PrimarySearch

Found 9 hits affinity hit(s) for enzyme = 17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3) with UniProtKB: P42330
Target (Institution)	Ligand	Target Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	pH	Temp °C
17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3) Homo sapiens (human)	EM-1404 ((2R,15'S)-5,5,15'-trimethyl-6-oxospiro[oxane-2,14'...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PDB PubChem	PDB PubMed	6.900	-48.45	n/a	n/a	n/a	7.5	37
CHUL			CSLS PDB PubChem	PDB PubMed	J Biol Chem. 282: 8368-79 (2007)
17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3) Homo sapiens (human)	Flufenamic acid (2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid \|...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CSLS DrugBank KEGG PDB PubChem	B.MOAD DrugBank PDB PubMed	140.0	-39.77	n/a	n/a	n/a	7	30
The University of Birmingham			B.MOAD CSLS DrugBank KEGG PDB PubChem	B.MOAD DrugBank PDB PubMed	Cancer Res. 64: 1802-10 (2004)
17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3) Homo sapiens (human)	Indomethacin (2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS DrugBank KEGG PDB PubChem	PDB PubMed	270.0	-38.12	n/a	n/a	n/a	7	30
The University of Birmingham			CSLS DrugBank KEGG PDB PubChem	PDB PubMed	Cancer Res. 64: 1802-10 (2004)
17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3) Homo sapiens (human)	Indomethacin (2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS DrugBank KEGG PDB PubChem	PDB PubMed	2100	-32.95	n/a	n/a	n/a	7	30
The University of Birmingham			CSLS DrugBank KEGG PDB PubChem	PDB PubMed	Cancer Res. 64: 1802-10 (2004)
17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3) Homo sapiens (human)	Flufenamic acid (2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid \|...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CSLS DrugBank KEGG PDB PubChem	B.MOAD DrugBank PDB PubMed	3100	-31.96	n/a	n/a	n/a	7	30
The University of Birmingham			B.MOAD CSLS DrugBank KEGG PDB PubChem	B.MOAD DrugBank PDB PubMed	Cancer Res. 64: 1802-10 (2004)
17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3) Homo sapiens (human)	3,5-dichlorosalicylic acid (3,5-dichloro-2-hydroxybenzoic acid)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PDB PubChem	PDB PubMed	94000	-22.98	n/a	n/a	n/a	7.4	25
Monash University			CSLS PDB PubChem	PDB PubMed	J Med Chem. 51: 4844-8 (2008)
17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3) Homo sapiens (human)	EM-1404 ((2R,15'S)-5,5,15'-trimethyl-6-oxospiro[oxane-2,14'...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PDB PubChem	PDB PubMed	n/a	n/a	3.2	n/a	n/a	6	22
CHUL			CSLS PDB PubChem	PDB PubMed	J Biol Chem. 282: 8368-79 (2007)
17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3) Homo sapiens (human)	EM-1424 ((2R,15'S)-5'-(2-methoxyethoxy)-5,5,15'-trimethyl-6...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PubChem	PubMed	n/a	n/a	9.5	n/a	n/a	6	22
CHUL			PubChem	PubMed	J Biol Chem. 282: 8368-79 (2007)
17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3) Homo sapiens (human)	EM-1396 ((2R,15'S)-5'-(2-methoxyethoxy)-5,5,15'-trimethyl-6...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	13.0	n/a	n/a	6	22
CHUL			CSLS PubChem	PubMed	J Biol Chem. 282: 8368-79 (2007)

Reorder this table by ec50
Reorder this table by ic50
Reorder this table by kd
Reorder this table by pH
Reorder this table by T
Change energy unit to: kcal/mole