can inhibit MALT1 protease activity, recombinant GSTMALT1 was purified from E. coli to establish ...


US Patent US9504692 (2016)


BindingDB Entry DOI: 10.7270/Q21C1VSR
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50133349
PNG
(CHEMBL3634993)
Show SMILES CN(C)C1=CC(=O)C(=O)c2ccccc12
Show InChI InChI=1S/C12H11NO2/c1-13(2)10-7-11(14)12(15)9-6-4-3-5-8(9)10/h3-7H,1-2H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...


J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
GST-MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM260164
PNG
(US9504692, 3950)
Show SMILES C(CN1CCCC1)CN1c2ccccc2Sc2ccccc12
Show InChI InChI=1S/C19H22N2S/c1-3-10-18-16(8-1)21(15-7-14-20-12-5-6-13-20)17-9-2-4-11-19(17)22-18/h1-4,8-11H,5-7,12-15H2
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n/an/a 2.67E+3n/an/an/an/an/a30



HELMHOLTZ ZENTRUM MUNCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH)

US Patent


Assay Description
To screen for small molecular weight compounds that can inhibit MALT1 protease activity, recombinant GSTMALT1 was purified from E. coli to establish ...


US Patent US9504692 (2016)


BindingDB Entry DOI: 10.7270/Q21C1VSR
More data for this
Ligand-Target Pair
GST-MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM260177
PNG
(US9504692, 4037)
Show SMILES C(N1c2ccccc2Sc2ccccc12)c1ccccc1
Show InChI InChI=1S/C19H15NS/c1-2-8-15(9-3-1)14-20-16-10-4-6-12-18(16)21-19-13-7-5-11-17(19)20/h1-13H,14H2
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n/an/a 2.67E+3n/an/an/an/an/a30



HELMHOLTZ ZENTRUM MUNCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH)

US Patent


Assay Description
To screen for small molecular weight compounds that can inhibit MALT1 protease activity, recombinant GSTMALT1 was purified from E. coli to establish ...


US Patent US9504692 (2016)


BindingDB Entry DOI: 10.7270/Q21C1VSR
More data for this
Ligand-Target Pair
GST-MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM260173
PNG
(US9504692, 3949)
Show SMILES CC(C)N1CCCC(CN2c3ccccc3Sc3ccccc23)C1
Show InChI InChI=1S/C21H26N2S/c1-16(2)22-13-7-8-17(14-22)15-23-18-9-3-5-11-20(18)24-21-12-6-4-10-19(21)23/h3-6,9-12,16-17H,7-8,13-15H2,1-2H3
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n/an/a 2.77E+3n/an/an/an/an/a30



HELMHOLTZ ZENTRUM MUNCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH)

US Patent


Assay Description
To screen for small molecular weight compounds that can inhibit MALT1 protease activity, recombinant GSTMALT1 was purified from E. coli to establish ...


US Patent US9504692 (2016)


BindingDB Entry DOI: 10.7270/Q21C1VSR
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50177153
PNG
(CHEMBL3814576)
Show SMILES COCCOc1nc(-c2ccc(Cl)cc2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C19H18Cl2N4O3/c1-27-10-11-28-19-23-18(13-2-4-14(21)5-3-13)25(24-19)16-8-6-15(7-9-16)22-17(26)12-20/h2-9H,10-12H2,1H3,(H,22,26)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Malt1 (unknown origin) at 1 to 100 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyphen...


Bioorg Med Chem 24: 3312-29 (2016)


Article DOI: 10.1016/j.bmc.2016.03.035
BindingDB Entry DOI: 10.7270/Q21G0P58
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50133338
PNG
(CHEMBL3635003)
Show SMILES CNC(=O)CNC1=CC(=O)C(=O)c2ccccc12
Show InChI InChI=1S/C13H12N2O3/c1-14-12(17)7-15-10-6-11(16)13(18)9-5-3-2-4-8(9)10/h2-6,15H,7H2,1H3,(H,14,17)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...


J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50177153
PNG
(CHEMBL3814576)
Show SMILES COCCOc1nc(-c2ccc(Cl)cc2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C19H18Cl2N4O3/c1-27-10-11-28-19-23-18(13-2-4-14(21)5-3-13)25(24-19)16-8-6-15(7-9-16)22-17(26)12-20/h2-9H,10-12H2,1H3,(H,22,26)
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n/an/a 3.02E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Malt1 (unknown origin) at 1 to 100 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyphen...


Bioorg Med Chem 24: 3312-29 (2016)


Article DOI: 10.1016/j.bmc.2016.03.035
BindingDB Entry DOI: 10.7270/Q21G0P58
More data for this
Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1)


(Homo sapiens (Human))
BDBM50133336
PNG
(CHEMBL3632800)
Show SMILES O=C(CNC1=CC(=O)C(=O)c2ccccc12)NCCc1ccccc1
Show InChI InChI=1S/C20H18N2O3/c23-18-12-17(15-8-4-5-9-16(15)20(18)25)22-13-19(24)21-11-10-14-6-2-1-3-7-14/h1-9,12,22H,10-11,13H2,(H,21,24)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...


J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
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