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Compile Data Set for Download or QSAR

Found 10 hits of non-affinity data for polymerid = 1406   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM29851
PNG
(N-(Pyridin-2-yl) arylsulfonamide, 13)
Show SMILES Cc1cccc(NS(=O)(=O)c2ccccc2C(F)(F)F)n1
Show InChI InChI=1S/C13H11F3N2O2S/c1-9-5-4-8-12(17-9)18-21(19,20)11-7-3-2-6-10(11)13(14,15)16/h2-8H,1H3,(H,17,18)
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n/an/an/an/an/an/an/a8.022



Pfizer



Assay Description
The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...


Bioorg Med Chem Lett 19: 3493-7 (2009)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM29852
PNG
(N-(Pyridin-2-yl) arylsulfonamide, 14)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1cccc(C)n1
Show InChI InChI=1S/C13H14N2O3S/c1-10-4-3-5-13(14-10)15-19(16,17)12-8-6-11(18-2)7-9-12/h3-9H,1-2H3,(H,14,15)
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n/an/an/an/an/an/an/a8.022



Pfizer



Assay Description
The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...


Bioorg Med Chem Lett 19: 3493-7 (2009)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM29853
PNG
(N-(Pyridin-2-yl) arylsulfonamide, 15)
Show SMILES Cc1cccc(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)n1
Show InChI InChI=1S/C16H20N2O2S/c1-12-6-5-7-15(17-12)18-21(19,20)14-10-8-13(9-11-14)16(2,3)4/h5-11H,1-4H3,(H,17,18)
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n/an/an/an/an/an/an/a8.022



Pfizer



Assay Description
The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...


Bioorg Med Chem Lett 19: 3493-7 (2009)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM29846
PNG
(N-(Pyridin-2-yl) arylsulfonamide, 6)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)Nc1cccc(CC(=O)N2CCN(Cc3ccccc3)CC2)n1
Show InChI InChI=1S/C25H27ClN4O3S/c1-19-22(26)10-6-11-23(19)34(32,33)28-24-12-5-9-21(27-24)17-25(31)30-15-13-29(14-16-30)18-20-7-3-2-4-8-20/h2-12H,13-18H2,1H3,(H,27,28)
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n/an/an/an/an/an/an/a8.022



Pfizer



Assay Description
The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...


Bioorg Med Chem Lett 19: 3493-7 (2009)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM29855
PNG
(N-(Pyridin-2-yl) arylsulfonamide, 17)
Show SMILES Cc1cccc(NS(=O)(=O)c2cccc3ccccc23)n1
Show InChI InChI=1S/C16H14N2O2S/c1-12-6-4-11-16(17-12)18-21(19,20)15-10-5-8-13-7-2-3-9-14(13)15/h2-11H,1H3,(H,17,18)
PDB
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n/an/an/an/an/an/an/a8.022



Pfizer



Assay Description
The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...


Bioorg Med Chem Lett 19: 3493-7 (2009)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM29848
PNG
(N-(Pyridin-2-yl) arylsulfonamide, 8)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)Nc1cccc(CC(O)=O)n1
Show InChI InChI=1S/C14H13ClN2O4S/c1-9-11(15)5-3-6-12(9)22(20,21)17-13-7-2-4-10(16-13)8-14(18)19/h2-7H,8H2,1H3,(H,16,17)(H,18,19)
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n/an/an/an/an/an/an/a8.022



Pfizer



Assay Description
The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...


Bioorg Med Chem Lett 19: 3493-7 (2009)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM29842
PNG
(N-(Pyridin-2-yl) arylsulfonamide, 2)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)Nc1cccc(CC(=O)N2CCOCC2)n1
Show InChI InChI=1S/C18H20ClN3O4S/c1-13-15(19)5-3-6-16(13)27(24,25)21-17-7-2-4-14(20-17)12-18(23)22-8-10-26-11-9-22/h2-7H,8-12H2,1H3,(H,20,21)
PDB
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n/an/an/an/an/an/an/a8.022



Pfizer



Assay Description
The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...


Bioorg Med Chem Lett 19: 3493-7 (2009)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM29844
PNG
(N-(Pyridin-2-yl) arylsulfonamide, 4)
Show SMILES CN1CCN(CC1)C(=O)Cc1cccc(NS(=O)(=O)c2cccc(Cl)c2C)n1
Show InChI InChI=1S/C19H23ClN4O3S/c1-14-16(20)6-4-7-17(14)28(26,27)22-18-8-3-5-15(21-18)13-19(25)24-11-9-23(2)10-12-24/h3-8H,9-13H2,1-2H3,(H,21,22)
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n/an/an/an/an/an/an/a8.022



Pfizer



Assay Description
The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...


Bioorg Med Chem Lett 19: 3493-7 (2009)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM29845
PNG
(N-(Pyridin-2-yl) arylsulfonamide, 5)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)Nc1cccc(CC(=O)N2CCSCC2)n1
Show InChI InChI=1S/C18H20ClN3O3S2/c1-13-15(19)5-3-6-16(13)27(24,25)21-17-7-2-4-14(20-17)12-18(23)22-8-10-26-11-9-22/h2-7H,8-12H2,1H3,(H,20,21)
PDB
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n/an/an/an/an/an/an/a8.022



Pfizer



Assay Description
The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...


Bioorg Med Chem Lett 19: 3493-7 (2009)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM29847
PNG
(N-(Pyridin-2-yl) arylsulfonamide, 7)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)Nc1cccc(CC(=O)N2CCCC2)n1
Show InChI InChI=1S/C18H20ClN3O3S/c1-13-15(19)7-5-8-16(13)26(24,25)21-17-9-4-6-14(20-17)12-18(23)22-10-2-3-11-22/h4-9H,2-3,10-12H2,1H3,(H,20,21)
PDB
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n/an/an/an/an/an/an/a8.022



Pfizer



Assay Description
The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...


Bioorg Med Chem Lett 19: 3493-7 (2009)

More data for this
Ligand-Target Pair