Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase BTK (Homo sapiens (human)) | BDBM206362![]() (US9260415, 113) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | 0.146 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Genentech, Inc. US Patent | Assay Description A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B... | US Patent US9260415 (2016) BindingDB Entry DOI: 10.7270/Q2WH2NT7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (human)) | BDBM206354![]() (US9260415, 105) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | 0.248 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Genentech, Inc. US Patent | Assay Description A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B... | US Patent US9260415 (2016) BindingDB Entry DOI: 10.7270/Q2WH2NT7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (human)) | BDBM50245852![]() (CHEMBL458333 | N3-(2,6-dimethylphenyl)-1-(3-methox...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Inhibition of BTK (unknown origin) | Bioorg Med Chem Lett 18: 6352-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.092 BindingDB Entry DOI: 10.7270/Q2B56JKZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (human)) | BDBM206355![]() (US9260415, 106) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | 0.306 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Genentech, Inc. US Patent | Assay Description A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B... | US Patent US9260415 (2016) BindingDB Entry DOI: 10.7270/Q2WH2NT7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (human)) | BDBM206360![]() (US9260415, 111) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | 0.494 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Genentech, Inc. US Patent | Assay Description A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B... | US Patent US9260415 (2016) BindingDB Entry DOI: 10.7270/Q2WH2NT7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (human)) | BDBM206366![]() (US9260415, 117) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | 0.576 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Genentech, Inc. US Patent | Assay Description A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B... | US Patent US9260415 (2016) BindingDB Entry DOI: 10.7270/Q2WH2NT7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (human)) | BDBM206356![]() (US9260415, 107) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | 0.612 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Genentech, Inc. US Patent | Assay Description A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B... | US Patent US9260415 (2016) BindingDB Entry DOI: 10.7270/Q2WH2NT7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (human)) | BDBM206359![]() (US9260415, 110) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | 0.683 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Genentech, Inc. US Patent | Assay Description A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B... | US Patent US9260415 (2016) BindingDB Entry DOI: 10.7270/Q2WH2NT7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (human)) | BDBM206350![]() (US9260415, 101) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | 0.792 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Genentech, Inc. US Patent | Assay Description A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B... | US Patent US9260415 (2016) BindingDB Entry DOI: 10.7270/Q2WH2NT7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (human)) | BDBM206351![]() (US9260415, 102) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | 0.864 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Genentech, Inc. US Patent | Assay Description A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B... | US Patent US9260415 (2016) BindingDB Entry DOI: 10.7270/Q2WH2NT7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (human)) | BDBM206363![]() (US9260415, 114) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | 0.888 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Genentech, Inc. US Patent | Assay Description A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B... | US Patent US9260415 (2016) BindingDB Entry DOI: 10.7270/Q2WH2NT7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (human)) | BDBM206353![]() (US9260415, 104) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | 0.915 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Genentech, Inc. US Patent | Assay Description A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B... | US Patent US9260415 (2016) BindingDB Entry DOI: 10.7270/Q2WH2NT7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (human)) | BDBM206367![]() (US9260415, 118) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Genentech, Inc. US Patent | Assay Description A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B... | US Patent US9260415 (2016) BindingDB Entry DOI: 10.7270/Q2WH2NT7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (human)) | BDBM206361![]() (US9260415, 112) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | 1.75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Genentech, Inc. US Patent | Assay Description A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B... | US Patent US9260415 (2016) BindingDB Entry DOI: 10.7270/Q2WH2NT7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (human)) | BDBM206364![]() (US9260415, 115) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | 2.16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Genentech, Inc. US Patent | Assay Description A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B... | US Patent US9260415 (2016) BindingDB Entry DOI: 10.7270/Q2WH2NT7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (human)) | BDBM206365![]() (US9260415, 116) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | 2.37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Genentech, Inc. US Patent | Assay Description A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B... | US Patent US9260415 (2016) BindingDB Entry DOI: 10.7270/Q2WH2NT7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (human)) | BDBM206357![]() (US9260415, 108) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | 2.57 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Genentech, Inc. US Patent | Assay Description A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B... | US Patent US9260415 (2016) BindingDB Entry DOI: 10.7270/Q2WH2NT7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (human)) | BDBM206358![]() (US9260415, 109) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | 4.33 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Genentech, Inc. US Patent | Assay Description A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B... | US Patent US9260415 (2016) BindingDB Entry DOI: 10.7270/Q2WH2NT7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (human)) | BDBM209866![]() (PF-06651600) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem | Article PubMed | 62.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Worldwide R&D | Assay Description Assay buffer was 20 mM HEPES, pH 7.5, 10 mM MgCl2, 0.01% BSA, 1 mM DTT, 0.0005% Tween 20, and 2% DMSO. Inactivation kinetic reactions were performed ... | ACS Chem Biol 11: 3442-3451 (2016) Article DOI: 10.1021/acschembio.6b00677 BindingDB Entry DOI: 10.7270/Q2PN94F8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (human)) | BDBM50245904![]() (CHEMBL459044 | N-(2,6-dimethylphenyl)-4-(2-ethoxyp...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | 78 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Inhibition of BTK (unknown origin) | Bioorg Med Chem Lett 18: 6352-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.092 BindingDB Entry DOI: 10.7270/Q2B56JKZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (human)) | BDBM50245853![]() (CHEMBL502156 | N3-(2,6-dimethylphenyl)-N6-(3-fluor...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 125 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Inhibition of BTK (unknown origin) | Bioorg Med Chem Lett 18: 6352-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.092 BindingDB Entry DOI: 10.7270/Q2B56JKZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (human)) | BDBM50341519![]() ((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals (Europe) Ltd. Curated by ChEMBL | Assay Description Inhibition of BTK | J Med Chem 54: 2341-50 (2011) Article DOI: 10.1021/jm101499u BindingDB Entry DOI: 10.7270/Q2KH0NPW | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (docked) |