Compile Data Set for Download or QSAR
(2D       Computed 3D by Vconf -m prep )

Data curated solely by BindingDB

Found 75 hits of affinity data for UniProtKB/TrEMBL: P55212

Target (Institution)	Ligand	Target Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	pH	Temp °C
Caspase-6 Homo sapiens (human)	Pyridine Scaffold 59 ((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	120.0	-39.50	n/a	n/a	n/a	7.4	25
Sunesis Pharmaceuticals					J Med Chem. 45: 5005-22 (2002)
Caspase-6 Homo sapiens (human)	Inhibitor 62b ((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	190.0	-38.36	n/a	n/a	n/a	7.4	25
Sunesis Pharmaceuticals					J Med Chem. 45: 5005-22 (2002)
Caspase-6 Homo sapiens (human)	Inhibitor 66a ((S)-5-5-(1-Carboxymethyl-2-oxo-ethylcarbamoyl)-thi...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	540.0	-35.77	n/a	n/a	n/a	7.4	25
Sunesis Pharmaceuticals					J Med Chem. 45: 5005-22 (2002)
Caspase-6 Homo sapiens (human)	Inhibitor 3 (5-{[(4-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	1000	-34.24	n/a	n/a	n/a	7.4	25
Sunesis Pharmaceuticals					J Med Chem. 45: 5005-22 (2002)
Caspase-6 Homo sapiens (human)	Isatin analog 2 (1-benzyl-5-nitro-2,3-dihydro-1H-indole-2,3-dione)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	1000	-34.82	n/a	n/a	n/a	7.4	30
GlaxoSmithKline					J Med Chem. 44: 2015-26 (2001)
Caspase-6 Homo sapiens (human)	Inhibitor 4 (5-{[(5-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	1400	-33.41	n/a	n/a	n/a	7.4	25
Sunesis Pharmaceuticals					J Med Chem. 45: 5005-22 (2002)
Caspase-6 Homo sapiens (human)	Isatin analog 1 (1-methyl-5-nitro-2,3-dihydro-1H-indole-2,3-dione)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	1700	-33.48	n/a	n/a	n/a	7.4	30
GlaxoSmithKline					J Med Chem. 44: 2015-26 (2001)
Caspase-6 Homo sapiens (human)	Inhibitor 64b ((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	2300	-32.18	n/a	n/a	n/a	7.4	25
Sunesis Pharmaceuticals					J Med Chem. 45: 5005-22 (2002)
Caspase-6 Homo sapiens (human)	Inhibitor 69b ((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	2400	-32.07	n/a	n/a	n/a	7.4	25
Sunesis Pharmaceuticals					J Med Chem. 45: 5005-22 (2002)
Caspase-6 Homo sapiens (human)	Isatin Sulfonamide 34 ((S)-1-Benzyl-5-{1-[2-(phenoxymethyl)pyrrolidinyl]s...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CHEBI CSLS PC cid PC sid	PubMed	>5000	>-30.76	n/a	n/a	n/a	7.4	30
GlaxoSmithKline					J Med Chem. 44: 2015-26 (2001)
Caspase-6 Homo sapiens (human)	Isatin Sulfonamide 26 ((S)-5-{1-[2-(Anilinomethyl)pyrrolidinyl]sulfonyl}i...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	7500	-29.74	n/a	n/a	n/a	7.4	30
GlaxoSmithKline					J Med Chem. 44: 2015-26 (2001)
Caspase-6 Homo sapiens (human)	Inhibitor 66b ((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	9700	-28.61	n/a	n/a	n/a	7.4	25
Sunesis Pharmaceuticals					J Med Chem. 45: 5005-22 (2002)
Caspase-6 Homo sapiens (human)	Inhibitor 47c (5-({[(5-{[(2S)-1-carboxy-4-{[(2-chlorophenyl)methy...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	22000	-26.58	n/a	n/a	n/a	7.4	25
Sunesis Pharmaceuticals					J Med Chem. 45: 5005-22 (2002)
Caspase-6 Homo sapiens (human)	Isatin Sulfonamide 16 ((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CHEBI CSLS PC cid PC sid	PubMed	>25000	>-26.70	n/a	n/a	n/a	7.4	30
GlaxoSmithKline					J Med Chem. 44: 2015-26 (2001)
Caspase-6 Homo sapiens (human)	Isatin Sulfonamide 29 ((S)-5-{1-[2-(Phenoxymethyl)pyrrolidinyl]sulfonyl}i...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CHEBI CSLS PC cid PC sid	PubMed	29000	-26.33	n/a	n/a	n/a	7.4	30
GlaxoSmithKline					J Med Chem. 44: 2015-26 (2001)
Caspase-6 Homo sapiens (human)	Isatin Sulfonamide 20 (5-(pyrrolidine-1-sulfonyl)-2,3-dihydro-1H-indole-2...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	>50000	>-24.96	n/a	n/a	n/a	7.4	30
GlaxoSmithKline					J Med Chem. 44: 2015-26 (2001)
Caspase-6 Homo sapiens (human)	Isatin Sulfonamide 27 ((R)-5-{1-[2-(Anilinomethyl)pyrrolidinyl]sulfonyl}i...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	57000	-24.63	n/a	n/a	n/a	7.4	30
GlaxoSmithKline					J Med Chem. 44: 2015-26 (2001)
Caspase-6 Homo sapiens (human)	Ac-VEID-CHO ((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	8.0	n/a	n/a	7.4	37
Washington University					J Med Chem. 52: 2188-91 (2009)
Caspase-6 Homo sapiens (human)	Ac-VEID-CHO ((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	60.5	n/a	n/a	7.4	37
Washington University School of Medicine					J Med Chem. 48: 7637-47 (2005)
Caspase-6 Homo sapiens (human)	Isoquinoline-1,3,4-trione 13c (4-Oxo-4-piperidin-1-yl-N-(1,3,4-trioxo-1,2,3,4-tet...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	124.0	n/a	n/a	7.5	35
Shanghai Institutes for Biological Sciences					J Med Chem. 49: 1613-23 (2006)
Caspase-6 Homo sapiens (human)	Isoquinoline-1,3,4-trione 13f (N-(2-Methoxy-phenyl)-N-(1,3,4-trioxo-1,2,3,4-tetra...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	137.0	n/a	n/a	7.5	35
Shanghai Institutes for Biological Sciences					J Med Chem. 49: 1613-23 (2006)
Caspase-6 Homo sapiens (human)	isatin Michael acceptor (IMA) analogue, 13a	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	151.0	n/a	n/a	7.4	37
Washington University					J Med Chem. 52: 2188-91 (2009)
Caspase-6 Homo sapiens (human)	isatin Michael acceptor (IMA) analogue, 18a	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	156.0	n/a	n/a	7.4	37
Washington University					J Med Chem. 52: 2188-91 (2009)
Caspase-6 Homo sapiens (human)	isatin Michael acceptor (IMA) analogue, 13b	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	188.0	n/a	n/a	7.4	37
Washington University					J Med Chem. 52: 2188-91 (2009)
Caspase-6 Homo sapiens (human)	isatin Michael acceptor (IMA) analogue, 18b	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	197.0	n/a	n/a	7.4	37
Washington University					J Med Chem. 52: 2188-91 (2009)
Caspase-6 Homo sapiens (human)	Isoquinoline-1,3,4-trione 12a (3-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-y...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	201.0	n/a	n/a	7.5	35
Shanghai Institutes for Biological Sciences					J Med Chem. 49: 1613-23 (2006)
Caspase-6 Homo sapiens (human)	Isoquinoline-1,3,4-trione 6k (2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydro...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid PDB	PubMed	n/a	n/a	216.0	n/a	n/a	7.5	35
Shanghai Institutes for Biological Sciences					J Med Chem. 49: 1613-23 (2006)
Caspase-6 Homo sapiens (human)	isatin Michael acceptor (IMA) analogue, 13c	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	230.0	n/a	n/a	7.4	37
Washington University					J Med Chem. 52: 2188-91 (2009)
Caspase-6 Homo sapiens (human)	isatin Michael acceptor (IMA) analogue, 19a	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	241.0	n/a	n/a	7.4	37
Washington University					J Med Chem. 52: 2188-91 (2009)
Caspase-6 Homo sapiens (human)	isatin Michael acceptor (IMA) analogue, 18c	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	280.0	n/a	n/a	7.4	37
Washington University					J Med Chem. 52: 2188-91 (2009)
Caspase-6 Homo sapiens (human)	Isoquinoline-1,3,4-trione 9k (3-Chloro-N-(1,2,3,4-tetrahydro-1,3,4-trioxoisoquin...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	283.0	n/a	n/a	7.5	35
Shanghai Institutes for Biological Sciences					J Med Chem. 49: 1613-23 (2006)
Caspase-6 Homo sapiens (human)	isatin Michael acceptor (IMA) analogue, 11a	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	325.0	n/a	n/a	7.4	37
Washington University					J Med Chem. 52: 2188-91 (2009)
Caspase-6 Homo sapiens (human)	isatin Michael acceptor (IMA) analogue, 19b	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	358.0	n/a	n/a	7.4	37
Washington University					J Med Chem. 52: 2188-91 (2009)
Caspase-6 Homo sapiens (human)	isatin Michael acceptor (IMA) analogue, 12a	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	425.0	n/a	n/a	7.4	37
Washington University					J Med Chem. 52: 2188-91 (2009)
Caspase-6 Homo sapiens (human)	isatin Michael acceptor (IMA) analogue, 12b	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	453.0	n/a	n/a	7.4	37
Washington University					J Med Chem. 52: 2188-91 (2009)
Caspase-6 Homo sapiens (human)	isatin Michael acceptor (IMA) analogue, 19c	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	468.0	n/a	n/a	7.4	37
Washington University					J Med Chem. 52: 2188-91 (2009)
Caspase-6 Homo sapiens (human)	Isoquinoline-1,3,4-trione 1 (1,2,3,4-tetrahydroisoquinoline-1,3,4-trione)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS MMDB PC cid PC sid PDB	PubMed	n/a	n/a	474.0	n/a	n/a	7.5	35
Shanghai Institutes for Biological Sciences					J Med Chem. 49: 1613-23 (2006)
Caspase-6 Homo sapiens (human)	isatin Michael acceptor (IMA) analogue, 11b	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	545.0	n/a	n/a	7.4	37
Washington University					J Med Chem. 52: 2188-91 (2009)
Caspase-6 Homo sapiens (human)	isatin Michael acceptor (IMA) analogue, 11c	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	568.0	n/a	n/a	7.4	37
Washington University					J Med Chem. 52: 2188-91 (2009)
Caspase-6 Homo sapiens (human)	isatin Michael acceptor (IMA) analogue, 12c	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	591.7	n/a	n/a	7.4	37
Washington University					J Med Chem. 52: 2188-91 (2009)
Caspase-6 Homo sapiens (human)	isatin Michael acceptor (IMA) analogue, 3	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CHEBI CSLS PC cid PC sid	PubMed	n/a	n/a	918.0	n/a	n/a	7.4	37
Washington University					J Med Chem. 52: 2188-91 (2009)
Caspase-6 Homo sapiens (human)	Isoquinoline-1,3,4-trione 14c (4-nitro-N-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquino...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	2850.0	n/a	n/a	7.5	35
Shanghai Institutes for Biological Sciences					J Med Chem. 49: 1613-23 (2006)
Caspase-6 Homo sapiens (human)	Isatin Sulfonamide 34 ((S)-1-Benzyl-5-{1-[2-(phenoxymethyl)pyrrolidinyl]s...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CHEBI CSLS PC cid PC sid	PubMed	n/a	n/a	>5000.0	n/a	n/a	7.4	37
Washington University					J Med Chem. 52: 2188-91 (2009)
Caspase-6 Homo sapiens (human)	Isatin Sulfonamide 34 ((S)-1-Benzyl-5-{1-[2-(phenoxymethyl)pyrrolidinyl]s...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CHEBI CSLS PC cid PC sid	PubMed	n/a	n/a	>5000.0	n/a	n/a	7.4	37
Washington University School of Medicine					J Med Chem. 48: 7637-47 (2005)
Caspase-6 Homo sapiens (human)	Pyrrolidine Isatin Analogue 11b ((S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-pyrroli...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CHEBI CSLS PC cid PC sid	PubMed	n/a	n/a	>5000.0	n/a	n/a	7.4	37
Washington University School of Medicine					J Med Chem. 48: 7637-47 (2005)
Caspase-6 Homo sapiens (human)	Pyrrolidine Isatin Analogue 11c ((S)-1-(4-Fluorobenzyl)-5-(2-phenoxymethyl-pyrrolid...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CHEBI CSLS PC cid PC sid	PubMed	n/a	n/a	>5000.0	n/a	n/a	7.4	37
Washington University School of Medicine					J Med Chem. 48: 7637-47 (2005)
Caspase-6 Homo sapiens (human)	Pyrrolidine Isatin Analogue 11d ((S)-1-(4-Methylthiobenzyl)-5-(2-phenoxymethyl-pyrr...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	>5000.0	n/a	n/a	7.4	37
Washington University School of Medicine					J Med Chem. 48: 7637-47 (2005)
Caspase-6 Homo sapiens (human)	Pyrrolidine Isatin Analogue 11e (4-[(2,3-dioxo-5-{[(2S)-2-(phenoxymethyl)pyrrolidin...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	>5000.0	n/a	n/a	7.4	37
Washington University School of Medicine					J Med Chem. 48: 7637-47 (2005)
Caspase-6 Homo sapiens (human)	Pyrrolidine Isatin Analogue 11f ((S)-1-(4-Hydroxybenzyl)-5-(2-phenoxymethyl-pyrroli...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CHEBI CSLS PC cid PC sid	PubMed	n/a	n/a	>5000.0	n/a	n/a	7.4	37
Washington University School of Medicine					J Med Chem. 48: 7637-47 (2005)
Caspase-6 Homo sapiens (human)	Pyrrolidine Isatin Analogue 11g ((S)-1-(6-Fluoropyridin-3-yl-methyl)-5-(2-phenoxyme...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	>5000.0	n/a	n/a	7.4	37
Washington University School of Medicine					J Med Chem. 48: 7637-47 (2005)

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