Compile Data Set for Download or QSAR
(2D       Computed 3D by Vconf -m prep )

Data curated solely by BindingDB

Found 69 hits of affinity data for UniProtKB/TrEMBL: Q9Y243

Target (Institution)	Ligand	Target Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	pH	Temp °C
Protein kinase B (Akt 3) Homo sapiens (human)	GSK690693 (4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	MMDB PC cid PC sid PDB	PubMed	n/a	n/a	9.0	n/a	n/a	7.5	22
GlaxoSmithKline					J Med Chem. 51: 5663-79 (2008)
Protein kinase B (Akt 3) Homo sapiens (human)	Staurosporine ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	B.MOAD CHEBI CSLS MMDB PC cid PC sid PDB	PubMed	n/a	n/a	10.0	n/a	n/a	7.5	22
Abbott Laboratories					Bioorg Med Chem Lett. 16: 2000-7 (2006)
Protein kinase B (Akt 3) Homo sapiens (human)	ARC-1028, 22 ((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	14.6	n/a	n/a	7.5	30
Institute of Chemistry in Estonia					J Med Chem. 52: 308-21 (2009)
Protein kinase B (Akt 3) Homo sapiens (human)	oxadiazole-containing compound, 14a (4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(3-{...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	16.0	n/a	n/a	7.5	22
GlaxoSmithKline					J Med Chem. 51: 5663-79 (2008)
Protein kinase B (Akt 3) Homo sapiens (human)	ARC-903 (N-[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidami...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	30.7	n/a	n/a	7.5	30
Institute of Chemistry in Estonia					J Med Chem. 52: 308-21 (2009)
Protein kinase B (Akt 3) Homo sapiens (human)	pyridine-base inhibitor 13a ((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	B.MOAD CSLS MMDB PC cid PC sid PDB	PubMed	n/a	n/a	35.0	n/a	n/a	7.5	22
Abbott Laboratories					Bioorg Med Chem Lett. 16: 2000-7 (2006)
Protein kinase B (Akt 3) Homo sapiens (human)	ARC-902 (6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CHEBI PC cid PC sid	PubMed	n/a	n/a	36.9	n/a	n/a	7.5	30
Institute of Chemistry in Estonia					J Med Chem. 52: 308-21 (2009)
Protein kinase B (Akt 3) Homo sapiens (human)	Isoquinoline-pyridine, 10e (6-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-2-eth...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	39.0	n/a	n/a	7.5	22
Abbott Laboratories					Bioorg Med Chem Lett. 16: 3150-5 (2006)
Protein kinase B (Akt 3) Homo sapiens (human)	oxadiazole-containing compound, 3b (4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(pip...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	40.0	n/a	n/a	7.5	22
GlaxoSmithKline					J Med Chem. 51: 5663-79 (2008)
Protein kinase B (Akt 3) Homo sapiens (human)	ARC-659-1b (6-{[(1S,3R,4R)-3-(6-amino-9H-purin-9-yl)-4-hydroxy...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	43.1	n/a	n/a	7.5	30
Institute of Chemistry in Estonia					J Med Chem. 52: 308-21 (2009)
Protein kinase B (Akt 3) Homo sapiens (human)	ARC-1027, 21 ((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	56.6	n/a	n/a	7.5	30
Institute of Chemistry in Estonia					J Med Chem. 52: 308-21 (2009)
Protein kinase B (Akt 3) Homo sapiens (human)	oxadiazole-containing compound, 3a (4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(4-aminobuto...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	69.0	n/a	n/a	7.5	22
GlaxoSmithKline					J Med Chem. 51: 5663-79 (2008)
Protein kinase B (Akt 3) Homo sapiens (human)	Isoquinoline-pyridine, 10a (6-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-2-chl...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	73.0	n/a	n/a	7.5	22
Abbott Laboratories					Bioorg Med Chem Lett. 16: 3150-5 (2006)
Protein kinase B (Akt 3) Homo sapiens (human)	Isoquinoline-pyridine, 10y (6-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	76.0	n/a	n/a	7.5	22
Abbott Laboratories					Bioorg Med Chem Lett. 16: 3150-5 (2006)
Protein kinase B (Akt 3) Homo sapiens (human)	pyridine-base inhibitor 1b (3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	B.MOAD CSLS MMDB PC cid PC sid PDB	PubMed	n/a	n/a	354.0	n/a	n/a	7.5	22
Abbott Laboratories					Bioorg Med Chem Lett. 16: 1679-85 (2006)
Protein kinase B (Akt 3) Homo sapiens (human)	pyridine-base inhibitor 1b (3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	B.MOAD CSLS MMDB PC cid PC sid PDB	PubMed	n/a	n/a	354.0	n/a	n/a	7.5	22
Abbott Laboratories					Bioorg Med Chem Lett. 16: 2000-7 (2006)
Protein kinase B (Akt 3) Homo sapiens (human)	oxadiazole-containing compound, 7 (4-[1-ethyl-7-(piperidin-4-ylmethoxy)-1H-imidazo[4,...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	380.0	n/a	n/a	7.5	22
GlaxoSmithKline					J Med Chem. 51: 5663-79 (2008)
Protein kinase B (Akt 3) Homo sapiens (human)	oxadiazole-containing compound, 1 (4-[1-ethyl-7-(piperidin-4-yloxy)-1H-imidazo[4,5-c]...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	398.0	n/a	n/a	7.5	22
GlaxoSmithKline					J Med Chem. 51: 5663-79 (2008)
Protein kinase B (Akt 3) Homo sapiens (human)	oxadiazole-containing compound, 9 (4-{1-ethyl-7-[(piperidin-4-ylamino)methyl]-1H-imid...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CHEBI CSLS PC cid PC sid	PubMed	n/a	n/a	646.0	n/a	n/a	7.5	22
GlaxoSmithKline					J Med Chem. 51: 5663-79 (2008)
Protein kinase B (Akt 3) Homo sapiens (human)	H-89 (N-(2-{[(2E)-3-(4-bromophenyl)prop-2-en-1-yl]amino}...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	B.MOAD CHEBI CSLS MMDB PC cid PC sid PDB	PubMed	n/a	n/a	662.0	n/a	n/a	7.5	30
Institute of Chemistry in Estonia					J Med Chem. 52: 308-21 (2009)
Protein kinase B (Akt 3) Homo sapiens (human)	ARC-1012, 15 ((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	774.0	n/a	n/a	7.5	30
Institute of Chemistry in Estonia					J Med Chem. 52: 308-21 (2009)
Protein kinase B (Akt 3) Homo sapiens (human)	quinoxaline 16c (1-[1-({4-[3-phenyl-6-(2H-1,2,3,4-tetrazol-5-yl)qui...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	1228.0	n/a	n/a	7.5	22
Merck Research Laboratories					Bioorg Med Chem Lett. 15: 761-4 (2005)
Protein kinase B (Akt 3) Homo sapiens (human)	oxadiazole-containing compound, 4 (4-(7-{[(3R)-3-aminopyrrolidin-1-yl]carbonyl}-1-eth...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	1290.0	n/a	n/a	7.5	22
GlaxoSmithKline					J Med Chem. 51: 5663-79 (2008)
Protein kinase B (Akt 3) Homo sapiens (human)	oxadiazole-containing compound, 2 (2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-[2-(met...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	1410.0	n/a	n/a	7.5	22
GlaxoSmithKline					J Med Chem. 51: 5663-79 (2008)
Protein kinase B (Akt 3) Homo sapiens (human)	oxadiazole-containing compound, 5 (4-[1-ethyl-7-(piperazin-1-ylcarbonyl)-1H-imidazo[4...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	1549.0	n/a	n/a	7.5	22
GlaxoSmithKline					J Med Chem. 51: 5663-79 (2008)
Protein kinase B (Akt 3) Homo sapiens (human)	ARC-1032, 6 (6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	1610.0	n/a	n/a	7.5	30
Institute of Chemistry in Estonia					J Med Chem. 52: 308-21 (2009)
Protein kinase B (Akt 3) Homo sapiens (human)	quinoxaline 16d (1-[1-({4-[3-phenyl-7-(2H-1,2,3,4-tetrazol-5-yl)qui...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	1613.0	n/a	n/a	7.5	22
Merck Research Laboratories					Bioorg Med Chem Lett. 15: 761-4 (2005)
Protein kinase B (Akt 3) Homo sapiens (human)	ARC-1044, 26 (6-{[(1S,3R,4R)-3-(6-amino-9H-purin-9-yl)-4-hydroxy...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	2038.0	n/a	n/a	7.5	30
Institute of Chemistry in Estonia					J Med Chem. 52: 308-21 (2009)
Protein kinase B (Akt 3) Homo sapiens (human)	imidazoquinoxaline 16h (1-{1-[(4-{7-phenyl-1H-imidazo[4,5-g]quinoxalin-6-y...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	2119.0	n/a	n/a	7.5	22
Merck Research Laboratories					Bioorg Med Chem Lett. 15: 761-4 (2005)
Protein kinase B (Akt 3) Homo sapiens (human)	oxadiazole-containing compound, 8 (2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-(piperi...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	2290.0	n/a	n/a	7.5	22
GlaxoSmithKline					J Med Chem. 51: 5663-79 (2008)
Protein kinase B (Akt 3) Homo sapiens (human)	pyrazoloquinoxaline 16g (1-{1-[(4-{7-phenyl-1H-pyrazolo[3,4-g]quinoxalin-6-...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	2400.0	n/a	n/a	7.5	22
Merck Research Laboratories					Bioorg Med Chem Lett. 15: 761-4 (2005)
Protein kinase B (Akt 3) Homo sapiens (human)	oxadiazole-containing compound, 6 (2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-(piperi...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	3020.0	n/a	n/a	7.5	22
GlaxoSmithKline					J Med Chem. 51: 5663-79 (2008)
Protein kinase B (Akt 3) Homo sapiens (human)	quinoxaline 16b (3-(4-{[4-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-y...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	3200.0	n/a	n/a	7.5	22
Merck Research Laboratories					Bioorg Med Chem Lett. 15: 761-4 (2005)
Protein kinase B (Akt 3) Homo sapiens (human)	ARC-1039, 25 (6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	3750.0	n/a	n/a	7.5	30
Institute of Chemistry in Estonia					J Med Chem. 52: 308-21 (2009)
Protein kinase B (Akt 3) Homo sapiens (human)	pyrazinone 14c (1-(1-{[4-(5-benzyl-6-oxo-3-phenyl-1,6-dihydropyraz...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	3973.0	n/a	n/a	7.5	22
Merck Research Laboratories					Bioorg Med Chem Lett. 15: 761-4 (2005)
Protein kinase B (Akt 3) Homo sapiens (human)	pyrazinone 14f (1-[1-({4-[5-(2-methylpropyl)-6-oxo-3-phenyl-1,6-di...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	21870.0	n/a	n/a	7.5	22
Merck Research Laboratories					Bioorg Med Chem Lett. 15: 761-4 (2005)
Protein kinase B (Akt 3) Homo sapiens (human)	pyrazinone 14b (1-(1-{[4-(5-methyl-6-oxo-3-phenyl-1,6-dihydropyraz...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	33100.0	n/a	n/a	7.5	22
Merck Research Laboratories					Bioorg Med Chem Lett. 15: 761-4 (2005)
Protein kinase B (Akt 3) Homo sapiens (human)	cyanopyridine 7f (6-(4-{[4-(1H-1,3-benzodiazol-1-yl)piperidin-1-yl]m...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	>50000.0	n/a	n/a	7.5	22
Merck Research Laboratories					Bioorg Med Chem Lett. 15: 905-9 (2005)
Protein kinase B (Akt 3) Homo sapiens (human)	cyanopyridine 7g (6-(4-{[4-(2-methyl-1H-1,3-benzodiazol-1-yl)piperid...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	>50000.0	n/a	n/a	7.5	22
Merck Research Laboratories					Bioorg Med Chem Lett. 15: 905-9 (2005)
Protein kinase B (Akt 3) Homo sapiens (human)	tetrazolylypyridine 8a (1-[1-({4-[3-phenyl-5-(1H-1,2,3,4-tetrazol-5-yl)pyr...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	>50000.0	n/a	n/a	7.5	22
Merck Research Laboratories					Bioorg Med Chem Lett. 15: 905-9 (2005)
Protein kinase B (Akt 3) Homo sapiens (human)	tetrazolylypyridine 8b (({4-[3-phenyl-5-(1H-1,2,3,4-tetrazol-5-yl)pyridin-...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	>50000.0	n/a	n/a	7.5	22
Merck Research Laboratories					Bioorg Med Chem Lett. 15: 905-9 (2005)
Protein kinase B (Akt 3) Homo sapiens (human)	tetrazolylypyridine 8d (6-methyl-2-[1-({4-[3-phenyl-5-(1H-1,2,3,4-tetrazol...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	>50000.0	n/a	n/a	7.5	22
Merck Research Laboratories					Bioorg Med Chem Lett. 15: 905-9 (2005)
Protein kinase B (Akt 3) Homo sapiens (human)	tetrazolylypyridine 8e (2-[1-({4-[3-phenyl-5-(1H-1,2,3,4-tetrazol-5-yl)pyr...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	>50000.0	n/a	n/a	7.5	22
Merck Research Laboratories					Bioorg Med Chem Lett. 15: 905-9 (2005)
Protein kinase B (Akt 3) Homo sapiens (human)	tetrazolylypyridine 8f (1-[1-({4-[3-phenyl-5-(1H-1,2,3,4-tetrazol-5-yl)pyr...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	>50000.0	n/a	n/a	7.5	22
Merck Research Laboratories					Bioorg Med Chem Lett. 15: 905-9 (2005)
Protein kinase B (Akt 3) Homo sapiens (human)	tetrazolylypyridine 8g (2-methyl-1-[1-({4-[3-phenyl-5-(1H-1,2,3,4-tetrazol...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	>50000.0	n/a	n/a	7.5	22
Merck Research Laboratories					Bioorg Med Chem Lett. 15: 905-9 (2005)
Protein kinase B (Akt 3) Homo sapiens (human)	quinoxaline 16a (2-(4-{[4-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-y...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	>50000.0	n/a	n/a	7.5	22
Merck Research Laboratories					Bioorg Med Chem Lett. 15: 761-4 (2005)
Protein kinase B (Akt 3) Homo sapiens (human)	2,3-diphenylquinoxaline 1 (2-[4-(3-phenylquinoxalin-2-yl)phenyl]propan-2-amin...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	>50000.0	n/a	n/a	7.5	22
Merck Research Laboratories					Bioorg Med Chem Lett. 15: 761-4 (2005)
Protein kinase B (Akt 3) Homo sapiens (human)	2,3-diphenylquinoxaline 5 (1-(1-{[4-(3-phenylquinoxalin-2-yl)phenyl]methyl}pi...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	>50000.0	n/a	n/a	7.5	22
Merck Research Laboratories					Bioorg Med Chem Lett. 15: 761-4 (2005)
Protein kinase B (Akt 3) Homo sapiens (human)	pyrazinone 13a (1-(1-{[4-(5-oxo-3-phenyl-4,5-dihydropyrazin-2-yl)p...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	>50000.0	n/a	n/a	7.5	22
Merck Research Laboratories					Bioorg Med Chem Lett. 15: 761-4 (2005)
Protein kinase B (Akt 3) Homo sapiens (human)	pyrazinone 14a (1-(1-{[4-(6-oxo-3-phenyl-1,6-dihydropyrazin-2-yl)p...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	CSLS PC cid PC sid	PubMed	n/a	n/a	>50000.0	n/a	n/a	7.5	22
Merck Research Laboratories					Bioorg Med Chem Lett. 15: 761-4 (2005)

Displayed 1 to 50 (of 69 total )  |  Next  |  Last  >>

Jump to:

• Reorder this table by ec50
• Reorder this table by ic50
• Reorder this table by kd
• Reorder this table by pH
• Reorder this table by T
• Change energy unit to:  kcal/mole