Compile Data Set for Download or QSAR
(2D       Computed 3D by Vconf -m prep )

Data curated solely by BindingDB

Found 253 hits of affinity data for UniProtKB/TrEMBL: P00749

Target (Institution)	Ligand	Target Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	pH	Temp °C
Urokinase (uPA) Homo sapiens (human)	cycloleucine deriv. 45 (2-[4-chloro-7-({1-[(4-methylpiperazin-1-yl)carbony...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	1.400	-52.56	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	cycloleucine deriv. 44 (2-(4-chloro-7-{[1-(morpholin-4-ylcarbonyl)cyclopen...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	1.600	-52.22	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	CRA-11852 (2-{5-[amino(iminiumyl)methyl]-6-chloro-1H-indol-2-...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	PC cid PC sid	PubMed	2.200	-48.91	n/a	n/a	n/a	7.4	22
Celera					J Mol Biol. 329: 93-120 (2003)
Urokinase (uPA) Homo sapiens (human)	cycloleucine deriv. 39 (1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	2.600	-50.97	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	CRA-11260 (2-{5-[amino(iminiumyl)methyl]-6-chloro-1H-indol-2-...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	PC cid PC sid	PubMed	2.600	-48.50	n/a	n/a	n/a	7.4	22
Celera					J Mol Biol. 329: 93-120 (2003)
Urokinase (uPA) Homo sapiens (human)	CRA-15441 (2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-4-(di...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	PC cid PC sid	PubMed	3.200	-47.99	n/a	n/a	n/a	7.4	22
Celera					J Mol Biol. 329: 93-120 (2003)
Urokinase (uPA) Homo sapiens (human)	substituted glycine deriv. 28 (1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	5.800	-48.90	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	substituted glycine deriv. 30 (4-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	PC cid PC sid	PubMed	7.400	-48.27	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	substituted glycine deriv. 27 (1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	7.400	-48.27	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	APC-8696 (2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-phe...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	B.MOAD CSLS PC cid PC sid PDB	B.MOAD PDB PubMed	8.000	-45.75	n/a	n/a	n/a	7.4	22
Axys Pharmaceutical					Chem Biol. 8: 1107-21 (2001)
Urokinase (uPA) Homo sapiens (human)	substituted glycine deriv. 29 (1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	8.000	-48.07	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	APC-10302 (6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-C...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	B.MOAD CSLS MMDB PC cid PC sid PDB	B.MOAD MMDB PDB PubMed	9.000	-45.46	n/a	n/a	n/a	7.4	22
Axys Pharmaceutical					Chem Biol. 8: 1107-21 (2001)
Urokinase (uPA) Homo sapiens (human)	cyclic deriv. 33 ((2R)-1-({4-chloro-1-[(diaminomethylidene)amino]iso...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS MMDB PC cid PC sid PDB	MMDB PDB PubMed	9.900	-47.52	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	UK-371804 (2-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	10.00	-47.49	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	cycloleucine deriv. 43 (1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	10.00	-47.49	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	cycloleucine deriv. 38 (1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	11.00	-47.25	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	APC-11092 (6-fluoro-2-(2-hydroxy-3-{[(1S,2S)-2-methylcyclohex...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	B.MOAD CSLS MMDB PC cid PC sid PDB	B.MOAD MMDB PDB PubMed	11.00	-44.96	n/a	n/a	n/a	7.4	22
Axys Pharmaceutical					Chem Biol. 8: 1107-21 (2001)
Urokinase (uPA) Homo sapiens (human)	substituted glycine deriv. 31 (4-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	PC cid PC sid	PubMed	11.00	-47.25	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	APC-10302 (6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-C...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	B.MOAD CSLS MMDB PC cid PC sid PDB	B.MOAD MMDB PDB PubMed	13.00	-44.55	n/a	n/a	n/a	7.4	22
Celera					J Mol Biol. 329: 93-120 (2003)
Urokinase (uPA) Homo sapiens (human)	APC-10302 (6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-C...)	B.MOAD GoogleScholar MMDB PDB	B.MOAD CSLS MMDB PC cid PC sid PDB	B.MOAD MMDB PDB PubMed	14.00	-44.37	n/a	n/a	n/a	7.4	22
Celera					J Mol Biol. 344: 527-47 (2004)
Urokinase (uPA) Homo sapiens (human)	cycloleucine deriv. 40 (ethyl 1-({4-chloro-1-[(diaminomethylidene)amino]is...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	PC cid PC sid	PubMed	14.00	-46.63	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	APC-11417 (CA-12 | CRA-11417 | {amino[6-fluoro-2-(2-hydroxy-3...)	B.MOAD GoogleScholar MMDB PDB	PC cid PC sid	PubMed	16.00	-44.04	n/a	n/a	n/a	7.4	22
Celera					J Mol Biol. 344: 527-47 (2004)
Urokinase (uPA) Homo sapiens (human)	UK-356202 (1-isoquinolinylguanidine 3 | 3-{4-chloro-1-[(diami...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	17.00	-46.13	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	CA-23 ([amino({5-[(3,4-dihydroxynaphthalene-2-)amido]pyri...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	PC cid PC sid	PubMed	17.00	-43.90	n/a	n/a	n/a	7.4	22
Celera					J Mol Biol. 344: 527-47 (2004)
Urokinase (uPA) Homo sapiens (human)	substituted glycine deriv. 22 ((2R)-2-({4-chloro-1-[(diaminomethylidene)amino]iso...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	19.00	-45.84	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	APC-11417 (CA-12 | CRA-11417 | {amino[6-fluoro-2-(2-hydroxy-3...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	PC cid PC sid	PubMed	20.00	-43.50	n/a	n/a	n/a	7.4	22
Axys Pharmaceutical					Chem Biol. 8: 1107-21 (2001)
Urokinase (uPA) Homo sapiens (human)	APC-11417 (CA-12 | CRA-11417 | {amino[6-fluoro-2-(2-hydroxy-3...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	PC cid PC sid	PubMed	20.00	-43.50	n/a	n/a	n/a	7.4	22
Celera					J Mol Biol. 329: 93-120 (2003)
Urokinase (uPA) Homo sapiens (human)	substituted glycine deriv. 21 ((2S)-2-({4-chloro-1-[(diaminomethylidene)amino]iso...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	21.00	-45.58	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	substituted glycine deriv. 24 ((2R)-2-({4-chloro-1-[(diaminomethylidene)amino]iso...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	22.00	-45.46	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	cyclic deriv. 35 ((2R)-1-({4-chloro-1-[(diaminomethylidene)amino]iso...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	23.00	-45.35	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	APC-11092 (6-fluoro-2-(2-hydroxy-3-{[(1S,2S)-2-methylcyclohex...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	B.MOAD CSLS MMDB PC cid PC sid PDB	B.MOAD MMDB PDB PubMed	25.00	-42.95	n/a	n/a	n/a	8.2	22
Axys Pharmaceutical					Chem Biol. 8: 1107-21 (2001)
Urokinase (uPA) Homo sapiens (human)	CRA-15566 (2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-4-nit...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	PC cid PC sid	PubMed	25.00	-42.95	n/a	n/a	n/a	7.4	22
Celera					J Mol Biol. 329: 93-120 (2003)
Urokinase (uPA) Homo sapiens (human)	substituted glycine deriv. 25 ((2S)-2-[benzyl({4-chloro-1-[(diaminomethylidene)am...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	27.00	-44.93	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	substituted glycine deriv. 20 ((2R)-2-({4-chloro-1-[(diaminomethylidene)amino]iso...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	28.00	-44.84	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	substituted glycine deriv. 17 (2-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	29.00	-44.75	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	CRA-14316 (2-{5-[amino(iminiumyl)methyl]-6-fluoro-1H-indol-2-...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	PC cid PC sid	PubMed	30.00	-42.50	n/a	n/a	n/a	7.4	22
Celera					J Mol Biol. 329: 93-120 (2003)
Urokinase (uPA) Homo sapiens (human)	cycloleucine deriv. 42 (1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	30.00	-44.66	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	CRA-11092 (2-{5-[amino(iminiumyl)methyl]-6-fluoro-1H-1,3-benz...)	B.MOAD GoogleScholar MMDB PDB	B.MOAD CSLS PC cid PC sid PDB	B.MOAD PDB PubMed	30.00	-42.50	n/a	n/a	n/a	7.4	22
Celera					J Mol Biol. 344: 527-47 (2004)
Urokinase (uPA) Homo sapiens (human)	substituted glycine deriv. 19 (2-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	31.00	-44.58	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	CRA-14783 (2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-4-met...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid PDB	PubMed	31.00	-42.42	n/a	n/a	n/a	7.4	22
Celera					J Mol Biol. 329: 93-120 (2003)
Urokinase (uPA) Homo sapiens (human)	CRA-11092 (2-{5-[amino(iminiumyl)methyl]-6-fluoro-1H-1,3-benz...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	B.MOAD CSLS PC cid PC sid PDB	B.MOAD PDB PubMed	33.00	-42.27	n/a	n/a	n/a	7.4	22
Celera					J Mol Biol. 329: 93-120 (2003)
Urokinase (uPA) Homo sapiens (human)	APC-8696 (2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-phe...)	B.MOAD GoogleScholar MMDB PDB	B.MOAD CSLS PC cid PC sid PDB	B.MOAD PDB PubMed	33.00	-42.27	n/a	n/a	n/a	7.4	22
Celera					J Mol Biol. 344: 527-47 (2004)
Urokinase (uPA) Homo sapiens (human)	substituted glycine deriv. 18 (2-[benzyl({4-chloro-1-[(diaminomethylidene)amino]i...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	35.00	-44.26	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	CA-23 ([amino({5-[(3,4-dihydroxynaphthalene-2-)amido]pyri...)	B.MOAD GoogleScholar MMDB PDB	PC cid PC sid	PubMed	41.00	-41.74	n/a	n/a	n/a	7.4	22
Celera					J Mol Biol. 344: 527-47 (2004)
Urokinase (uPA) Homo sapiens (human)	1-guanidino-7-sulfonamidoisoquinoline 15 (3-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	43.00	-43.73	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	1-guanidino-7-sulfonamidoisoquinoline 13 (2-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	48.00	-43.45	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	CRA-9678 (2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-bro...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	B.MOAD CSLS PC cid PC sid PDB	PubMed	50.00	-41.25	n/a	n/a	n/a	7.4	22
Celera					J Mol Biol. 329: 93-120 (2003)
Urokinase (uPA) Homo sapiens (human)	cyclic deriv. 37 ((2R)-1-({4-chloro-1-[(diaminomethylidene)amino]iso...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	54.00	-43.15	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	substituted glycine deriv. 16 (2-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	54.00	-43.15	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)
Urokinase (uPA) Homo sapiens (human)	1-guanidino-7-sulfonamidoisoquinoline 14 (3-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	58.00	-42.96	n/a	n/a	n/a	8.1	37
Pfizer					J Med Chem. 50: 2341-51 (2007)

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