Compile Data Set for Download or QSAR
(2D       Computed 3D by Vconf -m prep )

Data curated solely by BindingDB

Found 25 hits of affinity data for UniProtKB/TrEMBL: P50172

Target (Institution)	Ligand	Target Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	pH	Temp °C
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	2-Amino-1,3-thiazol-4(5H)-one, 8b (2-(hexahydro-2,5-methanopentalen-3a(1H)-ylamino)-1...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	120.0	-39.10	n/a	n/a	n/a	7.2	22
Biovitrum AB					J Med Chem. 51: 2933-43 (2008)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	adamantane ether 10 ((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	3.0	n/a	n/a	7.2	22
Abbott Laboratories					Bioorg Med Chem Lett. 17: 750-5 (2007)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	adamantane ether 22 (N-[(1R,2S,5R,7S)-5-[(carbamoylmethyl)carbamoyl]ada...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	4.0	n/a	n/a	7.2	22
Abbott Laboratories					Bioorg Med Chem Lett. 17: 750-5 (2007)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	adamantane ether 6 ((1R,3R,4S,7S)-4-(2-methyl-2-phenoxypropanamido)ada...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	4.0	n/a	n/a	7.2	22
Abbott Laboratories					Bioorg Med Chem Lett. 17: 750-5 (2007)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	adamantane ether 15 ((1R,3R,4S,7S)-4-[2-(4-methoxyphenoxy)-2-methylprop...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid PDB	PubMed	n/a	n/a	4.0	n/a	n/a	7.2	22
Abbott Laboratories					Bioorg Med Chem Lett. 17: 750-5 (2007)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	adamantane ether 24 (2-(4-chlorophenoxy)-N-[(1R,2S,5R,7S)-5-(hydroxymet...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	6.0	n/a	n/a	7.2	22
Abbott Laboratories					Bioorg Med Chem Lett. 17: 750-5 (2007)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	adamantane ether 7 ((1R,3R,4S,7S)-4-[2-(2-chlorophenoxy)-2-methylpropa...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	8.0	n/a	n/a	7.2	22
Abbott Laboratories					Bioorg Med Chem Lett. 17: 750-5 (2007)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	adamantane ether 23 (2-(4-chlorophenoxy)-2-methyl-N-[(1R,2S,5R,7S)-5-{[...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	8.0	n/a	n/a	7.2	22
Abbott Laboratories					Bioorg Med Chem Lett. 17: 750-5 (2007)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	adamantane ether 26 (2-(2-chloro-4-fluorophenoxy)-2-methyl-N-[(1R,2S,5R...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	10.0	n/a	n/a	7.2	22
Abbott Laboratories					Bioorg Med Chem Lett. 17: 750-5 (2007)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	adamantane ether 20 ((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	11.0	n/a	n/a	7.2	22
Abbott Laboratories					Bioorg Med Chem Lett. 17: 750-5 (2007)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	adamantane ether 16 (4-({[(1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methyl...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	12.0	n/a	n/a	7.2	22
Abbott Laboratories					Bioorg Med Chem Lett. 17: 750-5 (2007)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	adamantane ether 21 ((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	14.0	n/a	n/a	7.2	22
Abbott Laboratories					Bioorg Med Chem Lett. 17: 750-5 (2007)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	adamantane ether 18 ((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	18.0	n/a	n/a	7.2	22
Abbott Laboratories					Bioorg Med Chem Lett. 17: 750-5 (2007)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	adamantane ether 19 ((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	24.0	n/a	n/a	7.2	22
Abbott Laboratories					Bioorg Med Chem Lett. 17: 750-5 (2007)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	adamantane ether 17 ((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	25.0	n/a	n/a	7.2	22
Abbott Laboratories					Bioorg Med Chem Lett. 17: 750-5 (2007)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	adamantane ether 27 ((1R,3R,4S,7S)-4-[2-(2-chlorophenoxy)-2-methylpropa...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	28.0	n/a	n/a	7.2	22
Abbott Laboratories					Bioorg Med Chem Lett. 17: 750-5 (2007)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	adamantane ether 8 ((1R,3R,4S,7S)-4-[2-(3-chlorophenoxy)-2-methylpropa...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	51.0	n/a	n/a	7.2	22
Abbott Laboratories					Bioorg Med Chem Lett. 17: 750-5 (2007)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	adamantane ether 9 ((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	70.0	n/a	n/a	7.2	22
Abbott Laboratories					Bioorg Med Chem Lett. 17: 750-5 (2007)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	adamantane ether 5 ((1R,3R,4S,7S)-4-(2-methyl-2-phenoxypropanamido)ada...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	119.0	n/a	n/a	7.2	22
Abbott Laboratories					Bioorg Med Chem Lett. 17: 750-5 (2007)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	adamantane ether 25 (2-{[(1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylp...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	210.0	n/a	n/a	7.2	22
Abbott Laboratories					Bioorg Med Chem Lett. 17: 750-5 (2007)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	spiro-carboxamide scaffold, 13	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	377.0	n/a	n/a	7.4	37
Merck-Serono					Bioorg Med Chem Lett. 19: 3682-5 (2009)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	adamantane ether 28 ((1R,3R,4S,7S)-N-(benzenesulfonyl)-4-[2-(2-chloroph...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	1000.0	n/a	n/a	7.2	22
Abbott Laboratories					Bioorg Med Chem Lett. 17: 750-5 (2007)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	spiro-carboxamide scaffold, 3	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	2600.0	n/a	n/a	7.4	37
Merck-Serono					Bioorg Med Chem Lett. 19: 3682-5 (2009)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	spiro-carboxamide scaffold, 5	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	3400.0	n/a	n/a	7.4	37
Merck-Serono					Bioorg Med Chem Lett. 19: 3682-5 (2009)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) Mus musculus (mouse)	spiro-carboxamide scaffold, 6	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	3400.0	n/a	n/a	7.4	37
Merck-Serono					Bioorg Med Chem Lett. 19: 3682-5 (2009)

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