Affinity DataIC50: 1nMAssay Description:Inhibition of Hsp90 in human A375 cells assessed as pS6 degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 2nMAssay Description:Inhibition of Hsp90 in human A375 cells assessed as Hsp70 induction after 24 hrs by high content screeningMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Concentration of test compound required for inhibition of binding of rHsp90 in MCF-7 cell lysateMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of Hsp90 in human AU565 cells assessed as Her2 degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of FITC-GDA binding to human HSP90-beta incubated for 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of Hsp90 in human A375 cells assessed as Hsp70 induction after 24 hrs by high content screeningMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of HSP90-mediated Her2 degradation in human AU565 cells after 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:Inhibition of Hsp90 in human MDA-MB-231 cells assessed as her2 degradationMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of FITC-GDA binding to human HSP90-beta incubated for 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Binding affinity to human recombinant HSP90More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of HSP90 in human A375 cells assessed as induction of HSP70 synthesis after 24 hrs by TRITC assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 5.40nMAssay Description:Binding affinity to Hsp90 after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of HSP90 in Huntington's disease patient derived fibroblasts assessed as reduction of mHtt level after 48 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 6nM EC50: 40nMAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 6nM EC50: 6nMAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of HSP90-mediated client protein HER2 degradationMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of HSP90 in Huntington's disease patient derived fibroblasts assessed as reduction of mHtt level after 48 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of HSP90-mediated client protein HER2 degradationMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of HSP90-mediated client protein HER2 degradationMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of HSP90-mediated client protein HER2 degradationMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of HSP90-mediated client protein HER2 degradationMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of HSP90-mediated client protein HER2 degradation in human MCF7 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of Hsp90 in human A375 cells assessed as pS6 degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 7.40nMAssay Description:Binding affinity to Hsp90 after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.60nMAssay Description:Inhibition of Hsp90 in human MDA-MB-231 cells assessed as her2 degradationMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of Hsp90 in human AU565 cells assessed as pERK degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 8nM EC50: 70nMAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 8.60nMAssay Description:Binding affinity to Hsp90 after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 8.80nMAssay Description:Binding affinity to Hsp90 after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Concentration of test compound required for inhibition of binding of rHsp90 in MCF-7 cell lysateMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of HSP90 in human SKBR3 cells assessed as induction of Her2 degradationMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human HSP90 in HCT116 cells expressing Her2 gene assessed as degradation of Her2 after 4 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Binding affinity to Hsp90 after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Concentration of test compound required for half-maximal inhibition of binding of Heat shock 90 KD protein by MCF-7 cell lysate assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: <10nMAssay Description:Inhibition of HSP90 in human MDA-kb2 cells assessed as reduction in glucocorticoid receptor-dependent luciferase expression after 18 hrs by firefly l...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of HSP90-mediated pS6 phosphorylation in human A375 cells after 24 hrs by TRITC assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 11nM EC50: 65nMAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of Hsp90 in human AU565 cells assessed as pERK degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of HSP90 (unknown origin) assessed as HER2 degradation by cell-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of HSP90 (unknown origin) assessed as HER2 degradation by cell-based assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of HSP90-mediated client protein HER2 degradation in human MCF7 cellsMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
The University Of Notre Dame
Curated by ChEMBL
The University Of Notre Dame
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of HSP90-mediated client protein HER2 degradation in human MCF7 cellsMore data for this Ligand-Target Pair
