BindingDB PrimarySearch

Found 15 hits of ki data for polymerid = 1402
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein kinase Aurora-C (Homo sapiens (human))	BDBM13534 (CHEMBL572878 \| N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	0.00460	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description In vitro inhibition constant for Aurora-C				J Med Chem 49: 955-70 (2006) Article DOI: 10.1021/jm050786h BindingDB Entry DOI: 10.7270/Q24J0FXV
Centre de Recherches Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Aurora-C (Homo sapiens (human))	BDBM50315769 (3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Competitive inhibition of human Aurora C ATP binding site				J Med Chem 53: 3973-4001 (2010) Article DOI: 10.1021/jm901870q BindingDB Entry DOI: 10.7270/Q27082CK
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Aurora-C (Homo sapiens (human))	BDBM13534 (CHEMBL572878 \| N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	4.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of AURC				J Med Chem 51: 7898-914 (2008) Article DOI: 10.1021/jm8011036 BindingDB Entry DOI: 10.7270/Q2WS8T4C
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Aurora-C (Homo sapiens (human))	BDBM13534 (CHEMBL572878 \| N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	4.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of aurora C				Bioorg Med Chem Lett 20: 4709-11 (2010) Article DOI: 10.1016/j.bmcl.2010.04.119 BindingDB Entry DOI: 10.7270/Q2RF5VC3
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Aurora-C (Homo sapiens (human))	BDBM50004205 (MK-045 \| MK-0457 \| TOZASERTIB \| US9249124, VX680 \|...) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	4.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Taiwan National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal His6-tagged Aurora C (1 to 309 residues) (unknown origin) expressed in baculovirus expression system				Eur J Med Chem 124: 186-199 (2016) Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Aurora-C (Homo sapiens (human))	BDBM13534 (CHEMBL572878 \| N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	4.60	-11.3	n/a	n/a	n/a	n/a	n/a	7.5	22
Vertex Pharmaceuticals (Europe) Limited					Assay Description The kinase activity was determined by incubation of enzyme and its substrate, and test compound, in the presence ATP/[gamma-32P] ATP. After incubatio...				Nat Med 10: 262-7 (2004) Article DOI: 10.1038/nm1003 BindingDB Entry DOI: 10.7270/Q25M63ZF
Vertex Pharmaceuticals (Europe) Limited					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Aurora-C (Homo sapiens (human))	BDBM50004205 (MK-045 \| MK-0457 \| TOZASERTIB \| US9249124, VX680 \|...) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	4.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of N-terminal His-6-tagged recombinant Aurora 3 (1 to 309) (unknown origin) expressed in baculovirus expression system by radiometric assa...				Eur J Med Chem 78: 65-71 (2014) Article DOI: 10.1016/j.ejmech.2014.03.027 BindingDB Entry DOI: 10.7270/Q2Z60QKP
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Aurora-C (Homo sapiens (human))	BDBM13534 (CHEMBL572878 \| N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	4.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals (Europe) Ltd. Curated by ChEMBL					Assay Description Inhibition of aurora C kinase				J Med Chem 52: 2629-51 (2009) Checked by Author Article DOI: 10.1021/jm8012129 BindingDB Entry DOI: 10.7270/Q2B85920
Vertex Pharmaceuticals (Europe) Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Aurora-C (Homo sapiens (human))	BDBM13534 (CHEMBL572878 \| N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	4.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Competitive inhibition of Aurora C ATP binding site				J Med Chem 53: 3973-4001 (2010) Article DOI: 10.1021/jm901870q BindingDB Entry DOI: 10.7270/Q27082CK
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Aurora-C (Homo sapiens (human))	BDBM13534 (CHEMBL572878 \| N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	4.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of Aurora C kinase				Bioorg Med Chem Lett 18: 1623-7 (2008) Article DOI: 10.1016/j.bmcl.2008.01.068 BindingDB Entry DOI: 10.7270/Q261115V
National Health Research Institutes Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Aurora-C (Homo sapiens (human))	BDBM13534 (CHEMBL572878 \| N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	4.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Xuzhou Medical College Curated by ChEMBL					Assay Description Inhibition of aurora C (unknown origin)				Bioorg Med Chem Lett 23: 3523-30 (2013) Article DOI: 10.1016/j.bmcl.2013.04.039 BindingDB Entry DOI: 10.7270/Q26111Q1
Xuzhou Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Aurora-C (Homo sapiens (human))	BDBM13534 (CHEMBL572878 \| N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	4.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of Aurora C				Proc Natl Acad Sci USA 104: 19936-41 (2007) Article DOI: 10.1073/pnas.0707498104 BindingDB Entry DOI: 10.7270/Q24X58QS
Harvard Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Aurora-C (Homo sapiens (human))	BDBM50277585 (CHEMBL484950 \| N-(4-(4-(3-methyl-1H-pyrazol-5-ylam...) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals (Europe) Ltd Curated by ChEMBL					Assay Description Inhibition of Aurora-C				Bioorg Med Chem Lett 19: 3586-92 (2009) Article DOI: 10.1016/j.bmcl.2009.04.136 BindingDB Entry DOI: 10.7270/Q28K7944
Vertex Pharmaceuticals (Europe) Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Aurora-C (Homo sapiens (human))	BDBM12985 (5-Amido-pyrrolopyrazole 9d \| CHEMBL402548 \| N-{5-[...) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	61	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of Aurora C kinase				Bioorg Med Chem Lett 18: 1623-7 (2008) Article DOI: 10.1016/j.bmcl.2008.01.068 BindingDB Entry DOI: 10.7270/Q261115V
National Health Research Institutes Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Aurora-C (Homo sapiens (human))	BDBM50331612 (CHEMBL1290072 \| N-(4-methoxybenzyl)benzofuro[2,3-b...) Show SMILES COc1ccc(CNc2ccnc3oc4ccccc4c23)cc1 Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Martin Luther University Halle-Wittenberg Curated by ChEMBL					Assay Description Inhibition of human Aurora C				Bioorg Med Chem Lett 20: 6915-9 (2010) Article DOI: 10.1016/j.bmcl.2010.10.004 BindingDB Entry DOI: 10.7270/Q2GF0TQS
					More data for this Ligand-Target Pair